LOCUS       NM_001166576            4064 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 12 (Usp12), mRNA.
ACCESSION   NM_001166576 XM_341033
VERSION     NM_001166576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4064)
  AUTHORS   Jahan,A.S., Lestra,M., Swee,L.K., Fan,Y., Lamers,M.M.,
            Tafesse,F.G., Theile,C.S., Spooner,E., Bruzzone,R., Ploegh,H.L. and
            Sanyal,S.
  TITLE     Usp12 stabilizes the T-cell receptor complex at the cell surface
            during signaling
  JOURNAL   Proc Natl Acad Sci U S A 113 (6), E705-E714 (2016)
   PUBMED   26811477
REFERENCE   2  (bases 1 to 4064)
  AUTHORS   Belle,J.I. and Nijnik,A.
  TITLE     H2A-DUBbing the mammalian epigenome: expanding frontiers for
            histone H2A deubiquitinating enzymes in cell biology and physiology
  JOURNAL   Int J Biochem Cell Biol 50, 161-174 (2014)
   PUBMED   24647359
  REMARK    Review article
REFERENCE   3  (bases 1 to 4064)
  AUTHORS   Gangula,N.R. and Maddika,S.
  TITLE     WD repeat protein WDR48 in complex with deubiquitinase USP12
            suppresses Akt-dependent cell survival signaling by stabilizing PH
            domain leucine-rich repeat protein phosphatase 1 (PHLPP1)
  JOURNAL   J Biol Chem 288 (48), 34545-34554 (2013)
   PUBMED   24145035
REFERENCE   4  (bases 1 to 4064)
  AUTHORS   Cohn,M.A., Kee,Y., Haas,W., Gygi,S.P. and D'Andrea,A.D.
  TITLE     UAF1 is a subunit of multiple deubiquitinating enzyme complexes
  JOURNAL   J Biol Chem 284 (8), 5343-5351 (2009)
   PUBMED   19075014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Oct 29, 2022 this sequence version replaced NM_001166576.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1477881.1,
                                           SRR26360172.1851369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000012.1  13423858-13423990
            134-214             JAXUCZ010000012.1  13450113-13450193
            215-428             JAXUCZ010000012.1  13455723-13455936
            429-658             JAXUCZ010000012.1  13464884-13465113
            659-735             JAXUCZ010000012.1  13467435-13467511
            736-819             JAXUCZ010000012.1  13467622-13467705
            820-1017            JAXUCZ010000012.1  13472094-13472291
            1018-1096           JAXUCZ010000012.1  13473400-13473478
            1097-4064           JAXUCZ010000012.1  13474580-13477547
FEATURES             Location/Qualifiers
     source          1..4064
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..4064
                     /gene="Usp12"
                     /note="ubiquitin specific peptidase 12"
                     /db_xref="GeneID:360763"
                     /db_xref="RGD:1308045"
     exon            1..133
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1198
                     /gene="Usp12"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 12; ubiquitin
                     thiolesterase 12; ubiquitin thioesterase 12;
                     deubiquitinating enzyme 12; ubiquitin-specific-processing
                     protease 12"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 12"
                     /protein_id="NP_001160048.1"
                     /db_xref="GeneID:360763"
                     /db_xref="RGD:1308045"
                     /translation="MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNF
                     GNTCYCNSVLQALYFCRPFRDKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIP
                     PKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLRNGDVDS
                     EDNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRG
                     FSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY
                     RVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDD
                     IVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD"
     exon            134..214
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     exon            215..428
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     exon            429..658
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     exon            659..735
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     exon            736..819
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1017
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1096
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..4064
                     /gene="Usp12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggg ctgcggagcg agcgggcggc ccggctcccc gcgtcccccg cccgccgcga
       61 ctgtctggaa gatggcgccg ggcggatgga aatcctaatg acagtctcca aattcgcctc
      121 catctgtacc atgggcgcca atgcctcggc attagagaaa gagattggtc cagaacagtt
      181 tccggtcaac gagcactatt ttggattagt caattttggg aatacctgct actgcaactc
      241 cgttctccaa gcactttatt tttgtcgtcc gtttcgggac aaagttctgg catacaagag
      301 tcagcccaga aaaaaggaaa gcctcctcac ctgcctggca gacctcttcc acagcatagc
      361 cacccagaag aagaaggtcg gcgtgatccc gcccaagaag ttcatcacca gattgcggaa
      421 ggaaaacgag ctgtttgata actacatgca acaagatgcc catgaattct taaattacct
      481 actcaataca attgctgata ttctacaaga agaaagaaag caggagaagc aaaatggccg
      541 attacgtaac ggggatgtgg acagcgagga taacaacagc acaccagacc caacgtgggt
      601 ccacgagatt tttcagggaa cattaactaa tgaaaccagg tgtcttactt gtgaaactat
      661 aagcagcaaa gatgaagatt ttttagacct ttctgttgac gtggaacaaa acacatcaat
      721 cactcactgc ctaagagggt tcagtaacac ggagactctg tgcagtgaat acaaatacta
      781 ctgtgaagaa tgccggagca agcaggaggc acacaaacgg atgaaagtta agaaactacc
      841 catgatcctg gctctgcacc tgaagaggtt taagtacatg gaccagcttc atcgatatac
      901 aaagctttct taccgggtgg tgtttccttt agaactccgt ctgtttaaca cttcaggaga
      961 cgcaaccaac cctgacagaa tgtatgacct ggtcgctgtt gtggttcact gtggaagtgg
     1021 tcccaatcga ggccattata ttgcaatagt taagagtcat gatttttggt tgttatttga
     1081 tgacgacatt gtagaaaaaa tagacgcaca agctattgaa gaattctacg gactgacatc
     1141 tgacatctcc aagaactctg agtctgggta catccttttc tatcagtctc gggactgaaa
     1201 ggtgccgcag tggaaagaag cttctgcttg cttctctggt tgcttccgaa aggatcgagc
     1261 tgatgtttaa gaagagagaa agagagacag acagacgcag gacgctcagg gcagtagctc
     1321 actttgcata caataaagca aaggctggat taacacgccc ttccggtcac gttagttgaa
     1381 ttttttgctc aggaatcatg ctgtctgcag ttccacacaa ggacgtgatc agagatacca
     1441 gctcttgtga agcagctgcc agctgccgac acggtttccg tagtcatcgc accaaggatg
     1501 atgtgagttc ttcgggaggg cagtggagga gttaggatgt gctagggtga ttgagcacac
     1561 cgcactgtgc gccagcgcgc gggatgcgtg tgtgcactgt gcatggagca gtgacggtct
     1621 cttcaagcat cccgaaaagt acctttgggc ccaacacttg cagttgcctt cctgacgcac
     1681 agagcacaga cacggagccc agtgtcagga ggtcaaagat acctgcttct ctggagaagc
     1741 gtgtgatcat atacagtgta tgtacatgga gggaacagct ggtcaaaact ggcttcttga
     1801 ttccccaagg ggagagactg gctttgtaat gatctttttt ccttatttat tttacttaaa
     1861 ctggttgagt ccaagcattg tatgaagtgc ccgtgattct accagctagt cttggcgtat
     1921 ttgattagtt tgtcagctga ggcagtcctg ttgtccgttt ctgttttcaa ggtgaactga
     1981 acattgtaac tgaatcacta aggtaatcat gagaggatcg tagtgagcgg ggtcagtgct
     2041 gtcccgaggg actgtctctg gctgagcagt gagcgggggg gtcagtgctg tcccgaggga
     2101 ctgtctctgg ctgagcactt gctccttggt tatagtttgt cacttttttt taaagcttta
     2161 aatgcagtga agtaggagtt ccctgttgct agagtgataa aggaagcccc agcatgaggc
     2221 tggcgtgctg ccagcccgaa ccccaggacg tcggtgcgta cagctgtggc agtctttagt
     2281 cctgttttag ccttgggaag gactaataga gcagccagaa ccccatcagc cagggcagct
     2341 caagcccttt ggaagattac attttggtag tgtagtaatc tcaaaaagaa gcccctcgcc
     2401 ctcctgacct gagtgtccta ttagagcgct gttcagacac ttacagctag atctgttggg
     2461 agtttaggga acagtacggg agtctccaca tatggccagg catcaagtgt atgacagtgg
     2521 ctgaatgtaa cttgcagtaa gtggttgagg attctactca aagtccagct tcagactctg
     2581 ggtagccatc ctcacacaca ctcctcatag tgtggtggcg gcctgttgat aaagcccctg
     2641 gttttctaaa gctattttac taaaactgtt gactgagaag aaaacagcaa aaagaaatgt
     2701 tttttgtgct gctatgatta acatttattt tctaccttta gctcaggaaa tgacttcatc
     2761 tattcatccc ataagcagat ttgcaacggg gtcacttagc taatcgggct tcgtagacag
     2821 atgtgctggg agaaaaagat gaccttttgg caaactcatt ttgatagttt ctgaagcctt
     2881 accctggctg ggtttcgtga tctgccagca ttgcacagag aacggcaacc aagagcacgg
     2941 gggttagagc tgcgcgcgag agagcacacg cccgtcgggc ccacaccaga ctgtgttgga
     3001 attcagaact gcattctctg cagctttgtg ttcaaagaaa aggcataaag tagggctgag
     3061 gccttgaggc tgccgtgcgc agccctgaag tactgtgtct gcttgcacac gttattttga
     3121 agcaggaaaa gcctagttaa gttctccaca aggcaagtta tagcaggggg ccaagctcca
     3181 ggcaggcagc cttgcttggc tcaggtctgt gctgtacggt ttgcagggga cggaatcctg
     3241 ggtgttggct ctaaatttac tttttatcct tagtgcagat ggatctgagt aagacatttt
     3301 gaattttatc agaaactcag taaacttaaa aaaacataca gggtttgggt tggggactgg
     3361 gataacaggt ataagaagtg agaaagaaag gtgacccacc cagcacacat ttcaggtgat
     3421 tgtttgcctg tgattatgat gagggcagat gcgagtttgg acaaggctgg ttgctctgta
     3481 attatgtaca tgtttgcttg ggcagccgtc ccaaattttg tatattagaa caagagtttc
     3541 tatgaattat cataactaaa gtaaatattc taagtggagc ccacttgcga tcatcagcct
     3601 ctgtcacgag gattttacct ttagaaggtt actcaagaca ggagccggtg gcttaggaag
     3661 gggcaaggaa atgtgctgta gcggcctgtg gcctcagcca tcagcatccc tcggggtttt
     3721 ctttccatga tggccataga agacctcact ttgataacat gctcctcctg atgctttctg
     3781 taaagatgtt cttcataagc agtctctcgt gagggatgtg gctgggagct gggaggcaag
     3841 ggactgcagt gaacttagct gtgtgacctt gggcaagtca cctaacctct ctgtgcttca
     3901 gtctccctct tgtaaatggg agtaatacct acctcacagg gttgttgtgg ggattaatta
     3961 gagaggaagt ctgtaaagca tttaaaaggt tcttgaagaa ggcgctatat aaatacaaaa
     4021 taatatctat taaagttggc ttatttgtgc ttgtcggttt ttaa
//
