LOCUS       NM_001415063            3979 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 33 (Usp33), mRNA.
ACCESSION   NM_001415063 XM_039102496
VERSION     NM_001415063.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3979)
  AUTHORS   Zhang,X., Jiang,Y., Han,W., Liu,A., Xie,X., Han,C., Fan,C.,
            Wang,H., Zhang,H., Ding,S., Shan,Z. and Teng,W.
  TITLE     Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine
            Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary
  JOURNAL   Biol Trace Elem Res 174 (2), 377-386 (2016)
   PUBMED   27156111
  REMARK    GeneRIF: High iodine intake had no discernible effects on USP20.
            Temporary increases in USP33 and USP19 mRNA levels were observed.
            The enzymes related to D2 ubiquitination change with prolonged high
            iodine intake. Increased D2 ubiquitination suppresses the activity
            of D2, causing a decrease in negative feedback of the
            hypothalamic-pituitary-thyroid axis.
REFERENCE   2  (bases 1 to 3979)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   3  (bases 1 to 3979)
  AUTHORS   Li,J., D'Angiolella,V., Seeley,E.S., Kim,S., Kobayashi,T., Fu,W.,
            Campos,E.I., Pagano,M. and Dynlacht,B.D.
  TITLE     USP33 regulates centrosome biogenesis via deubiquitination of the
            centriolar protein CP110
  JOURNAL   Nature 495 (7440), 255-259 (2013)
   PUBMED   23486064
REFERENCE   4  (bases 1 to 3979)
  AUTHORS   Thorne,C., Eccles,R.L., Coulson,J.M., Urbe,S. and Clague,M.J.
  TITLE     Isoform-specific localization of the deubiquitinase USP33 to the
            Golgi apparatus
  JOURNAL   Traffic 12 (11), 1563-1574 (2011)
   PUBMED   21801292
REFERENCE   5  (bases 1 to 3979)
  AUTHORS   Yuasa-Kawada,J., Kinoshita-Kawada,M., Rao,Y. and Wu,J.Y.
  TITLE     Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling
            in inhibiting breast cancer cell migration
  JOURNAL   Proc Natl Acad Sci U S A 106 (34), 14530-14535 (2009)
   PUBMED   19706539
REFERENCE   6  (bases 1 to 3979)
  AUTHORS   Berthouze,M., Venkataramanan,V., Li,Y. and Shenoy,S.K.
  TITLE     The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic
            receptor recycling and resensitization
  JOURNAL   EMBO J 28 (12), 1684-1696 (2009)
   PUBMED   19424180
REFERENCE   7  (bases 1 to 3979)
  AUTHORS   Shenoy,S.K., Modi,A.S., Shukla,A.K., Xiao,K., Berthouze,M., Ahn,S.,
            Wilkinson,K.D., Miller,W.E. and Lefkowitz,R.J.
  TITLE     Beta-arrestin-dependent signaling and trafficking of
            7-transmembrane receptors is reciprocally regulated by the
            deubiquitinase USP33 and the E3 ligase Mdm2
  JOURNAL   Proc Natl Acad Sci U S A 106 (16), 6650-6655 (2009)
   PUBMED   19363159
REFERENCE   8  (bases 1 to 3979)
  AUTHORS   Fekete,C., Freitas,B.C., Zeold,A., Wittmann,G., Kadar,A.,
            Liposits,Z., Christoffolete,M.A., Singru,P., Lechan,R.M.,
            Bianco,A.C. and Gereben,B.
  TITLE     Expression patterns of WSB-1 and USP-33 underlie cell-specific
            posttranslational control of type 2 deiodinase in the rat brain
  JOURNAL   Endocrinology 148 (10), 4865-4874 (2007)
   PUBMED   17628004
  REMARK    GeneRIF: Correlation between relative mRNA levels of WSB-1 and
            USP-33 in numerous tissues that do not express type 2
            deiodinase(D2) suggests that these ubiquitin-related enzymes share
            additional substrates besides D2.
REFERENCE   9  (bases 1 to 3979)
  AUTHORS   Allen,M.D. and Bycroft,M.
  TITLE     The solution structure of the ZnF UBP domain of USP33/VDU1
  JOURNAL   Protein Sci 16 (9), 2072-2075 (2007)
   PUBMED   17766394
REFERENCE   10 (bases 1 to 3979)
  AUTHORS   Li,Z., Na,X., Wang,D., Schoen,S.R., Messing,E.M. and Wu,G.
  TITLE     Ubiquitination of a novel deubiquitinating enzyme requires direct
            binding to von Hippel-Lindau tumor suppressor protein
  JOURNAL   J Biol Chem 277 (7), 4656-4662 (2002)
   PUBMED   11739384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2022 this sequence version replaced XM_039102496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.12549.1,
                                           SRR26360194.40836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000002.1  243943210-243943350
            142-251             JAXUCZ010000002.1  243952923-243953032
            252-387             JAXUCZ010000002.1  243954432-243954567
            388-441             JAXUCZ010000002.1  243954741-243954794
            442-501             JAXUCZ010000002.1  243955211-243955270
            502-654             JAXUCZ010000002.1  243956820-243956972
            655-757             JAXUCZ010000002.1  243958425-243958527
            758-827             JAXUCZ010000002.1  243960138-243960207
            828-941             JAXUCZ010000002.1  243962592-243962705
            942-1020            JAXUCZ010000002.1  243963143-243963221
            1021-1438           JAXUCZ010000002.1  243964502-243964919
            1439-1579           JAXUCZ010000002.1  243966528-243966668
            1580-1692           JAXUCZ010000002.1  243970002-243970114
            1693-1862           JAXUCZ010000002.1  243971346-243971515
            1863-1957           JAXUCZ010000002.1  243971614-243971708
            1958-1991           JAXUCZ010000002.1  243972785-243972818
            1992-2037           JAXUCZ010000002.1  243975518-243975563
            2038-2218           JAXUCZ010000002.1  243976163-243976343
            2219-2345           JAXUCZ010000002.1  243977261-243977387
            2346-2515           JAXUCZ010000002.1  243978598-243978767
            2516-2597           JAXUCZ010000002.1  243979499-243979580
            2598-2706           JAXUCZ010000002.1  243980849-243980957
            2707-2809           JAXUCZ010000002.1  243984973-243985075
            2810-2878           JAXUCZ010000002.1  243986746-243986814
            2879-3979           JAXUCZ010000002.1  243987324-243988424
FEATURES             Location/Qualifiers
     source          1..3979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..3979
                     /gene="Usp33"
                     /note="ubiquitin specific peptidase 33"
                     /db_xref="GeneID:310960"
                     /db_xref="RGD:1307848"
     exon            1..141
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            142..251
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            252..387
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..3036
                     /gene="Usp33"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 33"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 33"
                     /protein_id="NP_001401992.1"
                     /db_xref="GeneID:310960"
                     /db_xref="RGD:1307848"
                     /translation="MTTFRNHCPHLDSVGEITKEDLIQKSHGACQDCKVRGPNLWACL
                     ENRCSYVGCGESQDHSTIHSKKTKHYLTVNLTTLRVWCYACSKEVFLDRKLGTPPSLP
                     HVRQPQQTQENSVQDFKIPSNTALKTPLVAVFEDLDIEVEEEDELKARGLTGLKNIGN
                     TCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVP
                     ANLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEIEEEPQALTSEETVE
                     EEKSQSDVDFQSCESCSSSSEKGENESVSKGGPEDSTETTMLIQDEEDLEMAKDWQKE
                     KMCNKSNKADSDGEPDKDRDTVCETVDLNSQETVKVQIHGRASEYITDVHLNDLSTPQ
                     ILPSNESVNPRLSASPPKSGNLWPGLTPPHKKAQSSSPKRKKQHKKYRSVISDIFDGT
                     IISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTIVKAGSCGEAYAPQG
                     WIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNG
                     VKFCKVQKFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTY
                     DLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKS
                     SEEAQRERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGIPP
                     RKASYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIF
                     IRLNRAFQEEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLK
                     QGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDALQAEEKIEVETRSL"
     exon            388..441
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            442..501
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            502..654
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            655..757
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            758..827
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            828..941
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1020
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1438
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1579
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1692
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1862
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1957
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..1991
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2037
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2218
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2345
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2515
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2597
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2706
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2809
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2878
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3979
                     /gene="Usp33"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggctgct aagggaagcg tcgggcagcg gccgggattc tgcgggccgc gctgcggaac
       61 cgttttgcgg ccctgtgaat ccgagcgctc aggctgcgag gaggagcgcg gcgggcggcg
      121 ggcggcgggc ggcgggctga gttctggaag tttctatgtg tgctggtgaa ggagaaccat
      181 gatcatcgtt cttagccagc tgtgaactgt gcaagctacc acagcagctg tcttggcaga
      241 cacacccact ggttttgcct gattggaaaa gccttgagaa agagaaaaaa aaaaaaaact
      301 aagaaaatga cgacttttcg aaatcattgt ccacatttgg attcagttgg tgaaataaca
      361 aaagaggatt tgatacaaaa atctcatggt gcttgtcagg actgtaaagt cagaggacca
      421 aacctgtggg catgcctaga gaataggtgt tcctatgttg gctgcgggga gtcacaagat
      481 catagcacca tacactcgaa gaagacaaag cattatctaa ctgtgaacct caccaccctt
      541 cgagtatggt gttatgcttg cagcaaagaa gtattcttgg atagaaaatt aggaactcct
      601 ccttcattac ctcatgtaag acagcctcaa caaacacaag aaaacagtgt ccaggatttt
      661 aaaataccca gtaatacagc attgaaaacc cctctggttg ctgtatttga agatctggat
      721 atagaagtgg aagaggaaga tgagctgaag gctagaggcc tgacaggttt gaaaaacatt
      781 ggaaatactt gctatatgaa tgccgctctg caagctctct ctaactgccc acctttgaca
      841 cagttctttc ttgattgtgg aggactggct agaacagata agaaaccagc catttgtaaa
      901 agttatctca aactaatgac agaattgtgg cacaagagca ggccaggatc tgttgtgcct
      961 gctaatctgt tccaaggaat taaaactgta aatccaactt ttcgaggcta ttctcagcag
     1021 gatgcccagg aattccttcg ctgtttaatg gatctgcttc atgaagagtt gaaggagcag
     1081 gtcatggaaa tagaggaaga gcctcaagca ctaacttctg aggagacagt ggaggaagag
     1141 aagagccagt cagatgtgga ttttcagtcc tgcgagtcat gtagcagcag cagtgagaaa
     1201 ggggaaaatg agagtgtctc taagggcggc cctgaagaca gcactgagac caccatgctc
     1261 attcaggatg aggaggacct agagatggcc aaagactggc aaaaagagaa gatgtgcaac
     1321 aagagcaaca aagcagattc tgacggagaa ccggataaag acagagacac ggtgtgtgaa
     1381 acagttgacc taaacagcca ggagaccgtc aaggtgcaga tacacggcag agcctcagaa
     1441 tatatcactg atgtccattt gaatgaccta tctacaccac agatccttcc atcaaatgaa
     1501 agtgttaatc cacgtttatc agcaagtcct cctaagtcag gcaatctgtg gccaggattg
     1561 acacctccac acaagaaagc tcagtcttca tctccaaaga ggaaaaagca gcataagaag
     1621 tacagaagtg tcatctctga catatttgat gggacaatca ttagttcagt acagtgtctg
     1681 acgtgtgata gggtgtctgt aaccctcgag acctttcagg atctgtcctt gccgattcct
     1741 ggcaaggaag acctggctaa gctgcactcc tccagtcacc caactatagt caaagcaggg
     1801 tcgtgtggcg aagcctacgc tccacagggg tggatagctt tcttcatgga gtacgtgaag
     1861 aggtttgttg tctcatgtgt ccctagctgg ttttggggtc cagtagtaac cttgcaagat
     1921 tgtcttgctg ccttcttcgc cagagatgaa cttaaaggtg ataatatgta cagttgtgaa
     1981 aaatgcaaaa agttgaggaa tggagtaaag ttttgtaaag tacaaaagtt tcctgagatt
     2041 ttgtgtatcc accttaaaag atttcgacat gaactgatgt tttccaccaa aattagcacc
     2101 catgtttcct tccccctgga aggcctggac cttcagccat ttcttgcaaa ggatagccca
     2161 gctcagatcg tgacatatga tctcctgtca gtcatctgtc atcatgggac tgcaagtagt
     2221 gggcactaca ttgcctactg cagaaacaat ttaaataacc tgtggtatga gtttgatgac
     2281 cagagcgtca ctgaagtttc agagtccacc gtacagaatg ccgaagccta cgtccttttc
     2341 tacaggaaga gcagtgaaga ggcacaaagg gagaggcgaa ggatatccaa tttgttgaac
     2401 ataatggagc caagcctcct tcagttctat atatctcgac agtggttgaa taaatttaag
     2461 acctttgctg aacctggccc tatttcaaat aatgactttc tctgtattca tggaggtatt
     2521 cctccacgaa aagcaagtta tattgaagac ttagttttga tgctgcctca gaacatttgg
     2581 gataacctct acagcaggta tggaggaggg cctgctgtca accacctcta catttgtcac
     2641 acttgccaaa ttgaggcaga gaagattgaa aaacgaagaa aaactgaatt ggaaattttt
     2701 attcggctca acagagcatt tcaagaggaa gactctccag ctacttttta ctgtatcagc
     2761 atgcagtggt ttagagaatg ggagagtttt gtaaagggta aggatggaga tcctccaggt
     2821 ccaatagaca acactaaaat tgcagtcact aagtgtggta atgtgatgct caagcaagga
     2881 gcagattctg gtcaaatttc agaagaaaca tggaatttcc tgcaatctat atatggtggg
     2941 ggacctgaag ttatcctccg acctccagtt gttcatgttg accctgatgc actacaagca
     3001 gaggaaaaga ttgaagtaga aactcgctct ttgtagttgt gagggcagag ctctaatgga
     3061 gtcatcctca cttgatgcgc acacattcaa aacattcctc aaagcatgtt gactctcttg
     3121 atttccatct ttttcctcat ttattccttt gtactgggca ttatggaagg gtatgttaaa
     3181 tatgttatat aagttggtat atttaatgtt aagtaactta ccggattatc tttcagtgta
     3241 ctattttgaa aggaaaggga cagttggtaa ttaggttcta caggcagatt cagcataccc
     3301 tttgtagcag tgtaaatact ttggctttga aacattttta ttactctaat ccgtcataag
     3361 tggctaagct ttcatttctt caaaaaacaa gttaaattgt ctacttttga catggttttg
     3421 catagtaagg agcctatttt aaatctaaag tagtggtcag aacactgtta atttcctaaa
     3481 gctcaggaaa cattaggatg ttacttcttt tgcactgcag cgtataaaat tgcatattaa
     3541 aatttacaaa atgtcttttt tgaatgtaac aggatgtatt cagtttcagt ggaatttgtt
     3601 accagatatc agtaaattat tgccacttat aatgtaaaat gttaaacttt agttatatag
     3661 acctgaatgg tattcattaa tgttagtaac aaaaaacccc cttagtttta ggccactttt
     3721 attttgagag catgaagtat ggaatgtgtc aaatgagact gttgataaag ctgaaaccac
     3781 ttgcaacatg attttttaat gaaatgcata atgtcttttt gaataagagt attcactgct
     3841 gtttggtgat catgtgacat caaaagctca gttatatcca agtacaaaca tgcaggtgac
     3901 aaagtatgga acagcattca tggtgacttt gcaatgttgt taaaactcat tcaataaaaa
     3961 taattctaaa atatgtaaa
//
