LOCUS       NM_001395561            8521 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 45 (Usp45), mRNA.
ACCESSION   NM_001395561 XM_006237938
VERSION     NM_001395561.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8521)
  AUTHORS   Yi,Z., Ouyang,J., Sun,W., Xiao,X., Li,S., Jia,X., Wang,P. and
            Zhang,Q.
  TITLE     Biallelic mutations in USP45, encoding a deubiquitinating enzyme,
            are associated with Leber congenital amaurosis
  JOURNAL   J Med Genet 56 (5), 325-331 (2019)
   PUBMED   30573563
REFERENCE   2  (bases 1 to 8521)
  AUTHORS   Perez-Oliva,A.B., Lachaud,C., Szyniarowski,P., Munoz,I.,
            Macartney,T., Hickson,I., Rouse,J. and Alessi,D.R.
  TITLE     USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA
            damage responses
  JOURNAL   EMBO J 34 (3), 326-343 (2015)
   PUBMED   25538220
REFERENCE   3  (bases 1 to 8521)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jul 19, 2021 this sequence version replaced XM_006237938.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.26660.1,
                                           SRR26643292.21100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000005.1  40115409-40115465
            58-167              JAXUCZ010000005.1  40118530-40118639
            168-340             JAXUCZ010000005.1  40121339-40121511
            341-444             JAXUCZ010000005.1  40122769-40122872
            445-545             JAXUCZ010000005.1  40124556-40124656
            546-688             JAXUCZ010000005.1  40137290-40137432
            689-784             JAXUCZ010000005.1  40137804-40137899
            785-915             JAXUCZ010000005.1  40138989-40139119
            916-1003            JAXUCZ010000005.1  40145956-40146043
            1004-1085           JAXUCZ010000005.1  40161634-40161715
            1086-1177           JAXUCZ010000005.1  40165790-40165881
            1178-1234           JAXUCZ010000005.1  40167349-40167405
            1235-1378           JAXUCZ010000005.1  40167857-40168000
            1379-2039           JAXUCZ010000005.1  40173265-40173925
            2040-2137           JAXUCZ010000005.1  40175194-40175291
            2138-2224           JAXUCZ010000005.1  40179198-40179284
            2225-2378           JAXUCZ010000005.1  40180915-40181068
            2379-8521           JAXUCZ010000005.1  40182719-40188861
FEATURES             Location/Qualifiers
     source          1..8521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..8521
                     /gene="Usp45"
                     /note="ubiquitin specific peptidase 45"
                     /db_xref="GeneID:313098"
                     /db_xref="RGD:1310976"
     exon            1..57
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            58..167
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2509
                     /gene="Usp45"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 45; ubiquitin specific
                     petidase 45"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 45"
                     /protein_id="NP_001382490.1"
                     /db_xref="GeneID:313098"
                     /db_xref="RGD:1310976"
                     /translation="MRVKDPSKDLPEKGKRSKRPLLPHDEDSSDDIAVGLTCQHISYA
                     VSVNHVKKAVAETLWSVCSECLKERRLCDGQPVLPSDVWLCLKCGFQGCGKNSESQHS
                     LRHFKSSGAESHCVVISLSTWVIWCYECNEKLSTHCNKKVLAQIVDFLQKHVFKTQTD
                     AFSRIIKLCEEKREAGEIKKGKKGCAVPSVKGITNLGNTCFFNAVIQNLAQTYILFEL
                     MNEIKEDGTKFKISLSSAPQLEPLVVELSSPGPLTSALFLFLHSMKEAEKGPLSPKVL
                     FNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQASILKAFNNPTTKTADEET
                     RKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEERVSK
                     PVLLGKMSKCRSLQETDQDHNKGTVTVENTHPPRAAKKHSSPKDKTLLSHDRKHLRKW
                     PSEEERTVGTHPNSENSEASPLAGILSNEASLNESPTEGSERDTSLESSVDADSEASE
                     PEVAYKPSVLLRSSGDPGAHGEQHPHLPLASELPHTKETHDCDEEMAEAMAELHLSGT
                     VTGNRDFHREKQPLNVPNNVCFSEGKHTKLHSAQNAFQTLSQSYVTTSKECSVQSCLY
                     QFTSMELLMGNNKLLCEDCTEKKRKCQKETSSAERKAGGVYTNARKQLLISAVPAILI
                     LHLKRFHQAGLSLRKVNRHVDFPLTLDLAPFCAATCKNISVGEKVLYGLYGIVEHSGS
                     MRGGHYTAYVKVRVPSRKLSECITGRKTAPGLKEADSELGGHWVHVSDTYVQVVPESR
                     ALSAQAYLLFYERIL"
     exon            168..340
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            341..444
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            445..545
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            546..688
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            689..784
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            785..915
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1003
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1085
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1177
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1234
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1378
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..2039
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2137
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2224
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2378
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..8521
                     /gene="Usp45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccctctgca caggcgcaga agctcctgcg tgtggaagct gcggcccggc gggcggggaa
       61 ataacagatg cgggtaaaag atccatccaa agatctacct gagaaaggca aaagaagtaa
      121 aagaccactg ctacctcacg atgaagattc ttcagatgac attgctgtag gtttaacatg
      181 ccagcacatc agttatgctg tcagtgtgaa ccatgtgaag aaggcagtag ctgagactct
      241 ctggtcagtt tgttcagagt gtttgaaaga gagaagactc tgtgatggac agccggtact
      301 tccttccgat gtttggttgt gcctcaagtg cggttttcag ggatgcggta agaactcaga
      361 aagccagcat tcactgagac acttcaagag ctctggggcg gagtcccatt gtgttgtcat
      421 tagcctgagc acatgggtca tatggtgtta tgaatgtaat gaaaaattat cgacacattg
      481 caacaagaaa gttttggctc agatagttga ttttctccag aaacatgttt ttaaaacaca
      541 aacagatgca ttttctagaa tcataaaact ttgtgaagaa aaacgtgaag caggggaaat
      601 aaagaagggg aagaaaggct gtgctgtgcc atctgtcaaa ggaattacaa acttaggaaa
      661 tacttgcttt tttaatgccg tcatccagaa cttggctcag acttacattc tttttgaact
      721 gatgaacgag ataaaagaag atggcaccaa attcaagatt tctctttcgt cagctccaca
      781 gctggagccg ttagtggtgg aactttcaag ccctggacca ttgacttcag ccttgttcct
      841 gtttcttcac agcatgaagg aagctgaaaa aggaccactt tctcctaaag ttcttttcaa
      901 tcagctctgt cagaaggctc ctcgatttaa aggtttccag caacaggaca gccaggagct
      961 tctgcaccat ttgttggatg cagtgaggac agaggagaca aagaggatac aagctagcat
     1021 tctaaaagcg ttcaacaatc caactaccaa gactgctgat gaggaaacta gaaaaaaagt
     1081 caaagcctat ggaaaggaag gcgtgaagat gaacttcata gatcggatct tcattggcga
     1141 attaactagc acagtcatgt gtgaagaatg tgctaacatc tctaccatga aggatccctt
     1201 catagatatt tcacttccta tcatagaaga aagggtttca aaacctgtac ttttggggaa
     1261 aatgagtaaa tgcagaagtt tacaggaaac agaccaagat cataacaagg gcaccgttac
     1321 agtagaaaat acccatccac caagagctgc caagaagcat tcctcaccta aagataagac
     1381 tctgctaagt catgacagaa aacatttaag aaaatggccg tctgaagaag agagaactgt
     1441 tggtacacat ccgaacagtg aaaactcgga agccagccct ttggccggca tcctcagcaa
     1501 tgaggcatcg ctgaacgaaa gccccactga gggcagtgag agagacacca gcctagaaag
     1561 cagtgtggat gcggacagcg aggcttctga acccgaggtg gcttacaagc cgtctgtgct
     1621 gctccgatcc agtggtgatc ccggcgcgca cggggaacag cacccacacc tcccactggc
     1681 aagtgaattg ccacacacca aggagacgca cgactgcgat gaggaaatgg cggaagcgat
     1741 ggctgagctt catttgagcg gcactgtaac tggaaataga gattttcaca gggaaaaaca
     1801 gccactaaat gtcccaaata atgtgtgttt ttcagaggga aaacatacga agcttcacag
     1861 tgcccaaaat gcttttcaga ctctttctca gagctatgta actacttcta aagaatgctc
     1921 agttcagtcc tgtctctacc agttcacatc catggagtta ctaatgggca acaacaagct
     1981 gctctgtgag gactgcactg aaaagaaacg gaagtgccaa aaggaaacca gttctgcaga
     2041 aaggaaggca ggaggagttt atactaatgc caggaagcaa ctactcatat ctgctgttcc
     2101 agctatccta atccttcatc ttaaaaggtt ccaccaggct ggcttgagtc ttcgtaaagt
     2161 aaacagacat gtagacttcc cgcttaccct tgacttagca ccgttctgtg ctgctacctg
     2221 taagaatata agtgtggggg agaaggttct ctatggtctc tacggtatag tggagcacag
     2281 cggctcaatg agaggaggcc actacactgc ttacgtgaag gtgcgagtgc cctccaggaa
     2341 gctgtccgag tgcatcaccg ggaggaagac tgcaccaggt ttgaaagaag ctgatagtga
     2401 attgggaggc cactgggtcc atgtcagcga cacttatgtg caagtggttc cagaatcaag
     2461 agcactgagt gcgcaagctt atctcctttt ttatgaaaga atattataat tatctgttaa
     2521 ttgttattta gttcattttt attttaatgc tgaagtcgta actgtaatat gtaatgtgcc
     2581 tttgtagtct gtagaaatag tgcgtccttc cagtgttact taactttgtc gatatgcagt
     2641 gaatccttta aagaaattaa ttaatgtgac aggcagttgt ggtgctcgcc tttattccag
     2701 cacttggaag gcagaggcag gcagatctgt gaaaaacctt gtcttgaaaa ataaaacaaa
     2761 aaagtaatta atgctttcaa atctatattc ttaagtgtag aaacatgttt tatgttaatt
     2821 ttcatgtcca tggagattgc cactcaccac caaaaaaaaa aagaaaagaa agaaaaagtt
     2881 gatggtagtg gagagatccc cttcgcgacg tgactcgtca ctacagacat tcagagacga
     2941 tgctggatcg ggtctctagt ggatccttct cgagtggacg cagtgtatct tgtgcttact
     3001 tttgttttag ccttttacaa tctcggccct gttttgaatc actcttcaca tttctctgtg
     3061 cgtgtcattt ttctagtaaa cattggtgta agtttataac tatgaaagaa aaattgccca
     3121 tccttgcacc accccactta aaatcatctc agggctttgc agtggttggt gtgtgtgtta
     3181 gtcgatggga aaagtttcta gaacagtctg aactagtgcc taatgtaaca taataatttt
     3241 ttcatatttt atgtgactca gtagtatgaa aaggaaccat tgtaattttg gtactgtgag
     3301 tttacaagta ataaattgat tcgcttatcg ccttgaatat ttgaagatat tgagacattt
     3361 cataaactaa tcatttgcaa tcctttaaag acagtttgca agtgattggt taaggccaaa
     3421 ataaaaatat agagaatttt gacacataga actagcatat agaagttggt ggtctatata
     3481 ggaacatagg atactttaaa gtttaaggat gtctttgaac tataaactac caaactatat
     3541 ttatgagtgg tagaaatcat attcttataa ttaacaacaa atataatact ttttttactt
     3601 ctgtacatta ataaatgtta aatatggttt tgtcttcata agcattattt gaaaagacag
     3661 gtggctagtt ggggatgtag ttcaatggca gagaacttgc ttggcctgtg taaggtcctg
     3721 gttccatccc cagacacacg aataaaacat tcaggtcaat ttggctttga ctttaatggg
     3781 gcacagagct gctacttctg ttccctttaa atacgtagaa acacaggaga gtttctcctt
     3841 ccaaaattca aagaattgaa ctgtgaaaac ttagcatgaa aaatattact acgaagattt
     3901 taaataatca atgaaatggt tcagtgatac atagtattaa agcaagatgt aagggaacgg
     3961 gtccagcgtc ttagtcttca gtgcctgtgt ttgattcaat gggcaaatgt aggggagaga
     4021 ggctgtaagc tgtacagacc tttagccagc gtcgagcctt cttggcatgt gtaacataag
     4081 gtcaccttat gatgatgcct cttaatatgc ggcggctagg tgaaactgat ttgtctaatg
     4141 gagaaatttt aaaataccat ggcataactt ctatttttaa gttgcagagg aattttcaat
     4201 agtattttaa agattttttt gtattgaaga taaagaacta tattttatct gtagagccca
     4261 gttgtgtcct ctaaaaagaa ctttccagtg tcttctgttt catcagacat tcagagttta
     4321 ttaatctatt gacacgaaat agtctagcac cagagcaatg agctagaaaa atttgctcaa
     4381 gtcggcttct cattcatagc agttgcccca ccaaacaaat gtaaatagtt aacctttttt
     4441 tctctctctc ctagaaaaga tactattaag aggtgtacag tctaggcagg ttccaatacc
     4501 tggcatatga cagtatttta tcacccttta aaacagaaaa acctgccgag ggtggtggtg
     4561 cacgcctcag actcagcact cgggaggcag aggcaggtgc atttgagttc cagggcaccc
     4621 aaggctacac agagaaaccc tgtctcaaaa cacttgaaga gaaaagaagc accctaaaat
     4681 ctatatatga tttttataca ttatcctagt agtgacgtgc agataaaatg ttcatttatt
     4741 acctagtgct aaggagattc tgaaatgcat ttttatgacc taaagtttgt tttttcttgc
     4801 catctaaaaa tggagaaaaa tggtttgatt ttgataccta ggagtttcct atcaagctta
     4861 tgttgtagat aaaaatcaca cagatgtaca cttaaatttt tgttcttatt ttgaagtttt
     4921 ccaaagcaca tttgtagaaa ttttaaattg cgaggctact gtactaacaa tagtttccag
     4981 attacctcag gaaacagtgc aaataaacaa gaatgtttac agatcaacaa aactactcgg
     5041 tgttttggca cagtgaattt gaaaggtaaa agagagaagt ttttatccag aaactggttt
     5101 acagggtaaa cccaattctc ccctggctct cccgtattta aaatgatgtg ccaattatgt
     5161 gaatgtttgt gacataaaca aatgtacatc tatatttaag atttattgtt taatgtttta
     5221 aaaaataata tgaagactgc ttctgtaggt agtcaaggag atgatcatcg tagcagctca
     5281 gagtcgtata tcaacagagc tattttacca tatctaataa tccttagctt gcatgtgtga
     5341 ttcattagtg attttataca gtagttgaat aaaattttct gaagacttag ctgtgaaatg
     5401 tcaccgcaca tcaaattttt tagtacacaa tagcatcctg cctactttca tgaactttat
     5461 actcagcata tttttctgca tgacatctgg tccaataaac cttaaccaag tctgtgcact
     5521 aaaaccaagc tttcagagag catccattgc attattggag aaattatttc tgtactaaac
     5581 tggttttgtt catgtagaaa tcatcagttc aactgtgttt aaaagatgat tatttttggg
     5641 tatcaataat aaattcctag tatcattcct tctcttttat ccaattttac agtattttaa
     5701 aaatatctat gtaacttatt gatcattatt tggccattgc tgtatatata aacatcctaa
     5761 taaatatgaa attcttatgt tagcagatta ggcctggagc tttgcattat acattattga
     5821 caggatatta ataaacattg tgttcatatc tattttagtc ccctggcttt ctataaacaa
     5881 aatataattt aagaagctta tgaacaacaa aaatttattt cctttacttt tagcaaccag
     5941 gaagctcaag acaaagacaa acagatccat tttccaaatg aggctctggt gatcctctct
     6001 gagcgttcac ctggttacta gggaaaggga gcagtagggt cgcctttatg agggcttcac
     6061 gtcagaacct aatcactttc taaatactcc agtcacagaa ctctcacctg gggagcttgc
     6121 gaatgggaca caaacattta gctcacagtg accttcaagt ttcaggaatg cgctatttaa
     6181 aaaaaaacct tgtcaccaac ccgatgctgg agattgtatc tagtagttct tccacccagc
     6241 tacattctca gtccagaaac caaacagacc tgtcagctat ttccctgaaa ggtttgagtt
     6301 acttagatag gattgtacac taagaaatat gttgtctaca tgtctgcttc tttaactttt
     6361 ttagagccat gaagcttcca gagattttga ggaaagttag atatttttct tttagagtgt
     6421 ataaagatgg gtttattgct cttgggcagg ttctgatccc aagagtgagg ccagggaagt
     6481 tgccataggg agggagacag aagggaggta gatgagaaag agaaagagtg tgtgcattca
     6541 gggaaaggaa aagcacagaa ggagaggggt agggggagag ggagaaagtt acatacttaa
     6601 catttttatt tgatcattta acaagtgttt gttgaatacc tgctctttgc ttggcattag
     6661 ggatatagca gtgaatgcaa gaaatcactc aagaagaaga ctgtcaagtg agtgtactgg
     6721 tcttcgtttc agtttctttt gctgtgatga aacatcataa ccacaagcaa ctaggagagg
     6781 agaaggttta tttcatttac atttgcatat cacagaggga gtgggggcag gatgtgatgc
     6841 agaggctggg gagtgctgct tactggctta ctctccatgt tgtctccagt tggctttcta
     6901 aagaaccaaa gtccaggcca ggggtagcat cactcacaat gctctggaac cttccacatc
     6961 aatcacttat ttgacagtgc ccaaaagact tgcctagagc cccatctaat agaggcattt
     7021 tctcaattga ggctcctttc tctcctctga atctagctgt gtcaagttga cataaaacta
     7081 gctggcacat aaggggaaaa aaaacccaaa taatactgct tacgtgctgt tgggagtaac
     7141 acctagcaaa gaaggatgtt ccagtgaggc acagaactta tgggatatct atatagtaag
     7201 tattaaggga atttattgta aggacttata gtcttcagtc caactaaccc aacagtgggc
     7261 agccatgaat aggaactcca ggaatctagt agttgctcag tcccacgagg ctggttgttt
     7321 cagctggaat cctgtgtaaa ctggaatcct aaagaagtag gttccggcag atgtgctggc
     7381 aagtagtgca cacaggaaaa gaagagcgag tcttcttctt ccattggcct tatgtaggcc
     7441 tccagcagaa ggtgtcactg agatacatag atgtatcacc atgcctggat ttggagcttt
     7501 ctttgtccca cgttggcctt gaactcagag atctggttac ctcgatctcc tgtttttaag
     7561 gtcatgtact accttgcctg gtcctaagct tttcatggcc actatacctc aagatctgga
     7621 tcaaaagcat gtgtcattta aagtgagata tgggtcagaa gcccatgttc tccagcctca
     7681 agatctggat gacaggtttg acctccattt ctggattgta gttcattcca gttgtagtca
     7741 agtcgacaac caggaatagc catcacaaca gatacgatag tacctaccaa agaaagctaa
     7801 gagagaagaa tgagccttaa tcgtagggcc ctctcctgca acagaagccg agaagagaaa
     7861 tcttgatatt tgtcctcaga aaaacattat ttgtcaaata tttgttgttt tagaagtttg
     7921 tgagtttcct gaaagcattt tcatatgttt caaggattac acccaagcag aaaaactcaa
     7981 aatgtgtgca aatagcatgt attttctaat gatttatttt acttttatgt actttgccat
     8041 tttgcttgat tgtgtgtctg tctgtgtgaa ggtgttggat ctcctggaac tatagagcta
     8101 gttgtaagct gccctgtggg tactgggatt gaacttgggc cctctggaag cccagccagt
     8161 gctcttaacc actgaattgt gacaaggacc ttagttggcc ccaggacctt agcacaactg
     8221 agttaatgat ggagtagtat cacatgagta atacaattca gcatgtaaac aatctcacct
     8281 cccaaaacaa aggcctaatc tatcaaaatc cgtaattctt ggaaagtctg tcagtgtact
     8341 aaccttgctg tttggctttt gtaggtctgc ttcatgctgt tttgttttct gatatttgtc
     8401 aacccagaac atagtttttg tgcttaaaag ctccccctga gaaagaatca gggctacact
     8461 ggcatgccaa accccaagtg tggtctctca tgggttatta aagattttct attgacttaa
     8521 a
//
