LOCUS       NM_001108911            1286 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus uroplakin 1A (Upk1a), mRNA.
ACCESSION   NM_001108911 XM_001079181 XM_008759176 XM_344879
VERSION     NM_001108911.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Hashimoto,J., Takahashi,M., Saito,A., Murata,M., Kurimura,Y.,
            Nishitani,C., Takamiya,R., Uehara,Y., Hasegawa,Y., Hiyama,Y.,
            Sawada,N., Takahashi,S., Masumori,N., Kuroki,Y. and Ariki,S.
  TITLE     Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic
            Escherichia coli To Protect the Bladder from Infection
  JOURNAL   J Immunol 198 (7), 2898-2905 (2017)
   PUBMED   28228557
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Zhou,G., Liang,F.X., Romih,R., Wang,Z., Liao,Y., Ghiso,J.,
            Luque-Garcia,J.L., Neubert,T.A., Kreibich,G., Alonso,M.A.,
            Schaeren-Wiemers,N. and Sun,T.T.
  TITLE     MAL facilitates the incorporation of exocytic uroplakin-delivering
            vesicles into the apical membrane of urothelial umbrella cells
  JOURNAL   Mol Biol Cell 23 (7), 1354-1366 (2012)
   PUBMED   22323295
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Zupancic,D., Ovcak,Z., Vidmar,G. and Romih,R.
  TITLE     Altered expression of UPIa, UPIb, UPII, and UPIIIa during
            urothelial carcinogenesis induced by
            N-butyl-N-(4-hydroxybutyl)nitrosamine in rats
  JOURNAL   Virchows Arch 458 (5), 603-613 (2011)
   PUBMED   21301865
  REMARK    GeneRIF: During urothelial carcinogenesis, UPII expression was the
            most decreased in all urothelial lesions, while UPIa, UPIb, and
            UPIIIa expression was differently altered in different types of
            lesions
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Zhou,G., Mo,W.J., Sebbel,P., Min,G., Neubert,T.A., Glockshuber,R.,
            Wu,X.R., Sun,T.T. and Kong,X.P.
  TITLE     Uroplakin Ia is the urothelial receptor for uropathogenic
            Escherichia coli: evidence from in vitro FimH binding
  JOURNAL   J Cell Sci 114 (Pt 22), 4095-4103 (2001)
   PUBMED   11739641
REFERENCE   6  (bases 1 to 1286)
  AUTHORS   Ogawa,K., Johansson,S.L. and Cohen,S.M.
  TITLE     Immunohistochemical analysis of uroplakins, urothelial specific
            proteins, in ovarian Brenner tumors, normal tissues, and benign and
            neoplastic lesions of the female genital tract
  JOURNAL   Am J Pathol 155 (4), 1047-1050 (1999)
   PUBMED   10514386
REFERENCE   7  (bases 1 to 1286)
  AUTHORS   Wu,X.R., Lin,J.H., Walz,T., Haner,M., Yu,J., Aebi,U. and Sun,T.T.
  TITLE     Mammalian uroplakins. A group of highly conserved urothelial
            differentiation-related membrane proteins
  JOURNAL   J Biol Chem 269 (18), 13716-13724 (1994)
   PUBMED   8175808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jan 13, 2022 this sequence version replaced
            XM_008759176.3, NM_001108911.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KU310911.1, SRR22582416.806438.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050755 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000001.1  94997493-94997580   c
            89-289              JAXUCZ010000001.1  94994674-94994874   c
            290-364             JAXUCZ010000001.1  94992284-94992358   c
            365-472             JAXUCZ010000001.1  94991994-94992101   c
            473-652             JAXUCZ010000001.1  94989038-94989217   c
            653-736             JAXUCZ010000001.1  94987790-94987873   c
            737-1286            JAXUCZ010000001.1  94987113-94987662   c
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1286
                     /gene="Upk1a"
                     /note="uroplakin 1A"
                     /db_xref="GeneID:365227"
                     /db_xref="RGD:1309849"
     exon            1..88
                     /gene="Upk1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..781
                     /gene="Upk1a"
                     /codon_start=1
                     /product="uroplakin-1a"
                     /protein_id="NP_001102381.2"
                     /db_xref="GeneID:365227"
                     /db_xref="RGD:1309849"
                     /translation="MASTATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQ
                     YRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIV
                     YIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRIMIEQECCG
                     TSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCF
                     EHISHAIDSYTWGISWFGFAILMWTLPVMMIAMYFYTIL"
     exon            89..289
                     /gene="Upk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            290..364
                     /gene="Upk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            365..472
                     /gene="Upk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            473..652
                     /gene="Upk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            653..736
                     /gene="Upk1a"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1286
                     /gene="Upk1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaagatg gcttctacag cgacagaggg agagaagggg tctcctgtgg ttgtggggct
       61 gctggtcgtg ggcaacatca ttattctgct gtcaggcctg gccctgtttg cggagacagt
      121 gtgggtgacg gctgaccagt accgtgtgta cccactgatg ggcgtctcag gcaaggacga
      181 cgtcttcgcc ggtgcctgga tcgccatctt ctgcggcttc tccttcttcg tggtggccag
      241 ctttggtgta ggagctgcgc tctgtcgtcg tcggtacatg atcctcacgt atctgctgct
      301 gatgcttata gtctacatct tcgagtgtgc ctcctgcatc acatcctaca cccaccgcga
      361 ctacatggtg tccaacccat ccctgataac caagcaaatg ttgaccttct acagtgcgga
      421 caccgaccag ggccaagagc taacccgcct ctgggaccgg atcatgattg agcaagagtg
      481 ctgcggcaca tctggcccca tggactgggt gaattacaca tcagccttca gggcagccac
      541 cccggaagtg gtgttcccgt ggcccccact gtgctgtcgc cggactggga actttattcc
      601 catcaatgaa gatggctgcc gagtaggcca catggactac ctgtttacca agggttgctt
      661 cgaacacatc agccatgcca ttgacagcta cacgtggggc atatcgtggt ttggctttgc
      721 aatcttgatg tggactctcc ctgtgatgat gatagccatg tatttctaca ccattctctg
      781 aggaggaagg gggaccacag atgcacgcag ctctgcccaa agctcctgct tctctgcggc
      841 ccttggacac catcaacctc ctccccagac cacctccgtg tacctcggct acaacccacc
      901 ccatccacct ccctccattt tccctccttg cgatccaaac atccctttct agatgtagga
      961 gctgccctgg accctcgctg tgcccgtggc cctggatttg tgtgcctgga ccctctcgac
     1021 cctgtgtcac ttggctgatc tgctgacaac agcatagcct gtcctcagaa gcccttcgct
     1081 gctcctcaca acccagcatg cacctctctg tggcttccag aacttcttgc aggcgtagcc
     1141 actgttactc agtagtttgt gtaagctctt atagatgctg cctgttgtaa gaagagggtg
     1201 acacactctg ctgtgggggg tccccatcgg caccctcaca ggcctctgag caagcgctgg
     1261 atttccaata aatactggct gggtga
//
