LOCUS       NM_031777               1685 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus upstream transcription factor 1 (Usf1),
            transcript variant 4, mRNA.
ACCESSION   NM_031777
VERSION     NM_031777.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Li,Y., Schulz,V.P., Deng,C., Li,G., Shen,Y., Tusi,B.K., Ma,G.,
            Stees,J., Qiu,Y., Steiner,L.A., Zhou,L., Zhao,K., Bungert,J.,
            Gallagher,P.G. and Huang,S.
  TITLE     Setd1a and NURF mediate chromatin dynamics and gene regulation
            during erythroid lineage commitment and differentiation
  JOURNAL   Nucleic Acids Res 44 (15), 7173-7188 (2016)
   PUBMED   27141965
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Wood,M.A., Mukherjee,P., Toocheck,C.A. and Walker,W.H.
  TITLE     Upstream stimulatory factor induces Nr5a1 and Shbg gene expression
            during the onset of rat Sertoli cell differentiation
  JOURNAL   Biol Reprod 85 (5), 965-976 (2011)
   PUBMED   21734262
  REMARK    GeneRIF: Upstream stimulatory factors (USF1 and USF2) induce Nr5a1
            and Shbg gene expression during the onset of rat Sertoli cell
            differentiation.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Chanda,D., Li,T., Song,K.H., Kim,Y.H., Sim,J., Lee,C.H.,
            Chiang,J.Y. and Choi,H.S.
  TITLE     Hepatocyte growth factor family negatively regulates hepatic
            gluconeogenesis via induction of orphan nuclear receptor small
            heterodimer partner in primary hepatocytes
  JOURNAL   J Biol Chem 284 (42), 28510-28521 (2009)
   PUBMED   19720831
  REMARK    GeneRIF: a novel signaling pathway inhibits hepatic gluconeogenesis
            through HGF/AMPK/USF-1/SHP
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Wong,R.H., Chang,I., Hudak,C.S., Hyun,S., Kwan,H.Y. and Sul,H.S.
  TITLE     A role of DNA-PK for the metabolic gene regulation in response to
            insulin
  JOURNAL   Cell 136 (6), 1056-1072 (2009)
   PUBMED   19303849
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Kim,K.S., Jung,H.S., Chung,Y.J., Jung,T.S., Jang,H.W., Lee,M.S.,
            Kim,K.W. and Chung,J.H.
  TITLE     Overexpression of USF increases TGF-beta1 protein levels, but G1
            phase arrest was not induced in FRTL-5 cells
  JOURNAL   J Korean Med Sci 23 (5), 870-876 (2008)
   PUBMED   18955796
  REMARK    GeneRIF: USF has a role in increasing TGF-beta1 protein levels, but
            not in indusing G1 phase arrest
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Bidder,M., Shao,J.S., Charlton-Kachigian,N., Loewy,A.P.,
            Semenkovich,C.F. and Towler,D.A.
  TITLE     Osteopontin transcription in aortic vascular smooth muscle cells is
            controlled by glucose-regulated upstream stimulatory factor and
            activator protein-1 activities
  JOURNAL   J Biol Chem 277 (46), 44485-44496 (2002)
   PUBMED   12200434
  REMARK    GeneRIF: USF regulates osteopontin gene transcription aortic
            vascular smooth muscle cells, entrained to changes in cellular
            glucose metabolism
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Casado,M., Vallet,V.S., Kahn,A. and Vaulont,S.
  TITLE     Essential role in vivo of upstream stimulatory factors for a normal
            dietary response of the fatty acid synthase gene in the liver
  JOURNAL   J Biol Chem 274 (4), 2009-2013 (1999)
   PUBMED   9890958
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Viollet,B., Lefrancois-Martinez,A.M., Henrion,A., Kahn,A.,
            Raymondjean,M. and Martinez,A.
  TITLE     Immunochemical characterization and transacting properties of
            upstream stimulatory factor isoforms
  JOURNAL   J Biol Chem 271 (3), 1405-1415 (1996)
   PUBMED   8576131
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Lefrancois-Martinez,A.M., Martinez,A., Antoine,B., Raymondjean,M.
            and Kahn,A.
  TITLE     Upstream stimulatory factor proteins are major components of the
            glucose response complex of the L-type pyruvate kinase gene
            promoter
  JOURNAL   J Biol Chem 270 (6), 2640-2643 (1995)
   PUBMED   7852331
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Gregor,P.D., Sawadogo,M. and Roeder,R.G.
  TITLE     The adenovirus major late transcription factor USF is a member of
            the helix-loop-helix group of regulatory proteins and binds to DNA
            as a dimer
  JOURNAL   Genes Dev 4 (10), 1730-1740 (1990)
   PUBMED   2249772
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031777.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088849.1, SRR22582416.1162798.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000013.1  86377762-86377807
            47-139              JAXUCZ010000013.1  86381208-86381300
            140-189             JAXUCZ010000013.1  86382027-86382076
            190-305             JAXUCZ010000013.1  86382226-86382341
            306-407             JAXUCZ010000013.1  86382648-86382749
            408-603             JAXUCZ010000013.1  86383412-86383607
            604-691             JAXUCZ010000013.1  86383800-86383887
            692-750             JAXUCZ010000013.1  86384025-86384083
            751-845             JAXUCZ010000013.1  86384188-86384282
            846-974             JAXUCZ010000013.1  86384507-86384635
            975-1685            JAXUCZ010000013.1  86384813-86385523
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1685
                     /gene="Usf1"
                     /note="upstream transcription factor 1"
                     /db_xref="GeneID:83586"
                     /db_xref="RGD:620974"
     exon            1..46
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            47..139
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1064
                     /gene="Usf1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     upstream stimulatory factor 1"
                     /codon_start=1
                     /product="upstream stimulatory factor 1 isoform 4"
                     /protein_id="NP_113965.1"
                     /db_xref="GeneID:83586"
                     /db_xref="RGD:620974"
                     /translation="MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPD
                     PNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGSGAISGYPATQSMTQAVIQGAFTSD
                     DAVDAEGTAAETHYTYFPSTAVGDGSGGTTSGSTTAVVTTQGSEALLGQATPPSTGQF
                     FVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNW
                     IVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDND
                     VLRQQVEDLKNKNLLLRAQLRHHGLEVVIKNDSN"
     exon            140..189
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..305
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..407
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..603
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..691
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..750
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..845
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..974
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1685
                     /gene="Usf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaacgct gccgggggaa attggcgact gaagcggcct gggccggatt tagcattcag
       61 accttggcgt caggagatac gaggtcctcc aaaaaaagac cagtgcctcg gatgagcccc
      121 ctcacagaga gatgaagggg cagcagaaaa cagccgaaac cgaagagggg acagtgcaga
      181 ttcaggaagg tgcagtggct actggagagg acccaactag tgtagctatc gccagcatcc
      241 aatcagctgc cactttcccc gaccccaacg tcaagtacgt cttccgaact gagaatgggg
      301 gccaggtgat gtacagggtg atccaggtgt ctgaggggca gctggatggc cagacagagg
      361 gctctggcgc tatcagtggc taccctgcca ctcagtctat gactcaggca gtaatccagg
      421 gggctttcac cagtgatgat gctgttgacg cggagggaac agctgccgag acccactaca
      481 cttacttccc cagcaccgca gtgggagatg ggtcaggggg tacgacatct gggagtacaa
      541 ccgccgtggt caccacccag ggctcagagg cactgctggg gcaggcaacc ccgcccagca
      601 caggccaatt ctttgtgatg atgtcaccac aagaagtgtt acagggaggg agccagcggt
      661 caattgcccc caggacccac ccttattccc cgaagtcaga ggctcccagg acaacgcgag
      721 atgagaaacg gagggctcaa cataacgaag tggagcgccg ccgccgggac aagatcaaca
      781 actggattgt acagctgtcc aaaatcatcc cagactgctc tatggagagc accaagtctg
      841 gccagagtaa gggtggaatc ctgtccaaag cctgtgacta tatccaggaa ctacgtcaga
      901 gcaaccaccg gctgtctgaa gagctgcagg ggttagatca gttgcagctc gacaatgacg
      961 tgcttcgaca gcaggtggaa gatcttaaaa acaagaacct gctactacga gctcagttac
     1021 ggcaccacgg attagaggtc gtcatcaaga atgacagcaa ctaactgtgg ggactcaggg
     1081 gctttgggcc cgagaactgc acatagccca ggagcaacag gctgacccca tgcccctctc
     1141 tttcactgcc tacttctggc gtgggactcg ggggagttgg gcaagtgtga ttttgaactg
     1201 aggcctgtgg catggcagtc tgcagtgagt gctgggaaac cgtgtggaca cgcaccgcca
     1261 gccttgcctg cccccaccgc gcagtccccg ggccctggtg ctcctttggc acactgcatg
     1321 tgctgtctcc ttggtggaca ctggacacac gaaatctggg ctcgccgcgt gcttgcttag
     1381 agtgcctggc agagggtctg tgggccgagt acttcactgg ttcttccttt ctctgaagca
     1441 gaagttaaga tacatacctg attactctgg ggagcaggct tactcaagag gtggggaagg
     1501 atgctagcgg gctgctctcc caggagtaga gggggcagtg agcagccgaa gcctctgcag
     1561 aaggccctgg agtcagggag agctataggc agggcgggtt cacagagagc ccgccctgtt
     1621 ccaggggtgg ttctttttat ttctttactt tttttttttt taagataaaa ttgtttagag
     1681 ccaca
//
