LOCUS       NM_053774               2086 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 2 (Usp2), mRNA.
ACCESSION   NM_053774
VERSION     NM_053774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2086)
  AUTHORS   Xu,Q., Liu,M., Zhang,F., Liu,X., Ling,S., Chen,X., Gu,J., Ou,W.,
            Liu,S. and Liu,N.
  TITLE     Ubiquitin-specific protease 2 regulates Ang -induced cardiac
            fibroblasts activation by up-regulating cyclin D1 and stabilizing
            beta-catenin in vitro
  JOURNAL   J Cell Mol Med 25 (2), 1001-1011 (2021)
   PUBMED   33314748
  REMARK    GeneRIF: Ubiquitin-specific protease 2 regulates Ang -induced
            cardiac fibroblasts activation by up-regulating cyclin D1 and
            stabilizing beta-catenin in vitro.
REFERENCE   2  (bases 1 to 2086)
  AUTHORS   Li,C., Zhang,J., Xu,H., Chang,M., Lv,C., Xue,W., Song,Z., Zhang,L.,
            Zhang,X. and Tian,X.
  TITLE     Retigabine ameliorates acute stress-induced impairment of spatial
            memory retrieval through regulating USP2 signaling pathways in
            hippocampal CA1 area
  JOURNAL   Neuropharmacology 135, 151-162 (2018)
   PUBMED   29501527
  REMARK    GeneRIF: results have identified USP2 as a key molecule that
            mediates stress-induced spatial memory retrieval impairment.
REFERENCE   3  (bases 1 to 2086)
  AUTHORS   Pouly,D., Chenaux,S., Martin,V., Babis,M., Koch,R., Nagoshi,E.,
            Katanaev,V.L., Gachon,F. and Staub,O.
  TITLE     USP2-45 Is a Circadian Clock Output Effector Regulating Calcium
            Absorption at the Post-Translational Level
  JOURNAL   PLoS One 11 (1), e0145155 (2016)
   PUBMED   26756164
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2086)
  AUTHORS   Kitamura,H., Kimura,S., Shimamoto,Y., Okabe,J., Ito,M.,
            Miyamoto,T., Naoe,Y., Kikuguchi,C., Meek,B., Toda,C., Okamoto,S.,
            Kanehira,K., Hase,K., Watarai,H., Ishizuka,M., El-Osta,A., Ohara,O.
            and Miyoshi,I.
  TITLE     Ubiquitin-specific protease 2-69 in macrophages potentially
            modulates metainflammation
  JOURNAL   FASEB J 27 (12), 4940-4953 (2013)
   PUBMED   24005904
REFERENCE   5  (bases 1 to 2086)
  AUTHORS   Yang,Y., Duguay,D., Bedard,N., Rachalski,A., Baquiran,G., Na,C.H.,
            Fahrenkrug,J., Storch,K.F., Peng,J., Wing,S.S. and Cermakian,N.
  TITLE     Regulation of behavioral circadian rhythms and clock protein PER1
            by the deubiquitinating enzyme USP2
  JOURNAL   Biol Open 1 (8), 789-801 (2012)
   PUBMED   23213472
REFERENCE   6  (bases 1 to 2086)
  AUTHORS   Allende-Vega,N., Sparks,A., Lane,D.P. and Saville,M.K.
  TITLE     MdmX is a substrate for the deubiquitinating enzyme USP2a
  JOURNAL   Oncogene 29 (3), 432-441 (2010)
   PUBMED   19838211
REFERENCE   7  (bases 1 to 2086)
  AUTHORS   Stevenson,L.F., Sparks,A., Allende-Vega,N., Xirodimas,D.P.,
            Lane,D.P. and Saville,M.K.
  TITLE     The deubiquitinating enzyme USP2a regulates the p53 pathway by
            targeting Mdm2
  JOURNAL   EMBO J 26 (4), 976-986 (2007)
   PUBMED   17290220
REFERENCE   8  (bases 1 to 2086)
  AUTHORS   Gousseva,N. and Baker,R.T.
  TITLE     Gene structure, alternate splicing, tissue distribution, cellular
            localization, and developmental expression pattern of mouse
            deubiquitinating enzyme isoforms Usp2-45 and Usp2-69
  JOURNAL   Gene Expr 11 (3-4), 163-179 (2003)
   PUBMED   14686789
REFERENCE   9  (bases 1 to 2086)
  AUTHORS   Park,K.C., Kim,J.H., Choi,E.J., Min,S.W., Rhee,S., Baek,S.H.,
            Chung,S.S., Bang,O., Park,D., Chiba,T., Tanaka,K. and Chung,C.H.
  TITLE     Antagonistic regulation of myogenesis by two deubiquitinating
            enzymes, UBP45 and UBP69
  JOURNAL   Proc Natl Acad Sci U S A 99 (15), 9733-9738 (2002)
   PUBMED   12107281
  REMARK    GeneRIF: myogenic differentiation of embryonic muscle cells is
            antagonistically regulated by two deubiquitinating enzymes, UBP45
            and UBP69, that are generated by alternative splicing[Usp2].
REFERENCE   10 (bases 1 to 2086)
  AUTHORS   Lin,H., Keriel,A., Morales,C.R., Bedard,N., Zhao,Q., Hingamp,P.,
            Lefrancois,S., Combaret,L. and Wing,S.S.
  TITLE     Divergent N-terminal sequences target an inducible testis
            deubiquitinating enzyme to distinct subcellular structures
  JOURNAL   Mol Cell Biol 20 (17), 6568-6578 (2000)
   PUBMED   10938131
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053774.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106659.1, BC085719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000008.1  53310870-53310953
            85-938              JAXUCZ010000008.1  53316665-53317518
            939-989             JAXUCZ010000008.1  53330268-53330318
            990-1113            JAXUCZ010000008.1  53331138-53331261
            1114-1225           JAXUCZ010000008.1  53332136-53332247
            1226-1336           JAXUCZ010000008.1  53332346-53332456
            1337-1401           JAXUCZ010000008.1  53333029-53333093
            1402-1505           JAXUCZ010000008.1  53333270-53333373
            1506-1586           JAXUCZ010000008.1  53333456-53333536
            1587-1665           JAXUCZ010000008.1  53333642-53333720
            1666-1773           JAXUCZ010000008.1  53333914-53334021
            1774-1894           JAXUCZ010000008.1  53334359-53334479
            1895-2086           JAXUCZ010000008.1  53334985-53335176
FEATURES             Location/Qualifiers
     source          1..2086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2086
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /note="ubiquitin specific peptidase 2"
                     /db_xref="GeneID:115771"
                     /db_xref="RGD:621073"
     exon            1..84
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            85..938
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1982
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /EC_number="3.4.19.12"
                     /note="deubiquitinating enzyme 2; ubiquitin thiolesterase
                     2; 41 kDa ubiquitin-specific protease;
                     ubiquitin-specific-processing protease 2;
                     ubiquitin-specific-processing protease testis; ubiquitin
                     specific protease 2; ubiquitin thioesterase 2"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 2"
                     /protein_id="NP_446226.3"
                     /db_xref="GeneID:115771"
                     /db_xref="RGD:621073"
                     /translation="MSQLSSTLKRYTESSRYTDAPYAKSGYGTYTPSSYGANLAASFL
                     EKEKLGFKPVSPTSFLPRPRTYGPSSILDCDRGRPLLRSDITGGSKRSESQTRGNERP
                     SGSGLNGGSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQSDLARDFSSLRTSDSY
                     RTSDGYRASDGFRIDPGNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYGRK
                     GSAPQVLTQAPPSRVPEVLSPTYRPSGRYTLWEKNKGQASGPSRSTSPGRDTMNSKSA
                     QGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAKL
                     IQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVAAR
                     PKPSPESLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP
                     FWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFP
                     KILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTT
                     MGGHYTAYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM"
     exon            939..989
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1113
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1225
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1336
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1401
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1505
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1586
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1665
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1773
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1894
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2086
                     /gene="Usp2"
                     /gene_synonym="UBP-t"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccagcttc tagactctac aacagccgtc ttttccctgc gaggaaagaa gcccccagat
       61 cccatccagt gcccccggac acagcccatg aggctcccag tacccactga gtaccaccct
      121 gaaggatgtc ccagctctcc tccaccctga agcgctatac agaatcgtcc cgctacacag
      181 atgcccctta tgccaaatcg ggctatggca cctacacccc ttcttcctat ggggccaacc
      241 tggccgcctc cttcctggag aaggaaaaac ttggtttcaa gccggtctcc cccaccagct
      301 tcctcccacg gccccgcacc tacggcccct cctccatcct ggactgtgac aggggccgcc
      361 ccctgctgag atctgacatc actgggggta gtaagcggtc tgagagccag acccgtggca
      421 atgaaaggcc ctcaggcagt ggactcaacg gaggcagtgg atttccttat ggagtgacca
      481 gcaactccct cagctacctg cccatgaatg ccagagacca gggcgtgacc ctgggccaga
      541 agaaatcgaa cagccaatca gacctggccc gggatttctc cagcctccgg acctcagata
      601 gctacaggac ttcagatggc taccgggcct cagatggctt taggatagac cccggaaacc
      661 tgggtcgcag ccccatgctg gcccgcacac gtaaggagct ctgtgccctg cagggcctct
      721 accaagcagc cagccgttct gagtacctaa cagactatct ggagaactat ggccgcaagg
      781 gcagtgcacc acaggtgctc acacaggccc ctccctcccg agtccccgaa gtcctcagtc
      841 ccacctaccg accaagtggc cgctacacac tgtgggagaa gaacaagggc caggcttctg
      901 ggcccagccg ctccacttct ccagggcgag acaccatgaa ttcaaagagt gcccagggtc
      961 tggctggtct tcgaaacctt gggaacacgt gcttcatgaa ctcaattctt cagtgtctga
     1021 gcaacacccg cgagttgaga gattactgcc tccagaggct gtacatgcgg gacctcggcc
     1081 ataccagcag tgcacacaca gctctcatgg aagagtttgc aaaactaatc cagaccatat
     1141 ggacgtcatc ccccaatgat gtggtgagcc catctgagtt caagacccag atccagagat
     1201 atgcaccacg cttcgttggc tataatcagc aggatgctca ggaattcctc cgtttccttc
     1261 tggatggcct ccacaacgag gtgaaccggg tggcagcaag gcctaagccc agccctgaga
     1321 gccttgatca tctccctgat gaagagaaag ggcgacagat gtggaggaag tatctagaaa
     1381 gggaagacag tcggattggg gatctcttcg ttgggcagct aaagagctcc ctgacgtgca
     1441 ccgactgcgg ctactgctct acagtgttcg atcccttctg ggacctctcg ttgcccattg
     1501 caaagagagg ctatcctgaa gtgacgttaa tggattgtat gaggctcttc accaaagagg
     1561 atgtgttgga tggggatgag aaaccaacat gctgccgctg ccgggccaga aaacgatgta
     1621 taaagaagtt ctctgtccag aggttcccaa agatcttggt gctccacctg aagcggttct
     1681 cagaatccag gatacgaacc agcaagctca caacatttgt gaatttccca ctaagagacc
     1741 tggacttgag agaatttgct tcagaaaaca ccaaccatgc tgtttacaac ctgtatgctg
     1801 tgtccaatca ctccggaacc accatgggag gtcactatac agcctactgc cgaagtccgg
     1861 ttacgggcga atggcacact ttcaatgact ccagtgtcac acccatgtcc tccagccaag
     1921 tgcgcaccag cgacgcctat ttgctcttct atgaactggc cagtccaccc tcccgtatgt
     1981 agcattgagg agctacaacc cttccctctt ccctgtggtg gccccacgtc ctaagttttt
     2041 ttttaaaaat tcagaaaaaa aaacaccaca aaaaaaaaaa aaaaaa
//
