LOCUS       NP_001008861             921 aa            linear   ROD 28-APR-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 11 [Rattus norvegicus].
ACCESSION   NP_001008861 XP_579253
VERSION     NP_001008861.2
DBSOURCE    REFSEQ: accession NM_001008861.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 921)
  AUTHORS   Fang,Y., Zhao,T., Ni,H., Li,Y., Zhu,Y., Gao,R., Zhang,L., Jia,Z.
            and Chen,G.
  TITLE     USP11 exacerbates neuronal apoptosis after traumatic brain injury
            via PKM2-mediated PI3K/AKT signaling pathway
  JOURNAL   Brain Res 1807, 148321 (2023)
   PUBMED   36898475
  REMARK    GeneRIF: USP11 exacerbates neuronal apoptosis after traumatic brain
            injury via PKM2-mediated PI3K/AKT signaling pathway.
REFERENCE   2  (residues 1 to 921)
  AUTHORS   Zhang,Y., Hailati,J., Ma,X., Midilibieke,H. and Liu,Z.
  TITLE     Ubiquitin-specific protease 11 Aggravates
            Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by
            Promoting TRAF3 Deubiquitination
  JOURNAL   Balkan Med J 40 (3), 205-214 (2023)
   PUBMED   37000116
  REMARK    GeneRIF: Ubiquitin-specific protease 11 Aggravates
            Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by
            Promoting TRAF3 Deubiquitination.
REFERENCE   3  (residues 1 to 921)
  AUTHORS   Xu,Z., Li,X., Chen,J., Zhao,J., Wang,J., Ji,Y., Shen,Y., Han,L.,
            Shi,J. and Zhang,D.
  TITLE     USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis
            Following Intracerebral Hemorrhage
  JOURNAL   J Mol Neurosci 58 (1), 16-27 (2016)
   PUBMED   26334325
  REMARK    GeneRIF: USP11 is upregulated in neurons adjacent to the hematoma
            following ICH.
REFERENCE   4  (residues 1 to 921)
  AUTHORS   Schoenfeld,A.R., Apgar,S., Dolios,G., Wang,R. and Aaronson,S.A.
  TITLE     BRCA2 is ubiquitinated in vivo and interacts with USP11, a
            deubiquitinating enzyme that exhibits prosurvival function in the
            cellular response to DNA damage
  JOURNAL   Mol Cell Biol 24 (17), 7444-7455 (2004)
   PUBMED   15314155
REFERENCE   5  (residues 1 to 921)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   6  (residues 1 to 921)
  AUTHORS   Ideguchi,H., Ueda,A., Tanaka,M., Yang,J., Tsuji,T., Ohno,S.,
            Hagiwara,E., Aoki,A. and Ishigatsubo,Y.
  TITLE     Structural and functional characterization of the USP11
            deubiquitinating enzyme, which interacts with the RanGTP-associated
            protein RanBPM
  JOURNAL   Biochem J 367 (Pt 1), 87-95 (2002)
   PUBMED   12084015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090333.1.
            
            On Sep 28, 2005 this sequence version replaced NP_001008861.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     Protein         1..921
                     /product="ubiquitin carboxyl-terminal hydrolase 11"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 11; ubiquitin
                     thioesterase 11; deubiquitinating enzyme 11;
                     ubiquitin-specific-processing protease 11"
                     /calculated_mol_wt=105108
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5D006.1)"
     Region          23..888
                     /region_name="UBP12"
                     /note="Ubiquitin C-terminal hydrolase [Posttranslational
                     modification, protein turnover, chaperones]; COG5560"
                     /db_xref="CDD:227847"
     Site            194
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P51784; propagated from
                     UniProtKB/Swiss-Prot (Q5D006.1)"
     Region          592..697
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5D006.1)"
     Site            596
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51784; propagated from
                     UniProtKB/Swiss-Prot (Q5D006.1)"
     Site            692
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5D006.1)"
     Region          893..921
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5D006.1)"
     Site            906
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51784; propagated from
                     UniProtKB/Swiss-Prot (Q5D006.1)"
     CDS             1..921
                     /gene="Usp11"
                     /gene_synonym="Uhx1"
                     /coded_by="NM_001008861.2:10..2775"
                     /db_xref="GeneID:408217"
                     /db_xref="RGD:1303052"
ORIGIN      
        1 maavaadpaa aavpasaedr etqpeampdl dqqwrqigng rerplrages wflvekhwyk
       61 qweayvkggd qdastfpgsi nnsglfedqi swhlrerlve gddyvllpap awnylvswyg
      121 lkddqppier kvielpgirk vevypielll vqhsdmetal tiqfsysdsv dlvlqtareq
      181 flvepqedtr lwtknsegsl drlcntqitl ldacletgql vimetrnkdg twpsaqlcgm
      241 nnmpdededf qgqpgicglt nlgntcfmns alqclsnvpq lteyflnnry leelnfrnpl
      301 gmkgelaeay adlvkqtwsg yhrsivpnvf knkvghfasq flgyqqhdsq ellsflldgl
      361 hedlnrvkkk eyvelcngag rpdlevaqea wqnhkrrnds vivdtfhglf kstlvcpdcg
      421 nvsvtfdpfc ylsvplpvcs rrvlevffvp mdprrkpeqh rvvvpkkgni sdlcvalsth
      481 tsvapdkmiv advfshrfyk lyqledplsg ildrddifvy evtgriepve gsrddivvpv
      541 ylrertpsrd ynnsyyglil fghpllvsvp rdrfswegly nilmyrlsry vtkptsdddd
      601 gdekgdened edveddssse eekeemsgpt dndgtqeseq eqagtssgvt grcpslldns
      661 lhtsqwpprr rrkqlftlqt vnsngtsdrt tspeeaqtqp yiamdwepem krryydevea
      721 egyvkhdcvg ymlkknpvql keciklfttv etlekenpwy cssckqhqla tkkldlwmlp
      781 evliihlkrf sfskfsrekl dtlvqfpird ldfsefvikp knesapdlyk ydliavsnhy
      841 ggmrdghytt facnkdsgqw hyfddnsvsp vnenqieska ayvlfyqrqd vgrrqsqtas
      901 setptspass stpnsdimdv n
//
