LOCUS       NP_660185                952 aa            linear   ROD 30-JUL-2024
DEFINITION  ubiquitin carboxyl-terminal hydrolase 15 [Rattus norvegicus].
ACCESSION   NP_660185
VERSION     NP_660185.1
DBSOURCE    REFSEQ: accession NM_145184.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 952)
  AUTHORS   Zhang,T., Wang,L. and Chen,L.
  TITLE     Alleviative effect of microRNA-497 on diabetic neuropathic pain in
            rats in relation to decreased USP15
  JOURNAL   Cell Biol Toxicol 39 (5), 1-16 (2023)
   PUBMED   35478295
  REMARK    GeneRIF: Alleviative effect of microRNA-497 on diabetic neuropathic
            pain in rats in relation to decreased USP15.
REFERENCE   2  (residues 1 to 952)
  AUTHORS   Wu,Z., Zhu,L., Nie,X., Wei,L. and Qi,Y.
  TITLE     USP15 promotes pulmonary vascular remodeling in pulmonary
            hypertension in a YAP1/TAZ-dependent manner
  JOURNAL   Exp Mol Med 55 (1), 183-195 (2023)
   PUBMED   36635430
  REMARK    GeneRIF: USP15 promotes pulmonary vascular remodeling in pulmonary
            hypertension in a YAP1/TAZ-dependent manner.
REFERENCE   3  (residues 1 to 952)
  AUTHORS   Zhang,L., Gao,X., Qin,Z., Shi,X., Xu,K., Wang,S., Tang,M., Wang,W.,
            Gao,S., Zuo,L., Zhang,L. and Zhang,W.
  TITLE     USP15 participates in DBP-induced testicular oxidative stress
            injury through regulating the Keap1/Nrf2 signaling pathway
  JOURNAL   Sci Total Environ 783, 146898 (2021)
   PUBMED   34088152
  REMARK    GeneRIF: USP15 participates in DBP-induced testicular oxidative
            stress injury through regulating the Keap1/Nrf2 signaling pathway.
REFERENCE   4  (residues 1 to 952)
  AUTHORS   Chen,X., Bao,G. and Liu,F.
  TITLE     Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by
            Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells
  JOURNAL   Cell Mol Neurobiol 40 (6), 999-1010 (2020)
   PUBMED   31933062
  REMARK    GeneRIF: Inhibition of USP15 Prevent Glutamate-Induced Oxidative
            Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
REFERENCE   5  (residues 1 to 952)
  AUTHORS   Nie,Z.Y., Yao,M., Yang,Z., Yang,L., Liu,X.J., Yu,J., Ma,Y.,
            Zhang,N., Zhang,X.Y., Liu,M.H., Jiang,L.L. and Luo,J.M.
  TITLE     De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis
            suppresses CML cell apoptosis and contributes to Imatinib
            resistance
  JOURNAL   J Exp Clin Cancer Res 39 (1), 17 (2020)
   PUBMED   31952546
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 952)
  AUTHORS   Elliott,P.R., Liu,H., Pastok,M.W., Grossmann,G.J., Rigden,D.J.,
            Clague,M.J., Urbe,S. and Barsukov,I.L.
  TITLE     Structural variability of the ubiquitin specific protease DUSP-UBL
            double domains
  JOURNAL   FEBS Lett 585 (21), 3385-3390 (2011)
   PUBMED   22001210
REFERENCE   7  (residues 1 to 952)
  AUTHORS   Inui,M., Manfrin,A., Mamidi,A., Martello,G., Morsut,L., Soligo,S.,
            Enzo,E., Moro,S., Polo,S., Dupont,S., Cordenonsi,M. and Piccolo,S.
  TITLE     USP15 is a deubiquitylating enzyme for receptor-activated SMADs
  JOURNAL   Nat Cell Biol 13 (11), 1368-1375 (2011)
   PUBMED   21947082
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 952)
  AUTHORS   Hetfeld,B.K., Helfrich,A., Kapelari,B., Scheel,H., Hofmann,K.,
            Guterman,A., Glickman,M., Schade,R., Kloetzel,P.M. and Dubiel,W.
  TITLE     The zinc finger of the CSN-associated deubiquitinating enzyme USP15
            is essential to rescue the E3 ligase Rbx1
  JOURNAL   Curr Biol 15 (13), 1217-1221 (2005)
   PUBMED   16005295
REFERENCE   9  (residues 1 to 952)
  AUTHORS   Angelats,C., Wang,X.W., Jermiin,L.S., Copeland,N.G., Jenkins,N.A.
            and Baker,R.T.
  TITLE     Isolation and characterization of the mouse ubiquitin-specific
            protease Usp15
  JOURNAL   Mamm Genome 14 (1), 31-46 (2003)
   PUBMED   12532266
REFERENCE   10 (residues 1 to 952)
  AUTHORS   Park,K.C., Choi,E.J., Min,S.W., Chung,S.S., Kim,H., Suzuki,T.,
            Tanaka,K. and Chung,C.H.
  TITLE     Tissue-specificity, functional characterization and subcellular
            localization of a rat ubiquitin-specific processing protease,
            UBP109, whose mRNA expression is developmentally regulated
  JOURNAL   Biochem J 349 (Pt 2), 443-453 (2000)
   PUBMED   10880343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF106657.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NP_660185.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     Protein         1..952
                     /product="ubiquitin carboxyl-terminal hydrolase 15"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 15; deubiquitinating
                     enzyme Ubp109; ubiquitin thioesterase 15; deubiquitinating
                     enzyme 15; ubiquitin-specific-processing protease 15;
                     ubiquitin carboxyl-terminal hydrolase of 109 kDa"
                     /calculated_mol_wt=109124
     Region          2..223
                     /region_name="Mediates interaction with SART3.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4E8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R085.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4E8; propagated from
                     UniProtKB/Swiss-Prot (Q9R085.1)"
     Region          12..903
                     /region_name="UBP12"
                     /note="Ubiquitin C-terminal hydrolase [Posttranslational
                     modification, protein turnover, chaperones]; COG5560"
                     /db_xref="CDD:227847"
     Site            573
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5H1; propagated from
                     UniProtKB/Swiss-Prot (Q9R085.1)"
     Region          597..665
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R085.1)"
     Region          923..952
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R085.1)"
     Site            932
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4E8; propagated from
                     UniProtKB/Swiss-Prot (Q9R085.1)"
     Site            936
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4E8; propagated from
                     UniProtKB/Swiss-Prot (Q9R085.1)"
     CDS             1..952
                     /gene="Usp15"
                     /gene_synonym="Ubp109"
                     /coded_by="NM_145184.1:36..2894"
                     /db_xref="GeneID:171329"
                     /db_xref="RGD:628795"
ORIGIN      
        1 maeggaadld tqrsdiatll ktslrkgdtw ylvdsrwfkq wkkyvgfdsw dkyqmgdqnv
       61 ypgpidnsgl lkdgdaqslk ehlideldyi llptegwnkl vswytlmegq epiarkvveq
      121 gmfvkhckve vyltelklce ngnmnnvvtr rfskadtidt iekeirkifn ipdekearlw
      181 nkymsntfep lnkpdstiqd aglyqgqvlv ieqknedgtw prgpsapnvk nsnyclpsyt
      241 ayknydysep grnneqpglc glsnlgntcf mnsaiqclsn tpplteyfln dkyqeelnfd
      301 nplgmrgeia ksyaelikqm wsgkfsyvtp rafktqvgrf apqfsgyqqq dcqellafll
      361 dglhedlnri rkkpyiqlkd adgrpdkvva eeawenhlkr ndsiivdifh glfkstlvcp
      421 ecakisvtfd pfcyltlplp mkkerslevy lvrmdplakp mqykvivpki gnildlctal
      481 salsgvpadk mivtdiynhr fhrifamden lssimerddi yvfeininrt edtehvvipv
      541 clrekfrhss ythhtgsslf gqpflmavpr nntedklynl lllrmcryvk msteteetdg
      601 plrccedqni ngngpngihe egspsemetd epddessqdq elpsenensq sedsvggdnd
      661 senglcteet ckgrltghkk rlftfqfnnl gntdinyikd dtrhirfddr qlrldersfl
      721 aldwdpdlkk ryfdenaaed fekhesveyk ppkrpfvklk dcielfttke klgaedpwyc
      781 pnckehqqat kkldlwslpp vlvvhlkrfs ysrymrdkld tlvdfpisdl dmseflinpn
      841 agpcrynlia vsnhyggmgg ghytafaknk ddgkwyyfdd ssvssasedq ivskaayvlf
      901 yqrqdtfsgt gffpldretk gasaatgvpl esdedsndnd ndlenencmh tn
//
