LOCUS       NM_001013124            1855 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus uracil-DNA glycosylase (Ung), mRNA.
ACCESSION   NM_001013124 XM_222272
VERSION     NM_001013124.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Ko SI, Park JH, Park MJ, Kim J, Kang LW and Han YS.
  TITLE     Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA
            glycosylase (hUNG) and stimulates its glycosylase activity
  JOURNAL   Mutat Res 648 (1-2), 54-64 (2008)
   PUBMED   18973764
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Shen HM, Tanaka A, Bozek G, Nicolae D and Storb U.
  TITLE     Somatic hypermutation and class switch recombination in
            Msh6(-/-)Ung(-/-) double-knockout mice
  JOURNAL   J Immunol 177 (8), 5386-5392 (2006)
   PUBMED   17015724
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Rada C, Di Noia JM and Neuberger MS.
  TITLE     Mismatch recognition and uracil excision provide complementary
            paths to both Ig switching and the A/T-focused phase of somatic
            mutation
  JOURNAL   Mol Cell 16 (2), 163-171 (2004)
   PUBMED   15494304
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Kruman II, Schwartz E, Kruman Y, Cutler RG, Zhu X, Greig NH and
            Mattson MP.
  TITLE     Suppression of uracil-DNA glycosylase induces neuronal apoptosis
  JOURNAL   J Biol Chem 279 (42), 43952-43960 (2004)
   PUBMED   15297456
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, Catalan N, Yel L,
            Forveille M, Kavli B, Krokan HE, Ochs HD, Fischer A and Durandy A.
  TITLE     Human uracil-DNA glycosylase deficiency associated with profoundly
            impaired immunoglobulin class-switch recombination
  JOURNAL   Nat Immunol 4 (10), 1023-1028 (2003)
   PUBMED   12958596
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas
            PA, Hagen L, Krokan HE and Slupphaug G.
  TITLE     hUNG2 is the major repair enzyme for removal of uracil from U:A
            matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1
            as a broad specificity backup
  JOURNAL   J Biol Chem 277 (42), 39926-39936 (2002)
   PUBMED   12161446
REFERENCE   8  (bases 1 to 1855)
  AUTHORS   Vinson RK and Hales BF.
  TITLE     Expression and activity of the DNA repair enzyme uracil DNA
            glycosylase during organogenesis in the rat conceptus and following
            methotrexate exposure in vitro
  JOURNAL   Biochem Pharmacol 64 (4), 711-721 (2002)
   PUBMED   12167490
REFERENCE   9  (bases 1 to 1855)
  AUTHORS   Olsen AK, Bjortuft H, Wiger R, Holme J, Seeberg E, Bjoras M and
            Brunborg G.
  TITLE     Highly efficient base excision repair (BER) in human and rat male
            germ cells
  JOURNAL   Nucleic Acids Res 29 (8), 1781-1790 (2001)
   PUBMED   11292851
REFERENCE   10 (bases 1 to 1855)
  AUTHORS   Nilsen H, Steinsbekk KS, Otterlei M, Slupphaug G, Aas PA and Krokan
            HE.
  TITLE     Analysis of uracil-DNA glycosylases from the murine Ung gene
            reveals differential expression in tissues and in embryonic
            development and a subcellular sorting pattern that differs from the
            human homologues
  JOURNAL   Nucleic Acids Res 28 (12), 2277-2285 (2000)
   PUBMED   10871356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091211.1.
            
            On Apr 20, 2005 this sequence version replaced XM_222272.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091211.1, EV777599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1855
                     /gene="Ung"
                     /note="uracil-DNA glycosylase"
                     /db_xref="GeneID:304577"
                     /db_xref="RGD:1307200"
     exon            1..363
                     /gene="Ung"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..966
                     /gene="Ung"
                     /EC_number="3.2.2.27"
                     /codon_start=1
                     /product="uracil-DNA glycosylase"
                     /protein_id="NP_001013142.1"
                     /db_xref="GeneID:304577"
                     /db_xref="RGD:1307200"
                     /translation="MGILGPRPLKLARSLRAPRGARLRSLTPDPDSWQASPAKKARVE
                     QDEPATPPSSPLSAEQLVRIQRNKAAALLRLAARNVPAGLGESWKQQLCGEFGKPYFV
                     KLMGFVAEERKHHKVYPPPEQVFTWTQMCDIRDVKVVILGQDPYHGPNQAHGLCFSVQ
                     RPVPPPPSLENIFKELSTDIDGFVHPGHGDLSGWARQGVLLLNAVLTVRAHQANSHKE
                     RGWEQFTDAVVSWLNQNLNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRG
                     FFGCRHFSKANELLQRSGKKPISWKEL"
     exon            364..459
                     /gene="Ung"
                     /inference="alignment:Splign:2.1.0"
     exon            460..557
                     /gene="Ung"
                     /inference="alignment:Splign:2.1.0"
     exon            558..646
                     /gene="Ung"
                     /inference="alignment:Splign:2.1.0"
     exon            647..825
                     /gene="Ung"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1828
                     /gene="Ung"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggagtcccg tggacgcgta ggcgggcgga gcgggttccg ggttcggctg gaccatgggc
       61 atcttggggc cgcggccttt gaagttggcg cgtagcctgc gcgcgccgcg gggagccagg
      121 ctgcggagcc ttactccgga ccccgactcc tggcaggcca gccccgccaa gaaggcccgg
      181 gtggagcagg atgagccggc cacaccgccc tcttcgccgc ttagcgccga gcagctcgtc
      241 cgcatccaga ggaacaaggc cgcggcgctg ctcaggctcg ccgcccgcaa tgtgcccgcc
      301 ggcctcggcg agagctggaa gcagcagctg tgcggggagt tcgggaagcc gtacttcgtc
      361 aagctcatgg gctttgttgc tgaagaaagg aaacaccaca aggtctatcc gcccccggag
      421 caggtgttca cgtggaccca gatgtgcgac atccgtgatg tgaaggttgt cattctggga
      481 caggatccat atcacggacc taatcaagct catgggctct gcttcagtgt ccagaggcca
      541 gttccacccc cgcccagttt ggaaaacatt tttaaagaac tgtctacaga catcgatggt
      601 tttgttcacc ctggccatgg ggatctgtca gggtgggcca gacaaggtgt cctcctcctc
      661 aacgccgtcc tcactgtccg cgcacaccaa gccaattccc ataaggagcg gggctgggag
      721 cagttcacgg atgcagttgt gtcgtggctg aatcagaacc tgaatggcct tgtcttcctc
      781 ctctggggct cctatgctca gaagaagggc agtgccatcg acaggaagcg tcaccatgtt
      841 ctgcagacag ctcatccctc cccgctgtcg gtgtacagag ggttctttgg atgtagacat
      901 ttttctaaag ccaatgaact gctccagagg tctggcaaga aacccatcag ctggaaggaa
      961 ctgtgaccct gcgggcagtg tctgtctaca gcaggctttc cagtgctgct gctgaagcat
     1021 tcgcccttag agcgtcactg aaaaggccct gttcttcagt tccctgtggg agcggagaag
     1081 agaaacagat aggtctctct agaaccacca tgagccgcca ggacacagaa actgtggctt
     1141 aaccaggcag aacccctcca ggccccgcaa ggtggctgtt gaaacaccaa cttctcagag
     1201 accggcatcc gtgtcctcgg tctgtgggct gcctggggtt tgaggagaga tctgtaactt
     1261 ttgaccagca gttcggtgcc agctgctgtc cgctgcccta tgctgttcgc tttacccttt
     1321 agcgttagat aacagagtgt ccgggtgtgt gcttccaaag gcccttttgt ctcaaggaac
     1381 ccatgggtgg ttggtgagtc ctgggaagtc tggcttacaa tggagtctgc ttcctggtca
     1441 caaagagcgt gggcgtctcc tgggctcacc agtggctgct gtctagcctg cttcttggct
     1501 cacttagcct tgagcaggtg ctggagtcca gtacagcaga gaatgggttt gatttgtttt
     1561 aactgagggt gggtggtttt tctagtgcct gtggagttaa ctgtttcctc acagcagact
     1621 gcctgccaca cgtgctgtgt gtagtggtgg gatccaactc caaggtgctg ttttatgggc
     1681 tgaattcaca cagattgtgc ctttctgcaa caccggagaa tgttatattt ttacgaagta
     1741 ggcaggtact tttatatttt ttctttcctt acttgggaga ctggagagcg gctgcgtaag
     1801 caggacaata aaagctggtt gaaccttgaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
