LOCUS       NM_001008301            2126 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 14 (Usp14), mRNA.
ACCESSION   NM_001008301 XM_214624
VERSION     NM_001008301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Kiprowska,M.J., Stepanova,A., Todaro,D.R., Galkin,A., Haas,A.,
            Wilson,S.M. and Figueiredo-Pereira,M.E.
  TITLE     Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes
            ubiquitinated proteins and Tau in rat cerebral cortical neurons:
            Relevance to Alzheimer's disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (6), 1157-1170 (2017)
   PUBMED   28372990
  REMARK    GeneRIF: pharmacologically inhibiting (with low or high IU1
            concentrations) or genetically down-regulating USP14 fail to
            enhance proteasomal degradation of Ub-proteins or Tau in neurons.
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   Liu,N., Chai,R., Liu,B., Zhang,Z., Zhang,S., Zhang,J., Liao,Y.,
            Cai,J., Xia,X., Li,A., Liu,J., Huang,H. and Liu,S.
  TITLE     Ubiquitin-specific protease 14 regulates cardiac hypertrophy
            progression by increasing GSK-3beta phosphorylation
  JOURNAL   Biochem Biophys Res Commun 478 (3), 1236-1241 (2016)
   PUBMED   27545607
  REMARK    GeneRIF: mediates the development of cardiac hypertrophy by
            promoting GSK-3beta phosphorylation.
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Nakashima,A., Ohnuma,S., Kodani,Y., Kaneko,Y.S., Nagasaki,H.,
            Nagatsu,T. and Ota,A.
  TITLE     Inhibition of deubiquitinating activity of USP14 decreases tyrosine
            hydroxylase phosphorylated at Ser19 in PC12D cells
  JOURNAL   Biochem Biophys Res Commun 472 (4), 598-602 (2016)
   PUBMED   26969276
  REMARK    GeneRIF: Activation of proteasome degradation by IU-1, which is an
            inhibitor for the deubiquitinating activity of USP14, decreased
            only the quantity of TH molecules phosphorylated at their Ser19.
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Jung,H., Kim,B.G., Han,W.H., Lee,J.H., Cho,J.Y., Park,W.S.,
            Maurice,M.M., Han,J.K., Lee,M.J., Finley,D. and Jho,E.H.
  TITLE     Deubiquitination of Dishevelled by Usp14 is required for Wnt
            signaling
  JOURNAL   Oncogenesis 2 (8), e64 (2013)
   PUBMED   23958854
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2126)
  AUTHORS   Mines,M.A., Goodwin,J.S., Limbird,L.E., Cui,F.F. and Fan,G.H.
  TITLE     Deubiquitination of CXCR4 by USP14 is critical for both
            CXCL12-induced CXCR4 degradation and chemotaxis but not ERK
            ativation
  JOURNAL   J Biol Chem 284 (9), 5742-5752 (2009)
   PUBMED   19106094
REFERENCE   6  (bases 1 to 2126)
  AUTHORS   Nagai,A., Kadowaki,H., Maruyama,T., Takeda,K., Nishitoh,H. and
            Ichijo,H.
  TITLE     USP14 inhibits ER-associated degradation via interaction with
            IRE1alpha
  JOURNAL   Biochem Biophys Res Commun 379 (4), 995-1000 (2009)
   PUBMED   19135427
REFERENCE   7  (bases 1 to 2126)
  AUTHORS   Koulich,E., Li,X. and DeMartino,G.N.
  TITLE     Relative structural and functional roles of multiple
            deubiquitylating proteins associated with mammalian 26S proteasome
  JOURNAL   Mol Biol Cell 19 (3), 1072-1082 (2008)
   PUBMED   18162577
REFERENCE   8  (bases 1 to 2126)
  AUTHORS   Wilson,S.M., Bhattacharyya,B., Rachel,R.A., Coppola,V.,
            Tessarollo,L., Householder,D.B., Fletcher,C.F., Miller,R.J.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Synaptic defects in ataxia mice result from a mutation in Usp14,
            encoding a ubiquitin-specific protease
  JOURNAL   Nat Genet 32 (3), 420-425 (2002)
   PUBMED   12368914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001008301.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085947.1, SRR26360190.333812.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000018.1  1330199-1330336     c
            139-284             JAXUCZ010000018.1  1324525-1324670     c
            285-317             JAXUCZ010000018.1  1322789-1322821     c
            318-422             JAXUCZ010000018.1  1318533-1318637     c
            423-526             JAXUCZ010000018.1  1317031-1317134     c
            527-585             JAXUCZ010000018.1  1310492-1310550     c
            586-716             JAXUCZ010000018.1  1309587-1309717     c
            717-797             JAXUCZ010000018.1  1307289-1307369     c
            798-883             JAXUCZ010000018.1  1303291-1303376     c
            884-998             JAXUCZ010000018.1  1302555-1302669     c
            999-1064            JAXUCZ010000018.1  1299769-1299834     c
            1065-1157           JAXUCZ010000018.1  1299230-1299322     c
            1158-1286           JAXUCZ010000018.1  1297864-1297992     c
            1287-1344           JAXUCZ010000018.1  1294982-1295039     c
            1345-1452           JAXUCZ010000018.1  1294389-1294496     c
            1453-2126           JAXUCZ010000018.1  1292745-1293418     c
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..2126
                     /gene="Usp14"
                     /note="ubiquitin specific peptidase 14"
                     /db_xref="GeneID:291796"
                     /db_xref="RGD:1311825"
     exon            1..138
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1604
                     /gene="Usp14"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 14; ubiquitin specific
                     peptidase 14 (tRNA-guanine transglycosylase)"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 14"
                     /protein_id="NP_001008302.1"
                     /db_xref="GeneID:291796"
                     /db_xref="RGD:1311825"
                     /translation="MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQ
                     KVMVKGGTLKDDDWGNIKMKNGMTVLMMGSADALPEEPSAKTVFVEDMTEEQLATAME
                     LPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLF
                     DSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAI
                     EDDSARETESSSASAVTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLS
                     CFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYK
                     EKESVNAKVLKDVKFPLMLDVYELCTPELQEKMISFRSKFKDLEDKKVNQQPNANDKN
                     SPPKEIKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKEDEWIKFD
                     DDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEDSEQ"
     exon            139..284
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            285..317
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            318..422
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            423..526
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            527..585
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            586..716
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            717..797
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            798..883
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            884..998
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1064
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1157
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1286
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1344
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1452
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2126
                     /gene="Usp14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaccggag ctgccgctac cactgcgctt cctctccggc cggctccgca agctgcttca
       61 tatacctcgg ctgcccttgt caggcccagc ctcccgcgcc gtttcttccc tcctgcctcg
      121 ccatgccact ctactctgtt acagtaaaat ggggaaagga gaaatttgaa ggtgtagaat
      181 tgaatactga tgaacctcca atggtgttca aggcccagct ttttgcattg actggagtcc
      241 agccagccag acaaaaagtt atggtgaaag gaggaaccct gaaggatgat gactggggaa
      301 acatcaaaat gaaaaatgga atgactgtac taatgatggg gtcagcagat gctcttccag
      361 aagaaccctc tgctaaaact gtcttcgtag aagacatgac agaagaacag ttagcaactg
      421 ctatggagtt gccgtgtgga ttgacaaacc tcggtaacac ttgttacatg aacgctacag
      481 ttcagtgtat tcgctctgtg cctgaactca aagacgccct taaaaggtat gcaggtgcct
      541 tgagagcttc aggggaaatg gcttcagcac agtatattac tgcagctctt agagatttgt
      601 ttgattccat ggataaaact tcttctagta tcccacctat tattctgctg cagtttctgc
      661 acatggcttt tccacagttt gcagagaagg gcgaacaagg gcagtatctt cagcaggatg
      721 ctaacgagtg ctggatacaa atgatgagag tcctgcaaca gaaactagaa gccatagagg
      781 atgattctgc tagagagacc gagtcttcat ctgcatcagc agtcacacct tctaaaaaga
      841 aaagcttaat tgatcagttt tttggtgttg agtttgaaac taccatgaaa tgtacagaat
      901 ctgaagaaga agaggtcacc aaaggaaagg aaaatcaact tcaacttagt tgtttcatta
      961 accaggaagt gaagtatctt ttcacagggc ttaaattgcg acttcaggaa gaaattacta
     1021 aacagtctcc aacattgcag agaaatgctt tgtacatcaa atcttctaag atcagccggc
     1081 tacctgctta cttaactatt cagatggttc gattttttta taaagagaaa gaatctgtga
     1141 acgccaaagt tcttaaggat gttaaatttc ctctcatgtt ggatgtgtat gaactctgta
     1201 caccggaact tcaagagaaa atgatctctt ttcggtcaaa attcaaggat ctagaagata
     1261 aaaaagtgaa tcagcaacca aatgcaaacg acaagaatag tcctccaaaa gagattaagt
     1321 atgaaccctt ttcatttgct gatgatattg gctccaataa ttgtggctac tatgacttac
     1381 aagcagtgtt aactcaccag ggaagatcta gttcttcggg tcattatgta tcatgggtga
     1441 aaagaaaaga agatgaatgg atcaaatttg atgacgataa ggtcagcatt gtaacaccag
     1501 aagatattct gcgactgtct ggaggtggag actggcacat tgcttatgtt ctactttatg
     1561 ggcctcgaag ggttgaaata atggaagaag acagtgaaca gtaaccttca atttagctat
     1621 ttatgcctag gtgtgatata aatgtgtgta tgtggtggtt tttttttttt gttttgaata
     1681 tttctataat cttgagctct aaagagaatg agaacagaac caagccactt gtgtatcatc
     1741 aatcttaaga ctacagataa ttacgtttgg gtgctaccta atgtaaaggt agctacaaga
     1801 cattctttaa aatcttttgc attaattgtt acaaattctt ggctgaaatc cattttatcc
     1861 cttgcctatt caacccaaga tttagcaatg atgtttattg cacacctatg tgttgttctt
     1921 gcatggttaa tatcaccgtt cagtagctgc ccgtcctttg ccttatctaa ccaatatttt
     1981 cctaggaggt ggaaaatgaa gtgttgctct catcgtgtaa ctcagtgctg ctgtccacat
     2041 cccatcaact gggtgcaatc aagtattgtc cagactgact gttgctggcc tttcatgact
     2101 ttacaataaa ttgtgattaa tacgaa
//
