LOCUS       NP_001401992             909 aa            linear   ROD 31-MAR-2024
DEFINITION  ubiquitin carboxyl-terminal hydrolase 33 [Rattus norvegicus].
ACCESSION   NP_001401992 XP_038958424
VERSION     NP_001401992.1
DBSOURCE    REFSEQ: accession NM_001415063.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 909)
  AUTHORS   Zhang,X., Jiang,Y., Han,W., Liu,A., Xie,X., Han,C., Fan,C.,
            Wang,H., Zhang,H., Ding,S., Shan,Z. and Teng,W.
  TITLE     Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine
            Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary
  JOURNAL   Biol Trace Elem Res 174 (2), 377-386 (2016)
   PUBMED   27156111
  REMARK    GeneRIF: High iodine intake had no discernible effects on USP20.
            Temporary increases in USP33 and USP19 mRNA levels were observed.
            The enzymes related to D2 ubiquitination change with prolonged high
            iodine intake. Increased D2 ubiquitination suppresses the activity
            of D2, causing a decrease in negative feedback of the
            hypothalamic-pituitary-thyroid axis.
REFERENCE   2  (residues 1 to 909)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   3  (residues 1 to 909)
  AUTHORS   Li,J., D'Angiolella,V., Seeley,E.S., Kim,S., Kobayashi,T., Fu,W.,
            Campos,E.I., Pagano,M. and Dynlacht,B.D.
  TITLE     USP33 regulates centrosome biogenesis via deubiquitination of the
            centriolar protein CP110
  JOURNAL   Nature 495 (7440), 255-259 (2013)
   PUBMED   23486064
REFERENCE   4  (residues 1 to 909)
  AUTHORS   Thorne,C., Eccles,R.L., Coulson,J.M., Urbe,S. and Clague,M.J.
  TITLE     Isoform-specific localization of the deubiquitinase USP33 to the
            Golgi apparatus
  JOURNAL   Traffic 12 (11), 1563-1574 (2011)
   PUBMED   21801292
REFERENCE   5  (residues 1 to 909)
  AUTHORS   Yuasa-Kawada,J., Kinoshita-Kawada,M., Rao,Y. and Wu,J.Y.
  TITLE     Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling
            in inhibiting breast cancer cell migration
  JOURNAL   Proc Natl Acad Sci U S A 106 (34), 14530-14535 (2009)
   PUBMED   19706539
REFERENCE   6  (residues 1 to 909)
  AUTHORS   Berthouze,M., Venkataramanan,V., Li,Y. and Shenoy,S.K.
  TITLE     The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic
            receptor recycling and resensitization
  JOURNAL   EMBO J 28 (12), 1684-1696 (2009)
   PUBMED   19424180
REFERENCE   7  (residues 1 to 909)
  AUTHORS   Shenoy,S.K., Modi,A.S., Shukla,A.K., Xiao,K., Berthouze,M., Ahn,S.,
            Wilkinson,K.D., Miller,W.E. and Lefkowitz,R.J.
  TITLE     Beta-arrestin-dependent signaling and trafficking of
            7-transmembrane receptors is reciprocally regulated by the
            deubiquitinase USP33 and the E3 ligase Mdm2
  JOURNAL   Proc Natl Acad Sci U S A 106 (16), 6650-6655 (2009)
   PUBMED   19363159
REFERENCE   8  (residues 1 to 909)
  AUTHORS   Fekete,C., Freitas,B.C., Zeold,A., Wittmann,G., Kadar,A.,
            Liposits,Z., Christoffolete,M.A., Singru,P., Lechan,R.M.,
            Bianco,A.C. and Gereben,B.
  TITLE     Expression patterns of WSB-1 and USP-33 underlie cell-specific
            posttranslational control of type 2 deiodinase in the rat brain
  JOURNAL   Endocrinology 148 (10), 4865-4874 (2007)
   PUBMED   17628004
  REMARK    GeneRIF: Correlation between relative mRNA levels of WSB-1 and
            USP-33 in numerous tissues that do not express type 2
            deiodinase(D2) suggests that these ubiquitin-related enzymes share
            additional substrates besides D2.
REFERENCE   9  (residues 1 to 909)
  AUTHORS   Allen,M.D. and Bycroft,M.
  TITLE     The solution structure of the ZnF UBP domain of USP33/VDU1
  JOURNAL   Protein Sci 16 (9), 2072-2075 (2007)
   PUBMED   17766394
REFERENCE   10 (residues 1 to 909)
  AUTHORS   Li,Z., Na,X., Wang,D., Schoen,S.R., Messing,E.M. and Wu,G.
  TITLE     Ubiquitination of a novel deubiquitinating enzyme requires direct
            binding to von Hippel-Lindau tumor suppressor protein
  JOURNAL   J Biol Chem 277 (7), 4656-4662 (2002)
   PUBMED   11739384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2022 this sequence version replaced XP_038958424.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.12549.1,
                                           SRR26360194.40836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..909
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     Protein         1..909
                     /product="ubiquitin carboxyl-terminal hydrolase 33"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 33"
                     /calculated_mol_wt=102651
     Region          30..89
                     /region_name="zf-UBP"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; pfam02148"
                     /db_xref="CDD:460464"
     Region          153..679
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     Region          701..770
                     /region_name="DUSP"
                     /note="DUSP domain; cl12116"
                     /db_xref="CDD:416436"
     Region          807..891
                     /region_name="DUSP"
                     /note="Domain in ubiquitin-specific proteases; smart00695"
                     /db_xref="CDD:197831"
     CDS             1..909
                     /gene="Usp33"
                     /coded_by="NM_001415063.1:307..3036"
                     /db_xref="GeneID:310960"
                     /db_xref="RGD:1307848"
ORIGIN      
        1 mttfrnhcph ldsvgeitke dliqkshgac qdckvrgpnl waclenrcsy vgcgesqdhs
       61 tihskktkhy ltvnlttlrv wcyacskevf ldrklgtpps lphvrqpqqt qensvqdfki
      121 psntalktpl vavfedldie veeedelkar gltglknign tcymnaalqa lsncppltqf
      181 fldcgglart dkkpaicksy lklmtelwhk srpgsvvpan lfqgiktvnp tfrgysqqda
      241 qeflrclmdl lheelkeqvm eieeepqalt seetveeeks qsdvdfqsce scssssekge
      301 nesvskggpe dstettmliq deedlemakd wqkekmcnks nkadsdgepd kdrdtvcetv
      361 dlnsqetvkv qihgraseyi tdvhlndlst pqilpsnesv nprlsasppk sgnlwpgltp
      421 phkkaqsssp krkkqhkkyr svisdifdgt iissvqcltc drvsvtletf qdlslpipgk
      481 edlaklhsss hptivkagsc geayapqgwi affmeyvkrf vvscvpswfw gpvvtlqdcl
      541 aaffardelk gdnmyscekc kklrngvkfc kvqkfpeilc ihlkrfrhel mfstkisthv
      601 sfplegldlq pflakdspaq ivtydllsvi chhgtassgh yiaycrnnln nlwyefddqs
      661 vtevsestvq naeayvlfyr ksseeaqrer rrisnllnim epsllqfyis rqwlnkfktf
      721 aepgpisnnd flcihggipp rkasyiedlv lmlpqniwdn lysrygggpa vnhlyichtc
      781 qieaekiekr rkteleifir lnrafqeeds patfycismq wfrewesfvk gkdgdppgpi
      841 dntkiavtkc gnvmlkqgad sgqiseetwn flqsiygggp evilrppvvh vdpdalqaee
      901 kievetrsl
//
