LOCUS       NM_001004250            1595 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus ubiquinol-cytochrome c reductase core protein 1
            (Uqcrc1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001004250 XM_217267
VERSION     NM_001004250.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1595)
  AUTHORS   Yi,T., Wu,X. and Li,H.
  TITLE     Ubiquinol-cytochrome c reductase core protein 1 overexpression
            protects H9c2 cardiac cells against mimic ischemia/reperfusion
            injury through PI3K/Akt/GSK-3beta pathway
  JOURNAL   Biochem Biophys Res Commun 529 (4), 904-909 (2020)
   PUBMED   32819597
  REMARK    GeneRIF: Ubiquinol-cytochrome c reductase core protein 1
            overexpression protects H9c2 cardiac cells against mimic
            ischemia/reperfusion injury through PI3K/Akt/GSK-3beta pathway.
REFERENCE   2  (bases 1 to 1595)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   3  (bases 1 to 1595)
  AUTHORS   Long,Z., Duan,G., Li,H., Yi,T., Wu,X., Chen,F., Wu,Z. and Gao,Y.
  TITLE     Ubiquinol-cytochrome c reductase core protein 1 may be involved in
            delayed cardioprotection from preconditioning induced by diazoxide
  JOURNAL   PLoS One 12 (7), e0181903 (2017)
   PUBMED   28750029
  REMARK    GeneRIF: These results showed that UQCRC1 might contribute to the
            loss-of-cardioprotection model induced by long-term diazoxide
            treatment and play a role in delayed cardioprotection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1595)
  AUTHORS   Yi,T., Wu,X., Long,Z., Duan,G., Wu,Z., Li,H., Chen,H. and Zhou,X.
  TITLE     Overexpression of Ubiquinol-Cytochrome c Reductase Core Protein 1
            May Protect H9c2 Cardiac Cells by Binding with Zinc
  JOURNAL   Biomed Res Int 2017, 1314297 (2017)
   PUBMED   28676853
  REMARK    GeneRIF: the overexpression of UQCRC1 can protect H9c2 cardiac
            cells against simulated ischemia/reperfusion, and this
            cardio-protective effect is likely mediated by zinc binding.
REFERENCE   5  (bases 1 to 1595)
  AUTHORS   Ma,S.L., Tang,N.L. and Lam,L.C.
  TITLE     Association of gene expression and methylation of UQCRC1 to the
            predisposition of Alzheimer's disease in a Chinese population
  JOURNAL   J Psychiatr Res 76, 143-147 (2016)
   PUBMED   26943237
REFERENCE   6  (bases 1 to 1595)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1595)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1595)
  AUTHORS   Sun,G., Kinter,M.T. and Anderson,V.E.
  TITLE     Mass spectrometric characterization of mitochondrial electron
            transport complexes: subunits of the rat heart ubiquinol-cytochrome
            c reductase
  JOURNAL   J Mass Spectrom 38 (5), 531-539 (2003)
   PUBMED   12794875
REFERENCE   9  (bases 1 to 1595)
  AUTHORS   Kim,S.H., Vlkolinsky,R., Cairns,N. and Lubec,G.
  TITLE     Decreased levels of complex III core protein 1 and complex V beta
            chain in brains from patients with Alzheimer's disease and Down
            syndrome
  JOURNAL   Cell Mol Life Sci 57 (12), 1810-1816 (2000)
   PUBMED   11130185
REFERENCE   10 (bases 1 to 1595)
  AUTHORS   Hoffman,G.G., Lee,S., Christiano,A.M., Chung-Honet,L.C., Cheng,W.,
            Katchman,S., Uitto,J. and Greenspan,D.S.
  TITLE     Complete coding sequence, intron/exon organization, and chromosomal
            location of the gene for the core I protein of human
            ubiquinol-cytochrome c reductase
  JOURNAL   J Biol Chem 268 (28), 21113-21119 (1993)
   PUBMED   8407948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078923.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001004250.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078923.1, FQ213124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1595              BC078923.1         3-1597
FEATURES             Location/Qualifiers
     source          1..1595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1595
                     /gene="Uqcrc1"
                     /note="ubiquinol-cytochrome c reductase core protein 1"
                     /db_xref="GeneID:301011"
                     /db_xref="RGD:1303314"
     exon            1..71
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1445
                     /gene="Uqcrc1"
                     /EC_number="7.1.1.8"
                     /note="cytochrome b-c1 complex subunit 1, mitochondrial;
                     core protein I; complex III subunit 1;
                     ubiquinol-cytochrome-c reductase complex core protein 1;
                     ubiquinol-cytochrome c reductase core protein I"
                     /codon_start=1
                     /product="cytochrome b-c1 complex subunit 1, mitochondrial
                     precursor"
                     /protein_id="NP_001004250.1"
                     /db_xref="GeneID:301011"
                     /db_xref="RGD:1303314"
                     /translation="MAASAVCRAACSGTQALLRTCRSPALLRLPALRGTATFVQALQS
                     VPETQVSVLDNGLRVASEQSSHPTCTVGVWIDVGSRYETEKNNGAGYFLEHLAFKGTK
                     NRPGNALEKEVESIGAHLNAYSTREHTAYLIKALSKDLPKVVELLADIVQNISLEDSQ
                     IEKERDVILREMQENDASMQNVVFDYLHATAFQGTPLAQAVEGPSENVRRLSRTDLTD
                     YLSRHYKAPRMVLAAAGGVKHQQLLDLAQDHFSSVSQVYEEDAVPSITPCRFTGSEIR
                     HRDDALPLAHVAIAVEGPGWANPDNVALQVANAIIGHYDCTYGGGVHLSSPLASVAVA
                     NKLCQSFQTFNISYSETGLLGAHFVCDAMSIDDMIFFLQGQWMRLCTSATESEVTRGK
                     NILRNALISHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIEEVDAQMVREVCSKYFY
                     DQCPAVAGYGPIEQLSDYNRIRSGMFWLRF"
     exon            72..212
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..299
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..429
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..628
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..708
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..824
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..968
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1129
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1215
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1304
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1380
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1567
                     /gene="Uqcrc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatggcggc gtccgcagtc tgccgagcgg cctgctctgg gacgcaagcg ctacttcgca
       61 cctgccgctc gccggccctg ctgaggctac ctgccttgcg gggtaccgca accttcgtcc
      121 aggccctcca gagcgtgccg gagacacagg tcagcgtatt ggacaacggg ctgcgtgtgg
      181 cctcggagca gtcctcgcat cctacctgca cggtgggagt gtggattgac gttggcagtc
      241 gctatgagac tgagaagaac aatggagcag gctacttttt ggaacatctg gctttcaagg
      301 gaacaaagaa ccgtcctggc aatgccttag agaaggaggt agagagtatt ggcgcccatc
      361 ttaatgccta cagcactcgg gagcacactg cttacctcat caaggcactg tccaaggacc
      421 tgccaaaagt tgtggagctc ctggcagata ttgtgcagaa cattagtctg gaagactcgc
      481 agatcgagaa ggagcgagat gtgatcctgc gggagatgca ggaaaacgat gcctctatgc
      541 agaatgtagt cttcgattac ctgcatgcaa cagcattcca gggcacacct ctagcccagg
      601 ctgtggaggg gcccagtgag aacgtcagga ggctgtcgcg cacagacttg actgactacc
      661 tcagcaggca ctacaaagct ccccgaatgg tgctggctgc cgctggaggg gtgaagcacc
      721 agcagctgct agaccttgcc caggatcact tcagcagtgt ctcccaggtg tatgaagaag
      781 acgctgtacc tagtataact ccatgtcgct tcactggcag tgagatccga catcgggatg
      841 atgccctgcc cttggcccat gtggccattg cagtagaggg acctggctgg gctaacccag
      901 acaacgtggc tctccaagtg gccaatgcca tcataggcca ctatgactgc acttacggtg
      961 gtggagtgca cctgtccagc ccgctggctt ccgttgctgt agctaacaag ctttgccaga
     1021 gtttccagac cttcaacatc tcctactctg agaccgggtt gctgggcgca cactttgtct
     1081 gtgatgccat gagcatcgat gacatgatct tcttcctgca aggccagtgg atgcgcctgt
     1141 gcaccagcgc tacagagagt gaggtgactc ggggcaaaaa catccttagg aatgccttga
     1201 tatctcattt ggatggcacc acccctgtgt gtgaagacat tggtcgcagc ctcctgactt
     1261 atggccgccg catccctctg gctgagtggg agagccggat tgaggaggtg gatgcccaga
     1321 tggttcgaga ggtttgctcc aagtactttt atgaccaatg tccagcagtg gctggatatg
     1381 gccccatcga acagctctca gactacaacc ggattcgcag tggcatgttc tggctgcgct
     1441 tctaggcagg aagtctgcgc aggcaggcag cagggcgggg ccggggactc ggggtccctg
     1501 ccacagacgc cactcctgct gctcagctgt gtgcagccag ttaccaccaa taaagtccta
     1561 ttgagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
