LOCUS       NM_001100501            2903 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 16 (Usp16), mRNA.
ACCESSION   NM_001100501 XM_001066902 XM_213676
VERSION     NM_001100501.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Belle,J.I. and Nijnik,A.
  TITLE     H2A-DUBbing the mammalian epigenome: expanding frontiers for
            histone H2A deubiquitinating enzymes in cell biology and physiology
  JOURNAL   Int J Biochem Cell Biol 50, 161-174 (2014)
   PUBMED   24647359
  REMARK    Review article
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   3  (bases 1 to 2903)
  AUTHORS   Frangini,A., Sjoberg,M., Roman-Trufero,M., Dharmalingam,G.,
            Haberle,V., Bartke,T., Lenhard,B., Malumbres,M., Vidal,M. and
            Dillon,N.
  TITLE     The aurora B kinase and the polycomb protein ring1B combine to
            regulate active promoters in quiescent lymphocytes
  JOURNAL   Mol Cell 51 (5), 647-661 (2013)
   PUBMED   24034696
REFERENCE   4  (bases 1 to 2903)
  AUTHORS   Shanbhag,N.M., Rafalska-Metcalf,I.U., Balane-Bolivar,C.,
            Janicki,S.M. and Greenberg,R.A.
  TITLE     ATM-dependent chromatin changes silence transcription in cis to DNA
            double-strand breaks
  JOURNAL   Cell 141 (6), 970-981 (2010)
   PUBMED   20550933
REFERENCE   5  (bases 1 to 2903)
  AUTHORS   Joo,H.Y., Zhai,L., Yang,C., Nie,S., Erdjument-Bromage,H.,
            Tempst,P., Chang,C. and Wang,H.
  TITLE     Regulation of cell cycle progression and gene expression by H2A
            deubiquitination
  JOURNAL   Nature 449 (7165), 1068-1072 (2007)
   PUBMED   17914355
REFERENCE   6  (bases 1 to 2903)
  AUTHORS   Pai,M.T., Tzeng,S.R., Kovacs,J.J., Keaton,M.A., Li,S.S., Yao,T.P.
            and Zhou,P.
  TITLE     Solution structure of the Ubp-M BUZ domain, a highly specific
            protein module that recognizes the C-terminal tail of free
            ubiquitin
  JOURNAL   J Mol Biol 370 (2), 290-302 (2007)
   PUBMED   17512543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ205918.1, BC112386.1, CV112036.1, BC087705.1 and BI282215.1.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_213676.4, XM_001066902.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BQ205918.1         587-636             c
            51-964              BC112386.1         1-914
            965-1637            CV112036.1         68-740
            1638-2700           BC087705.1         1502-2564
            2701-2903           BI282215.1         1-203               c
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2903
                     /gene="Usp16"
                     /note="ubiquitin specific peptidase 16"
                     /db_xref="GeneID:288306"
                     /db_xref="RGD:1307192"
     exon            1..102
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            103..204
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2621
                     /gene="Usp16"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thiolesterase 16; ubiquitin specific
                     protease 16; ubiquitin thioesterase 16; deubiquitinating
                     enzyme 16; ubiquitin-specific-processing protease 16"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 16"
                     /protein_id="NP_001093971.1"
                     /db_xref="GeneID:288306"
                     /db_xref="RGD:1307192"
                     /translation="MGKKRTKGKSVPEKASSESTEPMCRHLRKGLEQGNLKKALVNVE
                     WNICQDCKTDNKVKDKSEEEAEDPSVWLCLKCGHQGCGRDSQEQHALKHYTTPRSEPH
                     YLVLSLDNWSVWCYKCDEEIKYCSSNRLGQVVDYVRKQAGRITSKPEKNNGHIELENK
                     KLEKESKNEQEREKSESMAKENIPLDSASQITVKGLSNLGNTCFFNAVMQNLSQTPVL
                     RELLKEVKMSGTIVKIEPPDLALTEPLEVNLEPPGPLTLAMSQFLNEMQENKKRIVTP
                     KELFSQVCKKATRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDE
                     EVKNKVKDYEKKKAIPSFVDRIFGGELTSTIMCDDCRTVSLVHESFLDLSLPVLDDQS
                     GKKNINDKNVKKTMEEEDKDSEEEKDDSYMKTRSDVPSGTSKHTQKKAKKQAKKQAKN
                     QRRQQKIQERFLHFNEICTTNYTEDNDHEAETALPGEGEVDTEFNRGSQEELTQTELC
                     ANQKDVNGQEEMIESAADERKCPEHPEVKSVSTESDLGSLTSAPECPRDLNGAFLEER
                     TSGELDITNGLKNLTLNAAVDPDEISIEILNDSHSPALKVYEVMNEDPETAFCTLANR
                     EAFSTDECSIQHCLYQFTRNEKLQDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAK
                     KQMLVSLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEESTR
                     VLYSLYGVVEHSGTMRSGHYTAYAKERTASCHLSNLVLHGDIPQDCEMESTKGQWFHI
                     SDTHVQAVPITKVLNSQAYLLFYERIL"
     exon            205..380
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            381..484
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            485..588
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            589..773
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            774..869
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1000
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1088
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1167
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1259
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1316
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1490
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..2157
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2252
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2339
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2496
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2889
                     /gene="Usp16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggttccacc gcgtcgctct ctattcgtca cctggaggaa gcggagctgg cggccggctc
       61 cgggcccgtc gcgggaggca gttatgggcg ccgtctcacc ggattgtaat tttgtgtcag
      121 tgagcattcc ataaagtgcc aacatgggaa agaaacgaac aaaggggaaa agtgttccag
      181 aaaaggcttc ttctgaatct acagaaccaa tgtgcagaca ccttagaaaa gggttggaac
      241 aaggtaattt gaaaaaagct ttggtaaatg tggaatggaa tatctgccaa gactgtaaga
      301 ctgacaataa agtgaaagat aaatctgagg aagaagcaga agacccttcg gtttggctgt
      361 gtcttaaatg tggccatcag ggctgtggca gagattccca ggagcagcat gccctgaagc
      421 actacacaac accaaggtct gaacctcact acctggtgct tagtttggac aactggagcg
      481 tctggtgtta caagtgtgat gaggaaatca agtactgcag ttcaaaccgg ctgggccaag
      541 tggttgatta tgttagaaag caagctggca gaataacttc aaaaccagag aaaaataatg
      601 gacacattga gcttgaaaat aaaaaattgg agaaagagag taaaaatgaa caagagagag
      661 aaaaatcgga aagcatggct aaagaaaaca tccccttgga ctctgcttcc cagataacgg
      721 tgaaaggact cagcaacttg gggaatactt gtttcttcaa cgctgttatg cagaacttgt
      781 cacaaacgcc agtgcttaga gaactactaa aagaagtgaa gatgtctgga acaattgtaa
      841 aaatagagcc acctgatctg gcactcacag aacctttaga agtaaacctt gaacctccag
      901 gtcctcttac tttagccatg agccagtttc ttaatgagat gcaagagaac aaaaaacgaa
      961 ttgtaacacc taaagagctc ttttctcagg tctgtaaaaa agcaacacgt tttaaagggt
     1021 accaacaaca agacagccag gagctgcttc gctacctatt ggacgggatg agagcggaag
     1081 agcaccaaag agtgagtaaa ggaattctta aagcatttgg taattctact gaaaaattgg
     1141 atgaagaagt aaaaaataaa gttaaagatt atgaaaagaa aaaggcaatc ccaagttttg
     1201 tggaccgcat cttcggtggc gaactgacta gtacaatcat gtgtgatgac tgcaggactg
     1261 tctccttggt gcatgagtct ttccttgatt tgtctctccc agttttagat gatcagagtg
     1321 gtaagaaaaa tataaatgat aaaaatgtga agaagacaat ggaggaagaa gataaagaca
     1381 gtgaggaaga gaaagatgac agctacatga aaacacggag tgacgtgccc tcaggaacaa
     1441 gcaagcacac acagaagaaa gcaaagaagc aagccaaaaa gcaagccaag aaccaacgaa
     1501 ggcaacaaaa aattcaagaa aggtttcttc acttcaacga gatctgcacc actaactaca
     1561 ctgaagacaa tgaccatgaa gctgagacgg cacttccggg agaaggggaa gtggatactg
     1621 agttcaaccg tggctctcaa gaggagctca cacagacaga gctctgtgct aatcagaaag
     1681 atgtgaatgg ccaagaggaa atgatagaaa gcgctgccga tgagcggaaa tgcccagagc
     1741 acccggaggt gaaaagtgtc agcaccgaga gtgatctggg gagtttgact tctgctcctg
     1801 agtgtcctag agatttaaat ggtgccttcc tggaagaaag gaccagtgga gagctagaca
     1861 ttaccaatgg tttaaaaaac cttactttga atgctgctgt tgatcctgat gaaataagta
     1921 tagagattct gaatgacagc cattctcctg cgttaaaggt gtatgaggtc atgaatgagg
     1981 acccagaaac tgctttctgt acccttgcaa accgggaagc ttttagtact gatgagtgtt
     2041 caatccaaca ttgtttgtat cagttcaccc gcaatgagaa acttcaagat gcaaataaac
     2101 tgctttgtga agtgtgcaca agacggcagt gtaatggacc aaaggcaaat ataaaaggtg
     2161 aaaggaaaca tgtttacacc aatgccaaga agcagatgct ggtttccctt gctcctcctg
     2221 tactcactct tcatttaaag agatttcagc aggctggttt taacctacgc aaagttaaca
     2281 aacacataaa gtttccggaa atcttagatt tggctccttt ttgtaccctt aaatgtaaga
     2341 acgttgctga ggaaagtaca agagtgctgt attccttata tggagttgtg gaacacagtg
     2401 gcactatgag gtcagggcat tacactgcct acgcaaagga aagaactgca agctgtcatc
     2461 tctctaatct tgttcttcat ggtgacattc cgcaagattg tgaaatggag tcaaccaaag
     2521 ggcagtggtt tcacatcagc gacacacacg tgcaagcggt gcctataact aaagtactga
     2581 actcacaagc ttatctccta ttttatgaga gaatactgtg atgacaagaa gtgttttctc
     2641 tggaaatacg cctatggctt ttatactggc tattataaca ataaaaagtt aaactataaa
     2701 ttatgttcac ctaagtaaat gacagaaaaa aatcatgttt atttaaatac agacaaaatt
     2761 aacttacagc agtttttgta ttagcatact ggtttttact ctttctagtt tcaactttag
     2821 gaaagatttg aataactaaa ctgactgggt ggtagttctt gacacatcaa taaagtgata
     2881 ttcccaaaaa aaaaaaaaaa aaa
//
