LOCUS       NM_145184               3247 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 15 (Usp15), mRNA.
ACCESSION   NM_145184
VERSION     NM_145184.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Zhang,T., Wang,L. and Chen,L.
  TITLE     Alleviative effect of microRNA-497 on diabetic neuropathic pain in
            rats in relation to decreased USP15
  JOURNAL   Cell Biol Toxicol 39 (5), 1-16 (2023)
   PUBMED   35478295
  REMARK    GeneRIF: Alleviative effect of microRNA-497 on diabetic neuropathic
            pain in rats in relation to decreased USP15.
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Wu,Z., Zhu,L., Nie,X., Wei,L. and Qi,Y.
  TITLE     USP15 promotes pulmonary vascular remodeling in pulmonary
            hypertension in a YAP1/TAZ-dependent manner
  JOURNAL   Exp Mol Med 55 (1), 183-195 (2023)
   PUBMED   36635430
  REMARK    GeneRIF: USP15 promotes pulmonary vascular remodeling in pulmonary
            hypertension in a YAP1/TAZ-dependent manner.
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Zhang,L., Gao,X., Qin,Z., Shi,X., Xu,K., Wang,S., Tang,M., Wang,W.,
            Gao,S., Zuo,L., Zhang,L. and Zhang,W.
  TITLE     USP15 participates in DBP-induced testicular oxidative stress
            injury through regulating the Keap1/Nrf2 signaling pathway
  JOURNAL   Sci Total Environ 783, 146898 (2021)
   PUBMED   34088152
  REMARK    GeneRIF: USP15 participates in DBP-induced testicular oxidative
            stress injury through regulating the Keap1/Nrf2 signaling pathway.
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Chen,X., Bao,G. and Liu,F.
  TITLE     Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by
            Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells
  JOURNAL   Cell Mol Neurobiol 40 (6), 999-1010 (2020)
   PUBMED   31933062
  REMARK    GeneRIF: Inhibition of USP15 Prevent Glutamate-Induced Oxidative
            Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Nie,Z.Y., Yao,M., Yang,Z., Yang,L., Liu,X.J., Yu,J., Ma,Y.,
            Zhang,N., Zhang,X.Y., Liu,M.H., Jiang,L.L. and Luo,J.M.
  TITLE     De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis
            suppresses CML cell apoptosis and contributes to Imatinib
            resistance
  JOURNAL   J Exp Clin Cancer Res 39 (1), 17 (2020)
   PUBMED   31952546
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Elliott,P.R., Liu,H., Pastok,M.W., Grossmann,G.J., Rigden,D.J.,
            Clague,M.J., Urbe,S. and Barsukov,I.L.
  TITLE     Structural variability of the ubiquitin specific protease DUSP-UBL
            double domains
  JOURNAL   FEBS Lett 585 (21), 3385-3390 (2011)
   PUBMED   22001210
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   Inui,M., Manfrin,A., Mamidi,A., Martello,G., Morsut,L., Soligo,S.,
            Enzo,E., Moro,S., Polo,S., Dupont,S., Cordenonsi,M. and Piccolo,S.
  TITLE     USP15 is a deubiquitylating enzyme for receptor-activated SMADs
  JOURNAL   Nat Cell Biol 13 (11), 1368-1375 (2011)
   PUBMED   21947082
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Hetfeld,B.K., Helfrich,A., Kapelari,B., Scheel,H., Hofmann,K.,
            Guterman,A., Glickman,M., Schade,R., Kloetzel,P.M. and Dubiel,W.
  TITLE     The zinc finger of the CSN-associated deubiquitinating enzyme USP15
            is essential to rescue the E3 ligase Rbx1
  JOURNAL   Curr Biol 15 (13), 1217-1221 (2005)
   PUBMED   16005295
REFERENCE   9  (bases 1 to 3247)
  AUTHORS   Angelats,C., Wang,X.W., Jermiin,L.S., Copeland,N.G., Jenkins,N.A.
            and Baker,R.T.
  TITLE     Isolation and characterization of the mouse ubiquitin-specific
            protease Usp15
  JOURNAL   Mamm Genome 14 (1), 31-46 (2003)
   PUBMED   12532266
REFERENCE   10 (bases 1 to 3247)
  AUTHORS   Park,K.C., Choi,E.J., Min,S.W., Chung,S.S., Kim,H., Suzuki,T.,
            Tanaka,K. and Chung,C.H.
  TITLE     Tissue-specificity, functional characterization and subcellular
            localization of a rat ubiquitin-specific processing protease,
            UBP109, whose mRNA expression is developmentally regulated
  JOURNAL   Biochem J 349 (Pt 2), 443-453 (2000)
   PUBMED   10880343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF106657.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_145184.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3247
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /note="ubiquitin specific peptidase 15"
                     /db_xref="GeneID:171329"
                     /db_xref="RGD:628795"
     exon            1..124
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2894
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 15; deubiquitinating
                     enzyme Ubp109; ubiquitin thioesterase 15; deubiquitinating
                     enzyme 15; ubiquitin-specific-processing protease 15;
                     ubiquitin carboxyl-terminal hydrolase of 109 kDa"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 15"
                     /protein_id="NP_660185.1"
                     /db_xref="GeneID:171329"
                     /db_xref="RGD:628795"
                     /translation="MAEGGAADLDTQRSDIATLLKTSLRKGDTWYLVDSRWFKQWKKY
                     VGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVS
                     WYTLMEGQEPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDT
                     IEKEIRKIFNIPDEKEARLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDG
                     TWPRGPSAPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQ
                     CLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFK
                     TQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEE
                     AWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERSLEVY
                     LVRMDPLAKPMQYKVIVPKIGNILDLCTALSALSGVPADKMIVTDIYNHRFHRIFAMD
                     ENLSSIMERDDIYVFEININRTEDTEHVVIPVCLREKFRHSSYTHHTGSSLFGQPFLM
                     AVPRNNTEDKLYNLLLLRMCRYVKMSTETEETDGPLRCCEDQNINGNGPNGIHEEGSP
                     SEMETDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEETCKGRLTGHKKRL
                     FTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAED
                     FEKHESVEYKPPKRPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSL
                     PPVLVVHLKRFSYSRYMRDKLDTLVDFPISDLDMSEFLINPNAGPCRYNLIAVSNHYG
                     GMGGGHYTAFAKNKDDGKWYYFDDSSVSSASEDQIVSKAAYVLFYQRQDTFSGTGFFP
                     LDRETKGASAATGVPLESDEDSNDNDNDLENENCMHTN"
     exon            125..252
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            253..383
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            384..510
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            511..656
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            657..718
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            719..863
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1037
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1196
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1421
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1505
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1600
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1792
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1908
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2181
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2252
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2368
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2518
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2622
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2711
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..3174
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgctgccg cctccgctac cgctagtgga agaagatggc ggaaggcgga gcggcggacc
       61 tggacaccca gcgttctgac atcgcgacgc tgctcaaaac ctcgctccgg aaaggggaca
      121 cctggtatct agtagatagt cggtggttca aacagtggaa aaaatatgtt ggctttgaca
      181 gttgggacaa ataccagatg ggagatcaaa atgtctatcc tggacccatc gataactctg
      241 gacttctcaa agatggcgat gctcagtcac ttaaggaaca ccttatcgac gagttggatt
      301 acatactgtt gccgactgag ggctggaata aacttgtcag ctggtacaca ctgatggaag
      361 gccaagagcc aatagcaaga aaggtggtag aacagggcat gtttgtaaag cactgcaaag
      421 tggaagtcta cctcacagaa ctgaagctct gcgagaatgg gaacatgaac aatgttgtaa
      481 ctcggagatt tagcaaagct gacacaatag acacaattga aaaggaaata agaaagatct
      541 tcaatattcc agatgaaaag gaggccagac tgtggaacaa gtatatgagt aacacatttg
      601 agccactgaa taagccagac agcaccatcc aggatgccgg cctataccaa ggacaggtgt
      661 tagtgataga acaaaaaaat gaagacggaa cgtggcccag gggtccctct gctcctaatg
      721 tgaaaaactc caattattgt ctcccgtcat atactgctta caagaactat gattattcgg
      781 aacctggaag aaacaatgaa cagccaggcc tgtgtggcct aagtaacttg ggaaacacat
      841 gtttcatgaa ctcagccatt cagtgtttga gcaacacacc tccacttact gaatatttcc
      901 tcaatgataa gtaccaagaa gagctgaatt ttgacaatcc cttaggaatg agaggtgaaa
      961 tagctaaatc atatgctgaa ctcatcaagc agatgtggtc tggaaagttt agctatgtca
     1021 ctccaagagc atttaagaca caagtaggac gttttgcacc tcagttctct ggatatcaac
     1081 agcaagactg ccaagaacta ctagctttcc tattagatgg attacatgag gatttgaata
     1141 gaattaggaa aaaaccatat atccagttaa aagatgctga tgggaggcca gacaaggtgg
     1201 ttgctgaaga agcctgggaa aaccatttaa aaagaaatga ttctatcata gtagatatat
     1261 ttcatggcct tttcaagtct acgttagtgt gtcctgagtg tgctaagatc tcagtgacct
     1321 tcgacccttt ctgttacttg acacttccat tgcctatgaa aaaggaacgt agcttagaag
     1381 tttatttagt tagaatggat ccacttgcta aacctatgca atacaaagtc attgtgccca
     1441 aaattggaaa tatactagac ctttgtacag cactgtctgc tttgtcggga gtacctgcag
     1501 ataagatgat agtcactgac atatataatc atagatttca caggatattt gcaatggatg
     1561 agaacctgag tagtattatg gagcgggatg atatttatgt gtttgaaatt aacatcaaca
     1621 ggacagaaga cacagaacat gtggttattc ctgtttgcct aagagaaaag ttcagacact
     1681 caagttacac tcaccacact ggctcttcac tgttcggcca gccttttctt atggccgtgc
     1741 cacggaacaa tactgaagat aaactctaca atctcctgct cttgagaatg tgccggtatg
     1801 tcaagatgtc tactgaaact gaggaaactg atggacccct gcgttgctgt gaggaccaga
     1861 atattaatgg gaatggtcca aatggcatac atgaagaagg ctcaccaagt gagatggaga
     1921 cagatgaacc agatgatgag tccagccagg atcaagagct tccctcagaa aatgagaaca
     1981 gtcagtctga agattcagtc ggaggagata acgattctga aaatggattg tgtactgaag
     2041 aaacatgcaa aggtcgactg acgggacaca aaaagcgatt gtttacattc cagttcaaca
     2101 acttaggcaa cactgatatc aactatatca aagacgacac caggcatata agatttgatg
     2161 ataggcagct tcggctagat gaaagatctt ttctcgcctt ggactgggac cctgacttga
     2221 agaagagata ttttgatgag aatgctgcag aggattttga aaaacatgaa agcgtggaat
     2281 ataaacctcc aaaaagaccc tttgtgaagt taaaagactg cattgaactt ttcacaacaa
     2341 aagagaagct aggtgctgaa gacccctggt attgtccaaa ttgtaaagag catcagcaag
     2401 ccaccaagaa attagatctg tggtccctgc ctcccgttct tgtggtgcat ctcaagagat
     2461 tctcctatag tcgctacatg agagacaagc tagatacatt agtcgatttt cccatcagtg
     2521 acttggatat gtcggaattc ctaattaacc caaatgcagg cccttgccgc tataatttga
     2581 ttgctgtttc caatcactat ggagggatgg gaggaggaca ttatactgct tttgcaaaga
     2641 acaaagatga tggaaagtgg tactattttg atgacagtag cgtctccagt gcatctgaag
     2701 accaaattgt gtccaaagca gcatacgtgc tcttctacca gagacaggac actttcagtg
     2761 gaactggctt cttccctctc gaccgagaaa ctaaaggtgc ttcagctgcc acaggtgtcc
     2821 ccctggaaag tgacgaagac agcaatgata atgacaatga tctagaaaat gaaaactgta
     2881 tgcacactaa ttaatgaaag tccaagaagc catacgagag agagagaaag agagagagag
     2941 actttcctgc cggtggtatc tgtggagacg gagttaccca ccgcattaaa cagaggtttg
     3001 agaggaggcg tttcagatac ccgaatgtaa atcctttatc agattttaaa ttctgcagta
     3061 cttgccgtga aacacaatga aaactttaac agaaattgtt ttttaaaaca tttacagttt
     3121 tgtatttaca agctaaatat atataggaaa tcacaaataa atccctttta agttaaaaaa
     3181 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3241 aaaaaaa
//
