LOCUS       NM_198785               5706 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 48 (Usp48), mRNA.
ACCESSION   NM_198785 XM_342954
VERSION     NM_198785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5706)
  AUTHORS   Tian,Q.B., Okano,A., Nakayama,K., Miyazawa,S., Endo,S. and
            Suzuki,T.
  TITLE     A novel ubiquitin-specific protease, synUSP, is localized at the
            post-synaptic density and post-synaptic lipid raft
  JOURNAL   J Neurochem 87 (3), 665-675 (2003)
   PUBMED   14535949
  REMARK    GeneRIF: mRNA for synUSP was localized to dendrites as well as
            somas of neuronal cells; both mRNA and protein were localized in
            the post-synaptic compartments, suggesting a regulatory mechanism
            for the ubiquitin-related system at the post-synaptic sites
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_198785.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073880.1, SRR26360190.1927321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               JAXUCZ010000005.1  155084038-155084347
            311-431             JAXUCZ010000005.1  155093685-155093805
            432-588             JAXUCZ010000005.1  155095066-155095222
            589-716             JAXUCZ010000005.1  155096033-155096160
            717-841             JAXUCZ010000005.1  155097011-155097135
            842-950             JAXUCZ010000005.1  155097746-155097854
            951-1084            JAXUCZ010000005.1  155099401-155099534
            1085-1167           JAXUCZ010000005.1  155100424-155100506
            1168-1347           JAXUCZ010000005.1  155104912-155105091
            1348-1476           JAXUCZ010000005.1  155108154-155108282
            1477-1626           JAXUCZ010000005.1  155108817-155108966
            1627-1824           JAXUCZ010000005.1  155113141-155113338
            1825-1939           JAXUCZ010000005.1  155115017-155115131
            1940-2070           JAXUCZ010000005.1  155116867-155116997
            2071-2142           JAXUCZ010000005.1  155119524-155119595
            2143-2267           JAXUCZ010000005.1  155124799-155124923
            2268-2390           JAXUCZ010000005.1  155125025-155125147
            2391-2452           JAXUCZ010000005.1  155125492-155125553
            2453-2563           JAXUCZ010000005.1  155126447-155126557
            2564-2694           JAXUCZ010000005.1  155129199-155129329
            2695-2801           JAXUCZ010000005.1  155129618-155129724
            2802-2906           JAXUCZ010000005.1  155130662-155130766
            2907-3062           JAXUCZ010000005.1  155137046-155137201
            3063-3188           JAXUCZ010000005.1  155143136-155143261
            3189-3237           JAXUCZ010000005.1  155145672-155145720
            3238-3264           JAXUCZ010000005.1  155147937-155147963
            3265-5706           JAXUCZ010000005.1  155148767-155151208
FEATURES             Location/Qualifiers
     source          1..5706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5706
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /note="ubiquitin specific peptidase 48"
                     /db_xref="GeneID:362636"
                     /db_xref="RGD:735213"
     exon            1..310
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3287
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /EC_number="3.4.19.12"
                     /note="synaptic ubiquitin-specific protease; ubiquitin
                     thioesterase 48; deubiquitinating enzyme 48;
                     ubiquitin-specific-processing protease 48; ubiquitin
                     thiolesterase 48; ubiquitin specific protease 48;
                     ubiquitin specific protease 31; ubiquitin
                     carboxyl-terminal hydrolase 48-like"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 48"
                     /protein_id="NP_942080.2"
                     /db_xref="GeneID:362636"
                     /db_xref="RGD:735213"
                     /translation="MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVC
                     RRNCRGNPNCLVGIGEHIWLGEIDENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNT
                     FLQVWFLNLELRQALYLCPSTCSDYTKGDGIRGGKDYEPQTICEHLQYLFALLQNSNR
                     RYIDPSGFVKALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYA
                     YVTVCSQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSK
                     QNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSF
                     VYELSAVLIHRGVSAYSGHYIAHVKDPQSGDWYKFNDEDIEKMEGKKLQLGIEEDLAE
                     PSKSQTRKPKCGKGTHCSRNAYMLVYRLQTQEKNHTMVQVPAFLQELVDRDNSKFEEW
                     CVEMAEMRRQSVDKGRAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPID
                     NNACLCSHDKLHPDKISIMKRISEYAADIFYSRYGGGPRLTVKALCKDCVVERCRILR
                     LKNQLNEDYKTVNNLLKATMKGSDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKI
                     NGSPFSKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEAWSKLQQYFPK
                     APEFPSYKECCSQCKILEREGEENEALHKMIANEQKTSLPNLFQDKNRPCLSNWPEDT
                     DALYIVSHFFLDEWRKFVRKPARSTPVSSVGNAALLCPHGGLMFTFPSLTKEDSKLIA
                     LIWPSEWQMIQKLFVVDKVIKITRIEVGDVNPSQTQYISEPNLCPDCREGLLCQQQRD
                     LREYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPDGEKDPDFNQSNGG
                     TKRQKTSQQGYVAYQKQVIRRSTRHRKVRGEKALLVSANQTLKELKIQIMHAFSVAPF
                     DQNLSIDGKILNDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQVCMPEEGFKG
                     TGLLGH"
     exon            311..431
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            432..588
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            589..716
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            717..841
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            842..950
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1084
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1167
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1347
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1476
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1626
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1824
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1939
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2070
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2142
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2267
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2390
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2452
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2563
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2694
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2801
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2906
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3062
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3188
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3237
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3264
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..5706
                     /gene="Usp48"
                     /gene_synonym="synUSP; Usp31"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgggcgc gggcgggcgg gtgcggcggc tgtggcgcgc gcaggtgatt gactggtccc
       61 ttggctgagg ggagcgcttg gttctttcgg ctggcaggtg ccagtgcccg ttcgggcgga
      121 gacggaggcg gcgccggagg ccacccggct cggcgagtgc tatttcggtc aaggccatgg
      181 ctccgcggct gcagctagag aaggcggcct ggcgctgggc ggagacggtg cggcccgagg
      241 aggtgtcgca ggagcatatc gagaccgcct accgcatctg gctggagccc tgtatccgag
      301 gcgtgtgcag aagaaactgc agaggaaatc cgaattgctt agttgggatt ggcgagcaca
      361 tttggttagg agaaatagat gagaatagtt ttcataacat tgatgacccc aactgtgaga
      421 ggaggaaaaa gaattcgttt gtgggcctga ctaatctggg agccacctgt tacgtcaaca
      481 ccttcctcca ggtgtggttc ctcaacttgg agcttcggca ggcgctatac ttatgcccaa
      541 gcacctgtag tgattacacg aagggagatg gtatccgtgg aggaaaagat tatgagcctc
      601 agacaatttg tgagcatctt cagtacttgt ttgctttgtt gcaaaacagt aacagacgat
      661 acatcgatcc ttcaggattt gttaaagcct tgggcttgga cactggccag cagcaggatg
      721 cacaagagtt ttccaagctc tttatgtcgc tgttggaaga cactttgtct aaacagaaga
      781 acccggatgt tcggaacgtc gtgcagcagc agttctgtgg ggagtacgcc tatgtgacag
      841 tgtgcagtca gtgtggccga gagtctaagc tcgtatcgaa gttctatgaa ctggagttaa
      901 acatccaagg ccacaagcag ttaacagact gcatctccga gttcctgaag gaagaaaggt
      961 tagaaggaga caatcgatac ttctgtgaaa actgtcaaag caaacagaat gccacgcgga
     1021 aaatccgact tctgagcctc ccttgcactc tgaacttgca gctgatgcgt tttgtgtttg
     1081 accggcaaac tggacacaag aagaaactta atgcttatat tggcttctcg gagagcctag
     1141 atatggagcc atatgtggag cacaaaggcg ggtcctttgt gtacgagctc agcgcggtcc
     1201 tcatccacag aggagtcagt gcctattccg gccactacat cgcccacgtg aaagaccccc
     1261 agtctggaga ctggtacaag ttcaatgatg aggacataga gaagatggag gggaagaaac
     1321 tacagctagg gattgaggaa gatctagcag aaccttctaa gtcccagacc cgaaaaccca
     1381 agtgtggcaa aggaactcac tgctctcgaa atgcatacat gttggtttat agactgcaaa
     1441 cccaggaaaa gaaccacacg atggttcaag tcccagcctt tctccaagag ctggtggatc
     1501 gggataattc caaatttgaa gagtggtgtg tagaaatggc cgagatgcgc aggcagagtg
     1561 tggacaaggg cagagcgaag cacgaggagg tgaaggagct gtaccaaagg ttgcctgctg
     1621 gagctgagcc ctatgagttt gtctctcttg agtggctgca gaagtggctg gatgaatcaa
     1681 cccctaccaa acctattgat aataatgcct gcctgtgttc ccatgacaag ctccatccag
     1741 acaaaatatc aattatgaag agaatatcgg aatacgcagc tgacattttc tatagtcgat
     1801 atggaggagg tcccagactc actgtgaaag ccctctgtaa ggactgtgtt gtggagcgct
     1861 gtcgcatact gcgcctgaag aatcaactaa atgaagatta caaaactgtc aacaatttgc
     1921 tgaaagcaac aatgaagggc agtgatggat tttgggtagg aaagtcttcc ttgcgcagct
     1981 ggcgccagct ggctcttgag caactagatg agcaagacgg tgaggcggag caaagcaatg
     2041 gaaagataaa tgggagtccc ttcagtaaag atgaatcaaa ggaagaaaag aaggaagagg
     2101 aggaggaact aaattttaat gaagacattc tgtgtcctca tggagagtta agcatatctg
     2161 aaaatgaaag aaggctcgtt tctcaggagg cttggagcaa actgcagcag tatttcccaa
     2221 aggctcctga gttcccaagt tacaaagagt gctgctcgca atgcaagata ctagaacgag
     2281 aaggtgaaga aaatgaagcc ttgcataaaa tgattgcaaa tgagcaaaag acctcacttc
     2341 caaacttgtt ccaggacaaa aacagaccgt gcctcagtaa ctggccagag gacacggacg
     2401 ctctctatat tgtgtcgcac ttctttttag atgaatggcg gaaattcgtt aggaagcctg
     2461 cgaggtccac tcccgtgtcc tcagttggga acgctgccct tctctgtcca catggaggac
     2521 tcatgtttac atttccttcc ctcaccaaag aagactcgaa acttatagct ctcatatggc
     2581 ccagcgaatg gcaaatgatt caaaagctct ttgttgtgga taaagtaatt aaaatcacaa
     2641 gaattgaagt gggagacgta aacccttctc aaacacagta tatttctgag cctaatctct
     2701 gtccagattg cagagaaggt ctgctgtgcc agcagcagag ggaccttcga gagtataccc
     2761 aagccaccat ctatgtccac aaagttgtgg acaacaaaaa ggtgatgaag gactcagctc
     2821 cagagttgaa tgtgagtagt tctgagacgg aggaggacaa ggaggaagct aagccagacg
     2881 gagagaaaga ccctgacttt aatcaaagca atggaggtac caagcgacag aaaacatccc
     2941 aacagggcta tgtggcctac cagaagcaag tcatccggag gagcacgcgg caccggaagg
     3001 ttcggggaga gaaagcactg ctggtgtctg ccaaccagac gttaaaagaa ctgaagattc
     3061 agatcatgca tgcattctca gttgctccgt ttgaccagaa tttgtcaatt gatggaaaga
     3121 ttttaaatga tgactgtgct acccttggta ccctcggtgt cattcctgag tctgtcattt
     3181 tattaaaggc agatgagcca atcgcagact acgctgcaat ggatgatgtc atgcaagttt
     3241 gtatgccgga agagggcttt aaaggtacag gcctgcttgg acattaatct ttgaccactt
     3301 gttgactgcc aaggaatgac cagaaaggaa gatgaacttg acctgttagg gcattaaaga
     3361 aaatgtggat ttaagaatta aactcttacc tggctcttcc aaaaggcaaa aatccattca
     3421 aagagactgt cccaattgcc ttatgtcaaa taaagcagat tgcactggtg gacatcagac
     3481 ttgaaggaaa tgtttcaggt tttctattta gggtgggagg gagagggcga gagaggactg
     3541 agcaggcaga gtaaatcatg tttacacagg agggagtaaa gtcctggtca gtttcacaca
     3601 gatgtcctgg tcagtagtgg atttgtcaca gtacatgggc tagcatcctg ctccaaactc
     3661 tcaagtgact tgtctagaga cgcgacctgc taacccaccc tgtctttgac ctgtactcat
     3721 cttccaataa agcatgaaag tgaaggactt gccaacaagg aacgggtctt cagagcgcca
     3781 ctcccgcagg acagccacag ccctgcggcc tgctccgtgt ctgtcagttc tgggttgaaa
     3841 gcacccgtgt gctttccttg tcaagccagg gaccgtctca gtttatctcc atcattccag
     3901 aggtgatggg aaatgttcag caaagaaagt atccctgaac atttgaaaag ccggacagaa
     3961 gagtgaccgc ttgcctgaag ctccgtagga cagcacgggt ttttatagac aaccctccca
     4021 ttctccagtt cctctttcct cggacctcac ttctttctga aaaccattct tctgatacat
     4081 cctacagggg cattttgaaa ggaggaacaa aagactatac agggcgtgct gtctctccag
     4141 ctcaggatca cattgattag tctaagcatc aggatctgca ggaacagaaa ggctttagca
     4201 gagcatgcgg ctgggctggg cagatttgca ttgtctgtcg agtggatgtt ggtatgtttg
     4261 tggcccagtt gctcacacag atttttttgt tgttgttact tttttccttt taaatctcta
     4321 gtttaaaaac cttaactgat gtgtacaagc tgatctcaac attagcagca tcttttgata
     4381 gctttctgcc agtgcttatg gctgctgggt aaaactctga ttgtggtgtt taggattgca
     4441 atgaagagtg ttctctaggt ggtgagcagc gcagagcaga gccgggagag ctgcacaccg
     4501 tcctggagga gtactcacgg agctcctgcc tttggggaca cagggactca ggtgacacta
     4561 gttttcaggt ctgttcttta ctgagcacca cagatatggg accaagcctc actcaccaag
     4621 agcctactct ttcccagggc caagacaatt gaaaggtcgc caaatatttg acaagtgacc
     4681 tttattgtcc ttacaaagaa acccggagct tgaggctgtg tgacaaagcg ttggtaggac
     4741 ctctgcaccc ctaaaaggtg ctggggataa gtggcaaaaa gctgtgtgca ccccctcccc
     4801 cgtccccctt cttgggattg taagtgcaca agccagaagt tagcactgtg agattgtttg
     4861 cataggcatc ttttgtttcc tttgcataat attagcaaag taatagccat tgactcttgt
     4921 caggcaaatg caggtggggc agacccagtg tcagcaaccc agtgtctgcc gcttccgcct
     4981 cgacagcagt cgcccatcgc ccactgcaga gccttattgg aacttcagct cagaccccgc
     5041 acccaccgaa cacggccact cccgaaaagc ttgggacccc tgggctgcgg cctcctcaca
     5101 gcttgaagca gacaaatttc caagtatcca cgtggactta gcagctgcca tgccctgctt
     5161 tctaatccgt gctgtttggt tgtcttctga actgtggtgg ctctacagca caggctagct
     5221 cttggttcta aagccacatc cagaaaccgc actaaaccag attatgaatc tccaggcttc
     5281 tttatgtttc ttttgtcttt cccagacagg gtctcctgta acccaggctg gcctcagact
     5341 cactatgtaa ccaggataac cttaacttcc cacttcctcc tcccaggtgc tgggattgca
     5401 ggctcgtggc cactgtgaca ggtttcctgt gctgtgtgga ggcccgaacc catggtttcg
     5461 tgcacactag acaagcgttc tgcacactga cccatgtccc cagctctacc catgtatatt
     5521 tctaatcatt ctttaatccc aagcaaacgt ggagtctcct atgctgagtc cattaccaga
     5581 ctgtaggtta tcatttgatg tctttattcc ctgagagaaa cctcttctgt atttatgaac
     5641 ttgattattg agaatcactg ttaatctttc tgccaaatta aagacaccca tgtctgtttc
     5701 cacgga
//
