LOCUS       NM_001107542            5691 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 47 (Usp47), mRNA.
ACCESSION   NM_001107542 XM_001074180 XM_001074204 XM_218997
VERSION     NM_001107542.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5691)
  AUTHORS   Xiao Q, Tang Y, Xia J, Luo H, Yu M, Chen S, Wang W, Pu L, Wang L,
            Li G and Li Y.
  TITLE     Ubiquitin-specific protease 47 is associated with vascular
            calcification in chronic kidney disease by regulating osteogenic
            transdifferentiation of vascular smooth muscle cells
  JOURNAL   Ren Fail 44 (1), 752-766 (2022)
   PUBMED   35509185
  REMARK    GeneRIF: Ubiquitin-specific protease 47 is associated with vascular
            calcification in chronic kidney disease by regulating osteogenic
            transdifferentiation of vascular smooth muscle cells.
REFERENCE   2  (bases 1 to 5691)
  AUTHORS   Hu Y, Ma Z, Chen Z and Chen B.
  TITLE     USP47 promotes apoptosis in rat myocardial cells after
            ischemia/reperfusion injury via NF-kappaB activation
  JOURNAL   Biotechnol Appl Biochem 68 (4), 841-848 (2021)
   PUBMED   32761659
  REMARK    GeneRIF: USP47 promotes apoptosis in rat myocardial cells after
            ischemia/reperfusion injury via NF-kappaB activation.
REFERENCE   3  (bases 1 to 5691)
  AUTHORS   Shi J, Liu Y, Xu X, Zhang W, Yu T, Jia J and Liu C.
  TITLE     Deubiquitinase USP47/UBP64E Regulates beta-Catenin Ubiquitination
            and Degradation and Plays a Positive Role in Wnt Signaling
  JOURNAL   Mol Cell Biol 35 (19), 3301-3311 (2015)
   PUBMED   26169834
REFERENCE   4  (bases 1 to 5691)
  AUTHORS   Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM
            and Dianov GL.
  TITLE     USP47 is a deubiquitylating enzyme that regulates base excision
            repair by controlling steady-state levels of DNA polymerase beta
  JOURNAL   Mol Cell 41 (5), 609-615 (2011)
   PUBMED   21362556
REFERENCE   5  (bases 1 to 5691)
  AUTHORS   Peschiaroli A, Skaar JR, Pagano M and Melino G.
  TITLE     The ubiquitin-specific protease USP47 is a novel beta-TRCP
            interactor regulating cell survival
  JOURNAL   Oncogene 29 (9), 1384-1393 (2010)
   PUBMED   19966869
REFERENCE   6  (bases 1 to 5691)
  AUTHORS   Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske
            WA, Morin D, Penn SG, Jovanovich SB, Plopper CG and Buckpitt AR.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166609.1, EV771677.1, CV106232.1, CA512624.1, CO571839.1,
            CF109520.1 and CB325126.1.
            
            On May 29, 2008 this sequence version replaced NM_001107542.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2081              BC166609.1         1-2081
            2082-2670           EV771677.1         190-778
            2671-3061           CV106232.1         310-700
            3062-3704           CA512624.1         81-723
            3705-4271           CO571839.1         72-638
            4272-5303           CF109520.1         479-1510
            5304-5691           CB325126.1         1-388               c
FEATURES             Location/Qualifiers
     source          1..5691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..5691
                     /gene="Usp47"
                     /note="ubiquitin specific peptidase 47"
                     /db_xref="GeneID:308896"
                     /db_xref="RGD:1310411"
     exon            1..401
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..4430
                     /gene="Usp47"
                     /note="ubiquitin specific protease 47"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 47"
                     /protein_id="NP_001101012.2"
                     /db_xref="GeneID:308896"
                     /db_xref="RGD:1310411"
                     /translation="MVPGEENQLVPKEIENAAEEPRVLCIIQDTTNSKTVNERITVNL
                     PASTPVRKLFEDVANKVGYINGTFDLTWGNGINTADLAPLDHTSDKSLLDANFEPGKK
                     NFLHLTDKDGEQPQMLLDDSSHVDDSVHDRFIGPLPREGSVASTSDYVSQSYSYSSIL
                     NKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQR
                     LFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADL
                     INELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPE
                     ILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFP
                     EELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESST
                     GSEKISKPGLEKNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRIT
                     QEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLV
                     QKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKM
                     MDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKP
                     DQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVLEFKQLISKATHLPAEPM
                     RIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRH
                     ANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERAKGPAGSLKSVDAILEES
                     TEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSD
                     PENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITS
                     SRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKADPYTADEGSGEGHK
                     WLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDN
                     KITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQ
                     CGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQ
                     LAILTRRWRPSEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCD
                     ISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKES
                     SRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD"
     exon            402..605
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            606..719
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            720..858
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            859..955
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1101
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1181
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1331
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1427
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1580
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1748
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1880
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1957
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2013
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2126
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2231
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2439
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2555
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2675
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..3453
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3629
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3710
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3826
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            3827..3945
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4076
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4124
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4255
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..5673
                     /gene="Usp47"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggcagag caagaggtga gaagatcccg agctcgccac ggcagcacac gttcctcagg
       61 ccaggcgccg ggccgcgcgc ccactgagct gaattctcgc gagagcggca gccgccattt
      121 ttccattgat tgccgcgggc cgggggaggg gcggcggcgg cggcggcagc agcagcggcg
      181 gcgccctggg tcggtgtctg cgcgctggtg tctaaggcct gagcggaggc ctccgcagtt
      241 gctggagcgc aggcggctgg gaggatgact accactgcca ttctttcctg agacgcagag
      301 ccaccgccac ctccacccgt cctccgcagg ctgggcggag acgagcggtc ggagtctgag
      361 cgatggtgcc cggcgaggag aaccaactgg tcccgaagga gatagaaaat gctgctgaag
      421 aacctagagt cttatgtata atacaggaca ctactaactc aaagacagtg aatgaacgga
      481 tcacagtgaa tttaccagca tctaccccag tcagaaagct ctttgaagat gtggccaaca
      541 aagtaggcta cataaacgga acctttgatt tgacatgggg aaatggaatc aatactgctg
      601 atttggcacc actggatcac accagtgaca agtctcttct tgatgctaat tttgagccag
      661 gaaagaagaa ctttctgcat ttgacagata aagatggaga acagcctcag atgctattgg
      721 atgactccag tcacgtggac gacagcgtgc atgacaggtt tataggtcca cttccaagag
      781 aagggtctgt ggcttctacc agtgattatg tcagccagag ctactcctat tcatcaattt
      841 tgaacaagtc agaaactggt tatgtgggat tagtaaacca ggcgatgacg tgctatttga
      901 atagcctttt gcaaacactt tttatgactc ctgaatttag gaatgcctta tataagtggg
      961 agtttgaaga gtctgaagaa gatcctgtaa cgagcatccc ataccagctt cagaggcttt
     1021 ttgttctgtt acaaaccagc aaaaagagag caattgagac cacagatgtc acaaggagct
     1081 ttggatggga tagcagtgag gcttggcaac agcatgatgt acaagaactg tgccgtgtta
     1141 tgtttgatgc tttggaacag aaatggaagc aaacagaaca ggctgatctt ataaatgagc
     1201 tgtaccaagg caaactgaaa gactatgtga ggtgtctgga atgcggttat gaaggctgga
     1261 gaattgacac gtaccttgat attccactgg tcatccgacc ttatgggtct agccaagcat
     1321 ttgccagtgt ggaagaagca ttgcatgcat ttattcaacc agagatcttg gatggcccaa
     1381 atcaatactt ctgtgaacgt tgtaagaaga agtgcgatgc tcgtaagggc cttcggtttt
     1441 tgcactttcc ctatctgctg actttacagt tgaaaaggtt tgattttgat tatacaacca
     1501 tgcatagaat taaactgaat gatcgaatgt catttccaga ggagctggat atgagcacat
     1561 ttattgatat tgaagatgag aaatctcctc agactgaaag ttgcactgat agtggagcgg
     1621 aaaatgaagg cagttgccac agcgaccaga tgagcaatga tttctccacg gatgatgctg
     1681 ttgatgaagg gatatgcctg gagagcagta ctgggagtga gaagatttca aaacctggcc
     1741 tggaaaagaa ctccctgatg tatgagctct tctcggtgat ggtacattca gggagtgctg
     1801 ctgggggaca ctattatgct tgcataaagt ctttcagcga cgatcagtgg tacagtttca
     1861 atgaccaaca tgtgagcagg ataacacaag aagacattaa gaagacacac ggtgggtctt
     1921 caggaagcag aggctactac tccagtgctt ttgcaagctc aacaaatgca tatatgctga
     1981 tatacagact gaaggatcca acaagaaatg caaaatttct ggaagtggat gagtacccag
     2041 aacacattaa gaacctggtg cagaaggaga gagaattgga agaacaggaa aagaggcaac
     2101 gagaaattga acgaaacaca tgcaagataa aattattctg tttacatcct gtgaaacaag
     2161 taatgatgga aaacaagttg gaggttcata aggacaagac attaaaggaa gcagtagaaa
     2221 tggcttataa gatgatggat ttagaagacg tgattccctt ggattgctgt cgcctggtaa
     2281 aatatgatga gtttcatgat tacctggaac gatcctatga gggagaagaa gatacgccaa
     2341 tggggctgct tctaggagga gtcaagtcaa cgtacatgtt tgatctgctg ttggagacaa
     2401 gaaagcctga tcaaattttt cagtcttata aacctggaga agtgatggtg aaagttcatg
     2461 ttgtcgatct gaaggcagag actgtcgctg ctcctgtaac agtgcgtgct tatttaaatc
     2521 agacagtttt ggagttcaaa cagctgatct caaaggccac acacttacct gcagaaccca
     2581 tgaggatcgt gctggagcgc tgctacaacg acctgcgcct gctcagcatg cccagcaaga
     2641 ccctgaaggc tgagggcttc tttagaagta acaaggtgtt tgttgaaagc tctgagacag
     2701 tagatcacca ggcagccttc acagactccc acttgtggaa actcctggat cgacatgcaa
     2761 atacaatccg gttatttgtt ttgctgcctg aacaatctcc agggtcttat tcgaaaagga
     2821 cagcatacca gaaagctgga ggggattctg gtaatgtgga cgatgactgt gaaagagcca
     2881 agggacctgc aggaagttta aagtctgtgg atgccattct agaagagagc actgaaaaac
     2941 tcaaaagcct gtcactgcag cagcagcagg atggggacaa cggagacagc agcaaaagca
     3001 ctgagacaag tgactttgag aatattgaat cccctctcaa tgagaggggc tcttccacct
     3061 ctgtggataa tcgagaactt gaacaacaca ttcagacttc tgacccagaa aactttcagt
     3121 ctgaagaacg ctcagactca gatgtgaata atgaccggag tacaagttcg gtagacagcg
     3181 atattcttag ctctagtcac agcagcgaca ctttgtgcaa tgcagacagc gctcagattc
     3241 ctttggccaa tggactcgat tctcacagta tcacaagtag tagaagaact aaggcaaacg
     3301 aagggaaaaa ggagacatgg gacacagctg aagaagactc tgggactgac agtgaatatg
     3361 atgagagtgg caagagcagg ggggagatgc agtacatgta cttcaaagct gacccctaca
     3421 ctgcggacga aggctctggg gaaggacaca aatggttgat ggtgcatgtt gataagagaa
     3481 tcaccctggc agctttcaaa cagcatttag agccttttgt tggagtcctc tcctctcact
     3541 tcaaggtttt tcgagtgtac accagcaatc aagagtttga gaccgtccgg ttgaatgaga
     3601 ccctttcatc attttcagat gacaataaga tcacaatccg actggggaga gcactgaaga
     3661 agggagagta cagagttaaa gtgtgccagc tcttagtcaa tgagcaagag ccatgcaagt
     3721 ttctgctaga cgccgtattt gctaaaggca tgactgtgcg gcaatcgaaa gaggagctga
     3781 ttcctcaact cagggagcag tgtggcttag acctcagcat cgacaggttt cgtctaagga
     3841 agaaaacatg gaagaatcct ggcactgttt ttttggatta tcatatttat gaagaagata
     3901 ttaatatttc tagcaactgg gaagttttcc tggaagttct tgatggtgtg gagaagatga
     3961 agtccatgtc acagcttgcc attttaacca gacggtggag gccttcggag atgaagttgg
     4021 atcccttcca ggagcttgtg ttggagagca atagtgttga tgagcttcga gagaagctga
     4081 gtgaaatcag tgggattcct ttggaagaca ttgaatttgc caagggtagg ggaaccttcc
     4141 cctgtgatat ttctgtcctt gatattcatc aagatttgga ctggaaccct aaagtctcta
     4201 ccttgaatgt gtggcctctt tatatctgtg atgatggtgc cgtcatattt tatagggata
     4261 gaacagaaga agtaatggaa ttgacagatg agcaaaggaa tgaactgatg aaaaaggaaa
     4321 gcagccgact gcagaagacg ggacatcgtg tgacatactc ccctcgcaaa gagaaagcac
     4381 tcaagatcta cctggatggg gcgccaaata aagacgtagc tcaagactga ccgccagtgc
     4441 agcctttccc ctgagggctc tttaagtaga tggttcacta ctgctgggta gtgccatttt
     4501 ggccggacat ggtttggtaa ccccatgaca ccagcactga ttggaccgcc cttcaccaat
     4561 cagaagctca gtgcccagtg ggccactgtc ttgacttgga atcatgttgt gcactatggt
     4621 cagatgtact gtaaagccaa ggatgtgcaa gagaaacaag caaagcctgc tactatgaag
     4681 ggagggggac aagtagattc attgattgcg gacaaatgtg cacatagccg ctagtaaaac
     4741 tagcctcaaa caggatgctc atagcttaat aataaaagct gtgcaaaggc catgaatgaa
     4801 tgaatcttct gtttatttca ttgatacaca cattacctca ttgacagttc tgaagcaaat
     4861 gcaactgtgt tgacttttga aaagcagcaa agaggagtgg aaggagttgt tagaaccagc
     4921 gtagcccaca gaggaattag gaaggtgtgt tattttgttt gactttttgc aaagtattaa
     4981 gaaccttagg gagacagccc aacatctgtg tccttgggcc atgcccagta gttgtgctca
     5041 gctgctacag gtttgtgact agaaccaact gtaagctgtg gatatagaga atgtctcctt
     5101 ccttcactcg gcgtgtaaat acagcggccc tgttgagttc tcccggctgc agctctgctg
     5161 tctgccaagg ctctttgcct ctcatccgtc atgcacattg tgtaccctga agcctagcag
     5221 tccgtctgtg tactcctcat tgaacgccat aggatgtatt tgcttgttaa tgagggttct
     5281 ctgttcagta gcttcaagat cttttctctg tacatttatt ttcaaagaat tgcttcaagt
     5341 ttgagtcttc tagaatgcct gtaaagtccc gttttaattt ttaagagtca gtttgtagtt
     5401 ctgtagttta acttggggaa ccatctgccc atcgtatgga atagtttctc gggggccttg
     5461 gtgcagacct ggtgccacat gattcatcgc agagtgcgct ggagtcagca ggctgcttct
     5521 gctctgccaa gtacagtgtc aaagagtaga attccaaata aactttgaaa tactatctaa
     5581 tttataaaag tcaataaaag gttttggtaa aattttttca tgcaagatgc tgtttacaac
     5641 actgaacatg ccaataaaac atttgttcat gttaaaaaaa aaaaaaaaaa a
//
