LOCUS       NM_001001516            4292 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 19 (Usp19), mRNA.
ACCESSION   NM_001001516 XM_341471 XM_341472
VERSION     NM_001001516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4292)
  AUTHORS   Miao,R., Lu,Y., He,X., Liu,X., Chen,Z. and Wang,J.
  TITLE     Ubiquitin-specific protease 19 blunts pathological cardiac
            hypertrophy via inhibition of the TAK1-dependent pathway
  JOURNAL   J Cell Mol Med 24 (18), 10946-10957 (2020)
   PUBMED   32798288
  REMARK    GeneRIF: Ubiquitin-specific protease 19 blunts pathological cardiac
            hypertrophy via inhibition of the TAK1-dependent pathway.
REFERENCE   2  (bases 1 to 4292)
  AUTHORS   Zhang,X., Jiang,Y., Han,W., Liu,A., Xie,X., Han,C., Fan,C.,
            Wang,H., Zhang,H., Ding,S., Shan,Z. and Teng,W.
  TITLE     Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine
            Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary
  JOURNAL   Biol Trace Elem Res 174 (2), 377-386 (2016)
   PUBMED   27156111
  REMARK    GeneRIF: High iodine intake had no discernible effects on USP20.
            Temporary increases in USP33 and USP19 mRNA levels were observed.
            The enzymes related to D2 ubiquitination change with prolonged high
            iodine intake. Increased D2 ubiquitination suppresses the activity
            of D2, causing a decrease in negative feedback of the
            hypothalamic-pituitary-thyroid axis.
REFERENCE   3  (bases 1 to 4292)
  AUTHORS   Wiles,B., Miao,M., Coyne,E., Larose,L., Cybulsky,A.V. and Wing,S.S.
  TITLE     USP19 deubiquitinating enzyme inhibits muscle cell differentiation
            by suppressing unfolded-protein response signaling
  JOURNAL   Mol Biol Cell 26 (5), 913-923 (2015)
   PUBMED   25568336
  REMARK    GeneRIF: Deubiquitination by USP19 does modulate muscle cell
            differentiation and that this function requires the ER-localized
            isoform and appears to act through regulation of the
            unfolded-protein response (UPR) signaling.
REFERENCE   4  (bases 1 to 4292)
  AUTHORS   Nakamura,N., Harada,K., Kato,M. and Hirose,S.
  TITLE     Ubiquitin-specific protease 19 regulates the stability of the E3
            ubiquitin ligase MARCH6
  JOURNAL   Exp Cell Res 328 (1), 207-216 (2014)
   PUBMED   25088257
REFERENCE   5  (bases 1 to 4292)
  AUTHORS   Lee,J.G., Kim,W., Gygi,S. and Ye,Y.
  TITLE     Characterization of the deubiquitinating activity of USP19 and its
            role in endoplasmic reticulum-associated degradation
  JOURNAL   J Biol Chem 289 (6), 3510-3517 (2014)
   PUBMED   24356957
REFERENCE   6  (bases 1 to 4292)
  AUTHORS   Ogawa,M., Yamaji,R., Higashimura,Y., Harada,N., Ashida,H.,
            Nakano,Y. and Inui,H.
  TITLE     17beta-estradiol represses myogenic differentiation by increasing
            ubiquitin-specific peptidase 19 through estrogen receptor alpha
  JOURNAL   J Biol Chem 286 (48), 41455-41465 (2011)
   PUBMED   21971047
REFERENCE   7  (bases 1 to 4292)
  AUTHORS   Sundaram,P., Pang,Z., Miao,M., Yu,L. and Wing,S.S.
  TITLE     USP19-deubiquitinating enzyme regulates levels of major
            myofibrillar proteins in L6 muscle cells
  JOURNAL   Am J Physiol Endocrinol Metab 297 (6), E1283-E1290 (2009)
   PUBMED   19773579
  REMARK    GeneRIF: USP19 modulates transcription of major myofibrillar
            proteins.
REFERENCE   8  (bases 1 to 4292)
  AUTHORS   Hassink,G.C., Zhao,B., Sompallae,R., Altun,M., Gastaldello,S.,
            Zinin,N.V., Masucci,M.G. and Lindsten,K.
  TITLE     The ER-resident ubiquitin-specific protease 19 participates in the
            UPR and rescues ERAD substrates
  JOURNAL   EMBO Rep 10 (7), 755-761 (2009)
   PUBMED   19465887
REFERENCE   9  (bases 1 to 4292)
  AUTHORS   Lu,Y., Adegoke,O.A., Nepveu,A., Nakayama,K.I., Bedard,N., Cheng,D.,
            Peng,J. and Wing,S.S.
  TITLE     USP19 deubiquitinating enzyme supports cell proliferation by
            stabilizing KPC1, a ubiquitin ligase for p27Kip1
  JOURNAL   Mol Cell Biol 29 (2), 547-558 (2009)
   PUBMED   19015242
  REMARK    GeneRIF: study reports that the USP19 deubiquitinating enzyme
            interacts with and stabilizes KPC1, thereby modulating p27(Kip1)
            levels and cell proliferation
            Erratum:[Mol Cell Biol. 2009 Jun;29(11):3241]
REFERENCE   10 (bases 1 to 4292)
  AUTHORS   Combaret,L., Adegoke,O.A., Bedard,N., Baracos,V., Attaix,D. and
            Wing,S.S.
  TITLE     USP19 is a ubiquitin-specific protease regulated in rat skeletal
            muscle during catabolic states
  JOURNAL   Am J Physiol Endocrinol Metab 288 (4), E693-E700 (2005)
   PUBMED   15562254
  REMARK    GeneRIF: USP19 is regulated in rat skeletal muscle during catabolic
            states.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY605065.1.
            
            On Feb 21, 2013 this sequence version replaced NM_001001516.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY605065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4292              AY605065.1         1-4292
FEATURES             Location/Qualifiers
     source          1..4292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4292
                     /gene="Usp19"
                     /note="ubiquitin specific peptidase 19"
                     /db_xref="GeneID:361190"
                     /db_xref="RGD:1303276"
     CDS             1..4074
                     /gene="Usp19"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 19; ubiquitin
                     thiolesterase 19; ubiquitin thioesterase 19;
                     deubiquitinating enzyme 19; ubiquitin-specific-processing
                     protease 19"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 19"
                     /protein_id="NP_001001516.1"
                     /db_xref="GeneID:361190"
                     /db_xref="RGD:1303276"
                     /translation="MSAGTSATGPRRGPPGLEEATSKKKQKDRANQESKDGDPRRVSM
                     PRKEPTKDELLLDWRQSSDKVVVKLRVGTGPICLEEVDAAFTDTDCVVRLPDGRQWGG
                     VFFAKIQSSCTKVQTRKGGLLQLALPKKVPLLTWPSLLKKPLGTQELVPGLRCQENGQ
                     ELSPIALEPGSEPRRAKQEARNQKRAQGRGEVGSGASPGAQAGPSAKRAVHLCRGPEG
                     EGSMDGPGPQGDAPSFLSDSATQVEAEEQLHVPPVNPQTSLLGSEKNLALLTVEKTVS
                     PRSDSVSPVMIRNRDPEKDDHFKEEMAVGADPAALADEPESMVNLAFVKNDSYEKGPD
                     SVVVHVYVKESRRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRNL
                     IEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPATRVGGAKVAVPTGPTPLDSTPPGG
                     GPLPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVTPKPEPHLASPKPTCMVP
                     PMPHSPVSGDSVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHD
                     RSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTGYA
                     QHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIV
                     DLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPIYYFAREPHSKPIKFLV
                     SVSKENSSASEVLESLSQSVHVKPESLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLC
                     FELLSPELAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEDEKLKRCTRCYRVGYC
                     NQFCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPF
                     QPGRMALESQSPGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAEGDTGAHRMWPPA
                     DRGPVPSTSGISSEMLASGPMEGCSLLAGERVSRPEAAVPGYQHSRESVSAHTPQFFI
                     YKIDASSREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSA
                     GEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQL
                     KRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGH
                     YTACARLPSDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR
                     AAHAEHHPDLGPAAEAAASQASRIWQELEAEEEMVPEGPGPLGPWGPQDWVGPPPRGP
                     TTSDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR"
     exon            1..124
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            125..157
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            158..286
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            287..420
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            421..723
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            724..940
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1097
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1169
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1285
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1500
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1696
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1830
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1989
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2100
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2211
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2313
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2454
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2573
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2711
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..3025
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3136
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3353
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3506
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3667
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3846
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
     exon            3847..4292
                     /gene="Usp19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctgctg gcaccagtgc tacaggccca aggagggggc ctccgggatt ggaggaggca
       61 actagtaaga agaaacagaa ggatcgagca aaccaggaaa gtaaggatgg agatcctagg
      121 agagtgtcca tgcctcgaaa ggagcccacc aaagatgaac tgttgctcga ttggagacag
      181 agttcagata aggtggttgt taagctgcgc gtgggaacag gtcccatatg tctggaggaa
      241 gtagatgctg ctttcacaga cacggactgt gtggtgaggc ttccagatgg tcggcagtgg
      301 ggtggtgtct tctttgctaa aatacaaagt tcttgtacca aagtgcagac tcgcaagggt
      361 ggtcttctac agttggcact accaaagaag gtgcctcttc tcacgtggcc ctctctcctg
      421 aagaaacctc tagggaccca agaactggtg ccaggattgc ggtgccagga gaacggacaa
      481 gaactgtctc ccattgccct ggagccaggt tctgagcccc gcagagctaa acaggaagct
      541 cgaaaccaga agagggccca gggccgtggt gaggtaggct caggggctag ccctggggca
      601 caggcagggc ccagtgccaa gagggctgtt catctctgca gagggccaga aggtgaaggg
      661 tccatggatg ggcctggccc ccagggtgat gccccatcct tcctgtccga ctcagctacg
      721 caggttgagg ctgaggagca gctccatgtt ccaccagtga accctcaaac aagtctcttg
      781 ggctcagaga agaatttagc ccttttgaca gtagagaaga cagtgtcccc caggagtgac
      841 tcagtctccc cagtcatgat ccggaacaga gaccctgaga aagatgacca tttcaaagag
      901 gagatggcag ttggagctga tcctgcagcc ttagcggatg aaccagagtc tatggtgaac
      961 ctggcatttg tcaagaatga ttcgtatgag aaggggccgg attcagtggt ggtgcacgtg
     1021 tatgtgaagg agagccgcag ggatacctct cgagtacttt tccgagagca ggacttcacg
     1081 ctgatcttcc agaccaggga tggaaatttt ctgaggctgc atccgggctg tgggccccac
     1141 accatcttcc gctggcaggt gaagctcagg aacttgattg agccagagca atgtacgttt
     1201 tgtttcacgg cctctcgaat cgatatctgc ctccggaagc ggcagagtca gcgctggggg
     1261 ggactggagg cccctgctac acgagtgggt ggtgcaaagg ttgccgtgcc gacaggtcca
     1321 acccctttgg attcaacccc tccaggaggt ggccccctcc ctctgactgg ccaggaggaa
     1381 gccagggctg tagagaagga aaaacccaag gctcggtcag aggactcggg gctggatggt
     1441 gtggtggctc gcaccccctt ggagcatgtt accccaaagc cagaaccgca cttggcctcg
     1501 cccaaaccca catgtatggt gcctccaatg cctcatagtc cagtgagtgg agatagtgtg
     1561 gaggaggatg aagaggaaga gaagaaggtt tgtctcccag gctttactgg cctcgtcaac
     1621 ttagggaaca cctgcttcat gaatagtgtc attcagtctc tgtccaacac tcgggagctt
     1681 cgtgacttct tccacgaccg atcctttgag gctgagatta actacaataa cccattgggg
     1741 actggtgggc gtctggctat tggcttcgct gtgctgctcc gggccctgtg gaagggcact
     1801 caccaagcct ttcaaccctc caagctaaag gccattgtag caagcaaggc cagccagttt
     1861 acaggctacg cacagcatga tgcccaagag ttcatggctt tcttgttgga tgggctgcat
     1921 gaagacctga atcggatcca aaacaaaccc tacacagaga ctgtggactc agatgggcga
     1981 cctgacgagg tggtggctga agaagcatgg cagcggcaca agatgaggaa cgactcattc
     2041 attgtggacc tgtttcaggg ccagtacaag tcaaagctgg tgtgccctgt gtgtgccaag
     2101 gtctccatca cttttgaccc gttcctttat ctgccggtac ccttgccaca aaagcaaaag
     2161 gttctcccca tatattattt tgccagagag ccccatagca aacccatcaa gttcctggtg
     2221 agcgtcagca aggagaactc cagcgcaagc gaagttttgg agtccctctc tcagagtgtc
     2281 cacgtgaagc ctgagagcct gcgcctggct gaggtaatta agaatcgttt ccaccgtgtt
     2341 tttttgccct cccactcact ggatgctgtg tcgccaacgg acgtgctcct gtgctttgag
     2401 ctgctatccc cagaattggc taaggagagg gtagtggtgc tagaggtgca gcagcgcccc
     2461 caggtaccca gcatccctat ctccaagtgt gcagcctgcc agcggaagca gcaatcagaa
     2521 gatgaaaaac tgaagcgttg tacccgttgc taccgtgtgg gctactgcaa ccagttctgt
     2581 cagaaaaccc attggcctga ccacaaaggc ctctgccgcc ccgagaacat tggctacccc
     2641 ttcctggtca gtgtacctgc ttcacgcctc acttatgccc gtcttgctca gctactagaa
     2701 ggttatgccc ggtactctgt gagcgtattc caaccaccct tccagcctgg ccgaatggct
     2761 ttggaatcac agagccctgg ctgtaccacg ttgctttcaa ccagctctct ggaggctggg
     2821 gatagtgaaa gagaacccat tcagccttct gagctccagt tggtgactcc tgtggctgag
     2881 ggggataccg gggctcaccg catgtggcca cctgctgatc ggggtcctgt gcctagcacc
     2941 agtggaattt cttccgagat gctggccagt gggcctatgg aagggtgttc cttgcttgct
     3001 ggtgagaggg tgtctcggcc tgaagctgct gtgcctgggt accagcactc acgtgagtct
     3061 gtgagcgccc acacgcccca gttcttcatc tataaaattg atgcgtcaag ccgtgagcag
     3121 cggctggagg acaaagggga cactccactg gagctaggtg atgactgtag cctggctctg
     3181 gtgtggcgga acaacgaacg ccttcaggag tttgtgctgg tggcctccaa ggagctggag
     3241 tgtgctgaag acccaggctc cgctggtgag gctgcccgtg ctggccactt caccctggac
     3301 cagtgcctca atctctttac acggcctgaa gtgctggcac ctgaggaagc ctggtactgc
     3361 ccacagtgca aacagcatcg agaggcctcc aagcagctgc tgctgtggcg cctaccaaat
     3421 gtgctcatcg tgcagctcaa gcgtttctcc tttcgtagct tcatttggcg tgacaagatc
     3481 aatgacttgg tggagtttcc agttcggaac ctggacttga gcaagttctg tattggtcag
     3541 aaagaggagc agctgcctag ctatgacctg tatgcagtca tcaaccacta cggaggcatg
     3601 atcggcggcc actacactgc ctgtgcacgg ctgcccagtg accgtagtag ccagcgcagt
     3661 gacgtgggct ggcgcttgtt tgatgacagc acggtgacaa cagtagacga gagccaggtg
     3721 gtgacacgct atgcctatgt gctcttctac cgtcggcgga actctcctgt ggagaggccc
     3781 cccagggcag ctcacgctga acaccaccca gacctaggcc ctgcagccga ggctgctgcc
     3841 agccaggctt cccggatttg gcaggagctc gaggccgagg aggagatggt gcccgagggg
     3901 cctgggcctc tgggtccttg ggggccccaa gactgggtgg ggcccccgcc acgtggccct
     3961 accacatcag acgagggctg cctccgatac tttgtcctgg gtaccgtggc ggctttggtg
     4021 gcccttgtgc tcaacgtatt ctatcctctg gtatctcaga gtcgctggag atgagctccc
     4081 ctgcaggcgc ctgctgtgag ctggcctacc tatgctcacc aggacaggcc tgcctttgtg
     4141 gtgggagaca gctctgggct ctgagcctca gtgtatgtat ctggtgggag acttgttggg
     4201 actacagcct ctgtgggggc agagtatcct agggtgtgtg tccatccagt tgtctgtcct
     4261 cctgtttctc tgacccttgt cctagggctt gg
//
