LOCUS       NM_001107665            5044 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 13 (Usp13), mRNA.
ACCESSION   NM_001107665 XM_001066621 XM_227025
VERSION     NM_001107665.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5044)
  AUTHORS   Wu,D., Yuan,R., Zhang,L. and Sun,M.
  TITLE     USP13 reduces septic mediated cardiomyocyte oxidative stress and
            inflammation by inducing Nrf2
  JOURNAL   Allergol Immunopathol (Madr) 51 (2), 160-167 (2023)
   PUBMED   36916102
  REMARK    GeneRIF: USP13 reduces septic mediated cardiomyocyte oxidative
            stress and inflammation by inducing Nrf2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5044)
  AUTHORS   Yuan,L., Lv,Y., Li,H., Gao,H., Song,S., Zhang,Y., Xing,G., Kong,X.,
            Wang,L., Li,Y., Zhou,T., Gao,D., Xiao,Z.X., Yin,Y., Wei,W., He,F.
            and Zhang,L.
  TITLE     Deubiquitylase OTUD3 regulates PTEN stability and suppresses
            tumorigenesis
  JOURNAL   Nat Cell Biol 17 (9), 1169-1181 (2015)
   PUBMED   26280536
REFERENCE   3  (bases 1 to 5044)
  AUTHORS   Liu,Y., Soetandyo,N., Lee,J.G., Liu,L., Xu,Y., Clemons,W.M. Jr. and
            Ye,Y.
  TITLE     USP13 antagonizes gp78 to maintain functionality of a chaperone in
            ER-associated degradation
  JOURNAL   Elife 3, e01369 (2014)
   PUBMED   24424410
REFERENCE   4  (bases 1 to 5044)
  AUTHORS   Liu,J., Xia,H., Kim,M., Xu,L., Li,Y., Zhang,L., Cai,Y.,
            Norberg,H.V., Zhang,T., Furuya,T., Jin,M., Zhu,Z., Wang,H., Yu,J.,
            Li,Y., Hao,Y., Choi,A., Ke,H., Ma,D. and Yuan,J.
  TITLE     Beclin1 controls the levels of p53 by regulating the
            deubiquitination activity of USP10 and USP13
  JOURNAL   Cell 147 (1), 223-234 (2011)
   PUBMED   21962518
REFERENCE   5  (bases 1 to 5044)
  AUTHORS   Scortegagna,M., Subtil,T., Qi,J., Kim,H., Zhao,W., Gu,W., Kluger,H.
            and Ronai,Z.A.
  TITLE     USP13 enzyme regulates Siah2 ligase stability and activity via
            noncatalytic ubiquitin-binding domains
  JOURNAL   J Biol Chem 286 (31), 27333-27341 (2011)
   PUBMED   21659512
REFERENCE   6  (bases 1 to 5044)
  AUTHORS   Zhao,X., Fiske,B., Kawakami,A., Li,J. and Fisher,D.E.
  TITLE     Regulation of MITF stability by the USP13 deubiquitinase
  JOURNAL   Nat Commun 2, 414 (2011)
   PUBMED   21811243
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5044)
  AUTHORS   Zhang,Y.H., Zhou,C.J., Zhou,Z.R., Song,A.X. and Hu,H.Y.
  TITLE     Domain analysis reveals that a deubiquitinating enzyme USP13
            performs non-activating catalysis for Lys63-linked polyubiquitin
  JOURNAL   PLoS One 6 (12), e29362 (2011)
   PUBMED   22216260
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001107665.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GU459226.1, SRR26643296.5893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000002.1  117505443-117505675
            234-359             JAXUCZ010000002.1  117526685-117526810
            360-420             JAXUCZ010000002.1  117535461-117535521
            421-542             JAXUCZ010000002.1  117541487-117541608
            543-685             JAXUCZ010000002.1  117546612-117546754
            686-870             JAXUCZ010000002.1  117550050-117550234
            871-965             JAXUCZ010000002.1  117560219-117560313
            966-1153            JAXUCZ010000002.1  117561718-117561905
            1154-1225           JAXUCZ010000002.1  117566256-117566327
            1226-1319           JAXUCZ010000002.1  117567040-117567133
            1320-1445           JAXUCZ010000002.1  117574497-117574622
            1446-1599           JAXUCZ010000002.1  117577409-117577562
            1600-1774           JAXUCZ010000002.1  117580829-117581003
            1775-1863           JAXUCZ010000002.1  117587224-117587312
            1864-1986           JAXUCZ010000002.1  117589673-117589795
            1987-2013           JAXUCZ010000002.1  117590533-117590559
            2014-2157           JAXUCZ010000002.1  117591211-117591354
            2158-2315           JAXUCZ010000002.1  117592946-117593103
            2316-2469           JAXUCZ010000002.1  117594413-117594566
            2470-2554           JAXUCZ010000002.1  117611223-117611307
            2555-5044           JAXUCZ010000002.1  117612066-117614555
FEATURES             Location/Qualifiers
     source          1..5044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..5044
                     /gene="Usp13"
                     /note="ubiquitin specific peptidase 13"
                     /db_xref="GeneID:310306"
                     /db_xref="RGD:1306044"
     exon            1..233
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2648
                     /gene="Usp13"
                     /EC_number="3.1.2.15"
                     /note="ubiquitin thiolesterase 13; ubiquitin specific
                     protease 13 (isopeptidase T-3)"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 13"
                     /protein_id="NP_001101135.1"
                     /db_xref="GeneID:310306"
                     /db_xref="RGD:1306044"
                     /translation="MQRRGALFSVPGGGGKMAAGDLGELLVPHMPTIRVPRSGDRVYK
                     NECAFSYDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHMREKVRGAS
                     GGALPKRRNSKLFLDLDMDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTI
                     ACDAVLSSKSPYRKQDPDTWENELPVSKYANNLVQLDNGVRIPPSGWKCARCDLRENL
                     WLNLTDGSVLCGKWFFDSSGGNGHALEHYRDMGYPLAVKLGTITPDGADVYSFQEEGP
                     VSDPHLAKHLAHFGIDMLHTQGTENGFRDNDIKLRVSEWEVIQESGTKLKPMYGPGYT
                     GLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGL
                     LSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFF
                     LHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATN
                     KDELIAYELMRREAETNRRPLPELVRAKIPFSACLQAFAEPDNVDDFWSSALQAKSAG
                     VKTSRFASFPEYLVVQIKKFTFGLDWVPRKFDVSIDMPDLLDISHLRARGLQPGEEEL
                     PDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNTGAE
                     VAFNWIIVHMEEPDFAEPLAIPGYGGAGASAFGATGLDNQPPEEIVAIITAMGFQRSQ
                     AVQALQATNHNLERALDWIFSHPEFEEDSDFVIEMENNANANIMSEAKPEGPRVKDGS
                     GMYELFAFISHMGTSTMSGHYVCHIKKEGRWVIYNDHKVCASERPPKDLGYMYFYRRI
                     PS"
     exon            234..359
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            360..420
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            421..542
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            543..685
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            686..870
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            871..965
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1153
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1225
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1319
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1445
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1599
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1774
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1863
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1986
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2013
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2157
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2315
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2469
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2554
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..5044
                     /gene="Usp13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgctac gtccaggtcc tgctctccca ctgcgccgcg ttcctcccca ggcccgctgc
       61 gctcagcggc catgcagcgc cggggcgccc tgttcagcgt gccgggtggc ggcgggaaga
      121 tggctgcagg ggacctgggt gagctgctgg tgcctcacat gcccacgatc cgcgtgccta
      181 ggtcagggga ccgcgtctac aaaaacgagt gcgccttctc ctacgactct ccgaactctg
      241 aaggtggact ctatgtatgc atgaatacat ttttggcttt tggaagggaa cacgttgaaa
      301 gacattttcg gaaaactgga cagagcgtgt acatgcacct gaagaggcac atgcgagaga
      361 aggtaagagg agcttctggt ggagctttac ccaaaaggag gaattctaaa ctatttttag
      421 atctagatat ggatgacgat ttaaatagtg acgattacga atatgaagac gaagccaaac
      481 ttgttatatt cccagaccac tatgaaatag cccttcctaa cattgaggag ttaccagccc
      541 tggtaacaat tgcttgcgat gcagtgctca gctcaaagtc cccgtatagg aagcaggatc
      601 cagacacgtg ggaaaacgaa ctgccagtat cgaagtacgc caacaacctc gtgcaactgg
      661 acaacggggt caggattcct ccgagtggct ggaagtgtgc ccgatgtgac ctgcgggaga
      721 acctctggtt gaatctgact gacggctctg ttctgtgtgg gaagtggttt tttgacagct
      781 cggggggcaa tggccatgcg ctggagcatt acagagacat gggctatcct ctggccgtga
      841 agctgggcac catcacgcct gatggagcag atgtttattc ttttcaagaa gaggggcctg
      901 tttcggatcc tcatttggcc aaacacttag cacattttgg gattgacatg ctccacacac
      961 aagggacaga gaatgggttc cgggacaatg acatcaagct gagagtcagc gagtgggaag
     1021 tgatccagga gtcaggaact aagctgaagc caatgtatgg cccagggtac acgggcctga
     1081 agaacctggg caacagttgc tacctcagtt ctgtcatgca ggccatcttc agcatcccag
     1141 agttccagag agcgtatgta ggaaacctcc caaggatatt tgactactca ccattagatc
     1201 caacgcagga cttcaacaca cagatgacta agttgggaca tggcctcctc tctggccagt
     1261 actcgaagcc tccagtgaaa tctgagctca ttgaacaggt gatgaaggag gagcacaagc
     1321 ctcagcagaa tgggatctct ccacgaatgt tcaaggcctt tgtcagcaag agtcacccag
     1381 aattttcctc caatagacag caggatgccc aggagttttt cttgcatttg gttaatctgg
     1441 tagagaggaa tcgcattggc tcagaaaacc caagtgatgt tttccggttt ttggtggaag
     1501 agcgaattca atgctgtcag accagaaagg tccgctacac agagagggtg gactacctta
     1561 tgcagttacc agtggcaatg gaggcagcaa ccaacaaaga tgagctgatt gcctatgaac
     1621 taatgcggag ggaagcagaa accaacagga gaccccttcc agagctggta cgagccaaga
     1681 tcccattcag tgcctgtctt caggcctttg ctgaaccaga caatgtggat gatttctgga
     1741 gcagtgctct gcaggccaag tctgcagggg tcaaaacatc tcgctttgcc tcattccctg
     1801 aatacttggt agtgcagata aagaagttca cttttggtct tgactgggtt ccccgaaaat
     1861 ttgatgtttc tattgatatg ccagatctac tagatatcag ccatctcaga gccaggggct
     1921 tgcagccagg ggaagaggag cttcctgaca tcagcccccc catagtcatt cctgatgact
     1981 caaaagaccg cttgatgaac cagctgatag acccctcaga cattgatgag tcctcggtga
     2041 tgcaactggc tgagatgggc ttccctttgg aggcctgcag gaaggctgtg tacttcacgg
     2101 ggaatactgg agctgaggtg gccttcaact ggattatcgt gcacatggaa gagcctgatt
     2161 ttgctgaacc actggccata cctgggtatg gaggggctgg ggcctctgcc tttggtgcta
     2221 ctggactgga caaccaacct cctgaggaaa tcgtagctat tatcactgcc atgggattcc
     2281 agcgcagtca ggcggtacag gctctacaag ccacgaacca taacctggaa agagcactgg
     2341 actggatctt cagccaccct gagtttgaag aggacagtga ctttgtcatc gagatggaga
     2401 acaatgcgaa tgcaaacatc atgtctgagg ccaagccaga ggggcccaga gtcaaggatg
     2461 ggtctggaat gtatgagttg tttgcgttca tcagtcacat gggaacatct acgatgagtg
     2521 gccattatgt ttgccatatc aagaaggagg gacgatgggt gatctacaat gaccacaaag
     2581 tttgtgcctc agaaaggccc cccaaagacc tgggatatat gtacttttac cgcaggatac
     2641 caagctaaac ctcacaagaa ttggcgagaa gaagccatac acctttataa tttgccaaaa
     2701 aagaaaaaga aaaaaaaaaa gaaaaaggaa aaataaagga aaaaagttgg gacagccgga
     2761 tgcggaggac tacatgggta tttactgctc ctttcaagag cgtggtcact cgacgccttc
     2821 tggagaagaa ctgggaagaa aattctgttg gcggtgatat tctgtcctgg gagattttgt
     2881 aactcttcag ggagagagtg acggaagcaa aggcattgtc caccggcccc tcagagaggc
     2941 actgtcttcc cctctcttct acttgggggg gtcaccagtg agggcccccc acagtgagaa
     3001 aaatgcccac ttttaaaatt tttccacata ggaaatcaaa acctggactg gcttttattg
     3061 gtggcacttt gttttcattt cccacagtaa gttctgtgca cactaggaca tctgcagtga
     3121 gagctatttt taatttaaat cacgtcaaac tttatattac actgtatgag tgtgtgtgtg
     3181 tgtgtgtgtg tgtgtgtgtg agagagagag agagagagag agagagaggc agagagagag
     3241 agagagagag agagagagag agagagacct ttgtagtctg ctgtacgtct gatggattgg
     3301 tgttcaaagg ccaaatagct gcttttaggc atatttggaa aaggcaggca aacatcttta
     3361 aaaattataa ctcaggaaca attgttaaaa gtgagttccc cacttggatt ttaaagtaca
     3421 gagagctgag ctgtggcccc ttaagtgctg tctggcattc atgagggtct gtgtcgtttg
     3481 accttgatgc caggtgccta agtcttgtca ctgtgctttg ccaagggcag atgggatctc
     3541 ttcctcagta gggcattccc tcaaagcttt gtgtttagtt ttagttaaat aactggcctc
     3601 ccaagctcct gcttactccc tgggatcacg ttagatgcct gtggcttgtc tgattttttt
     3661 ggtccctgaa cttccttgtg ttttcacatc tctgcttctc tggggccagc ttcacctctg
     3721 ccctcactgc ctatctgctg tggcccatgg tacaacctgg ggcgctttaa ggatgcaagc
     3781 tgcagaaaca cctctgttgc agctgcaaag ccagggcctt ccttccttgt catttccggg
     3841 tcctagctgt ggtctgagat cagagcagag ttgtggatgt gcagtggaga ggaaccagag
     3901 ctctccataa ttttcttact acttctcatc aaattccagc ctctggagtt tctagttcag
     3961 attattgatc agatgggaaa ggatttattg ctgtctgctt gatgtgtgct tgtttgattg
     4021 atctttgcag gaactgcaga aaaaaaatga tgaaatagaa acggaatggg ctgagtaagc
     4081 agaggcattg ggttgggatg ggatgagtct gaacagtcag agttcaaacc ctggggccct
     4141 gtctcaagga agaccccgtg taagtccggg ctgtggggca gggccacggg cctgggtact
     4201 tctgggtgct gtctcagttg gctatgggcc agtccttcca tctgtgcctc attctcctca
     4261 tccgcacggt ggtcaggtga cacctccctc tttctagcag gctttgatta attctgaaga
     4321 acctccaatg aacagaaggt ggaacgtggt aggccccact ggagagtgct cctgtcttct
     4381 tgacttacct gttgcgtttt ccacttggga ataaatgaca tcacaggagg gagctcatga
     4441 ttctctctga cactgtccca ctgaggcacc tttgaggctt ggctcagaga tcctaagtct
     4501 ctgtcctgtg tgtccctgac cagcgcccct accccgaagt ggaaattcac acaccaagca
     4561 gccttacaaa tgtagtccct atagggccac atatggtagg ataatgactg accttcagtg
     4621 gctggtttgc agtgttacaa agcaaaggcc tttcacgtgg gtaggggact ctcaggaggt
     4681 ttgaattcaa atgtggtcag agatagtata tatattttgg acaaaataag aagtttttat
     4741 aaaacttttc aagctcaaca ttgtaaaatc cacattaaag attttaggct ataaactgtt
     4801 taattttatt aggtagaaga agcaaattaa tccttctgat gccaagacat acttcaagaa
     4861 agtggataat gactgccttt tccctgcctc acaaacacaa gggctattca tggcaaggtt
     4921 ttgtatatgt gctattcttc actcagatca ggagctggac gcaccggtgt gggcagtgcc
     4981 ttgctttctc gttagaaatg tgcttgcatg tgtctcctgg tataggcaaa ccagctctct
     5041 agag
//
