LOCUS       NM_001109523             822 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus uroplakin 2 (Upk2), mRNA.
ACCESSION   NM_001109523 XM_001060120
VERSION     NM_001109523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 822)
  AUTHORS   Zhou G, Liang FX, Romih R, Wang Z, Liao Y, Ghiso J, Luque-Garcia
            JL, Neubert TA, Kreibich G, Alonso MA, Schaeren-Wiemers N and Sun
            TT.
  TITLE     MAL facilitates the incorporation of exocytic uroplakin-delivering
            vesicles into the apical membrane of urothelial umbrella cells
  JOURNAL   Mol Biol Cell 23 (7), 1354-1366 (2012)
   PUBMED   22323295
REFERENCE   2  (bases 1 to 822)
  AUTHORS   Zupancic D, Ovcak Z, Vidmar G and Romih R.
  TITLE     Altered expression of UPIa, UPIb, UPII, and UPIIIa during
            urothelial carcinogenesis induced by
            N-butyl-N-(4-hydroxybutyl)nitrosamine in rats
  JOURNAL   Virchows Arch 458 (5), 603-613 (2011)
   PUBMED   21301865
  REMARK    GeneRIF: During urothelial carcinogenesis, UPII expression was the
            most decreased in all urothelial lesions, while UPIa, UPIb, and
            UPIIIa expression was differently altered in different types of
            lesions
REFERENCE   3  (bases 1 to 822)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 822)
  AUTHORS   Ogawa K, Johansson SL and Cohen SM.
  TITLE     Immunohistochemical analysis of uroplakins, urothelial specific
            proteins, in ovarian Brenner tumors, normal tissues, and benign and
            neoplastic lesions of the female genital tract
  JOURNAL   Am J Pathol 155 (4), 1047-1050 (1999)
   PUBMED   10514386
REFERENCE   5  (bases 1 to 822)
  AUTHORS   Wu XR, Lin JH, Walz T, Haner M, Yu J, Aebi U and Sun TT.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001060120.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840114,
                              SAMN16418971 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..822
                     /gene="Upk2"
                     /note="uroplakin 2"
                     /db_xref="GeneID:689093"
                     /db_xref="RGD:1597393"
     exon            1..136
                     /gene="Upk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..615
                     /gene="Upk2"
                     /codon_start=1
                     /product="uroplakin-2 precursor"
                     /protein_id="NP_001102993.1"
                     /db_xref="GeneID:689093"
                     /db_xref="RGD:1597393"
                     /translation="MASTLPVQTLRLFLILLAVLAPGAADFNISSLSGLLSPALTESL
                     LIALPPCHLTGGNATLMVRRANDSKVVKSGFVVPPCRGRRELVSVVDSGAGFTVTRLS
                     AYQVTNLTPGTKYYISYRVQKGMSTESSPETPMSTLPRRNMESIRLGMARTGGMVVIT
                     VLLSVAMFLLVVGLIIALALGAHK"
     exon            137..268
                     /gene="Upk2"
                     /inference="alignment:Splign:2.1.0"
     exon            269..407
                     /gene="Upk2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..478
                     /gene="Upk2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..822
                     /gene="Upk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggccctg gaagccccag cctgcctgaa gctgttccag gatccagttc ccagcacagt
       61 atggcatcca cactgcctgt ccagaccttg cgcctgtttc tgattttgct ggctgtcctg
      121 gctcccgggg ctgcagactt caacatctca agcctctctg gtctgctgtc cccagcgcta
      181 acagaaagcc tgctaattgc cttgcctccc tgtcacctca ccggaggtaa tgccacattg
      241 atggtccgga gagccaatga cagcaaagtg gttaagtcgg gctttgtggt gcctccgtgc
      301 cgtgggcgca gggagcttgt gagcgtggtg gacagcgggg caggcttcac cgtcacaagg
      361 ctcagcgcat atcaggtgac aaacctcaca ccaggaacca aatactacat atcctaccga
      421 gtacagaagg ggatgtccac tgagtccagt ccagagactc ccatgtccac gcttccccga
      481 agaaacatgg agtctatcag gttaggaatg gcccggacag gaggcatggt ggtcatcacg
      541 gtgctgctgt ctgtggccat gttcctgttg gtcgtgggac ttatcattgc cctggcactg
      601 ggtgcccaca aatgaaggct ctcctgcagc ccaggctctt ccaaacaggc agcagttacc
      661 ggcttctcct ccctctccct gccctcttca ctgagtccat tcctgacagt acccctctct
      721 ctgcttccaa cactccctgc cagcccccca ccccccgaag tcccaccaaa gctgattttt
      781 ctcttaactg tacttaattc tcacaataaa ggctgaccca cg
//
