LOCUS       NM_001127638            2184 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 21 (Usp21), mRNA.
ACCESSION   NM_001127638 XM_001054722 XM_001067071
VERSION     NM_001127638.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Khan,A., Giri,S., Wang,Y., Chakraborty,A., Ghosh,A.K.,
            Anantharaman,A., Aggarwal,V., Sathyan,K.M., Ha,T., Prasanth,K.V.
            and Prasanth,S.G.
  TITLE     BEND3 represses rDNA transcription by stabilizing a NoRC component
            via USP21 deubiquitinase
  JOURNAL   Proc Natl Acad Sci U S A 112 (27), 8338-8343 (2015)
   PUBMED   26100909
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Belle,J.I. and Nijnik,A.
  TITLE     H2A-DUBbing the mammalian epigenome: expanding frontiers for
            histone H2A deubiquitinating enzymes in cell biology and physiology
  JOURNAL   Int J Biochem Cell Biol 50, 161-174 (2014)
   PUBMED   24647359
  REMARK    Review article
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Urbe,S., Liu,H., Hayes,S.D., Heride,C., Rigden,D.J. and Clague,M.J.
  TITLE     Systematic survey of deubiquitinase localization identifies USP21
            as a regulator of centrosome- and microtubule-associated functions
  JOURNAL   Mol Biol Cell 23 (6), 1095-1103 (2012)
   PUBMED   22298430
  REMARK    GeneRIF: Studies indicate a key role for USP21 in the governance of
            microtubule- and centrosome-associated physiological processes.
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Nakagawa,T., Kajitani,T., Togo,S., Masuko,N., Ohdan,H.,
            Hishikawa,Y., Koji,T., Matsuyama,T., Ikura,T., Muramatsu,M. and
            Ito,T.
  TITLE     Deubiquitylation of histone H2A activates transcriptional
            initiation via trans-histone cross-talk with H3K4 di- and
            trimethylation
  JOURNAL   Genes Dev 22 (1), 37-49 (2008)
   PUBMED   18172164
REFERENCE   5  (bases 1 to 2184)
  AUTHORS   Gong,L., Kamitani,T., Millas,S. and Yeh,E.T.
  TITLE     Identification of a novel isopeptidase with dual specificity for
            ubiquitin- and NEDD8-conjugated proteins
  JOURNAL   J Biol Chem 275 (19), 14212-14216 (2000)
   PUBMED   10799498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Jul 21, 2021 this sequence version replaced NM_001127638.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166443.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760389,
                                           SAMN16676784 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000013.1  86240987-86241180   c
            195-815             JAXUCZ010000013.1  86239575-86240195   c
            816-875             JAXUCZ010000013.1  86238769-86238828   c
            876-996             JAXUCZ010000013.1  86238363-86238483   c
            997-1108            JAXUCZ010000013.1  86238040-86238151   c
            1109-1264           JAXUCZ010000013.1  86237705-86237860   c
            1265-1329           JAXUCZ010000013.1  86237140-86237204   c
            1330-1433           JAXUCZ010000013.1  86236825-86236928   c
            1434-1520           JAXUCZ010000013.1  86236547-86236633   c
            1521-1599           JAXUCZ010000013.1  86236224-86236302   c
            1600-1707           JAXUCZ010000013.1  86235903-86236010   c
            1708-1822           JAXUCZ010000013.1  86235702-86235816   c
            1823-2184           JAXUCZ010000013.1  86235127-86235488   c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2184
                     /gene="Usp21"
                     /note="ubiquitin specific peptidase 21"
                     /db_xref="GeneID:688466"
                     /db_xref="RGD:1588822"
     exon            1..194
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            195..815
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1913
                     /gene="Usp21"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin-specific protease 21; ubiquitin
                     thioesterase 21; deubiquitinating enzyme 21;
                     ubiquitin-specific-processing protease 21; ubiquitin
                     thiolesterase 21"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 21"
                     /protein_id="NP_001121110.1"
                     /db_xref="GeneID:688466"
                     /db_xref="RGD:1588822"
                     /translation="MPQASEHRLGRTREPPVNVQPRVGAKIPFPPRARSKERRNPVPG
                     PNSMLRPLPPRPGPPDERLKKLDLGRGRTSGSRPRGPLRADHGVPLPGSPPPTVALPL
                     PSRTNLTRSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRL
                     GGFPGPPTLLSIRTEPPPSHGSFHMISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLG
                     NTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCE
                     AVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVP
                     SPPRRGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST
                     TFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKL
                     TVQRFPRILVLHLNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKVGSPVYQLYALC
                     NHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL"
     exon            816..875
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            876..996
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1108
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1264
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1329
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1433
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1520
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1599
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1707
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1822
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2184
                     /gene="Usp21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagccgg tggccggtgg ccgggcggca ccaacaaaga tggcggcggc ccttgcggcg
       61 ggagcaagct gggcaacagc tgcggctaaa gctgcagcct ggcctgcggg gaggctgttc
      121 gggggtagga gggggtggcc ctgagctgga gctggacccc ggctggcctc ccccgccgcc
      181 tcaccggggg acaggtccag cctgcggtgc ccacaatgcc ccaggcttct gagcaccgcc
      241 tgggccggac tcgagagcca cctgtcaatg tacagccccg agtgggagcc aagataccgt
      301 ttcctccccg ggcccgcagc aaggagcgcc gaaacccagt tcctgggcca aactccatgt
      361 tacgaccttt gcctcccagg ccaggtcccc cagatgaaag gctcaagaaa ctggatttgg
      421 gtcggggtcg gacctcaggc tctcgtccta gaggtcccct tcgagcagat catggggttc
      481 ccttgcctgg ctcaccaccc ccaactgtgg ctctgcctct cccatcccgg accaacctaa
      541 cccgatccaa gtctgtgagc agtggggact tgcgtccaat ggggattgcc ttgggagggc
      601 accgtggcac tggcgagcta ggggctgcac tgagccgcct ggcactccgg cctgagccac
      661 ccactttgag acgtagtact tctctccggc gtcttggggg tttccctgga ccccctaccc
      721 tgctcagcat acggacagag ccccctcctt cccatggctc cttccacatg atatctgccc
      781 ggccttctga gcctttctac tctgatgaca agatggctca ccacacactg cttctgggct
      841 ctggtcatgt tggcctccga aatctaggaa atacatgctt cctgaacgcc gtgttacagt
      901 gtttgagcag cacaaggcct cttcgagact tttgtctgcg aagggacttc cggcaagagg
      961 tgcccggagg aggccgagcc caggaactca cagaagcctt tgcagatgtg attggtgccc
     1021 tctggcaccc tgactcctgt gaagctgtga atcctacccg attccgggct gtcttccaga
     1081 aatacgtccc ttccttctct ggatacagcc agcaggatgc ccaagagttc ctgaagctcc
     1141 ttatggagcg gttgcacctc gaaatcaacc gacgaggccg ccgggcacca ccaattctgg
     1201 ccagtggtcc agttccctcc ccacctcgcc gaggaggggc tctgcatgaa gaacctgaac
     1261 tgagtgatga tgaccgagcc aacttaatgt ggaagcgcta cctggagcga gaagacagca
     1321 agattgtgga cctgtttgtg ggccagctga aaagttgcct caagtgccag gcctgtgggt
     1381 atcgctccac gaccttcgag gttttttgtg acctgtccct gcccatcccc aagaaaggat
     1441 ttgctggggg caaagtgtct ttgcgggatt gcttcagcct tttcaccaag gaggaggagc
     1501 tagagtcgga gaatgcccca gtatgtgacc gatgtcggca gaaaacacga agtaccaaaa
     1561 agttgacagt acaaagattc ccccgaatcc tcgtgctcca tctgaaccga ttttccacct
     1621 cccgaggctc catcaagaaa agttcagtag gtgtagactt cccactgcag cgactaagcc
     1681 taggggactt tgccagcgac aaagtgggaa gccctgtcta ccagctgtat gccctttgca
     1741 accactcggg tagtgtccac tatggccact acacagccct gtgccggtgc cagactggtt
     1801 ggcatgtcta caatgactcc cgtgtctccc ctgtcagtga aaaccaggtg gcatccagtg
     1861 agggctacgt gctgttctac caattgatgc aggaaccacc tcggtgcctg tgacgccatc
     1921 ttgaagccct ggcacctgtg aaaaccttct caacaccctt aagcccccag gctccccact
     1981 tacctcacag acgtctattt ttgtgtcttt ttaatcgggg aggggaggag ggttggttgt
     2041 agctcccgtt atttttttta ttaagaagta cccttccacc ttgttttcct gtcccatgta
     2101 cagaaattac caggcccttg accatgtaca gcccccagaa cctctgcaat ctcacttttt
     2161 tgtgaataaa tttattaaga aaaa
//
