LOCUS       NM_212521               2172 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus USH1 protein network component harmonin (Ush1c),
            mRNA.
ACCESSION   NM_212521 XM_238806
VERSION     NM_212521.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2172)
  AUTHORS   Crawley,S.W., Weck,M.L., Grega-Larson,N.E., Shifrin,D.A. Jr. and
            Tyska,M.J.
  TITLE     ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation
  JOURNAL   Dev Cell 36 (2), 190-200 (2016)
   PUBMED   26812018
REFERENCE   2  (bases 1 to 2172)
  AUTHORS   Lelli,A., Michel,V., Boutet de Monvel,J., Cortese,M.,
            Bosch-Grau,M., Aghaie,A., Perfettini,I., Dupont,T., Avan,P.,
            El-Amraoui,A. and Petit,C.
  TITLE     Class III myosins shape the auditory hair bundles by limiting
            microvilli and stereocilia growth
  JOURNAL   J Cell Biol 212 (2), 231-244 (2016)
   PUBMED   26754646
REFERENCE   3  (bases 1 to 2172)
  AUTHORS   Crawley,S.W., Shifrin,D.A. Jr., Grega-Larson,N.E., McConnell,R.E.,
            Benesh,A.E., Mao,S., Zheng,Y., Zheng,Q.Y., Nam,K.T., Millis,B.A.,
            Kachar,B. and Tyska,M.J.
  TITLE     Intestinal brush border assembly driven by protocadherin-based
            intermicrovillar adhesion
  JOURNAL   Cell 157 (2), 433-446 (2014)
   PUBMED   24725409
REFERENCE   4  (bases 1 to 2172)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   5  (bases 1 to 2172)
  AUTHORS   Lentz,J.J., Jodelka,F.M., Hinrich,A.J., McCaffrey,K.E.,
            Farris,H.E., Spalitta,M.J., Bazan,N.G., Duelli,D.M., Rigo,F. and
            Hastings,M.L.
  TITLE     Rescue of hearing and vestibular function by antisense
            oligonucleotides in a mouse model of human deafness
  JOURNAL   Nat Med 19 (3), 345-350 (2013)
   PUBMED   23380860
REFERENCE   6  (bases 1 to 2172)
  AUTHORS   Ouyang,X.M., Xia,X.J., Verpy,E., Du,L.L., Pandya,A., Petit,C.,
            Balkany,T., Nance,W.E. and Liu,X.Z.
  TITLE     Mutations in the alternatively spliced exons of USH1C cause
            non-syndromic recessive deafness
  JOURNAL   Hum Genet 111 (1), 26-30 (2002)
   PUBMED   12136232
REFERENCE   7  (bases 1 to 2172)
  AUTHORS   Ahmed,Z.M., Riazuddin,S., Bernstein,S.L., Ahmed,Z., Khan,S.,
            Griffith,A.J., Morell,R.J., Friedman,T.B., Riazuddin,S. and
            Wilcox,E.R.
  TITLE     Mutations of the protocadherin gene PCDH15 cause Usher syndrome
            type 1F
  JOURNAL   Am J Hum Genet 69 (1), 25-34 (2001)
   PUBMED   11398101
REFERENCE   8  (bases 1 to 2172)
  AUTHORS   Zwaenepoel,I., Verpy,E., Blanchard,S., Meins,M.,
            Apfelstedt-Sylla,E., Gal,A. and Petit,C.
  TITLE     Identification of three novel mutations in the USH1C gene and
            detection of thirty-one polymorphisms used for haplotype analysis
  JOURNAL   Hum Mutat 17 (1), 34-41 (2001)
   PUBMED   11139240
REFERENCE   9  (bases 1 to 2172)
  AUTHORS   Verpy,E., Leibovici,M., Zwaenepoel,I., Liu,X.Z., Gal,A., Salem,N.,
            Mansour,A., Blanchard,S., Kobayashi,I., Keats,B.J., Slim,R. and
            Petit,C.
  TITLE     A defect in harmonin, a PDZ domain-containing protein expressed in
            the inner ear sensory hair cells, underlies Usher syndrome type 1C
  JOURNAL   Nat Genet 26 (1), 51-55 (2000)
   PUBMED   10973247
REFERENCE   10 (bases 1 to 2172)
  AUTHORS   Scanlan,M.J., Williamson,B., Jungbluth,A., Stockert,E., Arden,K.C.,
            Viars,C.S., Gure,A.O., Gordan,J.D., Chen,Y.T. and Old,L.J.
  TITLE     Isoforms of the human PDZ-73 protein exhibit differential tissue
            expression
  JOURNAL   Biochim Biophys Acta 1445 (1), 39-52 (1999)
   PUBMED   10209257
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098641.1.
            
            On Jul 13, 2005 this sequence version replaced NM_212521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098641.1, AY588414.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2172
                     /gene="Ush1c"
                     /note="USH1 protein network component harmonin"
                     /db_xref="GeneID:308596"
                     /db_xref="RGD:1303329"
     exon            1..154
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1765
                     /gene="Ush1c"
                     /note="harmonin a1; Usher syndrome 1C homolog"
                     /codon_start=1
                     /product="harmonin"
                     /protein_id="NP_997686.2"
                     /db_xref="GeneID:308596"
                     /db_xref="RGD:1303329"
                     /translation="MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVG
                     DLKLVINEPNRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSV
                     RGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTV
                     SIKVRHIGLIPVKSSPEEPLKWQYVDQFVSESGGVRGGLSSPGNRTTKEKKVFISLVG
                     SRGLGCSISSGPIQKPGIFVSNVKPGSLSAEVGLETGDQIVEVNGIDFTNLDHKEAVN
                     VLKSSRSLTISIVAGAGRELFMTDRERLEEARQHELQRQELLMQKRLAMESNKILQEQ
                     QEMERQRRKEIAQKAAEENERYRKEMEQISEEEEKFKKQWEEDWGSKEQLILPKTITA
                     EVHPVPLRKPKYDQGVEPADHLDGSTKKQRQQDFRKYEEGFDPYSMFSPEQIAGKDVR
                     LLRIKKEGSLDLALEGGVDSPVGKVVVSAVYEGGAAERHGGVVKGDEIMAINGKIVTD
                     YTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF"
     exon            155..222
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            223..366
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            367..505
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            506..614
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            615..639
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            640..697
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            698..792
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            793..877
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            878..937
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            938..994
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1137
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1203
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1328
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1390
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1432
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1486
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1586
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1696
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1752
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..2142
                     /gene="Ush1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctaactct gaaggaggca agtcctgtct tggtggctga cctgccgccg cctgagcacc
       61 gcagccaggc accctaagaa gcagaccgag ctgcaaagca actggatcag gctcagtcat
      121 ggaccggaag gtggcccgag aattccgaca caaggtggat tttctcattg aaaatgacgc
      181 ggagaaggac tatctttatg acgtgctgcg gatgtatcac cagaccatgg acgtggctgt
      241 gctcgtggga gacctgaagc tggtcatcaa tgagcccaac cgcctgccac tcttcgacgc
      301 catccggccc ctgatcccac tgaagcacca ggtggagtat gaccagctga caccccgacg
      361 ctccaggaaa ctgaaggagg tgcgtttgga ccgtctgcac ccagagggcc ttggcctcag
      421 cgtgcgtgga ggcctggaat ttggctgtgg gctcttcatc tcccatctca tcaaaggtgg
      481 ccaggcagac agcgttgggc tgcaggtagg ggacgagatt gtccggatca acggctattc
      541 catctcctcc tgcacccacg aggaagtcat caacctgatc cgcaccaaga agactgtgtc
      601 catcaaagtg agacacatcg gcctgatccc tgtgaagagc tcccccgagg agcccctcaa
      661 gtggcagtat gtggatcagt tcgtgtcgga atctggaggt gttcgaggtg gcttgagctc
      721 acctggcaat cgaacaacca aggagaagaa ggtgtttatc agtctagtag gttctcgggg
      781 cctgggctgc agcatttcca gtggccccat ccagaagcct ggcatcttcg tcagcaacgt
      841 gaaacctggt tccctgtctg cagaggtggg gttagagaca ggagaccaga ttgtggaagt
      901 caatggcatc gacttcacca acctggacca caaggaggcc gtgaatgtcc tgaagagcag
      961 ccgcagcctg accatctcca ttgttgctgg agctggccgg gagctgttta tgacagaccg
     1021 ggaacggctg gaagaggcac ggcagcatga gctgcagcgg caagagctcc tcatgcagaa
     1081 gcggctggcc atggagtcca acaagatcct ccaggagcag caggagatgg agcgtcagag
     1141 gagaaaggaa atcgcccaga aggccgctga ggagaatgag agataccgga aggagatgga
     1201 acagatctcg gaggaggaag agaagtttaa gaagcagtgg gaagaagact ggggttcaaa
     1261 ggaacagctc attctgccta aaaccatcac cgcagaggtg cacccggtgc cgcttcgcaa
     1321 gcccaagtat gatcagggag tggagcctgc tgaccacttg gatggaagca cgaagaagca
     1381 gagacagcag gatttccgaa aatatgaaga aggctttgat ccttactcca tgttctcgcc
     1441 agaacaaatt gcagggaagg atgtccggct gctgagaatc aagaaggagg ggtctttaga
     1501 cttggccttg gaggggggag tggactcccc cgtggggaag gtggtcgtct ctgctgttta
     1561 tgaaggagga gctgcagagc ggcatggtgg cgttgtgaaa ggggatgaga tcatggccat
     1621 caacggcaag atcgtgacgg actacaccct ggctgaggct gaggctgccc tgcagaaggc
     1681 ctggaatcag ggcggggact ggatagacct tgtggttgcc gtctgtcccc ccaaggaata
     1741 cgatgatgaa ctaaccttct tttaaagtcc agagacagaa gccagccaga cccatcctgg
     1801 aagctggcaa gctcggcacc cagcccctga agtcagcctg agagacacca gtcaccaggt
     1861 gtagaaaatc tccctggaaa ctgtcccccg aagccctgtg acctggcccc tcctctgaaa
     1921 gccagcaaaa ggtggagcaa ggaccaactg ctgttctgga gtggtctgtg ggattccact
     1981 cccatttctt ccagctctaa gttggccgta cctgctctag aatattcctt tcttgagacc
     2041 taagggcgcc caggtcctgc acctccctat tgcactccct cctactgtaa tccctgctgg
     2101 aaacctgatg gtgaactcac taataaatac actgactccg tcaaaaaaaa aaaaaaaaaa
     2161 aaaaaaaaaa aa
//
