LOCUS       NP_001100352             518 aa            linear   ROD 01-AUG-2024
DEFINITION  UNC5C-like protein isoform 1 [Rattus norvegicus].
ACCESSION   NP_001100352 XP_001063261 XP_063122912 XP_236916
VERSION     NP_001100352.2
DBSOURCE    REFSEQ: accession NM_001106882.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 518)
  AUTHORS   Heinz,L.X., Rebsamen,M., Rossi,D.C., Staehli,F., Schroder,K.,
            Quadroni,M., Gross,O., Schneider,P. and Tschopp,J.
  TITLE     The death domain-containing protein Unc5CL is a novel
            MyD88-independent activator of the pro-inflammatory IRAK signaling
            cascade
  JOURNAL   Cell Death Differ 19 (4), 722-731 (2012)
   PUBMED   22158417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jul 24, 2024 this sequence version replaced
            XP_063122912.1, NP_001100352.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.36661.1,
                                           SRR26643287.22050.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     Protein         1..518
                     /product="UNC5C-like protein isoform 1"
                     /note="UNC5C-like protein; unc-5 homolog C-like"
                     /calculated_mol_wt=58014
     Region          108..185
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     Region          243..355
                     /region_name="UPA"
                     /note="UPA domain; pfam17217"
                     /db_xref="CDD:465384"
     Region          408..488
                     /region_name="DD"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; cl14633"
                     /db_xref="CDD:472698"
     CDS             1..518
                     /gene="Unc5cl"
                     /coded_by="NM_001106882.3:138..1694"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:301225"
                     /db_xref="RGD:1587368"
ORIGIN      
        1 mspqessvqp fqflllvgip vasvlllvqc lrwhrcrwpp gscqkpddpe epvspstplp
       61 eyelpkqcqa ptlpevaafy qelhmptrgq titrqlmnkl lvfsarevdh rggclmlqdt
      121 gisllippga vtvgrqervs lvlvwdltda pslshkqglv spvvacgphg asflkpcilt
      181 fkhcaqqpsq vcayssntsl ldakdwrplg qpgthtsrde crillshfsl ytcvlepplg
      241 qtarkwlqla mfcsplapgq thlqlrvyfl nntpcalqwa itneqphggr mrgpcqlfdf
      301 tgaradqclk lkyisegwen vddsssqlvp hlhiwhgkcp frsfcfrrks angneecstl
      361 tneiivtmht fqdgletkym eilrfqasee etwavpppvs qpplcnrlpp elfeqlqmll
      421 epssvtgndw rklashlglc gmkirflscq rspaaailel feeqngslqe lhylmtsmer
      481 ldcasaiqny lnrtpgdspt rlrggtwenc gleldekf
//
