LOCUS       NM_001015015            3563 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 1 (Usp1), mRNA.
ACCESSION   NM_001015015 XM_233217
VERSION     NM_001015015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3563)
  AUTHORS   Huang,J., Zhou,H., He,L., Zhong,L., Zhou,D. and Yin,Z.
  TITLE     The promotive role of USP1 inhibition in coordinating osteogenic
            differentiation and fracture healing during nonunion
  JOURNAL   J Orthop Surg Res 18 (1), 152 (2023)
   PUBMED   36859264
  REMARK    GeneRIF: The promotive role of USP1 inhibition in coordinating
            osteogenic differentiation and fracture healing during nonunion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3563)
  AUTHORS   Williams,S.A., Maecker,H.L., French,D.M., Liu,J., Gregg,A.,
            Silverstein,L.B., Cao,T.C., Carano,R.A. and Dixit,V.M.
  TITLE     USP1 deubiquitinates ID proteins to preserve a mesenchymal stem
            cell program in osteosarcoma
  JOURNAL   Cell 146 (6), 918-930 (2011)
   PUBMED   21925315
REFERENCE   3  (bases 1 to 3563)
  AUTHORS   Terai,K., Abbas,T., Jazaeri,A.A. and Dutta,A.
  TITLE     CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote
            translesion DNA synthesis
  JOURNAL   Mol Cell 37 (1), 143-149 (2010)
   PUBMED   20129063
REFERENCE   4  (bases 1 to 3563)
  AUTHORS   Cohn,M.A., Kowal,P., Yang,K., Haas,W., Huang,T.T., Gygi,S.P. and
            D'Andrea,A.D.
  TITLE     A UAF1-containing multisubunit protein complex regulates the
            Fanconi anemia pathway
  JOURNAL   Mol Cell 28 (5), 786-797 (2007)
   PUBMED   18082604
REFERENCE   5  (bases 1 to 3563)
  AUTHORS   Huang,T.T., Nijman,S.M., Mirchandani,K.D., Galardy,P.J., Cohn,M.A.,
            Haas,W., Gygi,S.P., Ploegh,H.L., Bernards,R. and D'Andrea,A.D.
  TITLE     Regulation of monoubiquitinated PCNA by DUB autocleavage
  JOURNAL   Nat Cell Biol 8 (4), 339-347 (2006)
   PUBMED   16531995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092574.1.
            
            On Apr 20, 2005 this sequence version replaced XM_233217.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3563
                     /gene="Usp1"
                     /note="ubiquitin specific peptidase 1"
                     /db_xref="GeneID:313387"
                     /db_xref="RGD:1306461"
     exon            1..381
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..620
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..2805
                     /gene="Usp1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin thioesterase 1; deubiquitinating enzyme
                     1; ubiquitin-specific-processing protease 1; ubiquitin
                     thiolesterase 1; ubiquitin specific protease 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 1"
                     /protein_id="NP_001015015.1"
                     /db_xref="GeneID:313387"
                     /db_xref="RGD:1306461"
                     /translation="MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQE
                     DEEKASEYRGSEIDQVVPAAQSSPVSCEKRENLLPFVGLNNLGNTCYLNSILQVLYFC
                     PGFKAGVKHLFNIISRKKEALKDDSIQKDKGSCKEDPLASYELICSLQSLIISVEQLQ
                     ASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLL
                     KKEEIKNLTEFSSKVEEKSLQKEETGGISSTETDSTRNLDDLKEQLPKGNWKRKSDGE
                     SGNMKKKVKLSRESQPLEENQRQTRSKRKATGDTLEASPKIIPKCVSENESAKPSQKK
                     SKVKINWLKPATKQPSILSKFCSLGKITTNQRSKGQPKVNEGDLEEDLEKDGRDNTVN
                     GSGPASPGSSVTPVDSSEAKSINKGAEQIGFELVEKLFQGQLVLRTRCLECESLTERR
                     EDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCEN
                     CHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEE
                     WSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKP
                     EPLNEEEARGTAENYDDEVSIRVGGNAQPSKVLNKKNVEGIGLLGGQKSKADYELCSK
                     ASNPEKVVGTPFTDSRNSETNDTNGTQESDRSKESSDQTGINVSGLENKISYVVQSLK
                     EYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL"
     exon            621..741
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..846
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1007
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1699
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1870
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2072
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..3540
                     /gene="Usp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcactttc cgtggacgcc acctccagcc gcgacgctgg cgcgggcggg ggttcactcg
       61 cgggggtcct gagactgagg aaaacgcgcc aagttcccct cggcagctga gcggggaccc
      121 tgcggctccg gagcgccgcc accgctgtgc gcccgtagcc ttcccggccg ggctgcgccg
      181 gggatgtagt ggggccgcag cgggcaggac cgagcggcgg cccggctccc gctctgcgga
      241 cgaatggtca ctcccccgcg ggaggcgccc accagcgatc cctctcccgg gacggcggcg
      301 gagctcacct gtcgcgcccg cactctgccc ggctggtctc cccggcggcg gcgccgcgga
      361 ctcgctcagg gccatgaccg gatttaattg gtgattacag cttccttcaa taagttaatt
      421 ctcgtcaact ccttgcaatt ttgaaagaaa atgcctggcg tcatacctag tgaaagtaat
      481 gggctttcaa gaggcagtcc atccaagaag aacaggctgt ctttgaagtt ttttcagaaa
      541 aaggaaacta aaagagcctt agacttcact gattctcaag aagatgaaga aaaagcttct
      601 gaatatagag gatctgagat tgatcaagtt gttcctgctg cacagtcctc accagtaagc
      661 tgtgagaaga gagaaaactt gttaccgttt gtgggactga ataaccttgg caacacttgt
      721 tatctgaata gtattcttca ggtgttgtac ttttgtcctg gcttcaaggc tggagtgaag
      781 cacttattta atattatttc aaggaagaaa gaagctctga aggatgactc tattcagaag
      841 gataagggaa gctgcaaaga agatcctttg gcaagttatg agcttatatg cagtttacag
      901 tccttaataa tctcagttga acagcttcaa gctagttttc tcttaaatcc agaaaaatat
      961 acagatgaac ttgcgacaca gccaaggcga ctgcttaaca ccctgaggga actcaaccct
     1021 atgtatgaag gctatctcca gcacgatgca caggaagtgc tacagtgtat tctgggaaac
     1081 attcaagaaa catgccaact cctaaaaaaa gaagaaataa aaaacttgac tgaattttcc
     1141 agcaaggttg aagaaaaatc tcttcagaaa gaggagacag gtgggattag cagcacagag
     1201 actgacagta cgaggaatct ggacgacctc aaagaacaac tcccaaaagg gaactggaaa
     1261 agaaagagtg acggagaatc ggggaacatg aagaaaaagg ttaaactgtc cagggaatcc
     1321 cagccattgg aagaaaacca gagacaaacc agatcgaaaa gaaaagctac cggagacaca
     1381 ctagaggctt ctcctaaaat catccccaag tgtgtttctg aaaatgagag tgcaaagccc
     1441 tcacagaaga aatccaaagt taaaataaat tggttaaagc cggccactaa gcagcccagc
     1501 attctttcca agttctgtag tcttgggaaa ataacaacca accagcgctc caaagggcaa
     1561 cctaaagtaa acgagggtga ccttgaggag gatttggaga aggatggacg cgacaacaca
     1621 gttaatggta gtggacccgc atctccagga agtagcgtca cacctgtgga cagtagtgaa
     1681 gctaagtcca taaacaaagg tgcagagcag attggttttg aactagtaga gaaattgttt
     1741 caaggtcagc tagtactgag gactcgttgt ttggaatgtg aaagcttaac agaaagaaga
     1801 gaagactttc aggatattag tgtcccggta caagaagatg aactttctaa agtcgaggag
     1861 agctctgaga tttctccaga gccaaaaaca gaaatgaaga ccctgagatg ggcaatttca
     1921 cagtttgctt cagtggagag aattgtagga gaggataaat atttctgtga aaattgccat
     1981 cattatacgg aagcagagcg aagtctcttg tttgataaaa tgcctgaagt tatcactatt
     2041 catctgaagt gctttgctgc tagtggcttg gagtttgatt gttatggtgg tggactttcc
     2101 aagatcaaca ctcctttatt gacacctctt aaactgtcac tagaagaatg gagcacaaag
     2161 ccgactaatg acagctatgg attatttgct gttgtgatgc acagtggcat tactattagt
     2221 agtgggcact atactgcatc tgttaaagtc actgacctta acagtctaga actagataag
     2281 ggcaattttg tggttgacca gatgtgtgag ataggtaagc cagagccact gaatgaggag
     2341 gaagcaaggg ggacggctga aaattatgac gacgaagtat caattagagt tggtggtaat
     2401 gcccagccaa gtaaagtttt gaacaaaaaa aatgtagaag gtattggact tcttggagga
     2461 cagaagagca aagcagatta tgagctgtgc agcaaagcat ctaatcctga gaaagttgtc
     2521 gggacaccat tcactgacag tagaaattct gaaactaatg atactaacgg gacccaggaa
     2581 tctgacagga gcaaggagtc cagtgaccaa acaggcatta acgtgagtgg actggagaac
     2641 aaaatttcct atgtagtgca aagcttaaag gagtacgagg ggaagtggtt gctctttgat
     2701 gactctgaag taaaagttac agaagagaaa gactttctga attctctttc cccttctaca
     2761 tctcctacat ctactcccta cttgctattt tataaaaaac tatagtgagt gtattttcct
     2821 tgtaaatatt aaacagccct ggacagacgt tggtaaagtt gataacatct aagagtcttt
     2881 agttatcttt tgaagctatt ggatattatt ggtctctcta ggcttttata taaatagtga
     2941 gattttaaat actgaaaacc atgttaattt ttagaatcat attccttagt agagactagt
     3001 gatggataag ctgggaacaa acttgtgtag atactaaatg atccaaaatg gaagcttgaa
     3061 acagttcaca cttttggatt tacatgatct tttgtttgct ttttaaaata aagtgcttgt
     3121 atttgtattc tccatatttt ggagtaatta tctatctact tgatgtttat aggtctggct
     3181 tttcacccaa gaaacaatct cattcagtac atacatttag ctttataatc gtcatgaaac
     3241 caaatctttg ggctgtatca gaggcacaac gtctagaata tgtatagtca caatggtgta
     3301 tattttgtgc cttgaataac tttggaaagt gtctcagaaa acctggccat cccctctacc
     3361 ttcataagaa ttttatatgt atttatgagg atgactactc tagtcagtct ttttggcatg
     3421 actaattggt atctcttcat actcattctg catgatctgt acatagtaca tcaacttaga
     3481 ggtgtgacct ttaacttttt ttaaaaaact gtgaggtcaa taaaaattta aactgtttaa
     3541 aaaaaaaaaa aaaaaaaaaa aaa
//
