LOCUS       NM_001106481            2516 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus uridine phosphorylase 2 (Upp2), mRNA.
ACCESSION   NM_001106481 XM_001068315 XM_229938
VERSION     NM_001106481.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2516)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2516)
  AUTHORS   Chen S, Fragoza R, Klei L, Liu Y, Wang J, Roeder K, Devlin B and Yu
            H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 2516)
  AUTHORS   Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T,
            Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg
            BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Wanamaker
            SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan
            G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K,
            Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE,
            Iakoucheva LM, Xia Y and Vidal M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2516)
  AUTHORS   Roosild TP, Castronovo S, Villoso A, Ziemba A and Pizzorno G.
  TITLE     A novel structural mechanism for redox regulation of uridine
            phosphorylase 2 activity
  JOURNAL   J Struct Biol 176 (2), 229-237 (2011)
   PUBMED   21855639
REFERENCE   5  (bases 1 to 2516)
  AUTHORS   Zhang Y, Repa JJ, Inoue Y, Hayhurst GP, Gonzalez FJ and Mangelsdorf
            DJ.
  TITLE     Identification of a liver-specific uridine phosphorylase that is
            regulated by multiple lipid-sensing nuclear receptors
  JOURNAL   Mol Endocrinol 18 (4), 851-862 (2004)
   PUBMED   14715930
REFERENCE   6  (bases 1 to 2516)
  AUTHORS   Johansson M.
  TITLE     Identification of a novel human uridine phosphorylase
  JOURNAL   Biochem Biophys Res Commun 307 (1), 41-46 (2003)
   PUBMED   12849978
REFERENCE   7  (bases 1 to 2516)
  AUTHORS   Russell RL, Cao D, Zhang D, Handschumacher RE and Pizzorno G.
  TITLE     Uridine phosphorylase association with vimentin. Intracellular
            distribution and localization
  JOURNAL   J Biol Chem 276 (16), 13302-13307 (2001)
   PUBMED   11278417
REFERENCE   8  (bases 1 to 2516)
  AUTHORS   Watanabe S and Uchida T.
  TITLE     Cloning and expression of human uridine phosphorylase
  JOURNAL   Biochem Biophys Res Commun 216 (1), 265-272 (1995)
   PUBMED   7488099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000115.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_001106481.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001106481.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JACYVU010000115.1  36729869-36730349
            482-593             JACYVU010000115.1  36738416-36738527
            594-752             JACYVU010000115.1  36746406-36746564
            753-867             JACYVU010000115.1  36749995-36750109
            868-1077            JACYVU010000115.1  36754027-36754236
            1078-1218           JACYVU010000115.1  36756246-36756386
            1219-2516           JACYVU010000115.1  36772941-36774238
FEATURES             Location/Qualifiers
     source          1..2516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..2516
                     /gene="Upp2"
                     /note="uridine phosphorylase 2"
                     /db_xref="GeneID:295620"
                     /db_xref="RGD:1308188"
     exon            1..481
                     /gene="Upp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..1370
                     /gene="Upp2"
                     /EC_number="2.4.2.3"
                     /codon_start=1
                     /product="uridine phosphorylase 2"
                     /protein_id="NP_001099951.1"
                     /db_xref="GeneID:295620"
                     /db_xref="RGD:1308188"
                     /translation="MASILPASNRTMRPDKNPYERERSVYVRNPHLDAMDEGILYHLD
                     LGTKTHNLPAMFGDFVCVGGSSNRMKAFALFMHKELGLEGDGDDIEDICAGTDRYCMF
                     KTGPVLSLSHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGSVVITD
                     TAVDSFFKPRFEQVILDNVVTRSTELDKELATDLFNCSREIPNFLTLIGHTMCTYDFY
                     EGRLDGALCCFSREKKLDYLKRAYKAGVRNIEMESTVFAAMCGLCGLRAAVVCVTLLD
                     RLESDQINLSHDVLVEYQQRPQLLISNFIKKQLGLCDQMS"
     exon            482..593
                     /gene="Upp2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..752
                     /gene="Upp2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..867
                     /gene="Upp2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1077
                     /gene="Upp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1218
                     /gene="Upp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..2516
                     /gene="Upp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactgaaagt ggaattgcat ccgtgtacag ttgtctcaaa gcaaataagt ctgggtgtca
       61 caccagcctg atgctgggac caaggtcacg tgccacggac gggtgctggg atcaaagtta
      121 acaagctaac aaacctgctc aaagagaaag gataccacac cttccaaggg agcctaactc
      181 cctgggggat gattctctga gagcagggct gagtataaaa ggctatccag ggatggtgtt
      241 ttgactttgt cagaggggtt caaaatactc acggaagatt ttagagaaaa tttcaggagg
      301 aaacctcagt ttgaagggga ggtggtattc tgacttgagg ctgcatcact gtgattagct
      361 ctgtaattta acagcaggct ttcacactgc tttttcctgc tatctgccca gtgcagagta
      421 tggcttccat tttgcctgct tctaatagaa ccatgagacc tgacaagaat ccgtatgaga
      481 gagaacggtc tgtgtatgtt aggaatccac acttggatgc catggacgaa ggcattctct
      541 accacttgga tttagggacc aaaacacaca acctaccagc catgtttggg gattttgtct
      601 gcgttggtgg gagctcgaac agaatgaaag cgtttgcact gtttatgcac aaggaactcg
      661 ggttggaggg agatggagac gacatcgagg acatctgtgc ggggacagac agatactgca
      721 tgttcaaaac aggccctgtg ctctccctca gtcacgggat gggcatcccc tccatttcca
      781 ttatgctcca cgaactcatc aaattactcc accatgcacg ctgctgcgat gttaccatca
      841 tcagaattgg aacatcgggg ggaattggga ttgctccggg gtctgttgta ataacagata
      901 cagctgtaga ctccttcttc aagcctcggt ttgaacaggt catcttggat aacgtggtca
      961 cccgaagcac cgagcttgac aaagaactgg ctactgattt gttcaactgt agcagagaga
     1021 tccccaactt tctaaccctc atcggacaca cgatgtgtac ctatgacttt tacgaaggcc
     1081 gcttagatgg agcgctatgt tgtttctcga gagagaaaaa gctggactat ttgaagagag
     1141 cgtacaaagc tggagtcagg aacattgaaa tggaatcgac ggtgttcgcc gccatgtgtg
     1201 gactatgtgg cttgagagct gctgtggtct gtgtgacact tctcgacaga ctcgagagtg
     1261 accaaatcaa tctgtcccat gatgtcctgg tggagtacca gcaacggcca caactcctaa
     1321 tctcaaattt catcaaaaaa cagcttggac tttgtgacca gatgtcatag ctccgaatcc
     1381 cgcccctctc ctgagagttg gtacatggat ctgcaacgat gatgccatgt gttgtttata
     1441 atatttttat gtaattctca tccttgggct aaaaaaaatc ataaaagatt ttatgaaatc
     1501 ttttatcttg aagttcaatt tattgcaaga gaatttaata cccatgtgaa attaagttca
     1561 aattccattt tagaacgagt taactaaagc agtctaataa ttaatatttt aaactcatga
     1621 aatgtgacat ttggagtttc acatgtagca ttaattaagc ttatatcaaa atagatcagc
     1681 catttgtaga tgcttaccag ttgcttgctg aagcagatcc agcagtgtat gctaggatgt
     1741 tgtcagcact tctaggtgtt ggacaagtga caaaatttga tcatgcacat tcaaaatatt
     1801 tacaaaaatg tgtcagtgta atataggccg gtatggaaga attctccttg gggaaatatg
     1861 gccatccctt ttctccggtc cccgtacaat ttcagtgcac aaaaatggaa ttagaacctt
     1921 atgagtgtat gtgagaatca cagaacatca cagcttgagg tcacacttct gggtttttcc
     1981 ccccccctct tcaaatgaaa accctcagta acacagacct ccacccaccc acccacctcc
     2041 ccagctggaa atcagaagtg actcagttgc cttctcaaga tctttttatt cctacaagga
     2101 aatatgtcac acacacacac acacacacac acacacacac acacacacac acacacaaac
     2161 ctgtatttgt cgttgtctcg ataagaactg aataagctgc agaattagtt aataaccaaa
     2221 tttaaacttg aaatcaagat agtaactgaa tccatctcag gaactttgag gcgggtctcg
     2281 ttcagagcct gcacttaata agcctcccct ggttgacctt gagaggattc aagcagcaga
     2341 ggctccagga attgaccccg ccttccacgt tcttttgaac atttagaaac tggagtgtct
     2401 ggttggggta agagtggagg aggtcttgca aacttgtata gtatgtaatg ttgcatgtat
     2461 gtatatatgt atgtatatag ttgttgaatg aataaaatat atctttcatc acgctg
//
