LOCUS       NM_138844               4038 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus unc-13 homolog D (Unc13d), mRNA.
ACCESSION   NM_138844
VERSION     NM_138844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4038)
  AUTHORS   Higashio,H., Satoh,Y. and Saino,T.
  TITLE     Mast cell degranulation is negatively regulated by the
            Munc13-4-binding small-guanosine triphosphatase Rab37
  JOURNAL   Sci Rep 6, 22539 (2016)
   PUBMED   26931073
  REMARK    GeneRIF: results suggest that Rab37 is a Munc13-4-binding protein
            that inhibits mast cell degranulation through its effector protein,
            by counteracting the vesicle-priming activity of the Rab27-Munc13-4
            system
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4038)
  AUTHORS   Man,K.N., Imig,C., Walter,A.M., Pinheiro,P.S., Stevens,D.R.,
            Rettig,J., Sorensen,J.B., Cooper,B.H., Brose,N. and Wojcik,S.M.
  TITLE     Identification of a Munc13-sensitive step in chromaffin cell large
            dense-core vesicle exocytosis
  JOURNAL   Elife 4, e10635 (2015)
   PUBMED   26575293
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4038)
  AUTHORS   Zografou,S., Basagiannis,D., Papafotika,A., Shirakawa,R.,
            Horiuchi,H., Auerbach,D., Fukuda,M. and Christoforidis,S.
  TITLE     A complete Rab screening reveals novel insights in Weibel-Palade
            body exocytosis
  JOURNAL   J Cell Sci 125 (Pt 20), 4780-4790 (2012)
   PUBMED   22899725
REFERENCE   4  (bases 1 to 4038)
  AUTHORS   Peters,C.G., Michelson,A.D. and Flaumenhaft,R.
  TITLE     Granule exocytosis is required for platelet spreading: differential
            sorting of alpha-granules expressing VAMP-7
  JOURNAL   Blood 120 (1), 199-206 (2012)
   PUBMED   22589474
REFERENCE   5  (bases 1 to 4038)
  AUTHORS   Elstak,E.D., te Loo,M., Tesselaar,K., van Kerkhof,P., Loeffen,J.,
            Grivas,D., Hennekam,E., Boelens,J.J., Hoogerbrugge,P.M., van der
            Sluijs,P., van Gijn,M.E. and van de Corput,L.
  TITLE     A novel Dutch mutation in UNC13D reveals an essential role of the
            C2B domain in munc13-4 function
  JOURNAL   Pediatr Blood Cancer 58 (4), 598-605 (2012)
   PUBMED   21755595
  REMARK    GeneRIF: novel Dutch founder mutation leads to severe early onset
            of FHL3 due to misfolding and degradation of munc13-4(1-899).
REFERENCE   6  (bases 1 to 4038)
  AUTHORS   Crozat,K., Hoebe,K., Ugolini,S., Hong,N.A., Janssen,E.,
            Rutschmann,S., Mudd,S., Sovath,S., Vivier,E. and Beutler,B.
  TITLE     Jinx, an MCMV susceptibility phenotype caused by disruption of
            Unc13d: a mouse model of type 3 familial hemophagocytic
            lymphohistiocytosis
  JOURNAL   J Exp Med 204 (4), 853-863 (2007)
   PUBMED   17420270
  REMARK    Erratum:[J Exp Med. 2008 Mar 17;205(3):737]
REFERENCE   7  (bases 1 to 4038)
  AUTHORS   Menager,M.M., Menasche,G., Romao,M., Knapnougel,P., Ho,C.H.,
            Garfa,M., Raposo,G., Feldmann,J., Fischer,A. and de Saint Basile,G.
  TITLE     Secretory cytotoxic granule maturation and exocytosis require the
            effector protein hMunc13-4
  JOURNAL   Nat Immunol 8 (3), 257-267 (2007)
   PUBMED   17237785
REFERENCE   8  (bases 1 to 4038)
  AUTHORS   Neeft,M., Wieffer,M., de Jong,A.S., Negroiu,G., Metz,C.H., van
            Loon,A., Griffith,J., Krijgsveld,J., Wulffraat,N., Koch,H.,
            Heck,A.J., Brose,N., Kleijmeer,M. and van der Sluijs,P.
  TITLE     Munc13-4 is an effector of rab27a and controls secretion of
            lysosomes in hematopoietic cells
  JOURNAL   Mol Biol Cell 16 (2), 731-741 (2005)
   PUBMED   15548590
  REMARK    GeneRIF: Munc13-4 is a direct partner of rab27a.  The complex of
            the two proteins is an essential regulator of secretory granule
            fusion with the plasma membrane in hematopoietic cells.  Mutations
            in either of the two genes prevent formation of this complex.
REFERENCE   9  (bases 1 to 4038)
  AUTHORS   Feldmann,J., Callebaut,I., Raposo,G., Certain,S., Bacq,D.,
            Dumont,C., Lambert,N., Ouachee-Chardin,M., Chedeville,G.,
            Tamary,H., Minard-Colin,V., Vilmer,E., Blanche,S., Le Deist,F.,
            Fischer,A. and de Saint Basile,G.
  TITLE     Munc13-4 is essential for cytolytic granules fusion and is mutated
            in a form of familial hemophagocytic lymphohistiocytosis (FHL3)
  JOURNAL   Cell 115 (4), 461-473 (2003)
   PUBMED   14622600
REFERENCE   10 (bases 1 to 4038)
  AUTHORS   Koch,H., Hofmann,K. and Brose,N.
  TITLE     Definition of Munc13-homology-domains and characterization of a
            novel ubiquitously expressed Munc13 isoform
  JOURNAL   Biochem J 349 (Pt 1), 247-253 (2000)
   PUBMED   10861235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 1, 2020 this sequence version replaced NM_138844.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF159356.1, SRR26643289.30021.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               JAXUCZ010000010.1  101810108-101810409 c
            303-338             JAXUCZ010000010.1  101809395-101809430 c
            339-446             JAXUCZ010000010.1  101809074-101809181 c
            447-506             JAXUCZ010000010.1  101808926-101808985 c
            507-573             JAXUCZ010000010.1  101808771-101808837 c
            574-754             JAXUCZ010000010.1  101808359-101808539 c
            755-799             JAXUCZ010000010.1  101807423-101807467 c
            800-868             JAXUCZ010000010.1  101807261-101807329 c
            869-938             JAXUCZ010000010.1  101807057-101807126 c
            939-1043            JAXUCZ010000010.1  101806808-101806912 c
            1044-1136           JAXUCZ010000010.1  101806596-101806688 c
            1137-1240           JAXUCZ010000010.1  101806416-101806519 c
            1241-1358           JAXUCZ010000010.1  101803785-101803902 c
            1359-1483           JAXUCZ010000010.1  101803589-101803713 c
            1484-1574           JAXUCZ010000010.1  101803367-101803457 c
            1575-1631           JAXUCZ010000010.1  101803228-101803284 c
            1632-1729           JAXUCZ010000010.1  101803048-101803145 c
            1730-1781           JAXUCZ010000010.1  101802915-101802966 c
            1782-1906           JAXUCZ010000010.1  101802713-101802837 c
            1907-2027           JAXUCZ010000010.1  101802471-101802591 c
            2028-2171           JAXUCZ010000010.1  101801878-101802021 c
            2172-2270           JAXUCZ010000010.1  101801591-101801689 c
            2271-2477           JAXUCZ010000010.1  101801278-101801484 c
            2478-2546           JAXUCZ010000010.1  101801065-101801133 c
            2547-2626           JAXUCZ010000010.1  101800015-101800094 c
            2627-2732           JAXUCZ010000010.1  101798946-101799051 c
            2733-2804           JAXUCZ010000010.1  101798799-101798870 c
            2805-2888           JAXUCZ010000010.1  101798252-101798335 c
            2889-3009           JAXUCZ010000010.1  101798035-101798155 c
            3010-3133           JAXUCZ010000010.1  101797736-101797859 c
            3134-3330           JAXUCZ010000010.1  101797156-101797352 c
            3331-4038           JAXUCZ010000010.1  101795652-101796359 c
FEATURES             Location/Qualifiers
     source          1..4038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4038
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /note="unc-13 homolog D"
                     /db_xref="GeneID:192177"
                     /db_xref="RGD:628593"
     exon            1..302
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3452
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /note="contains two C2 domains"
                     /codon_start=1
                     /product="protein unc-13 homolog D"
                     /protein_id="NP_620199.2"
                     /db_xref="GeneID:192177"
                     /db_xref="RGD:628593"
                     /translation="MATHLSHPQRRPPLLRQAVKIRRRRVRDLQDPPPQATPEVQVQS
                     HHFSPEERDLLYEEALYTILHRLGQPEPNHVKEASELLCYLQEAFQVQPEEHQQMLQR
                     VRELEKPIFCLKATVKQAKGILGKDVSGFSDPYCLLGIEQKVGVPEGSPVSRRRQKAV
                     VRHTIPEEETHRTQVKTQTLNPVWDETFILEFEDITNASFHLDMWDLDTVESVRHKLG
                     ELTDLHGLRRIFKEARKDKGQDDFLGNVMLRLQDLRCREDQWFPLEPCTETYPDRGQC
                     HLQFQFIHKRRATVASRSQPSYTVHFHLLQQLVSHEVTQHQAGGTSWDASLSPQAVTI
                     LFLHATQKDLSDFHQSMAQWLAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQR
                     EELATSFTSLLAYGLSLIRKFRSVFPLSVSDSPSRLQSLLRVLVQMCKMKAFGELCPD
                     SAPLPQLVSEALRMGTVEWFHLMQQHHQPMVQGILEAGKALLSLVQDVMGDLYQCRRT
                     WNKIFHNVLKIDLFTMAFLELQWLVAKRVQDHTAAVGDLVSPDVGESLFQLYVSLREF
                     CQLGPSDSHEVLALDGFHRWFQSAIPSWLQRTYSVALERVQRAVQMDSLVPLGELTKH
                     STSAVDLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARAREL
                     SAVQKDQSQAADMLCVVVNNVERLRLIIDKLPTQLAWEALEQRVGAVLEQGQLQNTLH
                     TQLQGALAGLGHEIRTGVRTLAEQLEVGIATHIQKLIDAKGSILPEDAILPLMKFLEV
                     KLCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASHRNSSLASSRLKVALQNLEICFH
                     AEGCGLPPEALHTDTFLALQSDLELQAASSRELIQKYFRSRIQQQAETTSERLGAVTV
                     KASYRASEQKLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKE
                     LHPLFDETFEFLVPAEPCQKDGACLLLTVLDHDRLGADDLEGEAFLPLCRVPGLTGCV
                     EPGEAPQMRLPLTYPAPNGDPILRLLESRKGDREAQAFVKLRRQRAKQASQHAPATEP
                     "
     exon            303..338
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            339..446
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            447..506
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            507..573
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..754
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            755..799
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            800..868
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            869..938
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1043
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1136
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1240
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1358
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1483
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1574
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1631
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1729
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1781
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1906
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2027
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2171
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2270
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2477
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2546
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2626
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2732
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2804
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2888
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3009
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3133
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3330
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..4038
                     /gene="Unc13d"
                     /gene_synonym="Munc13-4; Unc13h4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcaaggctg aagggagttg ctgggaacct ggagaaggcc ccgccaaggc agtgacaccc
       61 taacccttcc atccctccac cctcctcggc agagtgtacc ctggggctct ttgcatcacc
      121 ctgcggcttc cttgtttcca cccggcagct ggggggtggc ggagtgaagg gcagagccaa
      181 ccaccatggc gacacacctc tcccaccccc agcggcgccc tccactcttg cgccaggccg
      241 tcaagataag gcgccgcagg gtcagagacc tgcaggatcc accgccccaa gccaccccgg
      301 aggtccaggt tcaatcccac cacttctccc cggaggagcg ggacctgctg tatgaggaag
      361 ccctctatac catcctgcac cgcctgggtc agccagagcc caaccatgtg aaggaggcct
      421 cggaactgct gtgctatctg caggaggctt tccaggtgca gcccgaggag caccagcaga
      481 tgctacagcg tgtcagggag cttgagaagc caatattttg tctgaaggca acagtgaaac
      541 aggccaaggg cattctgggc aaggatgtca gcgggttcag cgacccctat tgcctgctgg
      601 gcatcgagca gaaggttggt gtgccggagg gcagccctgt gtcccggcgt cggcagaagg
      661 ccgtggtgag gcacaccatc cctgaagagg agacccatcg cacccaagtc aagacccaga
      721 cacttaatcc cgtctgggac gagaccttta tcttggagtt tgaggatata actaacgcaa
      781 gctttcacct ggacatgtgg gacctggaca ctgtggagtc tgtcaggcac aagctcgggg
      841 agctcacaga cctgcatggg ctcaggagga tctttaaaga agctcggaag gataaaggcc
      901 aggacgactt tctggggaat gtgatgctaa gattgcagga cctgcgctgc cgagaggatc
      961 agtggttccc gctagagccc tgcacagaga cctacccaga ccgcggccag tgtcacctgc
     1021 agttccaatt cattcacaag cggagagcca cggtggccag ccgctcccag cccagctaca
     1081 ctgtacactt tcacctactg cagcagctgg tgtcccatga agtcacacag caccaggccg
     1141 gcggtacctc ctgggacgca tcgctgagtc cccaggccgt caccatcctc tttctccacg
     1201 ccacccagaa ggacctgtca gacttccacc agtccatggc gcagtggttg gcctacagcc
     1261 gcctctacca gagcctggag ttccctagca gctgcctcct gcaccccatc accagcatag
     1321 agtaccagtg gatccagggc cgactcaaag cggaacagcg ggaggagttg gccacctcct
     1381 tcacatccct gttggcctat ggcctctccc tcatccggaa gttccgctcc gtctttcccc
     1441 tgtctgtctc tgactccccg tccaggctgc agtccctcct cagagtcttg gtccagatgt
     1501 gcaagatgaa ggcctttgga gaactgtgcc cagacagtgc cccactgccc cagctggttt
     1561 ccgaagccct gcggatgggc acagttgaat ggtttcacct gatgcagcaa caccaccagc
     1621 cgatggtaca gggcatcttg gaggctggca aggccttgct gagcctggta caggacgtta
     1681 tgggtgatct gtaccagtgc cgtcgcacat ggaacaagat ttttcacaat gtcctcaaga
     1741 tagacctgtt caccatggcc ttcctggagc tgcaatggct ggtggccaag agggtacagg
     1801 accacacggc ggcggtcggc gaccttgttt ctccagatgt tggagagagt ctgtttcagc
     1861 tctatgtcag cctgagggag ttctgccagc tgggcccctc agacagccat gaagtcctgg
     1921 ccctggatgg tttccaccgc tggtttcagt cagccatccc ttcctggctg cagaggacct
     1981 atagcgttgc cctggagcgg gtgcagcgag ccgtacagat ggactcgctg gtacccctgg
     2041 gtgaactgac caagcatagc acttctgctg tggatctgtc tacctgcttt gcccaaatta
     2101 gccacactgc ccggcagctg gactggccag acccagagga ggccttcatg atcacggtca
     2161 agttcgtgga ggacacctgc cggctggccc tggtctactg cagccttata aaggcccggg
     2221 cccgagagct gtctgcggtt cagaaggacc agagccaggc agctgacatg ctgtgcgtgg
     2281 tggtaaataa tgtggagcga ctacggttga tcatcgacaa gctgcccacc caactggcat
     2341 gggaggcatt ggagcagcgg gtcggggctg tgctggagca ggggcagctg cagaacacgc
     2401 tacacactca gctgcagggc gccttggccg ggctgggcca cgagatccgt accggtgtcc
     2461 gtactctggc agagcagttg gaagtgggca ttgccacaca catccagaag ctcatcgatg
     2521 ccaaggggtc gattctgcct gaggatgcca ttctgcccct gatgaaattc ctggaggtga
     2581 agctttgtta catgaacacc aacctggtcc aggagaactt cagcagcctc ctgactctac
     2641 tgtggaccca cacacttacc gtgctggtgg aggcggcggc ttcccatcgt aactcgtcac
     2701 tggcttctag caggctgaag gtcgccctcc agaacctgga gatctgcttc catgctgagg
     2761 gctgtggtct accaccagag gccctgcaca cagacacctt cctggctctg cagagcgacc
     2821 tggagctgca ggcagcctcc agccgggagc tcatccagaa gtacttccgt agccggatcc
     2881 aacagcaggc ggaaaccact tctgagaggc tgggtgcagt cacggtcaag gcgtcctatc
     2941 gagcctctga gcagaagctg cacgtggagc tgctcagtgc ctccagcctg ctgccccttg
     3001 actccaatgg ttccagtgac ccctttgttc agctgacact ggaacccaga catgaattcc
     3061 ctgagctggc tccccgggag acccagaagc acaagaagga acttcacccg ctctttgatg
     3121 agacctttga attcctggtg cctgctgagc cgtgccaaaa agacggggcg tgcctcctgc
     3181 tcactgtgct ggaccacgac aggctgggag ctgatgacct ggagggagag gccttcttac
     3241 cgctctgcag ggtacctgga ctgacaggct gtgtggagcc tggcgaagca cctcagatgc
     3301 gcctgcctct cacataccct gcacccaatg gggatccgat tttacggctg ctggagagcc
     3361 ggaagggtga tcgcgaggcc caggcctttg tgaagctgag gaggcagcgg gccaagcagg
     3421 cctcccagca tgcccccgca acagagccat agcagcggaa gcaaagccag agtcctgaaa
     3481 gtttggggtt ttccttgccg cagggaagcc cttcatcctg gtgtaacata ggcagaacca
     3541 gtaggtggag ggcccagagt tctcgacaga acagcccttg gtgatggagc accatgacca
     3601 ggctttatcc tttcttgtgc cacggctgtg ttctctgccg tattctagtt cagaggaaca
     3661 tctctctgct cctccccctg ccccagaaaa gctgccttgg taggttagca gagtgtctag
     3721 ggccatctgc cttctagaac tgccagttcc agagactggg gtggggccag actactagga
     3781 ccagagctgt gggcacaaac ttcagaggac tctgtcaaag ccgccctggt gcagggaggg
     3841 ggtggccatt actgagggaa gtgggaaaaa agagactctg gctctgaggt gagagctggc
     3901 aggaaggagg gcaggcacag atggagagcc acacacagga gagtttggct gtctacagaa
     3961 gagccttcct ccctcagata acacctgcca cctagaaatg ttctcagtga aaataaaaat
     4021 aaaacattgt ccactgcc
//
