LOCUS       NM_001024253            1799 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus uroplakin 1B (Upk1b), mRNA.
ACCESSION   NM_001024253
VERSION     NM_001024253.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1799)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 1799)
  AUTHORS   Zhou,G., Liang,F.X., Romih,R., Wang,Z., Liao,Y., Ghiso,J.,
            Luque-Garcia,J.L., Neubert,T.A., Kreibich,G., Alonso,M.A.,
            Schaeren-Wiemers,N. and Sun,T.T.
  TITLE     MAL facilitates the incorporation of exocytic uroplakin-delivering
            vesicles into the apical membrane of urothelial umbrella cells
  JOURNAL   Mol Biol Cell 23 (7), 1354-1366 (2012)
   PUBMED   22323295
REFERENCE   3  (bases 1 to 1799)
  AUTHORS   Zupancic,D., Ovcak,Z., Vidmar,G. and Romih,R.
  TITLE     Altered expression of UPIa, UPIb, UPII, and UPIIIa during
            urothelial carcinogenesis induced by
            N-butyl-N-(4-hydroxybutyl)nitrosamine in rats
  JOURNAL   Virchows Arch 458 (5), 603-613 (2011)
   PUBMED   21301865
  REMARK    GeneRIF: During urothelial carcinogenesis, UPII expression was the
            most decreased in all urothelial lesions, while UPIa, UPIb, and
            UPIIIa expression was differently altered in different types of
            lesions
REFERENCE   4  (bases 1 to 1799)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1799)
  AUTHORS   Ogawa,K., Johansson,S.L. and Cohen,S.M.
  TITLE     Immunohistochemical analysis of uroplakins, urothelial specific
            proteins, in ovarian Brenner tumors, normal tissues, and benign and
            neoplastic lesions of the female genital tract
  JOURNAL   Am J Pathol 155 (4), 1047-1050 (1999)
   PUBMED   10514386
REFERENCE   6  (bases 1 to 1799)
  AUTHORS   Wu,X.R., Lin,J.H., Walz,T., Haner,M., Yu,J., Aebi,U. and Sun,T.T.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001024253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KU310910.1, BC093613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000011.1  75459381-75459441
            62-149              JAXUCZ010000011.1  75473060-75473147
            150-350             JAXUCZ010000011.1  75474119-75474319
            351-425             JAXUCZ010000011.1  75476636-75476710
            426-548             JAXUCZ010000011.1  75477280-75477402
            549-728             JAXUCZ010000011.1  75481881-75482060
            729-812             JAXUCZ010000011.1  75492909-75492992
            813-1799            JAXUCZ010000011.1  75495593-75496579
FEATURES             Location/Qualifiers
     source          1..1799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1799
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /note="uroplakin 1B"
                     /db_xref="GeneID:303924"
                     /db_xref="RGD:1307806"
     exon            1..61
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
     exon            62..149
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..863
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /note="uroplakin Ib"
                     /codon_start=1
                     /product="uroplakin-1b"
                     /protein_id="NP_001019424.1"
                     /db_xref="GeneID:303924"
                     /db_xref="RGD:1307806"
                     /translation="MAKDDSTVRCFQGLLIFGHVIVGMCGIALTAECIFFVSDQHSLY
                     PLLEATNNDDIFGAAWIGMFVGICLFCLSVLAIVGIMKSNRKILLAYFIMMFIVYGFE
                     VASCITAATQRDFFTTNLFLKQMLMRYQNNSPPTNDDKWKNSYVTKTWDRLMLQDHCC
                     GVNGPSDWQKYTSAFRVENSDADYPWPRQCCVMDKLQEPLNLDACKLGVPGYYHSQGC
                     YELISGPMDRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY"
     exon            150..350
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
     exon            351..425
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
     exon            426..548
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
     exon            549..728
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
     exon            729..812
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1799
                     /gene="Upk1b"
                     /gene_synonym="UP1b; UPIb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgtggag tgagtctgtg cagcgtcagg aagagacggc agaagagacc aggcagccag
       61 tccagtggga aatcctgaaa atggccaaag acgattccac cgttcgttgc ttccagggcc
      121 tgttgatttt tggacacgtg attgttggta tgtgtgggat cgccctgaca gcagagtgta
      181 tcttctttgt atctgaccaa cacagccttt atccacttct tgaagccacc aacaacgatg
      241 atatctttgg ggcagcttgg ataggcatgt ttgtgggcat ctgcctcttc tgcttgtctg
      301 ttctagccat agtaggaatt atgaagtcca acaggaaaat cctcttggcg tacttcatca
      361 tgatgtttat agtgtatggt tttgaagtgg cgtcttgcat cacagcagcc acacaacgag
      421 actttttcac gaccaacctc ttcctgaagc agatgctgat gaggtatcaa aacaacagcc
      481 ccccaaccaa tgacgacaaa tggaagaaca gctatgtcac caagacctgg gataggctca
      541 tgctgcagga ccactgctgt ggggtaaacg gtccgtcaga ctggcagaaa tacacctctg
      601 ccttccgagt ggagaatagc gatgctgact acccctggcc tcggcagtgc tgtgtcatgg
      661 acaagcttca agagcccctc aacctggacg cttgcaaact cggagtgcct ggttattacc
      721 acagtcaggg ctgttatgag ctaatctctg gaccaatgga tcggcacgcc tggggagttg
      781 cctggtttgg atttgctatt ctctgctgga ccttctgggt tctcctgggc accatgttct
      841 actggagcag aattgagtac taagcacaca gtgtctctcg gccatacctc cctcccgggt
      901 gactttgaat ttggtgctgg aacctgctgt ttcgtgacat gccctctggt gacacatgct
      961 tgtctctctc aagtgccagg ccaggtggaa cggctctcaa gatgctgcaa tccttagcag
     1021 aaatatttct cacccctgcc tgagattccg ccacatattt atatacgata agacagagag
     1081 tgtactatat gtgtgctata tgtacttata ttactatata taactatata tagtgtggta
     1141 cttacatgtt ctatataaga cagaaaactt ggagagggga ggtgactctc agccctgttt
     1201 atgtttaatg tggaggcaca gtgatgttca aaggaacctg cttcgccatt gtaagctctg
     1261 tctgtattga gttagcaaag tcatgaaaca cagagcccgt ctatctcaac gttttcttta
     1321 acctggcaag gcttttgctt gtcactgtgt aggttggggg gaggggagtt gcactgtgca
     1381 ggagggggaa atggcagagc tgtgccttct gcctctggtt ctgctgtgac ttctgtctgc
     1441 cccagtactg ttcctgacac ctttggatac tgttacgctc caggacgacc cttggttttc
     1501 atttaacgga gtgttcagac gtcctctcat gtcctgtggg gtgatgtgca tttagcaacc
     1561 cccgtctctg ttcacggaga gcttgtaaac cttggcagca ttccccatgc ccattttaca
     1621 tcagctcagt ctttgccctc aaggtttcaa cctgaaacag ttctcaaacc ctggtatcag
     1681 tgatttatgg ggacttgtgt ttgctgtcac aatagtttgc ttgcactaac gatcccgaag
     1741 gaagtcctga caagtcacca tttgtttgct tatccataaa taaagaagcc cataaaata
//
