LOCUS       NM_022206               3986 bp    mRNA    linear   ROD 11-APR-2024
DEFINITION  Rattus norvegicus unc-5 netrin receptor A (Unc5a), mRNA.
ACCESSION   NM_022206
VERSION     NM_022206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3986)
  AUTHORS   Webber,C.A., Christie,K.J., Cheng,C., Martinez,J.A., Singh,B.,
            Singh,V., Thomas,D. and Zochodne,D.W.
  TITLE     Schwann cells direct peripheral nerve regeneration through the
            Netrin-1 receptors, DCC and Unc5H2
  JOURNAL   Glia 59 (10), 1503-1517 (2011)
   PUBMED   21656855
  REMARK    GeneRIF: Unc5H Receptors have Prominent Expression in Adult Schwann
            cells.
REFERENCE   2  (bases 1 to 3986)
  AUTHORS   Manitt,C., Labelle-Dumais,C., Eng,C., Grant,A., Mimee,A., Stroh,T.
            and Flores,C.
  TITLE     Peri-pubertal emergence of UNC-5 homologue expression by dopamine
            neurons in rodents
  JOURNAL   PLoS One 5 (7), e11463 (2010)
   PUBMED   20628609
  REMARK    GeneRIF: Findings suggest that DCC:UNC5H ratios in DA neurons at
            critical periods may have important consequences for the
            organization and function of mesocorticolimbic DA systems.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3986)
  AUTHORS   Muramatsu,R., Nakahara,S., Ichikawa,J., Watanabe,K., Matsuki,N. and
            Koyama,R.
  TITLE     The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A'
            netrin-1 receptors on the growth cone regulates mossy fibre
            directionality
  JOURNAL   Brain 133 (Pt 1), 60-75 (2010)
   PUBMED   19858080
  REMARK    GeneRIF: Hyperactivity increases the surface expression of
            uncoordinated-5A (Unc5a), which is suppressed by blocking cyclic
            adenosine monophosphate signaling.
REFERENCE   4  (bases 1 to 3986)
  AUTHORS   Picard,M., Petrie,R.J., Antoine-Bertrand,J., Saint-Cyr-Proulx,E.,
            Villemure,J.F. and Lamarche-Vane,N.
  TITLE     Spatial and temporal activation of the small GTPases RhoA and Rac1
            by the netrin-1 receptor UNC5a during neurite outgrowth
  JOURNAL   Cell Signal 21 (12), 1961-1973 (2009)
   PUBMED   19755150
REFERENCE   5  (bases 1 to 3986)
  AUTHORS   Powell,A.W., Sassa,T., Wu,Y., Tessier-Lavigne,M. and Polleux,F.
  TITLE     Topography of thalamic projections requires attractive and
            repulsive functions of Netrin-1 in the ventral telencephalon
  JOURNAL   PLoS Biol 6 (5), e116 (2008)
   PUBMED   18479186
REFERENCE   6  (bases 1 to 3986)
  AUTHORS   Williams,M.E., Wu,S.C., McKenna,W.L. and Hinck,L.
  TITLE     Surface expression of the netrin receptor UNC5H1 is regulated
            through a protein kinase C-interacting protein/protein
            kinase-dependent mechanism
  JOURNAL   J Neurosci 23 (36), 11279-11288 (2003)
   PUBMED   14672991
  REMARK    GeneRIF: Surface expression of the netrin receptor UNC5H1 is
            regulated by Protein interacting with C kinase-1 and protein kinase
            C in neurons.
REFERENCE   7  (bases 1 to 3986)
  AUTHORS   Williams,M.E., Strickland,P., Watanabe,K. and Hinck,L.
  TITLE     UNC5H1 induces apoptosis via its juxtamembrane region through an
            interaction with NRAGE
  JOURNAL   J Biol Chem 278 (19), 17483-17490 (2003)
   PUBMED   12598531
REFERENCE   8  (bases 1 to 3986)
  AUTHORS   Barrett,C. and Guthrie,S.
  TITLE     Expression patterns of the netrin receptor UNC5H1 among developing
            motor neurons in the embryonic rat hindbrain
  JOURNAL   Mech Dev 106 (1-2), 163-166 (2001)
   PUBMED   11472849
  REMARK    GeneRIF: UNC5H1 expression colocalised with a number of cranial
            motor neuron subpopulations from embryonic day 11 (E11) to E14.
REFERENCE   9  (bases 1 to 3986)
  AUTHORS   Llambi,F., Causeret,F., Bloch-Gallego,E. and Mehlen,P.
  TITLE     Netrin-1 acts as a survival factor via its receptors UNC5H and DCC
  JOURNAL   EMBO J 20 (11), 2715-2722 (2001)
   PUBMED   11387206
REFERENCE   10 (bases 1 to 3986)
  AUTHORS   Leonardo,E.D., Hinck,L., Masu,M., Keino-Masu,K., Ackerman,S.L. and
            Tessier-Lavigne,M.
  TITLE     Vertebrate homologues of C. elegans UNC-5 are candidate netrin
            receptors
  JOURNAL   Nature 386 (6627), 833-838 (1997)
   PUBMED   9126742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Oct 24, 2022 this sequence version replaced NM_022206.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U87305.1, SRR26643296.36296.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000017.1  9675350-9675663     c
            315-536             JAXUCZ010000017.1  9634908-9635129     c
            537-680             JAXUCZ010000017.1  9630140-9630283     c
            681-784             JAXUCZ010000017.1  9629723-9629826     c
            785-965             JAXUCZ010000017.1  9629416-9629596     c
            966-1133            JAXUCZ010000017.1  9628642-9628809     c
            1134-1298           JAXUCZ010000017.1  9627924-9628088     c
            1299-1487           JAXUCZ010000017.1  9626445-9626633     c
            1488-1790           JAXUCZ010000017.1  9626033-9626335     c
            1791-1878           JAXUCZ010000017.1  9623414-9623501     c
            1879-2047           JAXUCZ010000017.1  9622966-9623134     c
            2048-2281           JAXUCZ010000017.1  9622565-9622798     c
            2282-2431           JAXUCZ010000017.1  9622289-9622438     c
            2432-2596           JAXUCZ010000017.1  9622040-9622204     c
            2597-2775           JAXUCZ010000017.1  9621358-9621536     c
            2776-3986           JAXUCZ010000017.1  9620005-9621215     c
FEATURES             Location/Qualifiers
     source          1..3986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3986
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /note="unc-5 netrin receptor A"
                     /db_xref="GeneID:60629"
                     /db_xref="RGD:621755"
     exon            1..314
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2941
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /note="netrin receptor UNC5A; unc-5 homolog 1; protein
                     unc-5 homolog A; protein unc-5 homolog 1; transmembrane
                     receptor Unc5H1"
                     /codon_start=1
                     /product="netrin receptor UNC5A precursor"
                     /protein_id="NP_071542.2"
                     /db_xref="GeneID:60629"
                     /db_xref="RGD:621755"
                     /translation="MAVRPGLWPVLLGIVLAAWLRGSGAQQSATVANPVPGANPDLLP
                     HFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDSSSGLPTM
                     EVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEV
                     SLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTAN
                     YTCVAKNIVARRRSTSAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLN
                     GGAFCEGQNVQKTACATLCPVDGSWSSWSKWSACGLDCTHWRSRECSDPAPRNGGEEC
                     RGADLDTRNCTSDLCLHTASGPEDVALYIGLVAVAVCLFLLLLALGLIYCRKKEGLDS
                     DVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQL
                     SNGHLLSPLGSGRHTLHHSSPTSEAEDFVSRLSTQNYFRSLPRGTSNMAYGTFNFLGG
                     RLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPVVSCGPPGV
                     LLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEESPSHLYYCQLEAGAC
                     YVFTEQLGRFALVGEALSVAATKRLRLLLFAPVACTSLEYNIRVYCLHDTHDALKEVV
                     QLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGT
                     QQYLHCTFTLERINASTSDLACKVWVWQVEGDGQSFNINFNITKDTRFAELLALESEG
                     GVPALVGPSAFKIPFLIRQKIIASLDPPCSRGADWRTLAQKLHLDSHLSFFASKPSPT
                     AMILNLWEARHFPNGNLGQLAAAVAGLGQPDAGLFTVSEAEC"
     exon            315..536
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..680
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..784
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..965
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1133
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1298
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1487
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1790
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1878
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2047
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2281
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2431
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2596
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2775
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..3986
                     /gene="Unc5a"
                     /gene_synonym="Unc5h1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggcggc tggctcggtg cgcggcgcgg ctggcgctgc gctccgcccc ggctgcattg
       61 ctgcgctccg ggtgcccagg ggagccacgc accgcgtgcg ccccgcagcc ggccgcccgg
      121 aggcagctcc gtcctctggc atgggccccg ggggcgcccc gaggtggggc tctcggctga
      181 ggcgctgaca gcctctctcc cgcccgcggg gccccgagtc ctgcccgctc gtccgcccgc
      241 ggccatggcc gtccggcccg gcctgtggcc agtgctcctg ggcatagtcc tcgccgcctg
      301 gcttcgtggt tcgggtgccc agcagagtgc cacggtggcc aatccagtgc ccggtgccaa
      361 ccccgacctg ctgccccact tcctggtaga gcctgaggac gtgtacattg tcaagaacaa
      421 gccggtgttg ttggtgtgca aggctgtgcc tgccacccag atcttcttca agtgcaatgg
      481 ggaatgggtc cgccaggtcg atcacgtaat tgaacgcagc accgacagca gcagcggatt
      541 gccaaccatg gaggtccgta tcaacgtatc gaggcagcag gtagagaaag tgtttgggct
      601 ggaggaatac tggtgccagt gtgtggcatg gagctcctcg ggtaccacca aaagtcagaa
      661 ggcctacatc cggattgcct atttgcgcaa gaactttgag caggagccac tggccaagga
      721 agtgtcactg gagcaaggca ttgtactacc ttgtcgcccc ccagaaggaa tccccccagc
      781 tgaggtggag tggcttcgaa atgaggacct cgtggacccc tccctcgatc ccaatgtgta
      841 catcacgcgg gagcacagcc tagtcgtgcg tcaggcccgc ctggccgaca cggccaacta
      901 cacctgtgtg gccaagaaca tcgtagcccg tcgccgaagc acctctgcag cggtcattgt
      961 ttatgtgaac ggtgggtggt cgacgtggac tgagtggtcc gtctgcagcg ccagctgtgg
     1021 gcgtggctgg cagaaacgga gccggagctg caccaacccg gcacctctca acgggggcgc
     1081 cttctgtgag gggcagaatg tccagaaaac agcctgcgcc actctgtgcc cagtggatgg
     1141 gagctggagt tcgtggagta agtggtcagc ctgtgggctt gactgcaccc actggcggag
     1201 ccgcgagtgc tctgacccag caccccgcaa tggaggtgag gagtgtcggg gtgctgacct
     1261 ggacacccgc aactgtacca gtgacctctg cctgcacacc gcttctggcc ccgaggacgt
     1321 ggctctctac atcggccttg tcgctgtggc tgtgtgcctc ttcttgctgt tgctggccct
     1381 tggcctcatt tactgtcgca agaaggaagg gctggactcc gatgtggccg actcgtccat
     1441 cctcacctcg ggcttccagc ctgtcagcat caagcccagc aaagcagaca acccccacct
     1501 gctcaccatc cagccagacc tcagcaccac cactaccacc taccagggca gtctatgtcc
     1561 gaggcaggat ggacccagcc ccaagttcca gctctctaat ggtcacctgc tcagcccact
     1621 ggggagtggc cgccatacgt tgcaccacag ctcacccacc tctgaggctg aggacttcgt
     1681 ctcccgcctc tccacccaaa actactttcg ttccctgccc cgcggcacca gcaacatggc
     1741 ctacgggacc ttcaacttcc tcgggggccg gctgatgatc cctaatacgg ggatcagcct
     1801 cctcataccc ccggatgcca tcccccgagg aaagatctac gagatctacc tcacactgca
     1861 caagccagaa gacgtgaggt tgcccctagc tggctgtcag accctgctga gtccagtcgt
     1921 tagctgtggg cccccaggag tcctgctcac ccggccagtc atccttgcaa tggaccactg
     1981 tggagagccc agccctgaca gctggagtct gcgcctcaaa aagcagtcct gcgagggcag
     2041 ttgggaggat gtgctgcacc ttggtgagga gtcaccttcc cacctctact actgccagct
     2101 ggaggccggg gcctgctatg tcttcacgga gcagctgggc cgctttgccc tggtaggaga
     2161 ggccctcagc gtggctgcca ccaagcgcct caggctcctt ctgtttgctc ccgtggcctg
     2221 tacgtccctt gagtacaaca tccgagtgta ctgcctacac gacacccacg acgctctcaa
     2281 ggaggtggtg cagctggaga agcagctagg tggacagctg atccaggagc ctcgcgtcct
     2341 gcacttcaaa gacagttacc acaacctacg tctctccatc cacgacgtgc ccagctccct
     2401 gtggaagagc aagctacttg tcagctacca ggagatccct ttttaccaca tctggaacgg
     2461 cacccagcag tatctgcact gcaccttcac cctggagcgc atcaacgcca gcaccagcga
     2521 cctggcctgc aaggtgtggg tgtggcaggt ggagggagat gggcagagct tcaacatcaa
     2581 cttcaacatc actaaggaca caaggtttgc tgaattgttg gctctggaga gtgaaggggg
     2641 ggtcccagcc ctggtgggcc ccagtgcctt caagatcccc ttcctcattc ggcaaaagat
     2701 catcgccagt ctggacccac cctgcagccg gggcgccgac tggagaactc tagcccagaa
     2761 acttcacctg gacagccatc ttagcttctt tgcctccaag cccagcccta cagccatgat
     2821 cctcaaccta tgggaggcac ggcacttccc caacggcaac ctcggccagc tggcagcagc
     2881 tgtggccgga ctgggccaac cagatgctgg cctcttcacg gtgtcggagg ccgagtgttg
     2941 agaccagcca ggccggtaat gcctacattc tcaccagctt tgacacctgc cagggacagg
     3001 caaaagccag acaggggccc ttcccccaca cccggggaga gctgcttgga caggccccct
     3061 cctggctgaa gttgtccctc gatgctggtc cttcagaccc tgcccaaact ccatccctcc
     3121 atggcctgcc cggccaggtt ggtctagcca cctgctctca ctctgccctg gtcccagggc
     3181 ccagagtaga cagtgcctgg agcctgggct gagcctcgcc agcccatctg tgtgtgtgtg
     3241 tatatgcgtg tgatgctacc tctcctcctg tcccttgcca ggggccccgc atacacacag
     3301 catgcacaca catgctgggc ttgggacacg gcccccagag ctcctgcctg aggtgggcct
     3361 tatgcaaaca tttccgtgcc tgctgggtag gggtatattt gaggggcctg gcttcaagcc
     3421 tgggggacta agggtcccag ctggacaggg gctggccctt ggattcaggc acacacgatc
     3481 accacacagg cgtgtgttca tgcatgcctt gtgtgctcat ctcacacgga ccccccctcc
     3541 caggtcatac aggaccctcc cccacgacac acatctcatg ctgtgcacct ggaggccgtt
     3601 cacgtctctc acgcccgggg tgtcggcaca catctgcctc tcacatgctg cccttctccc
     3661 tcccacccaa ccggggacac ctgacggctc ctccctgatc ctttccccga cccccctggc
     3721 ctcgaggtgc cccgcccagc ggggcgtgtg aatatgcaat gggagtccca ggctgggcag
     3781 tggcaggtgt gtgtgctgtg gcatgccagt ccccggggct ggccagtgcc cctgtgtggg
     3841 gcctgttgtg tgatgcttgt gtcctgactc tgtcttaagt gcacccgtgc acttacactt
     3901 ggccttatgt acacagcccg gctgccgggg cacgtaggga ttttagcgga tgtgaatgta
     3961 aataaattat atatatatat tgctaa
//
