LOCUS       NP_001390443             598 aa            linear   ROD 31-MAR-2024
DEFINITION  protein unc-93 homolog B1 [Rattus norvegicus].
ACCESSION   NP_001390443 XP_006230895
VERSION     NP_001390443.1
DBSOURCE    REFSEQ: accession NM_001403514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 598)
  AUTHORS   Caetano,B.C., Carmo,B.B., Melo,M.B., Cerny,A., dos Santos,S.L.,
            Bartholomeu,D.C., Golenbock,D.T. and Gazzinelli,R.T.
  TITLE     Requirement of UNC93B1 reveals a critical role for TLR7 in host
            resistance to primary infection with Trypanosoma cruzi
  JOURNAL   J Immunol 187 (4), 1903-1911 (2011)
   PUBMED   21753151
  REMARK    GeneRIF: Requirement of UNC93B1 reveals a critical role for TLR7 in
            host resistance to primary infection with Trypanosoma cruzi.
REFERENCE   2  (residues 1 to 598)
  AUTHORS   Defays,A., David,A., de Gassart,A., De Angelis Rigotti,F.,
            Wenger,T., Camossetto,V., Brousset,P., Petrella,T., Dalod,M.,
            Gatti,E. and Pierre,P.
  TITLE     BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid
            dendritic cells
  JOURNAL   Blood 118 (3), 609-617 (2011)
   PUBMED   21642595
REFERENCE   3  (residues 1 to 598)
  AUTHORS   Kumar,H., Kawai,T. and Akira,S.
  TITLE     Pathogen recognition by the innate immune system
  JOURNAL   Int Rev Immunol 30 (1), 16-34 (2011)
   PUBMED   21235323
  REMARK    Review article
REFERENCE   4  (residues 1 to 598)
  AUTHORS   Eidenschenk,C., Crozat,K., Krebs,P., Arens,R., Popkin,D.,
            Arnold,C.N., Blasius,A.L., Benedict,C.A., Moresco,E.M., Xia,Y. and
            Beutler,B.
  TITLE     Flt3 permits survival during infection by rendering dendritic cells
            competent to activate NK cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9759-9764 (2010)
   PUBMED   20457904
REFERENCE   5  (residues 1 to 598)
  AUTHORS   Isnardi,I., Ng,Y.S., Srdanovic,I., Motaghedi,R., Rudchenko,S., von
            Bernuth,H., Zhang,S.Y., Puel,A., Jouanguy,E., Picard,C.,
            Garty,B.Z., Camcioglu,Y., Doffinger,R., Kumararatne,D., Davies,G.,
            Gallin,J.I., Haraguchi,S., Day,N.K., Casanova,J.L. and Meffre,E.
  TITLE     IRAK-4- and MyD88-dependent pathways are essential for the removal
            of developing autoreactive B cells in humans
  JOURNAL   Immunity 29 (5), 746-757 (2008)
   PUBMED   19006693
REFERENCE   6  (residues 1 to 598)
  AUTHORS   Kim,Y.M., Brinkmann,M.M., Paquet,M.E. and Ploegh,H.L.
  TITLE     UNC93B1 delivers nucleotide-sensing toll-like receptors to
            endolysosomes
  JOURNAL   Nature 452 (7184), 234-238 (2008)
   PUBMED   18305481
REFERENCE   7  (residues 1 to 598)
  AUTHORS   Koehn,J., Huesken,D., Jaritz,M., Rot,A., Zurini,M., Dwertmann,A.,
            Beutler,B. and Korthauer,U.
  TITLE     Assessing the function of human UNC-93B in Toll-like receptor
            signaling and major histocompatibility complex II response
  JOURNAL   Hum Immunol 68 (11), 871-878 (2007)
   PUBMED   18082565
REFERENCE   8  (residues 1 to 598)
  AUTHORS   Brinkmann,M.M., Spooner,E., Hoebe,K., Beutler,B., Ploegh,H.L. and
            Kim,Y.M.
  TITLE     The interaction between the ER membrane protein UNC93B and TLR3, 7,
            and 9 is crucial for TLR signaling
  JOURNAL   J Cell Biol 177 (2), 265-275 (2007)
   PUBMED   17452530
REFERENCE   9  (residues 1 to 598)
  AUTHORS   Tabeta,K., Hoebe,K., Janssen,E.M., Du,X., Georgel,P., Crozat,K.,
            Mudd,S., Mann,N., Sovath,S., Goode,J., Shamel,L., Herskovits,A.A.,
            Portnoy,D.A., Cooke,M., Tarantino,L.M., Wiltshire,T.,
            Steinberg,B.E., Grinstein,S. and Beutler,B.
  TITLE     The Unc93b1 mutation 3d disrupts exogenous antigen presentation and
            signaling via Toll-like receptors 3, 7 and 9
  JOURNAL   Nat Immunol 7 (2), 156-164 (2006)
   PUBMED   16415873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 31, 2022 this sequence version replaced XP_006230895.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.6258.1,
                                           SRR22582416.835609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..598
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..598
                     /product="protein unc-93 homolog B1"
                     /note="unc-93 homolog B"
                     /calculated_mol_wt=66980
     Region          64..520
                     /region_name="MFS_unc93B1"
                     /note="Protein unc-93 homolog B1 of the Major Facilitator
                     Superfamily of transporters; cd17408"
                     /db_xref="CDD:340966"
     Site            order(74..75,78..79,82,123,172..173,175..177,180,229,
                     232..233,236,347,350..351,354..356,359,386,390,437..438,
                     442,446,471,474..475,478..479,482)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340966"
     CDS             1..598
                     /gene="Unc93b1"
                     /gene_synonym="Unc93b"
                     /coded_by="NM_001403514.1:28..1824"
                     /db_xref="GeneID:361689"
                     /db_xref="RGD:1311984"
ORIGIN      
        1 mevepplypv agvagpqgde drlgvhdgpe apldelvgay pnyneeeeer ryyrrkrlgv
       61 vknvlaastg gtltygvylg llqmqlilhy detyrevkyg nmglpdidsk mlmginvtpi
      121 aallytpvli rffgtkwmmf lavgiyalfv stnyweryyt lvpsavalgm aivplwasmg
      181 nyitrmsqky yeyshykeqd eqgpqqrppr gshapyllvf qaifysffhl sfacaqlpmv
      241 yflnhylydl nhtlfnvksc gtksygilng fnktvlrtlp rsrnlivves vlmavaflam
      301 llvlglcgaa yrpteeidlr svgwgnifql pfkhvrdfrl rhlvpffiys gfevlfactg
      361 ftlgygvcsm glerlaylli ayslgasaas vlgllglwlp rsvplvagag lhllltlslf
      421 fwapaprvlq hswifyfvaa lwgvgsalnk tglstllgil yedkerqdfi ftiyhwwqav
      481 aifvvylgss lpmkaklavl lvtlvaaats ylwmenklqq glvprqprip kpqhkvrgyr
      541 yleednsdes dvegeqgqgd caeeeapqag plgaepagpc rrpcpyeqal ggdgpeeq
//
