LOCUS       NM_001025424            2225 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 3 (Usp3), mRNA.
ACCESSION   NM_001025424 XM_343415
VERSION     NM_001025424.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   Belle,J.I. and Nijnik,A.
  TITLE     H2A-DUBbing the mammalian epigenome: expanding frontiers for
            histone H2A deubiquitinating enzymes in cell biology and physiology
  JOURNAL   Int J Biochem Cell Biol 50, 161-174 (2014)
   PUBMED   24647359
  REMARK    Review article
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Nicassio,F., Corrado,N., Vissers,J.H., Areces,L.B., Bergink,S.,
            Marteijn,J.A., Geverts,B., Houtsmuller,A.B., Vermeulen,W., Di
            Fiore,P.P. and Citterio,E.
  TITLE     Human USP3 is a chromatin modifier required for S phase progression
            and genome stability
  JOURNAL   Curr Biol 17 (22), 1972-1977 (2007)
   PUBMED   17980597
REFERENCE   4  (bases 1 to 2225)
  AUTHORS   Whalen,R., Liu,X. and Boyer,T.D.
  TITLE     Identification of a short form of ubiquitin-specific protease 3
            that is a repressor of rat glutathione S-transferase gene
            expression
  JOURNAL   Biochem J 394 (Pt 2), 519-526 (2006)
   PUBMED   16279867
  REMARK    GeneRIF: The study demonstrates that the short form of USP3 may be
            IL6DEX-NP and that it may play an important role in the negative
            regulation of proteins during the acute-phase response.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001025424.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ076481.1, SRR26360181.838868.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000008.1  76048958-76049151   c
            195-255             JAXUCZ010000008.1  76025522-76025582   c
            256-387             JAXUCZ010000008.1  76020243-76020374   c
            388-471             JAXUCZ010000008.1  76005863-76005946   c
            472-553             JAXUCZ010000008.1  76004207-76004288   c
            554-636             JAXUCZ010000008.1  76002547-76002629   c
            637-750             JAXUCZ010000008.1  76001030-76001143   c
            751-864             JAXUCZ010000008.1  75998545-75998658   c
            865-1011            JAXUCZ010000008.1  75991568-75991714   c
            1012-1118           JAXUCZ010000008.1  75988875-75988981   c
            1119-1199           JAXUCZ010000008.1  75988698-75988778   c
            1200-1318           JAXUCZ010000008.1  75977763-75977881   c
            1319-1432           JAXUCZ010000008.1  75977408-75977521   c
            1433-1500           JAXUCZ010000008.1  75977234-75977301   c
            1501-2225           JAXUCZ010000008.1  75974954-75975678   c
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2225
                     /gene="Usp3"
                     /note="ubiquitin specific peptidase 3"
                     /db_xref="GeneID:363084"
                     /db_xref="RGD:1308852"
     exon            1..194
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1666
                     /gene="Usp3"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 3; ubiquitin
                     thiolesterase 3"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 3"
                     /protein_id="NP_001020595.2"
                     /db_xref="GeneID:363084"
                     /db_xref="RGD:1308852"
                     /translation="MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTC
                     SSVHCGRYVNGHAKKHYEDAQIPLLNHKRSEKQEKAQHTVCMDCSSYSTYCYRCDDFV
                     VNDTKLGLVQKVREHLQNLENSAFTADRHRKRKLLENSSLNSKLLKVNGSTAAICATG
                     LRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDSNVSL
                     VEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLEL
                     QGGFNGVSRSAILQENSTLSANNKCCINGASTVVTTIFGGILQNEVNCLICGTESRKF
                     DPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQ
                     KSTKKFWIQKLPKALCLHLKRFHWTAYLRNKVDTYVQFPLRGLDMKCYLLEPENSGPD
                     SCLYDLAAVVVHHGSGVGSGHYTAYAVHEGRWFHFNDSTVTVTDEETVGKAKAYILFY
                     VERQARAGADKL"
     exon            195..255
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..387
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..471
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..553
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            554..636
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..750
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..864
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1011
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1118
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1199
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1318
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1432
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1500
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..2225
                     /gene="Usp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaccttc tgcccagcgc cgggtcagaa gcgaccccag acggagcctc cgaagtccct
       61 ccgccccaga gcctcggccg tccccgccgc cgtcctcgtg gccatggagt gtccgcacct
      121 cagctctagc gtctgcatcg ccccggactc agccaagttc cccaacggct ccccgtcgtc
      181 ctggtgctgc agcgtgtgca ggtccaacaa aagcccctgg gtctgtttga cttgttcaag
      241 tgtccactgt ggaaggtatg tgaatggcca tgcaaaaaaa cattatgaag atgcacagat
      301 acccttactc aaccataaga gatcagaaaa acaggagaaa gctcagcata cagtgtgtat
      361 ggattgcagt agctacagca catactgtta ccgctgtgat gattttgtgg tcaatgacac
      421 caagctgggc ctggtacaga aagtgagaga acacttacag aacttggaaa actcagcttt
      481 tacagctgac aggcacagaa aaagaaaatt attggaaaac tcatcactga atagcaagtt
      541 attaaaagta aatggaagta cggctgccat ttgtgccaca ggccttcgga atttgggcaa
      601 cacgtgcttc atgaatgcta tccttcagtc actcagtaac atcgagcagt tttgctgtta
      661 tttcaaagag ctgcctgctg tggagttaag gaatgggaaa acagcaggga ggcggacata
      721 ccacaccagg agccaagggg acagcaacgt gtctttggta gaagagttta gaaagacact
      781 gtgcgctttg tggcaaggca gccagactgc atttagtcct gagtccttgt tttatgttgt
      841 ttggaagatc atgcctaact ttaggggtta tcagcagcag gatgcccatg aattcatgcg
      901 ttaccttttg gatcatctgc acttggaact tcagggtggc ttcaacggtg tttcccgctc
      961 agcaattcta caggagaatt ctacactgtc tgcaaataac aaatgctgca taaatggagc
     1021 atcaactgtt gtcacaacaa tatttggagg aattctccag aatgaggtca actgcctcat
     1081 atgtgggaca gagtcgagga agtttgatcc attcctagat ctctccttag atattccaag
     1141 tcagttcaga agcaagcgct ctaagaatca ggaaaatggg cctgtttgct ccttacgaga
     1201 ttgtcttcgc agcttcactg acctagagga acttgatgag acggagttgt atatgtgcca
     1261 taagtgcaaa aagaaacaaa agtccacaaa aaagttttgg attcaaaaac ttcccaaggc
     1321 gctgtgcttg cacctgaaaa ggtttcactg gacagcatat ttacgaaaca aagtagatac
     1381 atacgttcag ttcccactga gaggcctgga catgaagtgc tacctactag agccagagaa
     1441 cagtggcccc gacagttgcc tgtatgacct cgctgccgtg gttgttcacc atggctctgg
     1501 ggttggttct gggcattaca cagcatatgc agttcacgaa ggccgctggt tccatttcaa
     1561 tgacagcact gtgacagtga ctgatgagga gaccgttggg aaggcgaagg cctacattct
     1621 gttttatgta gagcgtcagg ccagagctgg agcagataaa ctgtgatacc tcctgaccat
     1681 gattcatcta ctataccgga caacatttcc attctccata aatacttgat ccaagattta
     1741 atttcagtat gcacttttca atttccagtt tggggtttta gtttggtcag tggtagtaac
     1801 ttacccaata tgggcaccaa ctaatttttg ttgttctacc agaaaacctc agcaggcatt
     1861 ttgattggct gctttagttg taataattca atttttataa gtagtttcca gaacttagtt
     1921 ctgtttgact ttttatatta atgttttcag ttctcacgga ggcacatttt attgctctgt
     1981 actcacatgc tgagagccac cctgcctgct gtctgcatag caggcaggtc agcgactccg
     2041 ttgtgagggt cgtgtgtgca ggtctgtgac ccgccggttt cacagtgact gctcaggaat
     2101 cccttctgac tgtaggccgt agtagctgaa ggtcaggaga ccaggccatc accactgcct
     2161 gtgcctcagg gttgctgttt ctcagcatta aataaatttg tcagttccgt tgcgtctgtg
     2221 ctcaa
//
