LOCUS       NM_001107069            4263 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 36 (Usp36), mRNA.
ACCESSION   NM_001107069 XM_001081749 XM_221143
VERSION     NM_001107069.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4263)
  AUTHORS   Fraile,J.M., Campos-Iglesias,D., Rodriguez,F., Astudillo,A.,
            Vilarrasa-Blasi,R., Verdaguer-Dot,N., Prado,M.A., Paulo,J.A.,
            Gygi,S.P., Martin-Subero,J.I., Freije,J.M.P. and Lopez-Otin,C.
  TITLE     Loss of the deubiquitinase USP36 destabilizes the RNA helicase
            DHX33 and causes preimplantation lethality in mice
  JOURNAL   J Biol Chem 293 (6), 2183-2194 (2018)
   PUBMED   29273634
REFERENCE   2  (bases 1 to 4263)
  AUTHORS   DeVine,T., Sears,R.C. and Dai,M.S.
  TITLE     The ubiquitin-specific protease USP36 is a conserved histone H2B
            deubiquitinase
  JOURNAL   Biochem Biophys Res Commun 495 (3), 2363-2368 (2018)
   PUBMED   29274341
REFERENCE   3  (bases 1 to 4263)
  AUTHORS   Anta,B., Martin-Rodriguez,C., Gomis-Perez,C., Calvo,L.,
            Lopez-Benito,S., Calderon-Garcia,A.A., Vicente-Garcia,C.,
            Villarroel,A. and Arevalo,J.C.
  TITLE     Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor
            Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions
            over the Neurotrophin Receptor TrkA and Potassium Voltage-gated
            Channels 7.2/3 (Kv7.2/3)
  JOURNAL   J Biol Chem 291 (36), 19132-19145 (2016)
   PUBMED   27445338
  REMARK    GeneRIF: USP36 actions extend beyond TrkA because the presence of
            USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
REFERENCE   4  (bases 1 to 4263)
  AUTHORS   Sun,X.X., He,X., Yin,L., Komada,M., Sears,R.C. and Dai,M.S.
  TITLE     The nucleolar ubiquitin-specific protease USP36 deubiquitinates and
            stabilizes c-Myc
  JOURNAL   Proc Natl Acad Sci U S A 112 (12), 3734-3739 (2015)
   PUBMED   25775507
REFERENCE   5  (bases 1 to 4263)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   6  (bases 1 to 4263)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 4263)
  AUTHORS   Taillebourg,E., Gregoire,I., Viargues,P., Jacomin,A.C.,
            Thevenon,D., Faure,M. and Fauvarque,M.O.
  TITLE     The deubiquitinating enzyme USP36 controls selective autophagy
            activation by ubiquitinated proteins
  JOURNAL   Autophagy 8 (5), 767-779 (2012)
   PUBMED   22622177
REFERENCE   8  (bases 1 to 4263)
  AUTHORS   Endo,A., Matsumoto,M., Inada,T., Yamamoto,A., Nakayama,K.I.,
            Kitamura,N. and Komada,M.
  TITLE     Nucleolar structure and function are regulated by the
            deubiquitylating enzyme USP36
  JOURNAL   J Cell Sci 122 (Pt 5), 678-686 (2009)
   PUBMED   19208757
REFERENCE   9  (bases 1 to 4263)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221143.4, XM_001081749.1.
FEATURES             Location/Qualifiers
     source          1..4263
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..4263
                     /gene="Usp36"
                     /note="ubiquitin specific peptidase 36"
                     /db_xref="GeneID:303700"
                     /db_xref="RGD:1309937"
     exon            1..290
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            291..472
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            473..734
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..3499
                     /gene="Usp36"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 36"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 36"
                     /protein_id="NP_001100539.1"
                     /db_xref="GeneID:303700"
                     /db_xref="RGD:1309937"
                     /translation="MPIVDKLKEALKPGRKDSAEDGDLGKLLAASAKKVLLQRIEFEP
                     ASKSFSYQLESLKSKYVLLNPKAEGAGRHRSGDEPQARKPGTERMSGSGGDGVPAPQK
                     VLFPVERLSLRWERVFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKEHARSCH
                     QGSFCMLCVMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTID
                     AMQKACLNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCRSVSDTYDPYLDIALEIR
                     QAANIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFSIHRTSNVLTLSLKRFANF
                     SGGKITKDVGYPEFLNIRPYMSQSSGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNG
                     QWYQMNDSLVHSSNVKVVLSQQAYVLFYLRIPGSKKSPEGPVSRVGATLPSRPKVIPE
                     HPKKSPGNGVVSSPLMAKRQDSLMMRKLQSPEEVGMPVSRNGSISGLKLQNGCAPAKS
                     PAGSPSPRLAPTPTHMPTILDEPGEKVKKSAPPQSRTTSPTASQGFPGTGESRSQRPG
                     SWASRDSIFSTSPKLAKAITNGHRLKGEGNGVDLEKGDSSSSSPEHSASSDAAKAPQT
                     SEGRAAHVCDSQGTNCPATGHSKVLSNGVDAKMGKLKSPALSSTTTEPTSLMSPPPAK
                     KLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASPGPVSKTRAAAAPA
                     PQPSPHPHSASLSSSSAKPLGTSEPQSCCSSAWTPLPQVNGHFTSHLHQLPEANEALH
                     SPSRKRKKTPSGDPQRLGRDTHLPQCLEGAPATARRKKRKKKKDLEGVGDTATQQESQ
                     SQDQPWSPRGRKEEGTQLQVNGHQVSHILDSYHASSRKRRKRKRSEGLSQEATVCQDL
                     LQHGCSPADHWLGRAPLVTWNRDQEPDVVQELLQDSSDTAYGKKVLTWDGEPSAISQD
                     AMKDSRLARTQTVVDDWDEEFDRGKKKGENSAP"
     exon            735..956
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1067
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1170
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1238
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1309
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1392
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1504
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1645
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1746
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1885
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2551
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2682
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..3234
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3254
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3356
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3472
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..4263
                     /gene="Usp36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctcttaa agcgaccgcg ccctccatgc ggactccggg aagcaccccg cagtgccgct
       61 cctttaaacg tcttggtgac acgtgtgtga ggctctgaag gcccggatgg tgcgcatgct
      121 ggcccggccc ggagcgtacg ctggtgctgc gcgggccttc cgcgggttcc cgagaggcct
      181 aggaggtcga ggtcgggcgc ggcggaacgc aggaactttc gaggggcttg ggacgaggag
      241 ggtgtacgct cctggccgcg ggttttggga actccagcga aggctgacag gtgctgacct
      301 atttttgact ctacacttgg cagtgttggc gactgggcag gctggcagtg ttggctactg
      361 ggcaagctga agttcaggag agcgcctgcc aggtcagttc cgtgccaccc ttgagaacct
      421 ggtcccctta cctgctgcag agagaagcag cagccaggct caggcacccc aggcatgcac
      481 catgcccatc gtggataagc tgaaggaggc tctaaagcct ggccgcaagg actcggcaga
      541 ggatggggac ctgggcaagc tgctggcggc ctccgccaag aaggtcctcc tgcagaggat
      601 tgagtttgaa ccggccagca agagcttctc ttaccagctg gagtccttga agagcaaata
      661 tgtactgttg aaccccaagg ctgagggtgc cgggcgccac aggagcggag atgagccaca
      721 ggccaggaaa ccaggcaccg agcgcatgtc tggaagtgga ggcgatggag tccctgcccc
      781 acagaaagtg ctcttccctg tggagcgact gtccttgagg tgggaacgcg tattccgagt
      841 tggtgctggg ctgcacaacc tgggtaacac ctgcttcctg aactccacca ttcagtgctt
      901 gacttacacg ccacctctgg ccaactactt gctctccaag gagcacgcac ggagctgtca
      961 ccaaggaagc ttctgcatgc tgtgcgtcat gcagaaccac atggtccagg cctttgccaa
     1021 cagtggcaat gccatcaagc ctgtctcctt catcagagac ctgaaaaaga ttgcccggca
     1081 cttccgattt gggaaccaag aggatgcaca tgaattcctg cggtacacca tcgacgccat
     1141 gcagaaggcc tgcttgaatg gctatgctaa gttggatcgg cagacacagg ctactaccct
     1201 ggtgcatcag atctttggag gctatctcag gtcccgagtg aagtgttccg tgtgcagaag
     1261 cgtctcagac acatacgacc cctacttgga catagcgctg gagattcggc aagctgcaaa
     1321 tattgtgcgt gctctggaac tttttgtgaa atcagatgtc ctgagtggag agaacgccta
     1381 tatgtgtgct aagtgtaaga agaaggttcc agctagcaag cgcttcagca tccatagaac
     1441 atccaatgtc ctgactctgt ccctcaagcg ctttgccaac ttcagtgggg ggaagatcac
     1501 caaggatgtt ggctatccag agttcctgaa catccgtcca tacatgtcgc agagcagtgg
     1561 agaccctgtc atgtatgggc tctatgctgt tctggtgcac tcaggctaca gctgccacgc
     1621 ggggcactac tactgctacg tgaaggccag caatggacag tggtaccaga tgaacgactc
     1681 cttggtccat tccagcaatg tcaaggtggt tctgagccag caggcctacg tgctcttcta
     1741 tctgcggatt ccaggctcta agaaaagtcc tgagggccct gtctccaggg tgggtgccac
     1801 tcttcctagc cgtcccaagg tcattccaga gcaccccaag aagagccctg gcaatggggt
     1861 tgtttcctcc ccactgatgg caaagcgaca agactctcta atgatgagaa agttgcagtc
     1921 ccctgaggag gttggcatgc ctgtgtccag aaatggctcc atttctggtc tgaagttaca
     1981 gaatggatgt gctcctgcaa agtcacctgc cgggtccccc tccccgagac tcgctccgac
     2041 acccacacat atgcccacca ttctggacga gcctggggag aaggtgaaga agtcagcccc
     2101 gccacagtct cgcaccacgt ccccaactgc ttctcagggc tttcctggga ccggcgagtc
     2161 caggagccag cggcctggct cctgggcgag cagagacagc atcttctcta cctcaccaaa
     2221 gctggccaaa gccattacta acgggcacag gctgaagggg gaaggcaatg gtgtggacct
     2281 ggagaagggg gattccagca gctcgagccc cgagcactct gccagcagtg acgctgccaa
     2341 ggccccgcag acctcagagg gcagagctgc acatgtctgt gattctcagg gaacaaactg
     2401 cccagccact ggccattcaa aagtgctgtc gaacggagtc gatgccaaga tggggaagtt
     2461 gaagtcccct gccctgagca gcaccaccac cgagcccaca agcctcatgt cgcctccacc
     2521 agccaaaaaa ctggccctgt cagccaagaa ggccagcacc ctgcggaggg cgaccggcaa
     2581 tgacatcggt tcaccttccc cctcagcatt ctgcgatctc acctccccca tgaaagccac
     2641 ccaccccgtc gttgcctccc ctgggcctgt cagtaaaacc agggctgctg ccgcacctgc
     2701 tccccaaccg tctccccacc cccactctgc atcactgtcc agtagtagcg ccaagccctt
     2761 agggacatca gagccacaga gctgctgctc ctctgcctgg acacccctgc ctcaggtcaa
     2821 tggacacttc acgtcccact tacaccaact gccagaggcc aatgaggccc tacacagccc
     2881 ctccagaaag aggaagaaga ctcctagtgg agatccccag agactgggca gagacacaca
     2941 cctcccacag tgcctcgagg gagcacctgc aacagcacgc aggaagaaga ggaagaagaa
     3001 gaaggacctg gagggtgtgg gcgacacagc tacccagcag gaaagccagt ctcaggacca
     3061 gccttggagt cccaggggcc ggaaggaaga gggtacgcag cttcaggtaa atggccatca
     3121 agtgagtcac atcctggaca gttaccatgc gagcagcagg aaaaggagga agagaaaaag
     3181 atcagaaggg ctcagccaag aagccaccgt gtgccaggac ctacttcagc atggctgctc
     3241 ccctgcagac cactggctgg gacgggcacc tcttgttacc tggaacagag atcaagaacc
     3301 ggatgtggtc caggagttgc ttcaggactc gtctgatacg gcttatggga aaaaagtttt
     3361 gacctgggat ggtgagcctt cagccatcag tcaggacgcc atgaaagaca gcagactggc
     3421 ccggacccag accgtggttg atgactggga tgaagagttt gatcgaggga agaaaaaagg
     3481 agagaacagt gctccatgat gggtctgctg gttgagtctt ccagccgaac gtgatcagtc
     3541 atctttgtgt ggcctcggtt ccggatgtca tgtccaggag tgctgtgggc tccgtgttat
     3601 ctcgtgtggg ggggaggggg caggcacctt cagggacagg cattgtctct tcttctgagg
     3661 agttgccacc cttctggtag tagctgcttc ctgggtacat ttgtttttct ttacggcttt
     3721 ctctagtaga aagttgtaaa gctgccagca caaaatggat tgtctcccgt gtctcctcca
     3781 tattggttcc tttgtgcagt agattacaca ttgtaaagtc tccaggggca tatagtccac
     3841 tgtctcttgg gcagtcatga tcccccatct gccatcctga ctaatggcag cttgtgttgc
     3901 tgtcactgaa ggcaagtcct tttcttcctt agaagccatt aggaacaggc cataggcgga
     3961 atgagttctc ggtgacatgt actgacataa atgaagcttt tctaaaagta gtcatgctgt
     4021 tggatcaaat cagtttgaac tttgtgcttg gcagtagatg tggcttaggc ccacttgcag
     4081 agggccacct ccctggtgtt tctgttcttg ctcacctgcc tgttaggggc tgtttctgtc
     4141 caacatcctg tgtggctgcg tctgtgtgtg tgcaggactc cctgtactct tccccttcct
     4201 ctgtgggggt gcccagatag tgccaagatc ttggtgcaat aaagtaatgc attttctgtg
     4261 att
//
