LOCUS       NM_001008861            3423 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 11 (Usp11), mRNA.
ACCESSION   NM_001008861 XM_579253
VERSION     NM_001008861.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3423)
  AUTHORS   Fang,Y., Zhao,T., Ni,H., Li,Y., Zhu,Y., Gao,R., Zhang,L., Jia,Z.
            and Chen,G.
  TITLE     USP11 exacerbates neuronal apoptosis after traumatic brain injury
            via PKM2-mediated PI3K/AKT signaling pathway
  JOURNAL   Brain Res 1807, 148321 (2023)
   PUBMED   36898475
  REMARK    GeneRIF: USP11 exacerbates neuronal apoptosis after traumatic brain
            injury via PKM2-mediated PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 3423)
  AUTHORS   Zhang,Y., Hailati,J., Ma,X., Midilibieke,H. and Liu,Z.
  TITLE     Ubiquitin-specific protease 11 Aggravates
            Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by
            Promoting TRAF3 Deubiquitination
  JOURNAL   Balkan Med J 40 (3), 205-214 (2023)
   PUBMED   37000116
  REMARK    GeneRIF: Ubiquitin-specific protease 11 Aggravates
            Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by
            Promoting TRAF3 Deubiquitination.
REFERENCE   3  (bases 1 to 3423)
  AUTHORS   Xu,Z., Li,X., Chen,J., Zhao,J., Wang,J., Ji,Y., Shen,Y., Han,L.,
            Shi,J. and Zhang,D.
  TITLE     USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis
            Following Intracerebral Hemorrhage
  JOURNAL   J Mol Neurosci 58 (1), 16-27 (2016)
   PUBMED   26334325
  REMARK    GeneRIF: USP11 is upregulated in neurons adjacent to the hematoma
            following ICH.
REFERENCE   4  (bases 1 to 3423)
  AUTHORS   Schoenfeld,A.R., Apgar,S., Dolios,G., Wang,R. and Aaronson,S.A.
  TITLE     BRCA2 is ubiquitinated in vivo and interacts with USP11, a
            deubiquitinating enzyme that exhibits prosurvival function in the
            cellular response to DNA damage
  JOURNAL   Mol Cell Biol 24 (17), 7444-7455 (2004)
   PUBMED   15314155
REFERENCE   5  (bases 1 to 3423)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   6  (bases 1 to 3423)
  AUTHORS   Ideguchi,H., Ueda,A., Tanaka,M., Yang,J., Tsuji,T., Ohno,S.,
            Hagiwara,E., Aoki,A. and Ishigatsubo,Y.
  TITLE     Structural and functional characterization of the USP11
            deubiquitinating enzyme, which interacts with the RanGTP-associated
            protein RanBPM
  JOURNAL   Biochem J 367 (Pt 1), 87-95 (2002)
   PUBMED   12084015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090333.1.
            
            On Sep 28, 2005 this sequence version replaced NM_001008861.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3423              BC090333.1         1-3423
FEATURES             Location/Qualifiers
     source          1..3423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..3423
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /note="ubiquitin specific peptidase 11"
                     /db_xref="GeneID:408217"
                     /db_xref="RGD:1303052"
     exon            1..161
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2775
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 11; ubiquitin
                     thioesterase 11; deubiquitinating enzyme 11;
                     ubiquitin-specific-processing protease 11"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 11"
                     /protein_id="NP_001008861.2"
                     /db_xref="GeneID:408217"
                     /db_xref="RGD:1303052"
                     /translation="MAAVAADPAAAAVPASAEDRETQPEAMPDLDQQWRQIGNGRERP
                     LRAGESWFLVEKHWYKQWEAYVKGGDQDASTFPGSINNSGLFEDQISWHLRERLVEGD
                     DYVLLPAPAWNYLVSWYGLKDDQPPIERKVIELPGIRKVEVYPIELLLVQHSDMETAL
                     TIQFSYSDSVDLVLQTAREQFLVEPQEDTRLWTKNSEGSLDRLCNTQITLLDACLETG
                     QLVIMETRNKDGTWPSAQLCGMNNMPDEDEDFQGQPGICGLTNLGNTCFMNSALQCLS
                     NVPQLTEYFLNNRYLEELNFRNPLGMKGELAEAYADLVKQTWSGYHRSIVPNVFKNKV
                     GHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCNGAGRPDLEVAQEAWQ
                     NHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPVCSRRVLEVFFVP
                     MDPRRKPEQHRVVVPKKGNISDLCVALSTHTSVAPDKMIVADVFSHRFYKLYQLEDPL
                     SGILDRDDIFVYEVTGRIEPVEGSRDDIVVPVYLRERTPSRDYNNSYYGLILFGHPLL
                     VSVPRDRFSWEGLYNILMYRLSRYVTKPTSDDDDGDEKGDENEDEDVEDDSSSEEEKE
                     EMSGPTDNDGTQESEQEQAGTSSGVTGRCPSLLDNSLHTSQWPPRRRRKQLFTLQTVN
                     SNGTSDRTTSPEEAQTQPYIAMDWEPEMKRRYYDEVEAEGYVKHDCVGYMLKKNPVQL
                     KECIKLFTTVETLEKENPWYCSSCKQHQLATKKLDLWMLPEVLIIHLKRFSFSKFSRE
                     KLDTLVQFPIRDLDFSEFVIKPKNESAPDLYKYDLIAVSNHYGGMRDGHYTTFACNKD
                     SGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVGRRQSQTASSETPTSPASSSTPN
                     SDIMDVN"
     exon            162..271
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..402
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..520
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..666
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..728
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..828
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1002
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1161
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1386
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1470
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1565
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1772
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1822
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2101
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2172
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2285
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2435
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2551
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2640
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..3399
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggacggtga tggcggcggt cgcagcggac ccagctgcag ctgccgtccc ggcctctgct
       61 gaggacagag agacacagcc cgaggcaatg ccagacctgg atcaacagtg gcgccaaatc
      121 gggaatgggc gagagcgtcc actgcgagct ggcgaaagct ggttccttgt ggagaaacac
      181 tggtataaac agtgggaggc gtatgtgaag ggaggggatc aagatgctag cacctttcct
      241 ggcagtatca acaattcggg gctctttgaa gatcagataa gctggcacct cagggagaga
      301 ctggtagaag gagatgatta tgtgctgctc ccagcgcctg cttggaacta cctggtcagc
      361 tggtatggct taaaggatga ccagccacct attgagcgca aggtcataga acttcctggc
      421 attcgaaagg tggaagtgta cccaatagag ctgctgctcg ttcagcacag tgatatggaa
      481 acagctctca ccattcagtt tagctattct gattctgtcg acctagtctt gcaaacagcc
      541 cgggagcagt ttctggtaga gcctcaggaa gacacgcgcc tctggaccaa gaactcagag
      601 ggctctttgg atcgattatg taacacgcag atcacactgc ttgatgcctg ccttgagact
      661 gggcagttgg tcatcatgga gacccgaaac aaagatggca cttggcccag cgctcagctg
      721 tgtggcatga acaacatgcc ggacgaggat gaggacttcc agggccaacc aggcatctgt
      781 ggccttacca atctgggcaa cacgtgcttc atgaactcgg ccctacagtg cctcagcaat
      841 gtgccacagc ttacggagta ctttctcaac aaccgctacc tggaggagct caacttccgg
      901 aaccctctgg gcatgaaggg tgagcttgct gaggcctatg cagatctggt aaagcagact
      961 tggtctggct accaccgctc cattgtgccg aatgttttca agaacaaggt tggccatttc
     1021 gcatcccagt ttctgggcta ccagcagcat gactcacagg aactactgtc attcctcctg
     1081 gatggactac atgaggacct caatcgagtc aaaaagaaag aatatgttga gctatgcaat
     1141 ggtgctgggc ggcctgatct ggaagtggct caggaagcct ggcagaacca caaacgacga
     1201 aatgattctg tgattgtgga cactttccat ggcctcttca agtctacact ggtgtgccct
     1261 gattgtggca atgtttctgt gacctttgac cccttctgct acctcagtgt cccactgcct
     1321 gtctgctcca ggagggtctt ggaggtcttc tttgtcccca tggatccccg ccgcaagcca
     1381 gaacagcacc gggttgtagt ccctaagaag ggcaatatct cagatctgtg tgtggctctg
     1441 tccacacata caagtgttgc accagataag atgatagtag ctgatgtctt cagtcaccga
     1501 ttctataagc tctaccagct ggaggatcct ctgagtggca tcttggatcg tgatgatatc
     1561 tttgtatatg aggtgactgg acggattgag cctgttgagg gttcaagaga tgatattgtg
     1621 gttcctgttt acctgcggga gcgcaccccg tccagagact acaacaactc ctactacggt
     1681 ctgatacttt ttgggcaccc tctcctggtg tcagtgcccc gggaccggtt ctcctgggag
     1741 ggcctatata acatcttgat gtaccggctt tcacgatatg tgaccaaacc cacctcagat
     1801 gacgatgatg gggatgagaa aggtgatgag aatgaggatg aggatgtcga agatgacagc
     1861 agcagtgaag aagaaaagga ggaaatgtct ggacctaccg ataatgatgg tacccaagaa
     1921 tcagagcagg agcaggctgg gaccagctct ggggtcaccg gaagatgccc atccctctta
     1981 gacaacagcc tccacacatc gcagtggccc ccaaggcgac gacgaaagca attgtttact
     2041 ctgcagacag tgaactccaa tggaaccagt gaccggacca cctcccctga agaagcccaa
     2101 actcagccgt acattgccat ggattgggaa ccagagatga agaggcgcta ttatgatgaa
     2161 gtagaggctg agggctatgt gaagcatgac tgcgtgggat acatgctgaa gaagaatcca
     2221 gtgcagctga aggagtgcat caaactcttc accactgtgg aaacccttga gaaggagaac
     2281 ccttggtatt gctcctcctg caagcagcac cagctagcca ctaagaaact ggacctctgg
     2341 atgctacctg aagttctcat tatccatctg aagcgttttt cattttccaa attttcccgg
     2401 gagaagctgg acaccctggt gcagtttcct atccgggatc tggatttctc tgagtttgtc
     2461 atcaaaccaa agaatgagtc tgctccagac ctgtacaaat atgatctcat cgcagtttcc
     2521 aaccattatg gtggcatgcg tgatggacac tatacaacat ttgcctgcaa caaggacagt
     2581 ggccagtggc actactttga tgacaacagt gtctcacctg tgaatgagaa tcagattgag
     2641 tccaaggcag cctatgtctt gttctatcaa cgccaagatg tgggtcgacg ccagtcccag
     2701 actgcttcat ctgagacccc cacctctcct gcttcgagtt ctacacccaa ctctgacatc
     2761 atggatgtca actaaggaga cctgaaacct attgcagaga aggaagcccc ctttgccact
     2821 ctttcttgtc tactctctct cttacttgtg ttcatctttc ccctcccccc aacattgcag
     2881 gcttagtctg ttgctactgt tctcttgtac cgctgtatta ctctctcaga aagaagaggc
     2941 cctgtgcccc tggcggtgtg ctcctgcctg tgtgtgcccg tacagcagtg acttcccctc
     3001 ctagtcttat ttatgctccc cttccctctt ttcctcatgc caaagtgttc ttagtggctg
     3061 attcgggggg gttcacatga acacagagtg tattttctta ttgagaccat accttctctg
     3121 tgttaagtat acataaaaag accaagactc ctatgttcag cagtgtggtt tatttcttcg
     3181 tatgtactta ttatgcacca gccataggtc tttgttctgt gtaattactg aaggtatgtg
     3241 gttgatgcta ttctgaatgg gtttgttgat tttgagacag ggtctgtctg tatagctctc
     3301 gatgtcctgg aactcactgt ggaccaggct gaccttcagc tcagaaatta ggcctctgcc
     3361 tcctaagtgc tgggattaaa ggtatggcta caacacctaa aaaaaaaaaa aaaaaaaaaa
     3421 aaa
//
