LOCUS       NM_001191644            4328 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 22 (Usp22), mRNA.
ACCESSION   NM_001191644 XM_220534
VERSION     NM_001191644.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4328)
  AUTHORS   Ji,A.L., Li,T., Zu,G., Feng,D.C., Li,Y., Wang,G.Z., Yao,J.H. and
            Tian,X.F.
  TITLE     Ubiquitin-specific protease 22 enhances intestinal cell
            proliferation and tissue regeneration after intestinal ischemia
            reperfusion injury
  JOURNAL   World J Gastroenterol 25 (7), 824-836 (2019)
   PUBMED   30809082
  REMARK    GeneRIF: USP22 is correlated with promoting intestinal cell
            proliferation and accelerating intestinal tissue regeneration after
            intestinal ischemia reperfusion (I/R) injury and may serve as a
            potential target for therapeutic development for tissue repair
            during intestinal I/R injury.
REFERENCE   2  (bases 1 to 4328)
  AUTHORS   Li,W., Atanassov,B.S., Lan,X., Mohan,R.D., Swanson,S.K.,
            Farria,A.T., Florens,L., Washburn,M.P., Workman,J.L. and
            Dent,S.Y.R.
  TITLE     Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA
            Deubiquitinase Module
  JOURNAL   Mol Cell Biol 36 (22), 2855-2866 (2016)
   PUBMED   27601583
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4328)
  AUTHORS   Shi,J.X., Wang,Q.J., Li,H. and Huang,Q.
  TITLE     Silencing of USP22 suppresses high glucose-induced apoptosis, ROS
            production and inflammation in podocytes
  JOURNAL   Mol Biosyst 12 (5), 1445-1456 (2016)
   PUBMED   26953552
  REMARK    GeneRIF: high D-glucose induces increased expression of USP22 in
            cultured podocytes and diabetic rats. USP22 inhibition confers a
            protective effect against high glucose-induced podocyte depletion,
            apoptosis and inflammation.
REFERENCE   4  (bases 1 to 4328)
  AUTHORS   Belle,J.I. and Nijnik,A.
  TITLE     H2A-DUBbing the mammalian epigenome: expanding frontiers for
            histone H2A deubiquitinating enzymes in cell biology and physiology
  JOURNAL   Int J Biochem Cell Biol 50, 161-174 (2014)
   PUBMED   24647359
  REMARK    Review article
REFERENCE   5  (bases 1 to 4328)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   6  (bases 1 to 4328)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   7  (bases 1 to 4328)
  AUTHORS   Zhang,X.Y., Pfeiffer,H.K., Thorne,A.W. and McMahon,S.B.
  TITLE     USP22, an hSAGA subunit and potential cancer stem cell marker,
            reverses the polycomb-catalyzed ubiquitylation of histone H2A
  JOURNAL   Cell Cycle 7 (11), 1522-1524 (2008)
   PUBMED   18469533
REFERENCE   8  (bases 1 to 4328)
  AUTHORS   Zhang,X.Y., Varthi,M., Sykes,S.M., Phillips,C., Warzecha,C.,
            Zhu,W., Wyce,A., Thorne,A.W., Berger,S.L. and McMahon,S.B.
  TITLE     The putative cancer stem cell marker USP22 is a subunit of the
            human SAGA complex required for activated transcription and
            cell-cycle progression
  JOURNAL   Mol Cell 29 (1), 102-111 (2008)
   PUBMED   18206973
REFERENCE   9  (bases 1 to 4328)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   10 (bases 1 to 4328)
  AUTHORS   Lee,H.J., Kim,M.S., Shin,J.M., Park,T.J., Chung,H.M. and Baek,K.H.
  TITLE     The expression patterns of deubiquitinating enzymes, USP22 and
            Usp22
  JOURNAL   Gene Expr Patterns 6 (3), 277-284 (2006)
   PUBMED   16378762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001191644.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.34305.1,
                                           SRR21887620.1656697.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000010.1  46354626-46354939   c
            315-447             JAXUCZ010000010.1  46348531-46348663   c
            448-561             JAXUCZ010000010.1  46346925-46347038   c
            562-663             JAXUCZ010000010.1  46342784-46342885   c
            664-833             JAXUCZ010000010.1  46341830-46341999   c
            834-981             JAXUCZ010000010.1  46338452-46338599   c
            982-1087            JAXUCZ010000010.1  46337777-46337882   c
            1088-1246           JAXUCZ010000010.1  46336194-46336352   c
            1247-1373           JAXUCZ010000010.1  46335230-46335356   c
            1374-1465           JAXUCZ010000010.1  46334126-46334217   c
            1466-1528           JAXUCZ010000010.1  46332278-46332340   c
            1529-1678           JAXUCZ010000010.1  46331450-46331599   c
            1679-4328           JAXUCZ010000010.1  46328092-46330741   c
FEATURES             Location/Qualifiers
     source          1..4328
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4328
                     /gene="Usp22"
                     /note="ubiquitin specific peptidase 22"
                     /db_xref="GeneID:303201"
                     /db_xref="RGD:1310354"
     exon            1..314
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1721
                     /gene="Usp22"
                     /note="ubiquitin specific protease 22"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 22"
                     /protein_id="NP_001178573.1"
                     /db_xref="GeneID:303201"
                     /db_xref="RGD:1310354"
                     /translation="MVARPEPEVEAMDAELAVAPPGCSHLGSFKVDNWKQNLRAIYQC
                     FVWSGTAEARKRKAKSCVCHVCGIHLNRLHSCLYCVFFGCFTKKHIHDHAKSKRHNLA
                     IDLMYGGIYCFLCQDYIYDKDIEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKH
                     NPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSS
                     CLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHR
                     HCKGDDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS
                     STPFWPLSPGSEGSVVNGESHASGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQES
                     TKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQY
                     QQPLDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVL
                     DSEGYLLFYHKQFLEYE"
     exon            315..447
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            448..561
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            562..663
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            664..833
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            834..981
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1087
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1246
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1373
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1465
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1528
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1678
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..4328
                     /gene="Usp22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagctgc gcgagcggtc tgtgctgctg tcgtctgcct cggttctcaa cgcggtcttt
       61 gtccttccag ctttgttctc gccgcgctgg cgtcgtcctc gcccccgtcg ccgcctgccc
      121 cgcgcgcccg ggccttgccc accatggtgg ccaggcccga gcctgaggtc gaggccatgg
      181 acgctgagct ggcggtggcg ccgccaggct gctcgcacct gggcagcttc aaggtggaca
      241 actggaagca aaacctgcgg gccatctacc agtgcttcgt atggagcgga actgccgagg
      301 ctcgcaagcg caaggcaaag tcctgtgtct gccatgtctg cggcattcac ctgaaccggc
      361 tgcactcttg cctctactgt gtcttctttg gctgtttcac gaagaagcac atccatgacc
      421 atgctaagtc aaagcggcac aacctggcca ttgacctgat gtatggaggt atttactgct
      481 tcttgtgcca ggactacatc tatgacaaag acatagaaat cattgccaaa gaggagcagc
      541 gcaaggcttg gaagatgcaa ggtgttggag agaagttttc gacttgggaa ccaactaaac
      601 gagagctgga gctgctgaag cacaacccga agaggcggaa gatcacctcc aactgcacca
      661 taggtctgcg tggactgatc aacctgggga acacatgttt catgaactgc atcgtgcagg
      721 cgctaaccca cacgccgctt ctgagggact tctttctgtc agataggcac cgctgtgaga
      781 tgcagagccc cagctcctgc ctggtctgcg agatgtcctc tctcttccag gagttttact
      841 cggggcaccg ctccccacac attccgtaca agctgctgca cctggtgtgg acgcacgccc
      901 ggcacctggc aggttatgag cagcaggacg cccatgagtt cctcattgca gccctggacg
      961 tcctccaccg gcactgcaaa ggtgatgaca acgggaagaa agccaacaac cctaaccact
     1021 gcaattgcat cattgaccag atcttcacgg gtgggctcca gtctgatgtc acatgccagg
     1081 tctgccatgg ggtctccacc accatagacc ccttctggga catcagttta gacctgcccg
     1141 gttcttccac cccattctgg cccttaagcc cagggagcga gggcagtgtc gtcaatgggg
     1201 agagccacgc gtctgggacc accactctca cagactgcct gcgaagattt accagaccag
     1261 aacacttagg aagcagtgcc aagatcaagt gtagtggttg ccatagctac caagagtcca
     1321 caaagcagct caccatgaag aagctaccca ttgtggcctg cttccatctc aaacgatttg
     1381 aacactcagc caaacttcgg cggaagatca ccacatatgt gtcttttccc ctggaattgg
     1441 acatgacgcc ctttatggcc tccagcaaag agagcaggat gaatgggcag taccagcagc
     1501 ccctggacag tctcaacaat gacaacaaat actccttgtt tgctgtcgtt aaccaccaag
     1561 ggaccttgga gagtggccac tacaccagct tcatccggca gcacaaagac cagtggttca
     1621 agtgtgatga cgccatcatc accaaggcca gcatcaaaga tgtgctggac agcgaagggt
     1681 acctgctctt ctaccacaaa cagttcctgg aatatgagta gcctcctgcc ttgcaggcca
     1741 gaaaaatcga gagagaacaa gttggcaaac ttcctgacat gatccctgct tcccccgaat
     1801 cagaacatgg cattcctcct gtgcaggcga gcctcacatg tggcccccct gcactagggg
     1861 atgtgtcagg tgggatgagc gtaagagctg agtggggtgc gcccttggtg gaaaggagct
     1921 ccctctccag cacctgtctt ttcaaccttg taagctaggg atgggtgtct tcagagcaga
     1981 ccatctgtct gcctggtgct tcaccctgcc atcccacatg gtaaaaagca cctgcctcct
     2041 tgaaaatgag cccatcaaag ctgtagagtg ggcaaagatg atgccagagg gcagagtgct
     2101 tgcagcagcc ctctggcatg aagggcgggg ggcttgtcct ttctaaagtt gtaaggtagc
     2161 cctgggccca gggcgaggcc acccacaggc tacagataca actgtcctac agataactta
     2221 gcatcaactg catgtggaaa catcagccca gaggttccct ttgttgtcta gaagtaggca
     2281 tcttcttccc tgtaccccat tgctcctttc cacggtggtg atgttcataa acgtgatgat
     2341 agtgaggtga aggattattg agtttgtacg ggattctaga tgagcctctt ccccctgaga
     2401 gcaagtgtct ggcttgttga tcagtgttgt ttccttgccc tgtgccctga cttccttccc
     2461 acacggctgg tggccaggga tcggggccta gtatcttgat ctttgcagta gattccttca
     2521 tggtcccatt gacccaatcc tccatgtttc ttattggtct ctggtctttt tacctgcgag
     2581 ggtgggtgag tggctgcgtg agatttgaag ctgagtggtc caggtggaga ctgcattgca
     2641 tagtgtcacc cgcttgcctc tgctctgtgt tcactacagt ttcagtcaca gccagaataa
     2701 gaagactcca tcaccagttc tgttggcagg gtcaatcatg aagtttattg taagatattt
     2761 tgcatgtatc tctggacaag gcctaggttg ctcgcttcta agagattgaa atctaaagtc
     2821 ttggtgtttt ctcctttcac cactgccttt tcagtggtgc ttgtctggga gcctattggc
     2881 acccacccca ggagtttcag gaccggcaag tgtttcctaa gagccaggct ctgagccgta
     2941 ggtccatagc aagtaacacg tgcatcatgt ttgcatagca agtacgcctg tgatttacat
     3001 tacagataac tacagatttt gtacagattt ttttttttta actatttgaa aataagattt
     3061 ttttttcacg tacaggctat aaagagcagt acagggtcca gcccagctcc ttagctagtt
     3121 gtgatggaat gaggtagctg tggcagaatt aagtgactgc tgctcaattg atgtaaaagt
     3181 cacccgacgt cagaggcaac aaaagccacc tcgtgtggtg acacttgccc tgttcttctc
     3241 tggtgtgttt ctctttctgc atttaaagta aagaacagac tcgaagcatg ttttagaaaa
     3301 atcctttcag tatgacagcc tagactctcc ggcatggagc catgtttgtg ggactcggct
     3361 gtggagatgc cctggggcag cacatcgggc ttgtgaacaa gcctacagga agcctccctg
     3421 cagctcctgg gggtctgcct ccttggcact gcagtggatg gcgtcagagc agggtggggc
     3481 cagagcgggg gacgagcagg tgtgctggcc aggcctgctc ctctgtcccc acagcacaca
     3541 gcccgtttcc tcctgtattc ggggcacatg actgaccttt tctatcccaa agcattcact
     3601 ctgtacctat ggcaaggtca gccaactcca tgactgccac gcgtccatct ggccttacct
     3661 ctctgtcctg gagtccacag catgatgtct ccactagaca ggcatatgtg gatgactaag
     3721 gaaggccata tttgagcagt gggcttggga agttctctca gttcctcctc tggacagcta
     3781 ggcaggaaaa gggtttccca tccaagaccc acatagtgtg tgtgctcaga tggtcacgaa
     3841 gtgcatctcg ccacagggtg gctttgccca cccctcgtct ggagcagtga gcagacttca
     3901 tatactgctg gcatcagctg cacaggagag ggagggagcc ctcttccagt gtcctcagtg
     3961 agagattaag gtgttaggtg ggacctgcga tacctctctt catcccggaa gcccccctcg
     4021 agctgggcac tacctgagcg ccccacacca tgtgaacctg agtgctgttg tattggctcg
     4081 gtgtgtgtgc tttttcttgt gtaaaatcat tgttcttttt gacaagtggc ttgtttcatt
     4141 tattatggct ttgaaataaa aaattgtgag ggagaaaaaa tccaatgatt gtattgtggt
     4201 tagaagtttt attaccaaga cgtttatgta actttccttt cccttgtcat tttgaggggc
     4261 tgttcgactc ctccctgatg gcttttagtc tttcctatat cataataaaa ctgcatttta
     4321 ttctgaaa
//
