LOCUS       NM_001014058            1691 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 18 (Usp18), mRNA.
ACCESSION   NM_001014058 XM_232259
VERSION     NM_001014058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1691)
  AUTHORS   Wang,Y., Han,D., Chai,L., Qiu,Y., Liu,J., Li,D., Zhang,Q., Shen,N.,
            Chen,Y., Chen,H., Zhang,J., Wang,Q., Wang,J., Li,S., Xie,X. and
            Li,M.
  TITLE     MFN2-dependent mitochondrial dysfunction contributes to
            Relm-beta-induced pulmonary arterial hypertension via
            USP18/Twist1/miR-214 pathway
  JOURNAL   Eur J Pharmacol 980, 176828 (2024)
   PUBMED   39094924
  REMARK    GeneRIF: MFN2-dependent mitochondrial dysfunction contributes to
            Relm-beta-induced pulmonary arterial hypertension via
            USP18/Twist1/miR-214 pathway.
REFERENCE   2  (bases 1 to 1691)
  AUTHORS   Song,M., Yi,F., Zeng,F., Zheng,L., Huang,L., Sun,X., Huang,Q.,
            Deng,J., Wang,H. and Gu,W.
  TITLE     USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic
            Stroke Through Repressing m6A Modification of SIRT6
  JOURNAL   Mol Neurobiol 61 (9), 6658-6674 (2024)
   PUBMED   38340205
  REMARK    GeneRIF: USP18 Stabilized FTO Protein to Activate Mitophagy in
            Ischemic Stroke Through Repressing m6A Modification of SIRT6.
REFERENCE   3  (bases 1 to 1691)
  AUTHORS   Xie,Z., Huang,M., Xu,W., Liu,F. and Huang,D.
  TITLE     USP18 Curbs the Progression of Metabolic Hypertension by
            Suppressing JAK/STAT Pathway
  JOURNAL   Cardiovasc Toxicol 24 (6), 576-586 (2024)
   PUBMED   38691302
  REMARK    GeneRIF: USP18 Curbs the Progression of Metabolic Hypertension by
            Suppressing JAK/STAT Pathway.
REFERENCE   4  (bases 1 to 1691)
  AUTHORS   Yuan,L., Xu,J., Qin,F., Yi,X., Zhong,Z., Gu,X. and Gong,G.
  TITLE     USP18 overexpression protects against spinal cord
            ischemia/reperfusion injury via regulating autophagy
  JOURNAL   Neurosci Lett 810, 137359 (2023)
   PUBMED   37356565
  REMARK    GeneRIF: USP18 overexpression protects against spinal cord
            ischemia/reperfusion injury via regulating autophagy.
REFERENCE   5  (bases 1 to 1691)
  AUTHORS   Murakawa,M., Asahina,Y., Kawai-Kitahata,F., Nakagawa,M., Nitta,S.,
            Otani,S., Nagata,H., Kaneko,S., Asano,Y., Tsunoda,T., Miyoshi,M.,
            Itsui,Y., Azuma,S., Kakinuma,S., Tanaka,Y., Iijima,S., Tsuchiya,K.,
            Izumi,N., Tohda,S. and Watanabe,M.
  TITLE     Hepatic IFNL4 expression is associated with non-response to
            interferon-based therapy through the regulation of basal
            interferon-stimulated gene expression in chronic hepatitis C
            patients
  JOURNAL   J Med Virol 89 (7), 1241-1247 (2017)
   PUBMED   28036111
REFERENCE   6  (bases 1 to 1691)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   7  (bases 1 to 1691)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   8  (bases 1 to 1691)
  AUTHORS   Kim,K.I., Yan,M., Malakhova,O., Luo,J.K., Shen,M.F., Zou,W., de la
            Torre,J.C. and Zhang,D.E.
  TITLE     Ube1L and protein ISGylation are not essential for alpha/beta
            interferon signaling
  JOURNAL   Mol Cell Biol 26 (2), 472-479 (2006)
   PUBMED   16382139
REFERENCE   9  (bases 1 to 1691)
  AUTHORS   Giannakopoulos,N.V., Luo,J.K., Papov,V., Zou,W., Lenschow,D.J.,
            Jacobs,B.S., Borden,E.C., Li,J., Virgin,H.W. and Zhang,D.E.
  TITLE     Proteomic identification of proteins conjugated to ISG15 in mouse
            and human cells
  JOURNAL   Biochem Biophys Res Commun 336 (2), 496-506 (2005)
   PUBMED   16139798
REFERENCE   10 (bases 1 to 1691)
  AUTHORS   Malakhov,M.P., Malakhova,O.A., Kim,K.I., Ritchie,K.J. and
            Zhang,D.E.
  TITLE     UBP43 (USP18) specifically removes ISG15 from conjugated proteins
  JOURNAL   J Biol Chem 277 (12), 9976-9981 (2002)
   PUBMED   11788588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 2, 2020 this sequence version replaced NM_001014058.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.840505.1,
                                           SRR26360172.78405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000004.1  156143826-156143924
            100-350             JAXUCZ010000004.1  156150157-156150407
            351-447             JAXUCZ010000004.1  156151436-156151532
            448-593             JAXUCZ010000004.1  156152521-156152666
            594-673             JAXUCZ010000004.1  156155786-156155865
            674-820             JAXUCZ010000004.1  156156105-156156251
            821-916             JAXUCZ010000004.1  156156744-156156839
            917-1063            JAXUCZ010000004.1  156157299-156157445
            1064-1195           JAXUCZ010000004.1  156169131-156169262
            1196-1245           JAXUCZ010000004.1  156169588-156169637
            1246-1691           JAXUCZ010000004.1  156170847-156171292
FEATURES             Location/Qualifiers
     source          1..1691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1691
                     /gene="Usp18"
                     /note="ubiquitin specific peptidase 18"
                     /db_xref="GeneID:312688"
                     /db_xref="RGD:1359153"
     exon            1..99
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            100..350
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1291
                     /gene="Usp18"
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /product="ubl carboxyl-terminal hydrolase 18"
                     /protein_id="NP_001014080.1"
                     /db_xref="GeneID:312688"
                     /db_xref="RGD:1359153"
                     /translation="MGKGFGLLRKTCQSVVANPQQHSALEEEKNMKRKRVLSRELCSA
                     WDRPHGFVGLHNIGQTCCLNSLIQVFMMNVDFRMVLKRITVPRGAEEQKRSVPFQLLL
                     LLEKMQDSRQKAVLPTELVQCLQKYNVPLFVQHDAAHLFLTIWNLTKDQITDIDLAER
                     LQDLFTIWTEESLMCVGCGAESSRRGKLLTLSLPLFDMDSKPLKTLEDALRCFFQPKE
                     LASSDKCFCETCGKKTPCKQAQKLTGFPQTLTIHLMRFSVRNSQTVKICHSVYFPQSL
                     DFSQILPTTDQSEIHYELFAVIAHVGMADFGHYCAYIRNPVDGEWFCFNDSHVCWVTW
                     KDVQCTYGDHIYRWRETAYLLVYMKTGS"
     exon            351..447
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            448..593
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            594..673
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            674..820
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            821..916
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1063
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1195
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1245
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1691
                     /gene="Usp18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaggctgg gaggtgactt ggctgctctg ctccgcggtg ccacgttctc ctctggagcc
       61 ctttgcagat accgctcggt cttcgcttcg gtgcttgaga gggtcctttc tggcttgtgt
      121 agacccttcc tggaagtgaa gttgtggaat cctgacctcc agtcctgccc gttccaagcg
      181 tggggtttgg gtgtgatcac taatgggcaa agggtttggg ctcctgagga aaacctgcca
      241 gtcagttgtg gctaatcctc agcagcactc agctctggag gaagagaaga acatgaagag
      301 gaagagagtg ctgtctagag agctctgcag tgcctgggac cgccctcatg gtttcgttgg
      361 gttacacaac atcggtcaga catgttgcct taactccttg attcaggtgt tcatgatgaa
      421 tgtggacttc aggatggtat tgaagaggat aacagtgcca cgaggggcag aagaacagaa
      481 gagaagtgtc cccttccagc tgcttttgct gctggagaag atgcaggaca gccggcagaa
      541 ggcagtgctg cccacggagc tcgttcagtg cctccagaaa tacaacgtgc cattgtttgt
      601 ccagcacgat gctgctcatc tcttccttac aatctggaac ctgactaagg accagatcac
      661 ggacatagac ttggcagagc ggctgcagga tctgttcaca atctggaccg aggagtccct
      721 gatgtgcgtg ggctgtggag cagagagcag caggaggggc aagttgctca ctctctctct
      781 tcctcttttt gatatggatt caaagcccct aaaaacactg gaggatgcct tgagatgttt
      841 cttccagccc aaagagttag caagctcaga caagtgcttc tgtgagacct gcgggaagaa
      901 gacgccttgc aaacaggctc agaagctgac tggtttccct cagaccctga ccatccacct
      961 catgagattc tctgtcagga actcacagac agtaaagatc tgccactcag tgtacttccc
     1021 gcagagcttg gatttcagtc agattctgcc aaccacggat cagtctgaga tacactatga
     1081 actctttgct gtgattgccc atgttgggat ggcagacttc ggtcattact gtgcctacat
     1141 ccggaatccc gtggatggag aatggttctg cttcaatgat tcacatgttt gttgggtgac
     1201 ctggaaggat gtccagtgta cctatgggga tcacatatat cgttggaggg aaactgccta
     1261 tctcttggtt tacatgaaga ctggatcctg acagatatac tcacaccttc agagagtgac
     1321 agactctttt ctcctctcct gtacccacat ctgctgcatt tcaacgagaa tcgtaattta
     1381 aaaaccataa ttaagcccta tttataagca aggattatta ttattgctgt ggcttggctg
     1441 tagtttgtct cccaacagct cacacacaga aggcttggtc tttagtatgg aggcgtttgg
     1501 gtgacagaac ttttaaggga cagggcccag tgggaggtaa tcagttcatg ggatctctct
     1561 tctgtgcact aatagttcct tttctgtttc tccgtggtga tgcaaacagg gtgatccaac
     1621 atgccagtgc caagctggtt ggatcctcta gctttcaaaa ttccaagtca aataaatgtt
     1681 attacacact a
//
