LOCUS       NM_053768               1359 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus urate oxidase (Uox), mRNA.
ACCESSION   NM_053768
VERSION     NM_053768.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Fan,N., Yu,Y., Li,L., Xia,H., Dong,X., Li,Y., Chen,H. and Duan,W.
  TITLE     Uricase deficiency causes mild and multiple organ injuries in rats
  JOURNAL   PLoS One 16 (8), e0256594 (2021)
   PUBMED   34437605
  REMARK    GeneRIF: Uricase deficiency causes mild and multiple organ injuries
            in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1359)
  AUTHORS   Wu,M., Ma,Y., Chen,X., Liang,N., Qu,S. and Chen,H.
  TITLE     Hyperuricemia causes kidney damage by promoting autophagy and
            NLRP3-mediated inflammation in rats with urate oxidase deficiency
  JOURNAL   Dis Model Mech 14 (3) (2021)
   PUBMED   33648977
  REMARK    GeneRIF: Hyperuricemia causes kidney damage by promoting autophagy
            and NLRP3-mediated inflammation in rats with urate oxidase
            deficiency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1359)
  AUTHORS   Yu,Y., Zhang,N., Dong,X., Fan,N., Wang,L., Xu,Y., Chen,H. and
            Duan,W.
  TITLE     Uricase-deficient rat is generated with CRISPR/Cas9 technique
  JOURNAL   PeerJ 8, e8971 (2020)
   PUBMED   32368418
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1359)
  AUTHORS   Kratzer,J.T., Lanaspa,M.A., Murphy,M.N., Cicerchi,C., Graves,C.L.,
            Tipton,P.A., Ortlund,E.A., Johnson,R.J. and Gaucher,E.A.
  TITLE     Evolutionary history and metabolic insights of ancient mammalian
            uricases
  JOURNAL   Proc Natl Acad Sci U S A 111 (10), 3763-3768 (2014)
   PUBMED   24550457
REFERENCE   5  (bases 1 to 1359)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   6  (bases 1 to 1359)
  AUTHORS   Ito,M., Kato,S., Nakamura,M., Go,M. and Takagi,Y.
  TITLE     Identification of an amino acid residue involved in the
            substrate-binding site of rat liver uricase by site-directed
            mutagenesis
  JOURNAL   Biochem Biophys Res Commun 187 (1), 101-107 (1992)
   PUBMED   1520291
REFERENCE   7  (bases 1 to 1359)
  AUTHORS   Ito,M., Nakamura,M., Ogawa,H., Kato,S. and Takagi,Y.
  TITLE     Structural analysis of the gene encoding rat uricase
  JOURNAL   Genomics 11 (4), 905-913 (1991)
   PUBMED   1783398
REFERENCE   8  (bases 1 to 1359)
  AUTHORS   Wang,X.D., Kawano,H., Alvares,K., Reddy,P.G., Getto,H., Rao,M.S.
            and Reddy,J.K.
  TITLE     Rat urate oxidase: cloning and structural analysis of the gene and
            5'-flanking region
  JOURNAL   Gene 97 (2), 223-229 (1991)
   PUBMED   1999285
REFERENCE   9  (bases 1 to 1359)
  AUTHORS   Motojima,K. and Goto,S.
  TITLE     Organization of rat uricase chromosomal gene differs greatly from
            that of the corresponding plant gene
  JOURNAL   FEBS Lett 264 (1), 156-158 (1990)
   PUBMED   2338140
REFERENCE   10 (bases 1 to 1359)
  AUTHORS   Alvares,K., Nemali,M.R., Reddy,P.G., Wang,X.D., Rao,M.S. and
            Reddy,J.K.
  TITLE     The nucleotide sequence of a full length cDNA clone encoding rat
            liver urate oxidase
  JOURNAL   Biochem Biophys Res Commun 158 (3), 991-995 (1989)
   PUBMED   2920046
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M24396.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_053768.3.
            
            On Aug 30, 2012 this sequence version replaced NM_053768.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M24396.1, BC088112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1359              M24396.1           2-1360
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1359
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /note="urate oxidase"
                     /db_xref="GeneID:114768"
                     /db_xref="RGD:621369"
     exon            1..70
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..952
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /EC_number="1.7.3.3"
                     /note="urate oxidase 2"
                     /codon_start=1
                     /product="uricase"
                     /protein_id="NP_446220.1"
                     /db_xref="GeneID:114768"
                     /db_xref="RGD:621369"
                     /translation="MAHYHDDYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVA
                     TSVQLTLRSKKDYLHGDNSDIIPTDTIKNTVHVLAKFKGIKSIETFAMNICEHFLSSF
                     SHVTRAHVHVEEVPWKRFEKNGVKHVHAFIHTPTGTHFCDVEQVRNGPPIIHSGIKDL
                     KVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCKWRYQNRDVDFEATWGAVRDIVL
                     KKFAGPYDRGEYSPSVQKTLYDIQVLTLSQLPEIEDMEISLPNIHYFNIDMSKMGLIN
                     KEEVLLPLDNPYGKITGTVRRKLPSRL"
     exon            71..289
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..406
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..485
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..669
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..793
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..877
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1359
                     /gene="Uox"
                     /gene_synonym="UOX-2; Uri; Uri2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cattcttgaa accgaatctg aagttaaagg ctgagggaaa atggcccatt accatgacga
       61 ctatggaaag aatgatgaag tggagtttgt ccgaactggc tatgggaagg acatggtcaa
      121 agttctccat attcagaggg atggaaaata ccacagcatc aaagaggtgg cgacttcggt
      181 gcagttgact ctgaggtcca aaaaggatta cctccatggt gataattccg acatcatccc
      241 cacagacacc atcaagaaca cagtgcatgt cctggcgaag ttcaaaggga tcaaaagcat
      301 cgagaccttc gctatgaaca tctgcgagca cttcctctct tcctttagcc atgtcacccg
      361 agcccatgtc cacgtggaag aggtcccctg gaagcgtttt gaaaagaatg gagtcaaaca
      421 cgtccatgcc ttcatccaca ccccgacggg aactcacttc tgtgacgtgg agcaggtgag
      481 gaacggacct cccatcattc actctggaat caaagacctc aaggtcttga aaacaaccca
      541 gtctggattt gaaggattca tcaaggacca gttcactact ctccccgagg tgaaggaccg
      601 atgctttgcc actcaagtgt actgcaagtg gcgctaccag aatcgggacg tggatttcga
      661 ggctacctgg ggcgctgtcc gggacattgt cctgaagaaa tttgctgggc cctatgacag
      721 aggtgaatac tcaccttccg tgcagaagac cctctatgac atacaagtgc tgaccctgag
      781 ccagcttcct gagatagaag acatggaaat cagccttcca aacattcact actttaacat
      841 cgacatgtcc aaaatggggc tgatcaacaa ggaagaggtt ttgctgcctc tggacaaccc
      901 ctacggcaaa ataaccggga cggtgaggag gaagctgcct tccaggctgt gacgttatgg
      961 ctccagccag ttgtgatgct tgggataact gtgtgctcac ctgcaaaaat ttcaactcag
     1021 gatactgatt gctctgctct gtgtgaagta attgctcttc cgtttctagt ttagcaaggg
     1081 gcttgtagct gtgcgcacgt ggagccctgc attagcagac accgcaggct ccgtggcctt
     1141 gggcagattc ctttaaaact gtgatcggag aatcacagcg atatttctcc ttgctgttct
     1201 tgtgccctct gcctcagact ctgtctttag gatccgatcg ttaaggaaat agtcgtaaag
     1261 cactggctgc tgccacatcc gttgatctga acatgagatc aaacactgtc atactcctag
     1321 ggatgtctgg gttgtaccaa aaacgtaata aaaccatgt
//
