LOCUS       NM_001006970            1860 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquinol cytochrome c reductase core protein 2
            (Uqcrc2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001006970 XM_215042
VERSION     NM_001006970.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Zhang,X.M., Zhao,Y.Q., Yan,H., Liu,H. and Huang,G.W.
  TITLE     Inhibitory effect of homocysteine on rat neural stem cell growth in
            vitro is associated with reduced protein levels and enzymatic
            activities of aconitase and respiratory complex III
  JOURNAL   J Bioenerg Biomembr 49 (2), 131-138 (2017)
   PUBMED   27914013
  REMARK    GeneRIF: Proteomic analysis revealed that the expression levels of
            two mitochondrial proteins, cytochrome bc1 complex2 (UQCRC2, the
            major component of electron transport chain complex III) and
            aconitase (an enzyme involved in the tricarboxylic acid cycle),
            were decreased by homocysteine in neural stem cells
REFERENCE   4  (bases 1 to 1860)
  AUTHORS   Peralta,S., Torraco,A., Wenz,T., Garcia,S., Diaz,F. and Moraes,C.T.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
REFERENCE   5  (bases 1 to 1860)
  AUTHORS   Sanchez,E., Lobo,T., Fox,J.L., Zeviani,M., Winge,D.R. and
            Fernandez-Vizarra,E.
  TITLE     LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of
            mitochondrial Complex III assembly in human cells
  JOURNAL   Biochim Biophys Acta 1827 (3), 285-293 (2013)
   PUBMED   23168492
REFERENCE   6  (bases 1 to 1860)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   7  (bases 1 to 1860)
  AUTHORS   Diaz,F., Thomas,C.K., Garcia,S., Hernandez,D. and Moraes,C.T.
  TITLE     Mice lacking COX10 in skeletal muscle recapitulate the phenotype of
            progressive mitochondrial myopathies associated with cytochrome c
            oxidase deficiency
  JOURNAL   Hum Mol Genet 14 (18), 2737-2748 (2005)
   PUBMED   16103131
REFERENCE   8  (bases 1 to 1860)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1860)
  AUTHORS   Sun,G., Kinter,M.T. and Anderson,V.E.
  TITLE     Mass spectrometric characterization of mitochondrial electron
            transport complexes: subunits of the rat heart ubiquinol-cytochrome
            c reductase
  JOURNAL   J Mass Spectrom 38 (5), 531-539 (2003)
   PUBMED   12794875
REFERENCE   10 (bases 1 to 1860)
  AUTHORS   Hosokawa,Y., Suzuki,H., Toda,H., Nishikimi,M. and Ozawa,T.
  TITLE     The primary structure of the precursor to core protein II, a
            putative member of mitochondrial processing protease family, of rat
            mitochondrial cytochrome bc1 complex deduced from cDNA sequence
            analysis
  JOURNAL   Biochem Int 20 (4), 731-737 (1990)
   PUBMED   2162168
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083610.1.
            
            On Nov 22, 2004 this sequence version replaced XM_215042.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083610.1, SRR8487231.43820.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1860
                     /gene="Uqcrc2"
                     /note="ubiquinol cytochrome c reductase core protein 2"
                     /db_xref="GeneID:293448"
                     /db_xref="RGD:1359150"
     exon            1..70
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1396
                     /gene="Uqcrc2"
                     /EC_number="7.1.1.8"
                     /note="cytochrome b-c1 complex subunit 2, mitochondrial;
                     ubiquinol-cytochrome C reductase complex core protein 2,
                     mitochondrial precursor (Complex III subunit II); core
                     protein II; complex III subunit 2; ubiquinol-cytochrome-c
                     reductase complex core protein 2; ubiquinol-cytochrome c
                     reductase core protein II"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 2, mitochondrial
                     precursor"
                     /protein_id="NP_001006971.1"
                     /db_xref="GeneID:293448"
                     /db_xref="RGD:1359150"
                     /translation="MKLLSRAGSFSRFYSLKVAPKLKTSAPGGVPLQPQELEFTKLPN
                     GLVIASLENYAPLSRIGLFIKAGSRYENYNYLGTSHLLRLASTLTTKGASSFKITRGI
                     EAVGGKLSVTATRENMAYTVEGIRDDIEILMEFLLNVTTAPEFRRWEVAALRSQLKID
                     KAVAFQNPQTRIIENLHDVAYKNALANPLYCPDYRMGKITSEELHYFVQNHFTSARMA
                     LVGLGVSHSILKEVAEQFLNIRGGLGLAGAKAKYRGGEIREQNGDNLVHAAIVAESAA
                     IGNAEANAFSVLQHLLGAGPHIKRGNNTTSLLSQSVAKGSQQPFDVSAFNASYSDSGL
                     FGIYTVSQAAAAGDVINAAYNQVKAVAQGNLSSADVQAAKNKLKAGYLMSVETSEGFL
                     SEIGSQALATGSYMPPPTVLQQIDAVADADVVKAAKKFVSGKKSMTASGNLGHTPFLD
                     EL"
     exon            71..151
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..301
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            302..366
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..423
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..548
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..646
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..704
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..800
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1000
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1081
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1158
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1312
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1831
                     /gene="Uqcrc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctttga ccgtaggaaa gggcaactgc tagagccatg aagctcctca gcagggccgg
       61 gtccttctcg agattttatt ccctcaaagt tgccccaaag cttaaaactt cagcccctgg
      121 aggagtgcct ctgcagcctc aggaacttga gtttaccaaa ttaccaaatg gtttggtgat
      181 tgcttctctg gaaaactatg ctccactatc aagaattggc ttattcatta aagcaggcag
      241 tagatatgag aactacaact acttgggaac ctctcattta ctacgtcttg catctacttt
      301 gactaccaaa ggagcttcat ctttcaagat cacccgtgga attgaagcag ttggtggtaa
      361 attaagtgtg actgcaacaa gggaaaacat ggcatacact gtagaaggca ttcgggatga
      421 tattgaaatc ctgatggagt tcctgctcaa tgtcacaaca gcaccagaat ttcgccgctg
      481 ggaagttgct gcccttcggt ctcagctaaa gattgacaaa gctgttgcct ttcagaaccc
      541 acagactcgt atcattgaga acctacatga tgttgcctac aagaatgcct tggctaatcc
      601 cttgtactgt cctgactata ggatggggaa gataacatca gaggaattac attactttgt
      661 tcagaatcac ttcacaagtg caagaatggc tttggttgga cttggtgtga gtcattctat
      721 cctaaaggaa gttgctgaac aatttctcaa cattaggggt ggccttggtt tagctggtgc
      781 aaaagccaaa taccgcggag gtgaaattag agagcagaat ggagacaatc tggtccatgc
      841 tgctattgta gcagaaagtg ctgccattgg aaatgcagaa gcaaatgcat ttagtgtact
      901 tcagcatctt cttggtgctg gaccacatat caaaaggggc aacaacacca ccagcctcct
      961 gagccagagt gttgccaaag gaagtcaaca gccttttgat gtttctgcat ttaatgccag
     1021 ttactcagat tctgggctct ttggaattta cactgtctcc caggctgctg cggctggaga
     1081 tgttatcaat gctgcctaca accaagtaaa agcagttgct caaggaaacc tttccagtgc
     1141 agatgtccag gctgccaaga acaagctgaa agctggatat ctaatgtctg tggagacttc
     1201 agagggcttc ctgagtgaga tcgggtcaca ggctctagct acaggctctt acatgccacc
     1261 gcctactgtc cttcagcaaa ttgacgctgt ggctgatgcc gatgttgtaa aggctgcgaa
     1321 aaagtttgtt tctggcaaga agtcaatgac agcaagtgga aacttgggac atacgccttt
     1381 tcttgacgag ttataacaga tgcatgtatc caagtctcag cccagaccag caaacacatc
     1441 agagtcaggt ttcctaatta ttaatgttaa ttcaacattt ttctcaatga agaaaaaaac
     1501 ttaaaagtat agtcctccta gctgccatag agccaataaa acattgtatg taaatgtttt
     1561 tcttgtactc ttcctaggca gtcaacaggt atttattaaa tgctttaaag aaaacagtaa
     1621 tagagtaatt aagttcacta attacatcaa ttaagaaatt tcagaatctg ttaaaattga
     1681 ggctaagcag ctttaaaagt aaaaaattcc agattattac tgatggcttt ttaaaataaa
     1741 aacaacttta aaacttgctc agtttgggat aataacaatt gaacagtctg gattttgccc
     1801 cgtttacagt aaaagtacat ttctaaggaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
