LOCUS       NM_001130507            1026 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus uroplakin 3A (Upk3a), mRNA.
ACCESSION   NM_001130507 XM_001078189 XM_235546
VERSION     NM_001130507.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1026)
  AUTHORS   Fogelgren B, Polgar N, Lui VH, Lee AJ, Tamashiro KK, Napoli JA,
            Walton CB, Zuo X and Lipschutz JH.
  TITLE     Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in
            Mice Cause Ureteropelvic Junction Obstructions
  JOURNAL   PLoS One 10 (6), e0129346 (2015)
   PUBMED   26046524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1026)
  AUTHORS   Zhou G, Liang FX, Romih R, Wang Z, Liao Y, Ghiso J, Luque-Garcia
            JL, Neubert TA, Kreibich G, Alonso MA, Schaeren-Wiemers N and Sun
            TT.
  TITLE     MAL facilitates the incorporation of exocytic uroplakin-delivering
            vesicles into the apical membrane of urothelial umbrella cells
  JOURNAL   Mol Biol Cell 23 (7), 1354-1366 (2012)
   PUBMED   22323295
REFERENCE   3  (bases 1 to 1026)
  AUTHORS   Zupancic D, Ovcak Z, Vidmar G and Romih R.
  TITLE     Altered expression of UPIa, UPIb, UPII, and UPIIIa during
            urothelial carcinogenesis induced by
            N-butyl-N-(4-hydroxybutyl)nitrosamine in rats
  JOURNAL   Virchows Arch 458 (5), 603-613 (2011)
   PUBMED   21301865
  REMARK    GeneRIF: During urothelial carcinogenesis, UPII expression was the
            most decreased in all urothelial lesions, while UPIa, UPIb, and
            UPIIIa expression was differently altered in different types of
            lesions
REFERENCE   4  (bases 1 to 1026)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1026)
  AUTHORS   Hu P, Meyers S, Liang FX, Deng FM, Kachar B, Zeidel ML and Sun TT.
  TITLE     Role of membrane proteins in permeability barrier function:
            uroplakin ablation elevates urothelial permeability
  JOURNAL   Am J Physiol Renal Physiol 283 (6), F1200-F1207 (2002)
   PUBMED   12388410
REFERENCE   6  (bases 1 to 1026)
  AUTHORS   Ogawa K, Johansson SL and Cohen SM.
  TITLE     Immunohistochemical analysis of uroplakins, urothelial specific
            proteins, in ovarian Brenner tumors, normal tissues, and benign and
            neoplastic lesions of the female genital tract
  JOURNAL   Am J Pathol 155 (4), 1047-1050 (1999)
   PUBMED   10514386
REFERENCE   7  (bases 1 to 1026)
  AUTHORS   Wu XR, Lin JH, Walz T, Haner M, Yu J, Aebi U and Sun TT.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 27, 2008 this sequence version replaced
            XM_235546.4, XM_001078189.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680452,
                              SAMN16676809 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1026
                     /gene="Upk3a"
                     /note="uroplakin 3A"
                     /db_xref="GeneID:315190"
                     /db_xref="RGD:1310633"
     exon            1..80
                     /gene="Upk3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..892
                     /gene="Upk3a"
                     /note="uroplakin-3a"
                     /codon_start=1
                     /product="uroplakin-3a precursor"
                     /protein_id="NP_001123979.1"
                     /db_xref="GeneID:315190"
                     /db_xref="RGD:1310633"
                     /translation="MLLLWALLALGCLRCGWTVNLQPQLASVTFATNNPTLTTVALEK
                     PLCMFDSSEPLSGAYEVYLYAMVDSAISWNVSVQDSTGAPLSTTFRQTQGGRSGPYKA
                     VAFDLTPCGDLPSLDAVGDVTQASEILNAYLVRVGNNGTCFWDPNFQGLCNPPLTAAT
                     EYRFKYVLVNTSTGLVQDQTLWSDPIRTNRPSPYLAIDTWPGRRSGGMIVITSILGSL
                     PFFLLVGFAGAIILSFVDMGSSDGETTHDSQITQEAVPKTLGASEPSYSSVNRAPPLD
                     RAEVFSSKLQD"
     exon            81..236
                     /gene="Upk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            237..516
                     /gene="Upk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            517..599
                     /gene="Upk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            600..732
                     /gene="Upk3a"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1026
                     /gene="Upk3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgctctgt agaggctcat ctcgggcgat gctcctgctc tgggccctgc tggccctcgg
       61 atgcctgcgg tgtggctgga ctgtgaacct ccagccccaa ttggccagtg tgacctttgc
      121 caccaacaac cctaccctca ccaccgtggc cttggagaag cctctgtgca tgttcgatag
      181 ctcagagccg ctcagtggtg cttatgaggt ttacctctat gccatggtag actcagctat
      241 ctcctggaat gtgtctgtgc aggacagcac tggcgctccg ctgagcacca cgttccggca
      301 aacccagggt gggaggtccg gcccctataa agctgtggcc tttgacctga ccccttgtgg
      361 tgacttgccc agcctggatg ctgttggaga tgtgacccag gcctcagaga tcctgaatgc
      421 atatctagtc agggtgggca acaacgggac ctgtttttgg gaccccaact tccagggcct
      481 ctgcaaccca cccctgacag cagccactga gtacaggttc aagtatgtcc tggtcaacac
      541 gtccacaggc ttggtgcagg accagacact atggtcggat cccatccgga ccaaccggcc
      601 ctctccctac ttggccatcg acacgtggcc gggccgtcgg agcggaggca tgattgtcat
      661 tacatccatt ctgggctcct tgcccttctt cctgcttgtg ggtttcgctg gagccatcat
      721 cctcagcttt gtggacatgg gcagttctga tggagaaaca acacacgact cgcagatcac
      781 ccaggaggct gtccccaaga ccctgggggc ctctgaacct tcctactcat ctgtgaaccg
      841 ggccccaccc ctagacagag cggaggtgtt ctccagcaag ctccaagact gaaatgatcc
      901 ttggccccaa gccatcagcc ctgacctgtg gttggcagca atgcatttat gctctgactg
      961 ggccagatgt gaaataagac atcttggttc aatgtcatga aaacactaaa taaaatctta
     1021 agtgtt
//
