LOCUS       NM_001108144            4171 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28), mRNA.
ACCESSION   NM_001108144 XM_001070037 XM_236240
VERSION     NM_001108144.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4171)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 4171)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4171)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 4171)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 4171)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 4171)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            [WARNING] On Mar 13, 2025 this sequence was replaced by
            NM_001108144.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070037.1, XM_236240.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4171
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4171
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..60
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..3243
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thioesterase 28; deubiquitinating enzyme
                     28; ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28"
                     /protein_id="NP_001101614.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQELQYLF
                     ALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSN
                     PRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGAMVEG
                     DIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQVIYMD
                     RYMYKSKELIRSKRESIRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVIEFAS
                     TKPASESCLSGSVEHMTLPLPSVHCPISDLTAKESSSPKSCSQNAEGSFSSPEDALPN
                     SEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKNCIS
                     STTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYNDISVT
                     ESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVELRQY
                     IQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCLSSEH
                     AVIAKEQTAQAIANTAHAYEKSGVEAALSEVMLSPAMQGVLLAIAKARQTFDRDGSEA
                     GLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQFADRN
                     LSYDERSISIMKVAQAKLMEIGPEDMNMEEYKRWHEDYSLFRKVSVYLLTGLELFQKG
                     KYQEALSYLVYAYQSNAGLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDH
                     SVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQLCLGE
                     FLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK"
     exon            61..138
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            139..271
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            272..377
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            378..537
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            538..612
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            613..750
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            751..824
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            825..904
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1053
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1181
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1277
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1457
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1681
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1752
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1981
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2173
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2313
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2409
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2588
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2667
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2747
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2871
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3067
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..4171
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatgactg cggagctgca gcaggacgac gcggcggggg cggcggacgg ccatggctcg
       61 agctgccaga tgctgttaaa tcagctgcga gaaatcacgg gcatccagga tccttccttt
      121 cttcatgaag cattaaaggc cagtaatggt gacatcaccc aggctgtcag ccttctcaca
      181 gaccaaagag ttaaggagcc cagtcacgac acagctgcta cagaaccatc tgaagtagaa
      241 gagagtgcta ccagcaaaga tctcttagca aaagtgatag accttacaca tgacaacaaa
      301 gatgaccttc aggcagccat tgccttgagt ctcctggagt ctcctaacat tcagactgac
      361 agcagagatc ttaatagaat acatgaagct aactctgcag agactaaacg atcaaagaga
      421 aaacgctgtg aagtttgggg agaaaaccac aatcccaata actggaggag agtggatggt
      481 tggccagttg ggctgaaaaa tgttggcaac acatgttggt tcagtgctgt tattcagttg
      541 cctgaatttc gaagacttgt tctcagttac agcctgccac agaacattct tgaaaattgt
      601 cgaagtcaca ctgaaaaaag aaatatcatg tttatgcaag agcttcagta tttatttgct
      661 ctgttattgg gatcaaatcg gaaatttgta gatccttctg ctgccctgga tctactgaag
      721 ggggccttcc gatcctcaga ggagcaacag caagatgtga gtgaattcac acacaagctc
      781 ctggattggc tggaggatgc gttccagcta gctgttaatg ttaacagcaa tcccaggact
      841 aaatctgaaa accccatggt gcagctgttc tacggtacct tcctgacaga aggggtccga
      901 gaaggaaaac ccttttgtaa caacgagacc ttcggccagt accctcttca ggtaaacggt
      961 taccacaact tagacgagtg tttggaaggg gccatggtgg aaggtgacat tgcgctgctt
     1021 ccttctgatc gctcagtgaa atacggacaa gagcgttggt ttacaaagct gcctccagtg
     1081 ttgaccttcg aactctccag atttgagttt aatcagtctc ttgggcagcc tgagaaaatt
     1141 cataataagc tggaatttcc tcaggttatt tatatggata ggtacatgta caaaagcaaa
     1201 gagcttatcc gaagtaagag agagagcatt cgaaagttga aggaggaaat acaagttctg
     1261 cagcagaaat tagaaaggta tgtgaagtac ggctccggtc catctcgctt cccactcccc
     1321 gacatgttga aatacgttat tgaatttgcc agtacaaaac ctgcctctga aagctgtctg
     1381 tctggaagtg ttgagcatat gacgttacca cttccttctg tgcactgccc gatttctgac
     1441 ctcacagcca aggaaagttc aagtcccaaa agctgctctc agaatgctga gggttccttt
     1501 tcctctccgg aagatgctct acccaactct gaggtaatga atgggccatt tacttctcct
     1561 cactcttccc tggaaatgcc tgcaccccca ccagctcctc ggacagtcac agatgaggaa
     1621 atgaatttcg ttaagacctg tcttcagagg tggcggagtg aaattgaaca ggatatacaa
     1681 gacttaaaga attgtatctc gagcaccacc caggctattg agcagatgta ctgtgatcct
     1741 cttcttcgtc aggtgcctta tcgcttacat gcagttcttg ttcatgaagg acaagccagt
     1801 gcagggcact actgggcgta catctataac cagccccggc agatctggct caaatacaac
     1861 gacatctctg tcactgagtc ttcctgggaa gaacttgaaa gagattctta cgggggcctg
     1921 agaaatgtca gcgcatactg cttgatgtat atcaatgaca agttgcccca ctgcagtgca
     1981 gaggcagcgc atggtgaatc tgatcagact gcagaagtgg aagccctgtc tgtggaactc
     2041 aggcagtaca ttcaggaaga taactggagg tttgagcaag aggtggagga atgggaggaa
     2101 gaacagtcct gtaagatccc acagatggag tcctccccaa actcttcctc acaggatttt
     2161 tccacatcac aagagtcttc agcagcgtcc tcgcatggcg ttcgatgttt gtcttctgaa
     2221 catgctgtga ttgcaaagga gcagactgcc caggccatcg caaacacggc tcatgcctat
     2281 gagaagagcg gggtagaagc agccttgagt gaggtgatgc tgagccctgc catgcaaggg
     2341 gtcctcctgg ccatagctaa ggcgcgccag acctttgacc gagacgggtc tgaagcaggg
     2401 cttattaagg catttcatga agagtactcc aggctctatc agcttgccaa agagacaccc
     2461 acctctcaca gtgatcctcg ccttcagcat gttctcgtct actttttcca aaatgaagca
     2521 cccaagaggg tagtagaacg aacccttctg gaacagtttg cagatagaaa ccttagctat
     2581 gatgagagat ctatcagtat catgaaggtg gctcaggcca aactgatgga aattggtcca
     2641 gaggacatga acatggaaga gtataagagg tggcatgaag actatagtct gttccgaaag
     2701 gtgtctgtgt acctgctaac gggcctggaa ctcttccaaa aaggaaagta ccaggaagct
     2761 ttgtcctacc tggtgtacgc gtaccagagc aatgctggcc tgctggtgaa ggggccccgc
     2821 aggggcgtga aggagtctgt gattgctttg taccgcagaa aatgccttct ggagttgaat
     2881 gccaaggctg cttctctttt tgaaacaaat gacgaccatt ctgtaacaga gggcattaat
     2941 gtgatgaatg agctgatcat tccctgcatc cacctgatca ttaataatga catttccaag
     3001 gacgaccttg atgccatcga ggtcatgagg aaccactggt gctcttacct ggggaaggac
     3061 atcgcagaaa atctgcagct gtgtttaggg gagttcctac ccaggcttct agatccttcc
     3121 gcagaaatca tcgtcctaaa ggagcctcca actattcgac cgaattctcc ctatgatctt
     3181 tgcagccggt ttgcagctgt catggagtcc attcaaggag tttcaacagt aacagtgaag
     3241 taaactgcac atggacggtc aagactcatt ttggtctcca gtcacctgcc agttacacgg
     3301 cagtctgttg ttgcagactc ccctggagag agagattggg tgtctgagca agatttagac
     3361 cctctgccct ctctgatatg tgtttaaggg attaaggata aagttgcgca tttaggtaca
     3421 gaatcatgag agctctctca ctgaagaagg caggagcccg gtgcattaag gttttgaatt
     3481 atcccagaag acctgaattg cctttttaaa tctcccataa taattaccct tcgggcgcct
     3541 gtctcatcag aactgagccg gaggaacagt ttctggttct tttgtcaagt tcaggtgacg
     3601 tttctaagtc cttagctacc agagattggc aacaggggcc ttgcctggct cttgacagta
     3661 acacaaaggg tgctgctgag cctttccctc cacacaaggg tagagcgtaa ggcttcgccc
     3721 accatgaagc cacaggaaag ctgcctccat tttcggtctg tttatatttc agataaacca
     3781 gaaaacctca cactcagtct tgagtgaaag agaagcaagc atcctgggct ctcaccccag
     3841 tgctggtgta aagctgcaca agggacattt aatagctaat taagcaacat tgtggagatt
     3901 gtcacatgca ggtgtctaag gctacctggc ctgatagaat tttgattctc tctttccttt
     3961 tttttttttt agaaataagg gatgtgaatt tatatagaga gagaccatct atctgtgtat
     4021 atgtagagaa gctgcttttt aaagaacttt taattgggaa ttcatgtttt aacaaaattt
     4081 taaggattaa cgaggaatca tgggagggaa gaacacaact atgcagattt tataaatgtg
     4141 caataaaagt atttgtttta cctttggtgt g
//
