LOCUS       NM_001403514            2203 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus unc-93 homolog B1, TLR signaling regulator
            (Unc93b1), mRNA.
ACCESSION   NM_001403514 XM_006230833
VERSION     NM_001403514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Caetano,B.C., Carmo,B.B., Melo,M.B., Cerny,A., dos Santos,S.L.,
            Bartholomeu,D.C., Golenbock,D.T. and Gazzinelli,R.T.
  TITLE     Requirement of UNC93B1 reveals a critical role for TLR7 in host
            resistance to primary infection with Trypanosoma cruzi
  JOURNAL   J Immunol 187 (4), 1903-1911 (2011)
   PUBMED   21753151
  REMARK    GeneRIF: Requirement of UNC93B1 reveals a critical role for TLR7 in
            host resistance to primary infection with Trypanosoma cruzi.
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Defays,A., David,A., de Gassart,A., De Angelis Rigotti,F.,
            Wenger,T., Camossetto,V., Brousset,P., Petrella,T., Dalod,M.,
            Gatti,E. and Pierre,P.
  TITLE     BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid
            dendritic cells
  JOURNAL   Blood 118 (3), 609-617 (2011)
   PUBMED   21642595
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Kumar,H., Kawai,T. and Akira,S.
  TITLE     Pathogen recognition by the innate immune system
  JOURNAL   Int Rev Immunol 30 (1), 16-34 (2011)
   PUBMED   21235323
  REMARK    Review article
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Eidenschenk,C., Crozat,K., Krebs,P., Arens,R., Popkin,D.,
            Arnold,C.N., Blasius,A.L., Benedict,C.A., Moresco,E.M., Xia,Y. and
            Beutler,B.
  TITLE     Flt3 permits survival during infection by rendering dendritic cells
            competent to activate NK cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9759-9764 (2010)
   PUBMED   20457904
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Isnardi,I., Ng,Y.S., Srdanovic,I., Motaghedi,R., Rudchenko,S., von
            Bernuth,H., Zhang,S.Y., Puel,A., Jouanguy,E., Picard,C.,
            Garty,B.Z., Camcioglu,Y., Doffinger,R., Kumararatne,D., Davies,G.,
            Gallin,J.I., Haraguchi,S., Day,N.K., Casanova,J.L. and Meffre,E.
  TITLE     IRAK-4- and MyD88-dependent pathways are essential for the removal
            of developing autoreactive B cells in humans
  JOURNAL   Immunity 29 (5), 746-757 (2008)
   PUBMED   19006693
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Kim,Y.M., Brinkmann,M.M., Paquet,M.E. and Ploegh,H.L.
  TITLE     UNC93B1 delivers nucleotide-sensing toll-like receptors to
            endolysosomes
  JOURNAL   Nature 452 (7184), 234-238 (2008)
   PUBMED   18305481
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Koehn,J., Huesken,D., Jaritz,M., Rot,A., Zurini,M., Dwertmann,A.,
            Beutler,B. and Korthauer,U.
  TITLE     Assessing the function of human UNC-93B in Toll-like receptor
            signaling and major histocompatibility complex II response
  JOURNAL   Hum Immunol 68 (11), 871-878 (2007)
   PUBMED   18082565
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Brinkmann,M.M., Spooner,E., Hoebe,K., Beutler,B., Ploegh,H.L. and
            Kim,Y.M.
  TITLE     The interaction between the ER membrane protein UNC93B and TLR3, 7,
            and 9 is crucial for TLR signaling
  JOURNAL   J Cell Biol 177 (2), 265-275 (2007)
   PUBMED   17452530
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Tabeta,K., Hoebe,K., Janssen,E.M., Du,X., Georgel,P., Crozat,K.,
            Mudd,S., Mann,N., Sovath,S., Goode,J., Shamel,L., Herskovits,A.A.,
            Portnoy,D.A., Cooke,M., Tarantino,L.M., Wiltshire,T.,
            Steinberg,B.E., Grinstein,S. and Beutler,B.
  TITLE     The Unc93b1 mutation 3d disrupts exogenous antigen presentation and
            signaling via Toll-like receptors 3, 7 and 9
  JOURNAL   Nat Immunol 7 (2), 156-164 (2006)
   PUBMED   16415873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 31, 2022 this sequence version replaced XM_006230833.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.6258.1,
                                           SRR22582416.835609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000001.1  210596676-210596798
            124-265             JAXUCZ010000001.1  210597169-210597310
            266-419             JAXUCZ010000001.1  210597664-210597817
            420-581             JAXUCZ010000001.1  210599834-210599995
            582-714             JAXUCZ010000001.1  210600204-210600336
            715-808             JAXUCZ010000001.1  210600641-210600734
            809-933             JAXUCZ010000001.1  210600988-210601112
            934-1116            JAXUCZ010000001.1  210601389-210601571
            1117-1390           JAXUCZ010000001.1  210601881-210602154
            1391-1509           JAXUCZ010000001.1  210605180-210605298
            1510-2203           JAXUCZ010000001.1  210606886-210607579
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2203
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /note="unc-93 homolog B1, TLR signaling regulator"
                     /db_xref="GeneID:361689"
                     /db_xref="RGD:1311984"
     exon            1..123
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1824
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /note="unc-93 homolog B"
                     /codon_start=1
                     /product="protein unc-93 homolog B1"
                     /protein_id="NP_001390443.1"
                     /db_xref="GeneID:361689"
                     /db_xref="RGD:1311984"
                     /translation="MEVEPPLYPVAGVAGPQGDEDRLGVHDGPEAPLDELVGAYPNYN
                     EEEEERRYYRRKRLGVVKNVLAASTGGTLTYGVYLGLLQMQLILHYDETYREVKYGNM
                     GLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAVGIYALFVSTNYWERYYT
                     LVPSAVALGMAIVPLWASMGNYITRMSQKYYEYSHYKEQDEQGPQQRPPRGSHAPYLL
                     VFQAIFYSFFHLSFACAQLPMVYFLNHYLYDLNHTLFNVKSCGTKSYGILNGFNKTVL
                     RTLPRSRNLIVVESVLMAVAFLAMLLVLGLCGAAYRPTEEIDLRSVGWGNIFQLPFKH
                     VRDFRLRHLVPFFIYSGFEVLFACTGFTLGYGVCSMGLERLAYLLIAYSLGASAASVL
                     GLLGLWLPRSVPLVAGAGLHLLLTLSLFFWAPAPRVLQHSWIFYFVAALWGVGSALNK
                     TGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFVVYLGSSLPMKAKLAVLLVTLVAAA
                     TSYLWMENKLQQGLVPRQPRIPKPQHKVRGYRYLEEDNSDESDVEGEQGQGDCAEEEA
                     PQAGPLGAEPAGPCRRPCPYEQALGGDGPEEQ"
     exon            124..265
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            266..419
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            420..581
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            582..714
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            715..808
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            809..933
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1116
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1390
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1509
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2203
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcaagccc ttggtctgga tctggtcatg gaggtggagc ctccgcttta ccctgtggcc
       61 ggtgtcgcgg gtcctcaagg ggatgaagac cggctcggag ttcatgatgg gccagaggct
      121 cccctggacg aactcgtggg cgcgtacccc aactacaatg aggaggagga ggagcgtcgc
      181 tactaccgac gcaagcgtct cggagtggtc aagaacgtgc tggcggccag cacgggtggc
      241 acgctcactt acggcgtcta cctgggcctc ctgcagatgc aactgatcct gcactatgat
      301 gagacctaca gggaggtgaa gtatggcaac atgggcctgc cggacatcga tagcaagatg
      361 ctgatgggta tcaacgtgac gcccatcgct gccctgctct acacacctgt gctcatcagg
      421 ttttttggta ccaagtggat gatgttttta gctgtgggca tctatgccct cttcgtctct
      481 accaactact gggaacgcta ctacacgctg gtaccctctg ctgtggctct gggcatggcc
      541 attgtgcccc tctgggcctc catgggcaac tatatcacca ggatgtccca gaagtactac
      601 gaatattccc actacaagga gcaagacgag caggggcctc agcagcgccc accacgaggc
      661 tcccacgccc cctatctcct ggttttccag gccatcttct atagtttctt ccacttgagc
      721 ttcgcctgtg cccagctgcc catggtttac ttcctcaacc actacctgta tgacctgaac
      781 cacacactgt tcaacgtgaa gagctgcggc actaagagct atggcatcct gaatggcttc
      841 aacaagacgg ttcttcggac gctgccgcgc agcagaaatc ttattgttgt agagagcgtg
      901 ctcatggcgg tggccttctt ggccatgctg ctggttctag gcctgtgtgg agccgcttac
      961 cggcccacgg aagagatcga cctgcgcagc gtgggctggg gtaacatctt ccagctgccc
     1021 ttcaaacacg tgcgtgactt tcgcttacgc catctggtgc ccttctttat ctacagtggc
     1081 tttgaggtgc tctttgcctg cactggtttc accctgggct acggcgtgtg ctccatgggg
     1141 ctggagcggc ttgcgtacct gctcatagct tacagcctgg gtgcctcagc tgcctcggtc
     1201 ctggggctgc tgggactgtg gctccctcgc tctgtgcccc tcgtggctgg ggcaggactg
     1261 cacctgctgc tcacccttag cctctttttc tgggctccag cacctcgggt cctccagcac
     1321 agttggatct tttacttcgt ggctgctctc tggggtgtgg gcagtgccct caacaagacc
     1381 ggacttagca cactcctggg catcctatat gaagacaaag agaggcagga cttcatcttc
     1441 accatctatc actggtggca ggccgtggcc atcttcgttg tgtacctggg ctccagcttg
     1501 cccatgaagg ccaagctggc agtgttgctg gtgaccctgg tagcagcagc aacttcatac
     1561 ctgtggatgg aaaacaagtt gcagcaggga ctggtccccc gacagccgcg cattccgaag
     1621 ccacagcaca aagtccgcgg ctaccgctac ctggaggagg acaactcaga tgagagcgac
     1681 gtagagggcg agcagggtca gggggactgc gcagaggagg aagcgccaca ggcagggccc
     1741 ctgggtgcag agccagccgg cccctgccgc aggccctgtc cctatgaaca ggctctgggt
     1801 ggtgatggtc ctgaggagca gtgagggagc cagggtggcc agcccggccc tcagactcgg
     1861 ctttcagcct cccagtttca gtttactgcg tctcagattg gggatccccc atctgccaaa
     1921 agggccttct tttcctcctc agagcctggg gacacctggg acttcctcca aagagataag
     1981 ggtcaccctc caagccccca ttcctgttta agggatatac ctctgcctaa atcagcgaga
     2041 ttttccgcat gccactgctc aggtcaccct ctgcccctgt catgcggtgt aacgactttt
     2101 gactggagct ttgtacttct tgcccacagg ttcccccacc tcagagcagg gggcattttt
     2161 ttaaaataga aaataatcaa taaagacttt tgtattttct gga
//
