LOCUS       NM_001008888            1110 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquinol-cytochrome c reductase, Rieske
            iron-sulfur polypeptide 1 (Uqcrfs1), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001008888 XM_214457
VERSION     NM_001008888.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1110)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 1110)
  AUTHORS   Sanchez,E., Lobo,T., Fox,J.L., Zeviani,M., Winge,D.R. and
            Fernandez-Vizarra,E.
  TITLE     LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of
            mitochondrial Complex III assembly in human cells
  JOURNAL   Biochim Biophys Acta 1827 (3), 285-293 (2013)
   PUBMED   23168492
REFERENCE   3  (bases 1 to 1110)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   4  (bases 1 to 1110)
  AUTHORS   Munusamy,S., Saba,H., Mitchell,T., Megyesi,J.K., Brock,R.W. and
            Macmillan-Crow,L.A.
  TITLE     Alteration of renal respiratory Complex-III during experimental
            type-1 diabetes
  JOURNAL   BMC Endocr Disord 9, 2 (2009)
   PUBMED   19166612
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1110)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   6  (bases 1 to 1110)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1110)
  AUTHORS   Sun,G., Kinter,M.T. and Anderson,V.E.
  TITLE     Mass spectrometric characterization of mitochondrial electron
            transport complexes: subunits of the rat heart ubiquinol-cytochrome
            c reductase
  JOURNAL   J Mass Spectrom 38 (5), 531-539 (2003)
   PUBMED   12794875
  REMARK    GeneRIF: Mass spectrometric characterization of
            ubiquinol-cytochrome c reductase; ten of the 11 polypeptides
            present in this complex were detected directly by MALDI-TOFMS
            following electroelution of the active complex
REFERENCE   8  (bases 1 to 1110)
  AUTHORS   Jeyaseelan,R., Poizat,C., Wu,H.Y. and Kedes,L.
  TITLE     Molecular mechanisms of doxorubicin-induced cardiomyopathy.
            Selective suppression of Reiske iron-sulfur protein, ADP/ATP
            translocase, and phosphofructokinase genes is associated with ATP
            depletion in rat cardiomyocytes
  JOURNAL   J Biol Chem 272 (9), 5828-5832 (1997)
   PUBMED   9038198
REFERENCE   9  (bases 1 to 1110)
  AUTHORS   Joste,V., Goitom,Z. and Nelson,B.D.
  TITLE     Thyroid hormone regulation of nuclear-encoded mitochondrial inner
            membrane polypeptides of the liver
  JOURNAL   Eur J Biochem 184 (1), 255-260 (1989)
   PUBMED   2776768
REFERENCE   10 (bases 1 to 1110)
  AUTHORS   Nishikimi,M., Hosokawa,Y., Toda,H., Suzuki,H. and Ozawa,T.
  TITLE     Cloning and sequence analysis of a cDNA encoding the Rieske
            iron-sulfur protein of rat mitochondrial cytochrome bc1 complex
  JOURNAL   Biochem Biophys Res Commun 159 (1), 19-25 (1989)
   PUBMED   2538119
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085339.1.
            
            On Jan 6, 2005 this sequence version replaced XM_214457.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085339.1, FQ213498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1110
                     /gene="Uqcrfs1"
                     /gene_synonym="LRRGT00195"
                     /note="ubiquinol-cytochrome c reductase, Rieske
                     iron-sulfur polypeptide 1"
                     /db_xref="GeneID:291103"
                     /db_xref="RGD:628838"
     exon            1..269
                     /gene="Uqcrfs1"
                     /gene_synonym="LRRGT00195"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..880
                     /gene="Uqcrfs1"
                     /gene_synonym="LRRGT00195"
                     /EC_number="7.1.1.8"
                     /note="RISP; complex III subunit 5; rieske iron-sulfur
                     protein; cytochrome b-c1 complex subunit 5; Rieske protein
                     UQCRFS1; liver regeneration-related protein LRRGT00195;
                     ubiquinol-cytochrome c reductase iron-sulfur subunit"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit Rieske,
                     mitochondrial"
                     /protein_id="NP_001008888.1"
                     /db_xref="GeneID:291103"
                     /db_xref="RGD:628838"
                     /translation="MLSVAARSGPFAPVLSATSRGVAGALRPLLQSAVPATSEPPVLD
                     VKRPFLCRESLSGQAATRPLVATVGLNVPASVRYSHTDIKVPDFSDYRRAEVLDSTKS
                     SKESSEARKGFSYLVTATTTVGVAYAAKNAVSQFVSSMSASADVLAMSKIEIKLSDIP
                     EGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLERVKKPEWVILIGVCT
                     HLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPTYEFTSGDVVVVG"
     exon            270..1088
                     /gene="Uqcrfs1"
                     /gene_synonym="LRRGT00195"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgaacgg aaggtcgtcc ctgtgaccga ctaggtagtt ggagcagctg tcgccatgtt
       61 gtcggtcgct gcccgctcgg gcccgttcgc gcccgtccta tcggccacgt cccgcggggt
      121 ggcgggagcg ctgcggcccc tgctgcaaag cgcggtgccc gccacctcgg aaccaccggt
      181 tctggacgtg aagcgaccct tcctgtgccg tgagtcgctg agtggccagg ccgcgacccg
      241 tcctttggtg gccacagtgg gcctgaatgt tcctgcttct gttcgttatt cccacacaga
      301 catcaaggtg cccgacttct ctgactatcg ccgtgctgaa gttctagata gcacaaaatc
      361 ttctaaagag agcagtgagg ctagaaaagg cttctcttac ttggtaactg caactactac
      421 tgtgggtgtt gcatacgctg cgaaaaatgc agtctcccag tttgtttcca gcatgagtgc
      481 ttctgcggat gtactggcca tgtcgaagat cgagatcaag ttgtctgata ttccagaggg
      541 gaagaacatg gcttttaaat ggagaggcaa acctctgttt gtgcgccata gaaccaagaa
      601 ggagattgac caggaagctg cagttgaagt gtcccagtta agggacccac agcatgattt
      661 agagcgtgta aagaagcctg aatgggttat tctgatcggt gtctgtactc atcttggttg
      721 tgtacccatt gcaaacgcag gagattttgg tggctactat tgcccctgcc atgggtcaca
      781 ctatgatgct tctggcagga tcaggaaggg ccctgcacct ctcaacctgg aagtacctac
      841 ctatgagttc accagtggtg atgtagttgt tgtgggttag acacttggac tcagggccta
      901 ggtttctttc ggtcttcatg tcccctcaga agagttgaga gtaagccttg tgtacttcta
      961 ggttggttga tttaaaatat ttaagaattg ttaataacta ttggcaaaca ttaatgtgaa
     1021 gtaattgaat tcactgttga atattatcaa gcattagcat aataaaacca ctgttgaaca
     1081 tcattaaaaa aaaaaaaaaa aaaaaaaaaa
//
