LOCUS       NM_001136470            5363 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 49 (Usp49), mRNA.
ACCESSION   NM_001136470 XM_001064731 XM_236919
VERSION     NM_001136470.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5363)
  AUTHORS   Zhang,Z., Jones,A., Joo,H.Y., Zhou,D., Cao,Y., Chen,S.,
            Erdjument-Bromage,H., Renfrow,M., He,H., Tempst,P., Townes,T.M.,
            Giles,K.E., Ma,L. and Wang,H.
  TITLE     USP49 deubiquitinates histone H2B and regulates cotranscriptional
            pre-mRNA splicing
  JOURNAL   Genes Dev 27 (14), 1581-1595 (2013)
   PUBMED   23824326
REFERENCE   2  (bases 1 to 5363)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 5363)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Nov 1, 2008 this sequence version replaced
            XM_001064731.1, XM_236919.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643293.49033.1, SRR26360194.2180307.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               JAXUCZ010000009.1  20863321-20863667   c
            348-421             JAXUCZ010000009.1  20843964-20844037   c
            422-1796            JAXUCZ010000009.1  20816504-20817878   c
            1797-2001           JAXUCZ010000009.1  20815156-20815360   c
            2002-2110           JAXUCZ010000009.1  20810487-20810595   c
            2111-2316           JAXUCZ010000009.1  20809555-20809760   c
            2317-5363           JAXUCZ010000009.1  20805715-20808761   c
FEATURES             Location/Qualifiers
     source          1..5363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..5363
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /note="ubiquitin specific peptidase 49"
                     /db_xref="GeneID:316211"
                     /db_xref="RGD:1310513"
     exon            1..347
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /inference="alignment:Splign:2.1.0"
     exon            348..421
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /inference="alignment:Splign:2.1.0"
     exon            422..1796
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..2507
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thioesterase 49"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 49"
                     /protein_id="NP_001129942.1"
                     /db_xref="GeneID:316211"
                     /db_xref="RGD:1310513"
                     /translation="MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESAWACLKCSHV
                     ACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAV
                     RGQKQDLPARRGRTLRSTAAGEDVVPPQRTPQGQPQMLTALWYRRQRLLAKTLRLWFE
                     KSSRGRAQLEQRRQEEALERKKEAARQRRREVKRRLLEELASAPPRKSARLLLHAPGP
                     VAVRPATLATSRRMSAAALKPRRQLAVAPGVTGLRNLGNTCYMNSILQVLSHLQKFRE
                     CFLNLDPSTSEHLFPQATNGKAQIPSRPASSTAAGFSVRSDRAQGFEPQGFCWSSGAS
                     ISRSLELIQNKEPSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGY
                     DQQDAQEFLCELLHKVQQELESEGSTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQV
                     TCVSCNYKSNTIEPFWDLSLEFPERYHCVEKGFVPLNQTECLLTEMLAKFTETEALEG
                     RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGV
                     HVVFDQVLTMEPYCCGDMLSSLDKDTFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGGF
                     WVHCNDSKLDVCSVEEVCKTQAYILFYTRRTVQGSAKLSEPHLRAQVHSSSKDDRRTY
                     TFP"
     exon            1797..2001
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2110
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2316
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..5363
                     /gene="Usp49"
                     /gene_synonym="RGD1310513"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcaaggg agcctttctg tttcagaatg gactttatcc ctctcggaag tccttgaggc
       61 cactgccacc taggtctgat ttatttccca gtccctattt ggggagcgat gaaccttttc
      121 tagtcccgtc gaagaggatt tcgtaaaaca gctgaatgct gcctgagtca tcagtggcaa
      181 aagtccacac gtgtgtgttt gtctgggagc caagagtaac ttttgcaaaa cgctgtcgtc
      241 tcgagaacct ccaggttcgc tggctgctgc tacaccgtaa agaaaacaac aaaacataaa
      301 aatacgcgga agtggaaagg cctctttgga gcggtgagac acagaaggta acagagaaga
      361 ggcaaaccag ccagtgatta tgtgagaata tggaagacga tgggagcggc ttgttcaatg
      421 gattaagaaa gtggcgactg cgctaaaaca tggatagatg caaacatgta gggcggttac
      481 ggctcgccca ggatcactcc atcctgaacc cccagaagtg gtgctgtctg gagtgcgcca
      541 ccaccgagtc tgcgtgggct tgcctcaagt gctcccacgt ggcttgcggc cgctacattg
      601 aagaccatgc actaaaacac tttgaagaga ccggacaccc gctggccatg gaggtccggg
      661 atctctacgt gttctgctac ctgtgcaagg attacgtgct caatgacaac cccgaagggg
      721 acctgaagtt gctaagaagc tccctcctgg ctgttcgagg ccagaagcag gacctgcccg
      781 cgaggcgtgg gcggacgctg cggtccacag ctgcaggcga ggacgtggtc ccgccgcagc
      841 gtactcctca gggacagccg cagatgctca cggctctgtg gtaccggcgc cagcgcttgc
      901 tggccaagac gctgcggctc tggtttgaga agagctcccg cggccgtgcg cagctggagc
      961 agcggcggca ggaggaggcg ctggagcgta agaaggaggc ggcgcggcag cgacggcgcg
     1021 aggtcaagag gcggctgctg gaggagctgg ccagcgcgcc gccgcggaag agtgcgcgcc
     1081 tgctcctgca cgctcccggg cccgtggccg tgcgccctgc taccctcgct acctcccggc
     1141 gcatgtccgc tgctgccctc aagccgcgcc gtcagctggc ggtggccccg ggtgttactg
     1201 ggctgcgcaa cctgggtaac acctgctaca tgaactccat cctccaggtg ctcagccacc
     1261 tccagaagtt ccgggaatgt ttcctgaacc tcgacccctc cacctccgag cacctgtttc
     1321 cccaagcaac caacgggaag gctcagatcc ctagcaggcc agccagcagc actgccgcgg
     1381 ggttctcagt aaggagtgac cgggcccagg ggttcgaacc tcagggcttc tgctggagca
     1441 gcggagcctc catcagcagg agcctagagc tcattcagaa caaggaaccc agctcaaagc
     1501 acatttctct ctgccacgaa ctgcacaccc tcttccgagt catgtggtct gggaagtggg
     1561 cgctggtatc accctttgcc atgcttcact ccgtgtggag cctgattccc gccttccgag
     1621 gctacgatca gcaggatgcg caggaatttc tctgcgaact gctgcacaag gtacagcagg
     1681 agcttgagtc tgagggctcc acacgccgga tcctcatccc cttctcccag aggaagctca
     1741 ccaagcaggt cttaaaggtg gtgaacacta tatttcatgg gcagctgctc agtcaggtca
     1801 catgtgtatc atgcaattat aaatccaata ccattgagcc cttttgggat ctatccctgg
     1861 aatttcctga acgataccac tgcgtagaga aggggtttgt ccctttgaat cagacagagt
     1921 gcctgctcac tgaaatgcta gccaagttca ccgagacaga ggccctggag gggagaatct
     1981 acgcttgtga ccagtgtaac agcaaacgac gaaagtccaa ccccaaaccc cttgttctga
     2041 gtgaagctag gaagcagtta atgatctaca gactacctca ggtcctccgg ctacacctta
     2101 aaagattcag gtggtctggc cgtaaccatc gtgagaagat cggggtccat gtcgtctttg
     2161 atcaggtgtt aaccatggaa ccttactgct gcggggacat gctctcctcc cttgacaaag
     2221 acacctttgc ctatgacctc tccgcagtgg tcatgcatca cgggaaaggg tttggctcag
     2281 gacactacac agcctattgc tacaacacag agggaggttt ttgggtccac tgcaatgact
     2341 caaagctgga tgtatgcagt gtggaggaag tgtgcaaaac ccaggcctac attctttttt
     2401 acactcgaag aacagttcag ggcagcgcaa aactctcaga accccatctc cgagctcagg
     2461 tgcactccag cagcaaggac gatcgcagaa catacacatt tccctgactg ggaggcaagc
     2521 atcaaaatgg cctccagctc tcctctcggg aaataaggct tgccacagta acagattcct
     2581 ggggttgcca cactgggtct aggggagaaa tgccctgtga ttcctgctct gtcaaaaaat
     2641 tggtagttac tttcttgtga aaccatgcaa atccctcctt tcataaaaac aatctaaagg
     2701 agtagcttct atgaagattc ttttgtcaga tgcttctgga aaacagggac ctgggtagag
     2761 gagacggggt aagcgatgag ccagccatga gaacagtcat gtctgtctgt catgagtccc
     2821 ctattcatca ggccctcccc gaagcactgc acagagtaca tgagggcccc gggctgagag
     2881 ctggtggcaa agactggtcc caacacagaa ggtgaagtca caggagttat tcactctaag
     2941 aaggtaacca tcaagagtca tagcttgcag acttcatttc ttaggagaga acagttgaag
     3001 agtgaggggc atggagcccc tccatgccaa cgggaaggct gtctgtcata gcttgtcttc
     3061 tcctgagctg ttgtcacctt gtcactccac atggtgaagc tgagacttga gccatcccta
     3121 aggcagtcag gaggacacat agacctgtgt gtgcatggtc tgtgtgagct aagccatgga
     3181 cactcctgac ttccccagtc ctgtagcaag ggctgggctc agagtcatgg cttggtttgg
     3241 atcggttttt gtcagttgtc agaagctttc acagaatgca gtgagggtga gctgggcttg
     3301 tctgaatgac tgctgcccct aaggcctcac cttatgtgac atgaaggttc tcccctgccc
     3361 cttgcttccc tgtgtgtgag cagtgcttag ggatcggctg tgtggctgct gtggccctgg
     3421 cctgttctat cccagtgtgc tgttcttcac ccctgctgct ttggccacaa ggaatacagc
     3481 aagactgtct cttactctgg aatcagtaaa aacacatctc taaagtccac tccgtctctg
     3541 cgggaggagt gctcagagcc ttcctgtcag gcacagtaag cttcttcccc ttggcagtgg
     3601 cgactgcggt gccccacagc ctcccctgcg agtgctgtct tgattacgta gctcgtgttg
     3661 atgtctgcgt tcaggcagag cagttgtcac ttggtgggag ttgtaggggt ggggaacagg
     3721 atggggaggc tgaggaggca ccaccacacg tccaggcaca tctgtggtgt ttactgctgc
     3781 tctcctttga ggtgagctct cctgtaggcc tgccagacat cagcaacacg gaagaaatca
     3841 gacagaaagt ggctcatcct gacagggatg gcgtgctgga tttgaacttg ctttttaata
     3901 acactgtgag gtttctgtaa tatttagctt ttatttggaa gcgataacgt aaggcattgt
     3961 tgtgctgttt ggtttttact gcctatttca ggcttttttc tgagctttgc ttgggctcct
     4021 cctctcctgg gcactgtttt agggtgtccc ggctgcccac cctgcctgag gttctgatgt
     4081 aaagctgtac cccttcaggg aggtctacat tgctaagatg gctgatggtg atgatttgct
     4141 accgtggtag gaaagcccat tcgaaatcaa aacctgtgct gacacaccct gtaaggccag
     4201 cactcgttag gctgaggcag ggggatcatg aattcaaagc tccattgtga ggccctgttt
     4261 gaaaagcaaa atcaacaaac tatagagaat agaaaacaaa ggaagtaaga ctggactgca
     4321 cctcacctta aacctgtgtt gttttttcta gaaggagaac ctgtaggcag agaacacaga
     4381 cctgcctgtc tagggggaac acattagaag actcttactc agtttttaaa gatagtttta
     4441 tagcagctat cagcaggact ggtaagcaca ttagggactt cataaagctt aactgcccac
     4501 ccacctatga gattagtaaa atcgcttaaa gtaagtggga actgaaacca gcttctccac
     4561 tgagccaccc tcagggaggt ggacacctag cactggaagc agcagcgtga gggaggtaag
     4621 agtgtggtgc ttaaggagac ctctgctgca gaggagctat agggtccggg ctgctatgct
     4681 gcactgtcct ctgctctggt gcctgcacag ccaaagcaca gcactgtcag ctgcatcaca
     4741 gtgaaacatt ctaaaaagaa aggacagaca gatcttgact agctgactcc aggacaaacc
     4801 ctagtgctgc tctcccagct gcagtctcgg tctgtgaacc ctttgtaatt ggctggtgtg
     4861 tttacttact gctgtagcca gccaagacaa atatacccca gccctcaaaa atgacttctt
     4921 acctcagtct agcctggccc tcatgctgtg gttgcctctc agagcaggta ccatcactag
     4981 taccaagaca gcagggacac cttggcaccc agaaccgcag ctctcacccc agggcaggag
     5041 agcttttaga tgttgcttgg agcgtcaaga ataaaactgg aaactgtgga agagttactg
     5101 tgtcctatgg actcaatagc agagtttatt tttgttcaca gtggcaaggt ccatgattgt
     5161 atgaggtccc tgctctggct atgccttcag ctccatccac attcagggga agaaccaatg
     5221 aggtggactg gccagcagtg ccccgagtaa gccgagtcga tggtacagaa caaaaattga
     5281 ggggaggggg gatctgaaat ttgttttact gaaaaagctt tgtgaactaa ttttctacaa
     5341 ttgataaaat ttggtgcctt gta
//
