LOCUS       NM_001107114            4718 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 25 (Usp25), mRNA.
ACCESSION   NM_001107114 XM_001065002 XM_221722
VERSION     NM_001107114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4718)
  AUTHORS   Sui,J., Dai,F., Shi,J. and Zhou,C.
  TITLE     Ubiquitin-specific peptidase 25 exacerbated osteoarthritis
            progression through facilitating TXNIP ubiquitination and NLRP3
            inflammasome activation
  JOURNAL   J Orthop Surg Res 18 (1), 762 (2023)
   PUBMED   37814350
  REMARK    GeneRIF: Ubiquitin-specific peptidase 25 exacerbated osteoarthritis
            progression through facilitating TXNIP ubiquitination and NLRP3
            inflammasome activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4718)
  AUTHORS   Aslani,M.R., Sharghi,A., Boskabady,M.H., Ghobadi,H.,
            Keyhanmanesh,R., Alipour,M.R., Ahmadi,M., Saadat,S. and
            Naghizadeh,P.
  TITLE     Altered gene expression levels of IL-17/TRAF6/MAPK/USP25 axis and
            pro-inflammatory cytokine levels in lung tissue of obese
            ovalbumin-sensitized rats
  JOURNAL   Life Sci 296, 120425 (2022)
   PUBMED   35202642
  REMARK    GeneRIF: Altered gene expression levels of IL-17/TRAF6/MAPK/USP25
            axis and pro-inflammatory cytokine levels in lung tissue of obese
            ovalbumin-sensitized rats.
REFERENCE   3  (bases 1 to 4718)
  AUTHORS   Blount,J.R., Burr,A.A., Denuc,A., Marfany,G. and Todi,S.V.
  TITLE     Ubiquitin-specific protease 25 functions in Endoplasmic
            Reticulum-associated degradation
  JOURNAL   PLoS One 7 (5), e36542 (2012)
   PUBMED   22590560
REFERENCE   4  (bases 1 to 4718)
  AUTHORS   Meulmeester,E., Kunze,M., Hsiao,H.H., Urlaub,H. and Melchior,F.
  TITLE     Mechanism and consequences for paralog-specific sumoylation of
            ubiquitin-specific protease 25
  JOURNAL   Mol Cell 30 (5), 610-619 (2008)
   PUBMED   18538659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jul 2, 2021 this sequence version replaced NM_001107114.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.40411.1,
                                           SRR26643297.37374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               JAXUCZ010000011.1  29090653-29091052
            401-478             JAXUCZ010000011.1  29112086-29112163
            479-626             JAXUCZ010000011.1  29115722-29115869
            627-750             JAXUCZ010000011.1  29127154-29127277
            751-913             JAXUCZ010000011.1  29129271-29129433
            914-1000            JAXUCZ010000011.1  29139499-29139585
            1001-1138           JAXUCZ010000011.1  29143789-29143926
            1139-1215           JAXUCZ010000011.1  29147000-29147076
            1216-1289           JAXUCZ010000011.1  29153968-29154041
            1290-1438           JAXUCZ010000011.1  29157333-29157481
            1439-1566           JAXUCZ010000011.1  29160788-29160915
            1567-1662           JAXUCZ010000011.1  29161247-29161342
            1663-1824           JAXUCZ010000011.1  29162362-29162523
            1825-2051           JAXUCZ010000011.1  29163053-29163279
            2052-2122           JAXUCZ010000011.1  29166286-29166356
            2123-2351           JAXUCZ010000011.1  29167439-29167667
            2352-2552           JAXUCZ010000011.1  29169754-29169954
            2553-2692           JAXUCZ010000011.1  29175144-29175283
            2693-2871           JAXUCZ010000011.1  29188964-29189142
            2872-2950           JAXUCZ010000011.1  29190292-29190370
            2951-3030           JAXUCZ010000011.1  29192768-29192847
            3031-3154           JAXUCZ010000011.1  29195355-29195478
            3155-3350           JAXUCZ010000011.1  29196464-29196659
            3351-4718           JAXUCZ010000011.1  29196949-29198316
FEATURES             Location/Qualifiers
     source          1..4718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p11-q11"
     gene            1..4718
                     /gene="Usp25"
                     /note="ubiquitin specific peptidase 25"
                     /db_xref="GeneID:304150"
                     /db_xref="RGD:1309003"
     exon            1..400
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..3523
                     /gene="Usp25"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 25; ubiquitin
                     carboxyl-terminal hydrolase 25-like"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 25"
                     /protein_id="NP_001100584.1"
                     /db_xref="GeneID:304150"
                     /db_xref="RGD:1309003"
                     /translation="MTVEQNVLQQSAAQKHQQTFLNQLREITGINDAQILQQALKDSN
                     GNLELAVAFLTAKNAKTPPQEETAYYQTAALPGSDRYISVGSQADANVIDLTGDDKDD
                     LQRAIALSLAESNRTFRETGITDEEQAISRVLEASIAENKACLKRTPIEVWRDSRNPY
                     DRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHR
                     NLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLE
                     DAFQMKAEEETDEEKPKNPMVELFYGRFLAMGVLEGKKFENTEMFGQYPLQVNGFKDL
                     HECLEAAMIEGEIESLHSDNSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHN
                     KLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLV
                     DVLQYALEFASSKPVCTSPVDDIDATSSTSGSTSSQSLPSTTEQQGTPASDLPSSSPA
                     SGAALSLRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRD
                     LQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKY
                     NDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQALVGMETL
                     PPDLRDFVEEDNQRFEKELEDWDTQLAQRALQEKLLAAQKLREAESSAPTAQAGGPDY
                     LEQPSRSDLSKHWKEETLRVIAKASHDHEDKGPETVLQSAIKLEYSRLVKLAQEDTPP
                     ETDYRLHHVLVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKP
                     EEVNLEEYEEWHADYKKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKG
                     PYRGHDGDLISHYRRECLLKLNEQAAELFESGEDREVSNGLIIMNEFIVPFLPLLLVD
                     ETEERDILAVEDMRNRWCSYLGQDMEPNLQEKLTDFLPKLLDCSTEIKGFHEPPKLPS
                     YSAHELCERFARIMLSLSRTPADGR"
     exon            401..478
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            479..626
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            627..750
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            751..913
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1000
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1138
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1215
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1289
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1438
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1566
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1662
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1824
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2051
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2122
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2351
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2552
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2692
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2871
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2950
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3030
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3154
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3350
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..4718
                     /gene="Usp25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attccgggtg gccgctccct ccgtccgctt gccacccgcc cgcagtggtc ccccggagcg
       61 gtcaggcgaa gctgagtgcg aacgcgtgac gcggcccggc ttgctcgtgc tttccctcgc
      121 ctgcgcccat gggccgggcc gccgcggacc agcggcgctg aggaacgggg cacagaggac
      181 ctgaggcggc cgcggtggcg ctctccggca gcgtctcgcc gcttgcccgc ggggcccgcg
      241 ttcgcccgcc gccatcgcct tcgcgcccgg ctggcggggg cgccgtcctc ccgggccgtc
      301 cgcgtcgctg ccccgggccc ggtagagcgc gacaggcggg gccgccgcgg gggccatgac
      361 cgtggagcag aatgtgctgc agcagagcgc ggcgcagaag caccagcaga catttctgaa
      421 tcagctgaga gaaataactg ggatcaatga cgcccagata ctgcagcaag ccctgaagga
      481 tagtaatgga aacttggaat tagcagtggc cttcctcact gcaaagaatg ccaagacccc
      541 cccgcaggag gagacggcct attaccagac agcagcactt ccgggcagcg acaggtacat
      601 cagcgtgggg agccaggcag atgcgaatgt gattgatctc actggagacg acaaagatga
      661 tcttcagaga gcgattgctt tgagtttggc ggaatcaaac aggacgttca gggaaactgg
      721 cataaccgat gaggaacaag ccatcagcag agttcttgaa gccagcatag cagaaaataa
      781 agcatgtttg aagagaacac ctatagaagt ttggagggat tctcgaaacc cttatgaccg
      841 gaaaagacaa gataaggctc cggttgggct gaagaacgtt ggcaacacct gctggtttag
      901 cgcagttatt cagtcattat tcaatctttt ggaatttaga agattagttc tgaattacaa
      961 gcctccatca aatgctcaag atttaccccg aaaccaaaag gaacatcgga atttgccttt
     1021 tatgcgggaa ttgaggtatc tgtttgcact tcttgttggt acgaagagga aatatgttga
     1081 tccatccaga gcagttgaga ttctaaagga tgccttcaaa tcaaatgact cacagcagca
     1141 agatgtgagt gagtttacac acaagttatt ggattggctg gaagatgcct tccaaatgaa
     1201 agctgaagag gaaacggatg aagagaagcc aaagaaccct atggtagagt tgttctacgg
     1261 aagattccta gccatgggag tgcttgaagg aaaaaaattt gaaaacactg aaatgtttgg
     1321 tcagtatccg ctccaggtca atgggttcaa agacctacat gagtgcctgg aagctgcaat
     1381 gatcgaagga gagatcgagt ccttacactc ggataattca ggaaaatcgg gccaagagca
     1441 ttggttcact gaattgccac ctgtattaac atttgaactg tcaagatttg aatttaatca
     1501 ggcattggga agaccagaaa aaattcacaa taaactagaa tttccccaag ttttatacct
     1561 ggacaggtat atgcacagaa acagagaaat aacaagaatt aaacgtgaag agatcaagag
     1621 acttaaagat tacctcacag tattacaaca aagattagag agatatttaa gctatggctc
     1681 cggtcccaaa agattcccac tggtcgatgt tctacagtat gcgttggagt tcgcctccag
     1741 taagcctgtc tgcacctctc ctgtggatga tatcgatgct acttcctcaa ccagtggctc
     1801 cacatcatca cagtcgttac caagcacaac agaacagcag ggaacccctg cttcagacct
     1861 gcccagctcg tcacctgcat caggtgctgc cctgtcactg aggtcagtga tacacaaacc
     1921 cttcactcag tcgcggatcc ctccagactt gcccatgcat ccggcaccaa ggcacatcac
     1981 agaggaagaa ctgtctgtgc tggagagctg tttacatcgc tggaggacgg aaatagaaaa
     2041 tgacacacga gacctgcagg aaagcatatc tagaatccat cgaacaatcg aactgatgta
     2101 ctcggacaaa tccatgatcc aggtccctta ccgcctccat gctgtcttag ttcatgaggg
     2161 ccaggctaat gccggccact actgggcgta catctttgac catcgtgaga gcaggtggat
     2221 gaagtacaat gatattgctg tgaccaagtc atcatgggaa gaactagtga gggactcttt
     2281 tggtggttat agaaatgcca gtgcatactg cttaatgtac ataaatgaca aggcacagtt
     2341 cttaatacaa gaggagttca ataaagagac tgggcaggcc cttgttggaa tggaaacatt
     2401 acctccagac ttgagggatt ttgtggagga agacaaccag cgcttcgaga aggagctgga
     2461 agactgggac acacagctcg cccaacgagc actgcaagaa aagctgctgg ctgctcagaa
     2521 gctgcgggaa gcagagtctt ctgcgcccac agcacaagca ggaggaccag actatctaga
     2581 gcagccatca aggagtgact tgtcaaaaca ctggaaagaa gaaactctcc gagtgattgc
     2641 caaggcatca catgatcacg aagataaagg gccagagaca gttttgcagt cggcaataaa
     2701 attagagtat tcaaggctgg tcaagttggc ccaagaagat accccaccag aaacagatta
     2761 tcgtttacat catgtcctgg tctactttat ccagaaccag gcaccaaaga aaatcattga
     2821 gaaaacatta ctcgaacaat ttggagatag aaatttgagt tttgatgaaa ggtgtcacaa
     2881 cataatgaaa gttgcccaag ccaaactgga aatgatcaaa cctgaagaag tgaacttgga
     2941 ggaatatgag gagtggcacg cagattataa gaaattcaga gaaacaacta tgtatctcat
     3001 aattggacta gaaaactttc agagagaaag ttatatagac tccttgctgt tccttatctg
     3061 tgcttatcag aataacaaag agctcttgtc caagggtcca tacagagggc atgatggaga
     3121 cttgatatca cattacagaa gagagtgttt actgaaatta aatgagcaag cggcagagct
     3181 gttcgagtct ggagaggacc gagaagtgag caatggctta attattatga atgagtttat
     3241 cgttcccttt ttgcccttgt tgctggtgga tgaaacggaa gagagagata tccttgctgt
     3301 ggaggacatg aggaaccgat ggtgttcata cctggggcaa gacatggaac ccaacctcca
     3361 agaaaagctg acggattttc tgccaaaact gcttgattgt tctacagaga ttaaaggttt
     3421 ccacgagccg ccaaagttac cttcctattc tgcgcatgaa ctctgcgagc gattcgcccg
     3481 aatcatgttg tccctcagtc gcactcctgc tgatggaaga taaactgccc ggacttctca
     3541 tggtcaccat agaaactctg ttctcacccc agcttcctgc caggggggtt gcttgctgct
     3601 gctagagttt ttaacttttt attttaataa ctgcaaaaga caaaacgact atgccgacct
     3661 tagccaagac tacaaacaat aaacctgaga atcgcatggc actccccttg ttttatcgaa
     3721 accgatgtat aattacaaat gaattgattt cttgtggcaa ggctatgctt ttgctgcctt
     3781 ccattgcagt attgcctctc agttttcttt acaaacagct ttccgtttag tctggaactt
     3841 ttaagactaa gccattaagt gttcagcact gtgtatgata catactattt ggtagcttgt
     3901 aaatgaagtc aaagaataaa gttttattta tggctaccta tgtgtttgta agcaggcata
     3961 ttgtataatg gtgtgtattt tagttctata aaggactgta gttgtggggt tgacattggg
     4021 tggtgcacac aatagccctt ttgtgttagt gtaatggaac catgttggaa atgtactaag
     4081 tatttagcac ttcgatgtgt ccatatcaat tgagttcttg gacctaaaca tgttatgtcc
     4141 agtcagattt cattgaagtg aatgactgga ttttaagtca agctgcactg aagcttttaa
     4201 cctttcctta gattaaacgt ttgttctttt atgtatgtgt aaataataca aggtgattat
     4261 ttcaagagaa aactgaaaaa gtacttgaat aagggctatt gagaaattta aaaagaaaaa
     4321 aatgtgcaca tatacacaca tacatgcaca tacatgtatt cttcataatg gagggcaatg
     4381 tttttcatta tataattatt ctatttttgt aaattatata ctactttaat tgagaaatgt
     4441 cctctactaa tcaatgctgt gaaatgaaat tgatagttcg actaataatt ataagaatct
     4501 taacttttta ttcgcctcct tttttttttt ttcaaaaaag gtaaaagacg tagactattt
     4561 tatggacgga gctactgttt taagatcaat gaagtgatgt tgtgaatgaa aatctagatt
     4621 aatgctttaa aggtaatcat gttaccaccg atctattttt gaatttataa aaattcttta
     4681 taactgatac tttgttagca tagtaaacta tatcatta
//
