LOCUS       NM_001012068            1602 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus uroporphyrinogen III synthase (Uros), mRNA.
ACCESSION   NM_001012068 XM_219416
VERSION     NM_001012068.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Weiss Y, Balwani M, Chen B, Yasuda M, Nazarenko I and Desnick RJ.
  TITLE     Congenital erythropoietic porphyria and erythropoietic
            protoporphyria: Identification of 7 uroporphyrinogen III synthase
            and 20 ferrochelatase novel mutations
  JOURNAL   Mol Genet Metab 128 (3), 358-362 (2019)
   PUBMED   30454868
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Barupala DP, Dzul SP, Riggs-Gelasco PJ and Stemmler TL.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Cunha L, Kuti M, Bishop DF, Mezei M, Zeng L, Zhou MM and Desnick
            RJ.
  TITLE     Human uroporphyrinogen III synthase: NMR-based mapping of the
            active site
  JOURNAL   Proteins 71 (2), 855-873 (2008)
   PUBMED   18004775
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Li N, Ma DL, Liu X, Wu L, Chu X, Wong KY and Li D.
  TITLE     Characterization of his-tagged rat uroporphyrinogen III synthase
            wild-type and variant enzymes
  JOURNAL   Protein J 26 (8), 569-576 (2007)
   PUBMED   17763925
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Ajioka RS, Phillips JD and Kushner JP.
  TITLE     Biosynthesis of heme in mammals
  JOURNAL   Biochim Biophys Acta 1763 (7), 723-736 (2006)
   PUBMED   16839620
  REMARK    Review article
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Deybach JC, de Verneuil H, Boulechfar S, Grandchamp B and Nordmann
            Y.
  TITLE     Point mutations in the uroporphyrinogen III synthase gene in
            congenital erythropoietic porphyria (Gunther's disease)
  JOURNAL   Blood 75 (9), 1763-1765 (1990)
   PUBMED   2331520
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Tsai SF, Bishop DF and Desnick RJ.
  TITLE     Human uroporphyrinogen III synthase: molecular cloning, nucleotide
            sequence, and expression of a full-length cDNA
  JOURNAL   Proc Natl Acad Sci U S A 85 (19), 7049-7053 (1988)
   PUBMED   3174619
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Tsai,S.F., Bishop,D.F. and Desnick,R.J.
  TITLE     Purification and properties of uroporphyrinogen III synthase from
            human erythrocytes
  JOURNAL   J Biol Chem 262 (3), 1268-1273 (1987)
   PUBMED   3805019
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Oskarsson A and Fowler BA.
  TITLE     Alterations in renal heme biosynthesis during metal nephrotoxicity
  JOURNAL   Ann N Y Acad Sci 514, 268-277 (1987)
   PUBMED   3327431
  REMARK    Review article
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   Maines,M.D. and Kappas,A.
  TITLE     Enzymes of heme metabolism in the kidney: regulation by trace
            metals which do not form heme complexes
  JOURNAL   J Exp Med 146 (5), 1286-1293 (1977)
   PUBMED   925603
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083730.1.
            
            On Feb 11, 2005 this sequence version replaced XM_219416.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083730.1, SRR8487227.216425.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1602
                     /gene="Uros"
                     /note="uroporphyrinogen III synthase"
                     /db_xref="GeneID:309070"
                     /db_xref="RGD:1310396"
     exon            1..129
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            130..219
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..954
                     /gene="Uros"
                     /EC_number="4.2.1.75"
                     /note="urogen III synthase; uroporphyrinogen III
                     co-synthase"
                     /codon_start=1
                     /product="uroporphyrinogen-III synthase"
                     /protein_id="NP_001012068.1"
                     /db_xref="GeneID:309070"
                     /db_xref="RGD:1310396"
                     /translation="MKVLLLKDAKDDDSGQDPYIQELRLCGLEATLIPVLSFEFMSLP
                     SLSEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSA
                     TASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLRDKGI
                     PMESMHVYQTIPHPGIQGSLESYYENQGIPASITFFSPSGLKYSLEYIQALSGGSFDQ
                     IKFVAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRKALKPNSCC"
     exon            220..303
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            304..400
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            401..475
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            476..550
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            551..631
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            632..717
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            718..816
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1577
                     /gene="Uros"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaggagcac cggaacgctg gctgctggac gagaggccac tctcggttat cggtacttag
       61 cagccccggt ctggaccgtg agactcctgc cccgcggcgt gcaggttgtc ctgcctctta
      121 gcccgcgagg accttttata agagctgcca ggcacaatga aggttctctt actcaaagat
      181 gccaaggatg atgacagcgg ccaggatcca tatatccagg agctgcggtt gtgtggcctg
      241 gaagctacgc tgattcctgt tctgtcgttt gaatttatgt ctctgcccag tttgtcagaa
      301 aagctgtctc atcctgaagg ctttggagga ctcattttca ccagccccag ggcagtggaa
      361 gcagtgaagc tgtgtttgga gaaggacaat aaaactgaag cctgggagaa gtctctgaaa
      421 gacagatgga atgccaagtc tgtgtacgtg gttggaagtg ccaccgcttc tctagtgaat
      481 aaaattggcc tggatgcaga aggagctggc agtggaaatg cagaaaagct cgctgaatat
      541 atttgctcaa agccatcttc agagctgcct cttctctttc cctgtggaac tatcaaagga
      601 gacactcttc cgaaaatgct cagagacaaa gggattccca tggaaagcat gcacgtctat
      661 cagacaattc cacaccctgg aatccaaggg agcctggaga gctactatga aaatcagggc
      721 atcccagcca gcatcacatt cttcagcccc tccggcctta aatacagcct cgagtatatt
      781 caggcgttat ctggtggcag cttcgaccag atcaagtttg tagccatcgg ccccagtaca
      841 actcgtgcta tggctgccaa gggccttccg gtgagctgca ctgccgaaag ccccacacca
      901 caagccctgg ctgcaggcat caggaaagcg ctgaagccaa acagctgctg ctgaggtctg
      961 tgcagagcca gctccttccc tgtgcatggg acagctcact gctgcccgaa gatgaaccca
     1021 aattcagaaa ggagctctgg agaagctgtg tgtgagcatg tcgccgtcca ccatccactg
     1081 agtccagctt ggaacctagg ccaggttcac tggccattag acccagggag agagaacttc
     1141 ctgtgcctag aaagaaggaa acgaaatgga ccacgtggtg acttgtggtt gctgcccact
     1201 ctttaacaaa ctgtgtttct ttcatgtgta ccggtgtctt gtctgcatgc acatctgtgt
     1261 gccacctgca tacctggtgc ctggagaagc aaggcaaggg tggcagatcc cctagaactg
     1321 tgagttgggg acagctgtga gcagccatct gggtactggg aattgaaccc aggtcctctg
     1381 aaagaataag tcctctcaac cactgagcca tcactccggc ccacggtttt catctgtggt
     1441 tctcagggca aagcggtgtt ctggggcaac agaacgtcat agtctcgctg atgctgacct
     1501 gttaagaatg acaaatcgct atgtgtgaag tagatttagt cgtcatacaa aataaaataa
     1561 aaataagact aggccaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
