LOCUS       NM_001105850            1393 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus USH1 protein network component sans (Ush1g),
            mRNA.
ACCESSION   NM_001105850 XM_001081676 XM_221106
VERSION     NM_001105850.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Kazmierczak,P. and Muller,U.
  TITLE     Sensing sound: molecules that orchestrate mechanotransduction by
            hair cells
  JOURNAL   Trends Neurosci 35 (4), 220-229 (2012)
   PUBMED   22177415
  REMARK    Review article
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Wright,A.F., Chakarova,C.F., Abd El-Aziz,M.M. and Bhattacharya,S.S.
  TITLE     Photoreceptor degeneration: genetic and mechanistic dissection of a
            complex trait
  JOURNAL   Nat Rev Genet 11 (4), 273-284 (2010)
   PUBMED   20212494
  REMARK    Review article
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Yan,J., Pan,L., Chen,X., Wu,L. and Zhang,M.
  TITLE     The structure of the harmonin/sans complex reveals an unexpected
            interaction mode of the two Usher syndrome proteins
  JOURNAL   Proc Natl Acad Sci U S A 107 (9), 4040-4045 (2010)
   PUBMED   20142502
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Lefevre,G., Michel,V., Weil,D., Lepelletier,L., Bizard,E.,
            Wolfrum,U., Hardelin,J.P. and Petit,C.
  TITLE     A core cochlear phenotype in USH1 mouse mutants implicates fibrous
            links of the hair bundle in its cohesion, orientation and
            differential growth
  JOURNAL   Development 135 (8), 1427-1437 (2008)
   PUBMED   18339676
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Kikkawa,Y., Shitara,H., Wakana,S., Kohara,Y., Takada,T.,
            Okamoto,M., Taya,C., Kamiya,K., Yoshikawa,Y., Tokano,H.,
            Kitamura,K., Shimizu,K., Wakabayashi,Y., Shiroishi,T., Kominami,R.
            and Yonekawa,H.
  TITLE     Mutations in a new scaffold protein Sans cause deafness in Jackson
            shaker mice
  JOURNAL   Hum Mol Genet 12 (5), 453-461 (2003)
   PUBMED   12588793
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Ahmed,Z.M., Riazuddin,S., Bernstein,S.L., Ahmed,Z., Khan,S.,
            Griffith,A.J., Morell,R.J., Friedman,T.B., Riazuddin,S. and
            Wilcox,E.R.
  TITLE     Mutations of the protocadherin gene PCDH15 cause Usher syndrome
            type 1F
  JOURNAL   Am J Hum Genet 69 (1), 25-34 (2001)
   PUBMED   11398101
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Kitamura,K., Kakoi,H., Yoshikawa,Y. and Ochikubo,F.
  TITLE     Ultrastructural findings in the inner ear of Jackson shaker mice
  JOURNAL   Acta Otolaryngol 112 (4), 622-627 (1992)
   PUBMED   1442008
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Kitamura,K., Yagi,M., Yoshikawa,Y., Ochidubo,F. and Kato,M.
  TITLE     Vestibular pathology in a new-mutant mouse
  JOURNAL   Acta Otolaryngol Suppl 481, 121-124 (1991)
   PUBMED   1927362
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Kitamura,K., Yoshikawa,Y. and Ochikubo,F.
  TITLE     An ultrastructural study on vestibular sensory cells in a
            new-mutant mouse
  JOURNAL   Acta Otolaryngol 111 (6), 1013-1020 (1991)
   PUBMED   1763621
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_221106.3, XM_001081676.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132284,
                              SAMD00132287 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1393
                     /gene="Ush1g"
                     /note="USH1 protein network component sans"
                     /db_xref="GeneID:287819"
                     /db_xref="RGD:1304551"
     exon            1..167
                     /gene="Ush1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1389
                     /gene="Ush1g"
                     /note="Usher syndrome 1G (autosomal recessive); Usher
                     syndrome 1G homolog"
                     /codon_start=1
                     /product="pre-mRNA splicing regulator USH1G"
                     /protein_id="NP_001099320.1"
                     /db_xref="GeneID:287819"
                     /db_xref="RGD:1304551"
                     /translation="MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGN
                     LESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPL
                     DMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKMQRKHHER
                     MERRYRRELAERSDTLSFSSLTSSTLSRRLQHMTLGSQLPYSQATLHGTAKGKAKIQK
                     KLERRKQGVEGTFKVSEDGRKSVRSLSGLQLGNDVMFVRQGTYANPKEWGRAPLRDMF
                     LSDEDSVSRATLAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYVSSGLHGLGREDG
                     GLDGAGTPRGRLHSSPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDEDLEPETSPL
                     ETFLASLHMEDFASLLRHEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQAL
                     ERPLALEDTEL"
     exon            168..1393
                     /gene="Ush1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatgaatg accaatatca ccgggccgcc agggatggct atctggagct cctcaaggag
       61 gccacccgga aggagctgaa tgcccccgac gaggatggca tgaccccaac cctctgggct
      121 gcctaccatg gcaacctgga gtcgctgcgc ctcattgtga gccgcggagg tgacccggat
      181 aagtgtgaca tctggggaaa cacacccttg catttggcag cttccaatgg ccacctgcac
      241 tgcctgtcct tcctcgtgtc gttcggagcc aatatctggt gcctggacaa tgactaccac
      301 acgccgctgg acatggccgc tatgaagggc cacatggagt gtgtgcgcta tctggattcc
      361 atcgcagcca agcagagcag cctcaacccc aagttagtgg gcaagctgaa ggacaaggcg
      421 ttccgcgagg cggagcggcg catccgtgaa tgcgccaaga tgcagcgcaa gcaccacgag
      481 cgcatggagc ggcgctaccg gcgcgagctg gccgagcgct ccgacacgct cagcttctcc
      541 agcctcactt ctagtactct gagccgccgg ctgcagcaca tgacgttggg cagccagctg
      601 ccctactctc aggccacgct gcacggcacg gccaagggca aggccaagat ccagaagaag
      661 ctggaaaggc gcaagcaggg ggtcgagggc accttcaagg tctccgagga tgggcgcaaa
      721 agcgtgcgat cgctctcggg cctgcagctg ggcaacgatg tgatgtttgt gcgccagggc
      781 acctacgcca accccaagga gtggggccgt gccccactca gggacatgtt cctctcggac
      841 gaggacagcg tctcccgtgc cacgctggct gccgagcccg cccactcgga ggtcagcacc
      901 gattcaggcc acgactcctt gtttacccgc ccgggcctgg gtaccatggt gtttcgaagg
      961 aactatgtga gcagcgggtt gcacgggctg ggccgagagg atgggggctt ggatggggca
     1021 ggcacgccgc ggggtcggct ccatagttcc cccagcctgg acgacgacag cctgggcagt
     1081 gccaacagct tgcaggaccg cagttgcggg gaagagttgc cctgggatga actagacttg
     1141 ggcttggacg aggacctgga gcccgagacc agccccttgg agaccttcct ggcctcgctg
     1201 cacatggagg actttgcctc cctcctgcgg cacgagaaga ttgacctgga ggccctgatg
     1261 ctgtgctctg acctcgacct acgcagcatc agcgtgcccc tggggcctcg gaagaagatc
     1321 ctgggggccg tgaggaggcg caggcaggct ctggagagac ccctggccct ggaggacacg
     1381 gagctgtgag ttg
//
