LOCUS       NM_019209               1232 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus uroporphyrinogen decarboxylase (Urod), mRNA.
ACCESSION   NM_019209 XM_001067008 XM_342887
VERSION     NM_019209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Sopena,Y.E., Ferramola de Sancovich,A.M. and Sancovich,H.A.
  TITLE     Hexachlorobenzene treatment on hepatic mitochondrial function
            parameters and intracellular coproporphyrinogen oxidase location
  JOURNAL   Int J Toxicol 27 (6), 455-465 (2008)
   PUBMED   19482825
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Cunha,L., Kuti,M., Bishop,D.F., Mezei,M., Zeng,L., Zhou,M.M. and
            Desnick,R.J.
  TITLE     Human uroporphyrinogen III synthase: NMR-based mapping of the
            active site
  JOURNAL   Proteins 71 (2), 855-873 (2008)
   PUBMED   18004775
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Phillips,J.D., Bergonia,H.A., Reilly,C.A., Franklin,M.R. and
            Kushner,J.P.
  TITLE     A porphomethene inhibitor of uroporphyrinogen decarboxylase causes
            porphyria cutanea tarda
  JOURNAL   Proc Natl Acad Sci U S A 104 (12), 5079-5084 (2007)
   PUBMED   17360334
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Ajioka,R.S., Phillips,J.D. and Kushner,J.P.
  TITLE     Biosynthesis of heme in mammals
  JOURNAL   Biochim Biophys Acta 1763 (7), 723-736 (2006)
   PUBMED   16839620
  REMARK    Review article
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Navone,N.M., Polo,C.F., Frisardi,A.L., Andrade,N.E. and Battle,A.M.
  TITLE     Heme biosynthesis in human breast cancer--mimetic 'in vitro'
            studies and some heme enzymic activity levels
  JOURNAL   Int J Biochem 22 (12), 1407-1411 (1990)
   PUBMED   2276414
REFERENCE   7  (bases 1 to 1232)
  AUTHORS   Garey,J.R., Hansen,J.L., Harrison,L.M., Kennedy,J.B. and
            Kushner,J.P.
  TITLE     A point mutation in the coding region of uroporphyrinogen
            decarboxylase associated with familial porphyria cutanea tarda
  JOURNAL   Blood 73 (4), 892-895 (1989)
   PUBMED   2920211
REFERENCE   8  (bases 1 to 1232)
  AUTHORS   Blekkenhorst,G.H., Eales,L. and Pimstone,N.R.
  TITLE     Activation of uroporphyrinogen decarboxylase by ferrous iron in
            porphyria cutanea tarda
  JOURNAL   S Afr Med J 56 (22), 918-920 (1979)
   PUBMED   515872
REFERENCE   9  (bases 1 to 1232)
  AUTHORS   Elder,G.H., Lee,G.B. and Tovey,J.A.
  TITLE     Decreased activity of hepatic uroporphyrinogen decarboxylase in
            sporadic porphyria cutanea tarda
  JOURNAL   N Engl J Med 299 (6), 274-278 (1978)
   PUBMED   661926
REFERENCE   10 (bases 1 to 1232)
  AUTHORS   Louw,M., Neethling,A.C., Percy,V.A., Carstens,M. and Shanley,B.C.
  TITLE     Effects of hexachlorobenzene feeding and iron overload on enzymes
            of haem biosynthesis and cytochrome P 450 in rat liver
  JOURNAL   Clin Sci Mol Med 53 (2), 111-115 (1977)
   PUBMED   891100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY314066.1, EV767503.1, BI282626.1 and BF414694.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_342887.3, XM_001067008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158690.1, FQ234620.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DY314066.1         1-42
            43-658              EV767503.1         1-616
            659-1213            BI282626.1         18-572              c
            1214-1232           BF414694.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1232
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /note="uroporphyrinogen decarboxylase"
                     /db_xref="GeneID:29421"
                     /db_xref="RGD:3946"
     exon            1..57
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1141
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /EC_number="4.1.1.37"
                     /note="UPD; URO-D; uroporphyrinogen III decarboxylase;
                     porphyrinogen carboxylase"
                     /codon_start=1
                     /product="uroporphyrinogen decarboxylase"
                     /protein_id="NP_062082.1"
                     /db_xref="GeneID:29421"
                     /db_xref="RGD:3946"
                     /translation="MEANGLGLQNFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLP
                     EFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVP
                     GKGPSFPEPLREERDLERLRDPAAVASELGYVFQAITLTRQQLAGRVPLIGFAGAPWT
                     LMTYMVEGGSSSTMAQAKRWLYQKPLASHKLLGILTDALVPYLIGQVAAGAQALQLFE
                     SHAGHLGSELFSKFALPYIRDVAKRVKAGLQKAGLAPVPMIIFAKDGHFALEELAQAG
                     YEVVGLDWTVAPKKARERVGKTVTLQGNLDPCALYASEEEIGRLVQQMLNDFGPQRYI
                     ANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN"
     exon            58..170
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            171..250
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            251..313
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            314..511
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            512..673
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            674..811
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            812..912
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            913..979
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1216
                     /gene="Urod"
                     /gene_synonym="porphyrinogen carboxy-lyase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagattaaa gcggtgaccg ctcagttact gtttaccatg gaggcgaacg gcttgggact
       61 ccagaatttc ccggagctga agaatgacac gttcttgaga gcagcctggg gagaggaaac
      121 agactatact cctgtttggt gcatgagaca agcaggccgc tacttaccag agtttaggga
      181 aaccagggct gcccaggact tcttcagcac ctgtcgatct cctgaggctt gctgtgaact
      241 gactctgcag ccactgcgaa ggtttcctct ggatgctgct ataattttct ctgacatcct
      301 tgttgtaccc caggcactgg gcatggaggt gaccatggta cctggcaaag gacccagctt
      361 tccagagcca ttaagagaag agcgggactt agagcgtcta cgggatccag cagcagtggc
      421 ttcagagtta ggctatgtgt tccaagccat cacccttacc cgacaacagc tggctggacg
      481 tgtgccactg attggctttg ctggtgctcc gtggaccctg atgacgtaca tggttgaagg
      541 cggcagttca agtaccatgg ctcaggccaa gcgatggctc tatcagaagc cactggccag
      601 tcacaagctg cttggcatac tcactgatgc tctggtccca tatctaatag gacaagtagc
      661 tgctggtgct caggcattgc agctctttga gtcccacgca ggacatcttg gctccgagct
      721 cttcagcaag tttgcactgc cttacatccg tgatgtggcc aagcgagtga aggctgggtt
      781 gcagaaggcg ggcctggcac cagtgcccat gatcatcttt gccaaggatg gacattttgc
      841 cctggaagag ctggcccagg ctggctatga ggtagttgga cttgactgga cagtggctcc
      901 aaagaaagcc cgggaacgtg ttggaaagac agtgactctg caggggaacc tggatccctg
      961 tgccctgtat gcatctgagg aagagattgg tcgactggtg cagcagatgc tgaatgactt
     1021 tgggccacag cgctacattg ctaacctagg gcatgggctt taccctgaca tggacccaga
     1081 acacgtagga gcctttgtgg atgcagtaca caaacactca cgcctgcttc gacagaattg
     1141 agtatgtgct tttctgctca agtaccaccg acacagattg tttccaggag aataaaactt
     1201 ccagaaactt ccagagaaaa aaaaaaaaaa aa
//
