LOCUS       NM_001034146            3287 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 10 (Usp10), mRNA.
ACCESSION   NM_001034146 XM_226528
VERSION     NM_001034146.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3287)
  AUTHORS   Cai,B., Ma,W., Bi,C., Yang,F., Zhang,L., Han,Z., Huang,Q., Ding,F.,
            Li,Y., Yan,G., Pan,Z., Yang,B. and Lu,Y.
  TITLE     Long noncoding RNA H19 mediates melatonin inhibition of premature
            senescence of c-kit(+) cardiac progenitor cells by promoting
            miR-675
  JOURNAL   J Pineal Res 61 (1), 82-95 (2016)
   PUBMED   27062045
REFERENCE   2  (bases 1 to 3287)
  AUTHORS   Wang,W., Huang,X., Xin,H.B., Fu,M., Xue,A. and Wu,Z.H.
  TITLE     TRAF Family Member-associated NF-kappaB Activator (TANK) Inhibits
            Genotoxic Nuclear Factor kappaB Activation by Facilitating
            Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase
  JOURNAL   J Biol Chem 290 (21), 13372-13385 (2015)
   PUBMED   25861989
REFERENCE   3  (bases 1 to 3287)
  AUTHORS   Pan,L., Chen,Z., Wang,L., Chen,C., Li,D., Wan,H., Li,B. and Shi,G.
  TITLE     Deubiquitination and stabilization of T-bet by USP10
  JOURNAL   Biochem Biophys Res Commun 449 (3), 289-294 (2014)
   PUBMED   24845384
REFERENCE   4  (bases 1 to 3287)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3287)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3287)
  AUTHORS   Liu,J., Xia,H., Kim,M., Xu,L., Li,Y., Zhang,L., Cai,Y.,
            Norberg,H.V., Zhang,T., Furuya,T., Jin,M., Zhu,Z., Wang,H., Yu,J.,
            Li,Y., Hao,Y., Choi,A., Ke,H., Ma,D. and Yuan,J.
  TITLE     Beclin1 controls the levels of p53 by regulating the
            deubiquitination activity of USP10 and USP13
  JOURNAL   Cell 147 (1), 223-234 (2011)
   PUBMED   21962518
REFERENCE   7  (bases 1 to 3287)
  AUTHORS   Yuan,J., Luo,K., Zhang,L., Cheville,J.C. and Lou,Z.
  TITLE     USP10 regulates p53 localization and stability by deubiquitinating
            p53
  JOURNAL   Cell 140 (3), 384-396 (2010)
   PUBMED   20096447
REFERENCE   8  (bases 1 to 3287)
  AUTHORS   Bomberger,J.M., Barnaby,R.L. and Stanton,B.A.
  TITLE     The deubiquitinating enzyme USP10 regulates the post-endocytic
            sorting of cystic fibrosis transmembrane conductance regulator in
            airway epithelial cells
  JOURNAL   J Biol Chem 284 (28), 18778-18789 (2009)
   PUBMED   19398555
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105892.1.
            
            [WARNING] On Nov 12, 2024 this sequence was replaced by
            NM_001034146.2.
            
            On Oct 14, 2005 this sequence version replaced XM_226528.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105892.1, SRR8487230.47771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3287
                     /gene="Usp10"
                     /note="ubiquitin specific peptidase 10"
                     /db_xref="GeneID:307905"
                     /db_xref="RGD:1561965"
     exon            1..107
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2471
                     /gene="Usp10"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thioesterase 10; deubiquitinating enzyme
                     10; ubiquitin-specific-processing protease 10; ubiquitin
                     thiolesterase 10; ubiquitin specific protease 10"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 10"
                     /protein_id="NP_001029318.1"
                     /db_xref="GeneID:307905"
                     /db_xref="RGD:1561965"
                     /translation="MALHNPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTQCGIQAE
                     EELLDGQEHQRIEFGVDEVIEPSDGLQRAPSYSISSTLNPQAPEFILGCPTSKKTPDD
                     IEKDETYSSIDQYPASALALESSSNAEAETLENDSGAGGLGQRERKKKKKRPPGYYSY
                     LKDGSEEGASPAALVNGHATSVGTNSEGVEDPEFMVDMLPSVMPRTCDSPQNPMDLIS
                     DPVPDSPFPRTLGGDARTAGLPEGCRETDFEQPCLPTDNLLRTAVTQPNAGADTTENL
                     AVANGKILESLGEGTAAANGVELHTDESADLDPAKPESQSPPAESALSVSGAISISQP
                     AKSWASLFHDSKPSSSSPVAYVETKCSPPVPSPLASEKQMEVKEGLVPVSEDPVAIKI
                     AELLETVTLVHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQR
                     PCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVIK
                     SSLSEKGRQEDAEEYLGFILNGLHEEMLSLKKLLSPTHEKHSVSNGPGSHLIEDEELE
                     DTGEGSEDEWEQVGPKNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPF
                     FTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEVSRRVTLEKLPPVLVLHL
                     KRFVYEKTGGCQKLVKNIEYPVDLEISRELLSPGVKNKNFKCHRTYRLFAVVYHHGNS
                     ATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVRPSADRTAYLLYYRRVDLL"
     exon            108..176
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            177..234
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            235..1266
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1358
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1468
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1524
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1628
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1728
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1906
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2072
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2217
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2283
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..3261
                     /gene="Usp10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtctgtgc ggcgagaaga tggcggcgac gggggacgcg gcgtgaaaag ccggaggagc
       61 tccgaacctc attgagacgg gccgccatgg ccctccacaa cccacagtat atttttggcg
      121 atttcagccc tgatgaattc aatcagtttt ttgtgactcc ccgctcttca gtcgagctcc
      181 ctccatacag tgggactcag tgtggcattc aggctgaaga ggaacttctg gacggacaag
      241 aacatcagag gattgagttt ggtgtagacg aagtcatcga acccagtgat ggtctgcaga
      301 gagcccctag ctacagtatt tcaagcacct tgaaccctca ggcacctgaa tttatccttg
      361 gttgtccaac ttccaagaag acccctgatg acatagaaaa agacgagacc tacagctcca
      421 ttgatcagta cccggcctca gccttggctc tggaaagcag ctctaacgca gaggccgaga
      481 ccttggagaa tgacagtggc gctggtggtc ttggtcagag ggagcggaag aagaagaaga
      541 agcggccccc tgggtactac agttatctga aagatggtag tgaagagggt gcttccccgg
      601 ccgcccttgt caacggccat gccacgtcag tgggcacgaa cagcgagggt gtggaggatc
      661 ctgagttcat ggtggacatg cttccttcag tcatgcccag gacttgtgac agccctcaga
      721 accccatgga cttaatcagt gaccctgtcc ctgatagtcc tttccccagg acactaggtg
      781 gtgatgccag gactgcagga ctgcctgagg gctgccgtga aactgacttt gagcagccct
      841 gcctccctac agacaacctg ctaaggacag ctgtgacgca gcccaacgct ggcgccgaca
      901 ctactgagaa cctcgcagtt gctaatggaa aaatacttga atccttgggc gagggcactg
      961 ctgctgccaa tggggtagag ctgcacactg atgagagtgc agacttggac cctgcgaagc
     1021 ctgagagcca gtcacctcct gccgaaagtg cgctctctgt ctctggcgcc atttccatta
     1081 gccaacctgc aaagtcctgg gctagcctct ttcatgattc taagccttct tcctcctcac
     1141 ccgtggcgta tgtggaaact aagtgttccc cccctgtccc gtcccccctg gcctctgaaa
     1201 aacagatgga agtcaaagaa gggcttgttc ccgtgtcaga ggaccccgta gccataaaga
     1261 ttgcagagtt attggagact gtaaccctag tacataagcc agtgtcattg caaccccgtg
     1321 ggctgatcaa taaaggaaac tggtgctaca ttaatgccac cctgcaggca ttggtggctt
     1381 gccctccgat gtatcacctg atgaagttca ttcctctgta ctcaaaagtg caaaggccgt
     1441 gcacgtccac gcccatgata gatagctttg ttcggctcat gaacgagttt actaatatgc
     1501 cagtacctcc caaaccccgc caagctcttg gggataaaat cgtgagagat atccgcccag
     1561 gagctgcctt tgaacccaca tacatttatc gactcctgac agtcatcaag tcgagcctgt
     1621 ctgaaaaggg ccgacaggag gacgccgagg agtacctagg cttcatcctc aatggactcc
     1681 acgaggagat gctgagcctg aagaagcttc tctcacccac gcacgaaaag cactctgttt
     1741 ctaatgggcc cggaagccac ttgatagagg atgaggagct ggaagacaca ggcgagggca
     1801 gtgaggacga gtgggagcaa gtgggtccca agaacaagac gtctgtcacc cggcaggcgg
     1861 atttcgttca gacgcctatc actggcattt tcggtggaca catcaggtct gtggtttacc
     1921 agcagagttc caaagaatct gccacgctgc agccattttt cacactgcag ttggacatcc
     1981 agtccgacaa gattcgcaca gtccaggatg ccttggaaag cttggtggca agagagtctg
     2041 tccagggcta caccaccaag accaagcagg aggttgaagt cagccgtaga gtgactctgg
     2101 agaagcttcc ccctgtcctt gtgctccacc tgaagcgctt cgtctatgag aagacgggcg
     2161 gatgccagaa gctcgtcaag aacatcgagt accctgtgga cttggagatc agcagagaac
     2221 tgctttctcc aggcgtcaaa aataaaaact ttaaatgcca cagaacctat aggctgttcg
     2281 cagtggtcta ccatcatggc aacagtgcta caggtggcca ctacaccacg gacgtcttcc
     2341 agattgggct taacggctgg ctgcgaattg atgaccagac ggtcaaggtt atcaaccagt
     2401 accaggtggt gagaccaagt gctgaccgca ccgcctacct cctgtattac cgccgtgtgg
     2461 acctgctgta gctctgcccg tgtgtccgac gctgtctccc atatctccca gctcactaac
     2521 cgcccgcctc tccagtggct ctgtggagag aggctctccc tctgcgccag ggggcttgga
     2581 tggaagatgt ctggggggtc tgcacagcgc agctcatgct gactctgact tcagactgga
     2641 ctgtggcttg agtgaggaga cacacacgag ccgccgcttc tgaagagccg ctggttcctg
     2701 agcccctggg gaggtggctc gcactgggtc ccagtttgat gcgtagtgga ataagtcccg
     2761 caccagcagc tcttgtaaat ttgtgaaaat gaattttatc tttccttaaa aaaataattt
     2821 ttttaattca tcacactttc ttcctttacc ctttagtttt tgataaatga caaaaatgag
     2881 ccagttatca gagatgagat agctcttact tcaaaaggag ataaatataa aaaaaaatat
     2941 gttgctggtt cctaacagga aacgaatttt aaatgattgc aagagggaaa ctgctgacat
     3001 agacatcgcg ggtcagacat gtgggtagac gtcaggctgc agaggtggct ggcggattgt
     3061 aactttatca ccgtgaacag atttcaaatc gcattcatgt tctgtgtgca catgaacagt
     3121 gggcagaggg acggacactt gccggtgtct gctgtggagt ctgccacacc tctgatgcca
     3181 tgtccctgtt atacacagtg tagtgcttcc tcggagtata aagttgtcac ccgtcaataa
     3241 agatcacaaa gttggtttaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
