LOCUS       NM_001394071            2771 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 44 (Usp44),
            transcript variant 1, mRNA.
ACCESSION   NM_001394071
VERSION     NM_001394071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2771)
  AUTHORS   Belle,J.I. and Nijnik,A.
  TITLE     H2A-DUBbing the mammalian epigenome: expanding frontiers for
            histone H2A deubiquitinating enzymes in cell biology and physiology
  JOURNAL   Int J Biochem Cell Biol 50, 161-174 (2014)
   PUBMED   24647359
  REMARK    Review article
REFERENCE   2  (bases 1 to 2771)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   3  (bases 1 to 2771)
  AUTHORS   Zhang,Y., Foreman,O., Wigle,D.A., Kosari,F., Vasmatzis,G.,
            Salisbury,J.L., van Deursen,J. and Galardy,P.J.
  TITLE     USP44 regulates centrosome positioning to prevent aneuploidy and
            suppress tumorigenesis
  JOURNAL   J Clin Invest 122 (12), 4362-4374 (2012)
   PUBMED   23187126
REFERENCE   4  (bases 1 to 2771)
  AUTHORS   Zhang,Y., van Deursen,J. and Galardy,P.J.
  TITLE     Overexpression of ubiquitin specific protease 44 (USP44) induces
            chromosomal instability and is frequently observed in human T-cell
            leukemia
  JOURNAL   PLoS One 6 (8), e23389 (2011)
   PUBMED   21853124
REFERENCE   5  (bases 1 to 2771)
  AUTHORS   Suresh,B., Ramakrishna,S., Lee,H.J., Choi,J.H., Kim,J.Y., Ahn,W.S.
            and Baek,K.H.
  TITLE     K48- and K63-linked polyubiquitination of deubiquitinating enzyme
            USP44
  JOURNAL   Cell Biol Int 34 (8), 799-808 (2010)
   PUBMED   20402667
REFERENCE   6  (bases 1 to 2771)
  AUTHORS   Stegmeier,F., Rape,M., Draviam,V.M., Nalepa,G., Sowa,M.E.,
            Ang,X.L., McDonald,E.R. 3rd, Li,M.Z., Hannon,G.J., Sorger,P.K.,
            Kirschner,M.W., Harper,J.W. and Elledge,S.J.
  TITLE     Anaphase initiation is regulated by antagonistic ubiquitination and
            deubiquitination activities
  JOURNAL   Nature 446 (7138), 876-881 (2007)
   PUBMED   17443180
REFERENCE   7  (bases 1 to 2771)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 31, 2022 this sequence version replaced NM_001394071.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1094143.1,
                                           SRR26360181.2794536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000007.1  30251205-30251286
            83-143              JAXUCZ010000007.1  30262870-30262930
            144-217             JAXUCZ010000007.1  30282187-30282260
            218-1727            JAXUCZ010000007.1  30283697-30285206
            1728-1923           JAXUCZ010000007.1  30288396-30288591
            1924-2032           JAXUCZ010000007.1  30290397-30290505
            2033-2238           JAXUCZ010000007.1  30295591-30295796
            2239-2771           JAXUCZ010000007.1  30296703-30297235
FEATURES             Location/Qualifiers
     source          1..2771
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2771
                     /gene="Usp44"
                     /note="ubiquitin specific peptidase 44"
                     /db_xref="GeneID:314746"
                     /db_xref="RGD:1308216"
     exon            1..82
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
     exon            83..143
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
     exon            144..217
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
     exon            218..1727
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2441
                     /gene="Usp44"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thiolesterase 44; ubiquitin specific
                     protease 44"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 44"
                     /protein_id="NP_001381000.1"
                     /db_xref="GeneID:314746"
                     /db_xref="RGD:1308216"
                     /translation="MDRCKHIEQLQLAQGHSILNPQKWFCMVCNTTESIWACLSCSHV
                     ACGQYIQEHALKHFEESSHPVAFEVNDMYVFCYLCNDYVLNDNTAGDLKSLRSTLSAI
                     KGKSYPCVVQSDSVLQPVNAQADSYSLHDSTQSLPGSEDPMCTALWHRRRALMGKTFR
                     TWFEQSPIGRKRQEQTQEKTVAKREVKRRQQELEQQMKAELECTPPRKSLRLQGLSEA
                     ATVEILPVQAPPPPPASPAKEKALALPPSEDGKLKRVSDSLIKRRPAVTPGVTGLRNL
                     GNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAVAASDKARSYKHSAVTDAATAAAHQ
                     LNEGQEKEKGFACSRHPGLSSGLSGGASKGRNMELIQPREPSSPYSSLCHELHTLFQV
                     MWSGEWALVSPFAMLHSVWKLIPAFRGYAQQDAQEFLCELLDKIQRELETTGTKLPAL
                     IPTSQRRLIEQVLNVVNNIFHGQLLSQVTCLACNNKSNTIEPFWDLSLEFPERYQCSG
                     KDAASQPCLVTDMLGKFTETEALEGKIYVCDHCNSKRRKFSSKPVVLTEAQKQLMICH
                     LPQVLRLHLKRFRWSGRNNREKIGVHVVFEETLNMEPYCCSETLNALRPECFIYNLSA
                     VVIHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKLSMCTMEEVLRAQAYILFYTQRVTE
                     NGHSRLLPPELLSNSQQHPSEETDTSSNEVLS"
     exon            1728..1923
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2032
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2238
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2771
                     /gene="Usp44"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccaaaat ggaaagcttt ggatgaagag agcctgccgt ggtgagaagt cagaggattc
       61 agaaaggctg gtatgaggac agtggcttca gcatgatcca ctcagcttaa ttttaaaccg
      121 aagccgtcac ctggtaaatt ctgaattctt tgctgacttt atattgccca tagacaattt
      181 ggggagtgat gcagaccgag aatcctccaa gacccagttt tcagatgctc cccgtgttgt
      241 gaagagaggc ccgactggat tatgtgtttt tcagacagac tagatccctg ctaacaatgg
      301 ataggtgcaa gcacattgag cagctgcagc ttgctcaagg acattccatc ctcaaccctc
      361 agaaatggtt ctgcatggtc tgcaatacaa cggagtccat ttgggcttgc ctcagctgtt
      421 cccacgtcgc ctgtgggcag tatatccaag agcacgcact gaagcacttt gaagaaagca
      481 gccatcccgt ggcctttgag gtgaatgaca tgtatgtttt ttgttatctt tgtaacgatt
      541 atgtcctaaa cgataacaca gccggagatc tgaagtcact acgaagtaca ctaagtgcaa
      601 tcaaaggtaa aagttaccct tgtgtggttc agagtgactc ggtcttacag cctgtgaatg
      661 cgcaggccga ttcttactcc ctacacgaca gcacccagtc tctgcctgga agtgaagatc
      721 cgatgtgcac tgccctctgg cacaggagac gtgcgctcat gggaaaaacc tttcgaactt
      781 ggtttgaaca gtcaccgatt ggaaggaaaa ggcaagagca aactcaggag aaaacggtag
      841 ccaagagaga ggtgaagaga aggcagcagg agttagaaca gcagatgaaa gctgagctgg
      901 aatgcactcc tccgcgaaag agtttacgct tacaaggcct ctccgaggcg gccacggtcg
      961 aaatccttcc ggtgcaggca ccgccgccac ctccagcgtc cccagcgaag gagaaagcct
     1021 tagcgctacc tccctcggaa gacgggaaac ttaaaagagt aagtgactcc ttaatcaaac
     1081 gaaggcccgc ggtaactcct ggtgtaaccg gactgagaaa tttaggaaat acttgctata
     1141 tgaattctgt tcttcaagtg ttgagtcatt tactcatttt tcgacaatgt tttttaaagc
     1201 ttgacctgaa ccaatggctg gctgtggctg ccagcgataa agcccgatcc tataagcact
     1261 cagccgtcac ggatgccgcg acagcggcgg cacatcagct gaacgaaggg caagagaagg
     1321 agaaaggctt cgcgtgctcc agacacccgg gtttatcttc aggcctaagc ggaggagcct
     1381 ccaaaggtcg gaacatggag ctcattcagc caagggagcc cagttccccg tacagttctc
     1441 tctgccatga attgcacacc ctgttccaag tcatgtggtc cggagagtgg gccctggtct
     1501 cgccgtttgc catgcttcac tcagtgtgga agctgatccc tgctttccgt ggttacgccc
     1561 agcaagatgc gcaggaattt ctttgtgaac ttctggataa gatacagcga gaactagaga
     1621 caaccggaac caaattacca gctctcatcc ccacctccca aaggaggctc attgagcaag
     1681 ttctgaacgt cgtaaataac atttttcacg gacaactact tagtcaggtt acctgccttg
     1741 cttgcaacaa caaatccaat actatagagc cgttctggga cttgtcactg gaattcccag
     1801 agagatacca atgcagtggg aaagacgctg cctcgcagcc atgtctggtc actgatatgt
     1861 tgggcaagtt tacagaaaca gaagctttag aagggaaaat ctacgtgtgt gaccattgta
     1921 actcaaagcg tagaaagttt tcgtcaaaac cagttgtact cacagaagcc cagaaacagc
     1981 tcatgatatg ccacctccct caggttctca gactgcacct caagcgattc agatggtcag
     2041 gacgtaataa ccgagagaag attggtgttc atgttgtctt tgaggaaacc ttaaacatgg
     2101 agccctattg ctgcagtgag accctgaacg ctctcagacc agagtgcttt atctataatt
     2161 tatctgctgt cgtaatccac catggaaaag gatttggctc aggacactac actgcctact
     2221 gctacaattc tgaaggaggg ttctgggtac actgcaacga ctccaagcta agcatgtgca
     2281 ctatggaaga agtgctcagg gcccaggctt atatcttatt ctatacccag cgagtgactg
     2341 agaacggaca ttcgagactc ttgcctcctg agctcctgtc caacagccag cagcacccca
     2401 gtgaagaaac ggacacctct tctaatgaag tcctcagctg atccagaccg tgggctctcg
     2461 ttatttgtat atatactttt taaatgggct gacctacgat gctgggcttc attgttttta
     2521 ttctgtaatt atgatcagtg cctgctgttt acacattgtg tatttaacta caaagttttt
     2581 ctttttttac agagacaaac tataaatata tgtatatcaa ctataggcca actaaaactt
     2641 ttttcaaata tttgagtttt atacttttag tgtttacctc aatattatta cctcttatat
     2701 tttgatgtct taattgcctc aaatcatgaa tttgtgcaat ctactaaaga aattcaggtg
     2761 gcatcctttt a
//
