LOCUS       NM_022862               7769 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus unc-13 homolog B (Unc13b), transcript variant 1,
            mRNA.
ACCESSION   NM_022862
VERSION     NM_022862.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7769)
  AUTHORS   Piotrowski,C., Moretti,R., Ihling,C.H., Haedicke,A., Liepold,T.,
            Lipstein,N., Meiler,J., Jahn,O. and Sinz,A.
  TITLE     Delineating the Molecular Basis of the Calmodulin-bMunc13-2
            Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel
            CaM Binding Motif in bMunc13-2
  JOURNAL   Cells 9 (1), 136 (2020)
   PUBMED   31936129
  REMARK    GeneRIF: Delineating the Molecular Basis of the CalmodulinbMunc13-2
            Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel
            CaM Binding Motif in bMunc13-2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7769)
  AUTHORS   Persoon,C.M., Hoogstraaten,R.I., Nassal,J.P., van Weering,J.R.T.,
            Kaeser,P.S., Toonen,R.F. and Verhage,M.
  TITLE     The RAB3-RIM Pathway Is Essential for the Release of
            Neuromodulators
  JOURNAL   Neuron 104 (6), 1065-1080 (2019)
   PUBMED   31679900
REFERENCE   3  (bases 1 to 7769)
  AUTHORS   Kawabe,H., Mitkovski,M., Kaeser,P.S., Hirrlinger,J., Opazo,F.,
            Nestvogel,D., Kalla,S., Fejtova,A., Verrier,S.E., Bungers,S.R.,
            Cooper,B.H., Varoqueaux,F., Wang,Y., Nehring,R.B.,
            Gundelfinger,E.D., Rosenmund,C., Rizzoli,S.O., Sudhof,T.C.,
            Rhee,J.S. and Brose,N.
  TITLE     ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a
            specific subset of active zones
  JOURNAL   J Cell Biol 216 (4), 1143-1161 (2017)
   PUBMED   28264913
  REMARK    Erratum:[J Cell Biol. 2017 Apr 3;216(4):1205. doi:
            10.1083/jcb.20160608603092017c.. PMID: 28289090]
REFERENCE   4  (bases 1 to 7769)
  AUTHORS   Man,K.N., Imig,C., Walter,A.M., Pinheiro,P.S., Stevens,D.R.,
            Rettig,J., Sorensen,J.B., Cooper,B.H., Brose,N. and Wojcik,S.M.
  TITLE     Identification of a Munc13-sensitive step in chromaffin cell large
            dense-core vesicle exocytosis
  JOURNAL   Elife 4, e10635 (2015)
   PUBMED   26575293
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7769)
  AUTHORS   Imig,C., Min,S.W., Krinner,S., Arancillo,M., Rosenmund,C.,
            Sudhof,T.C., Rhee,J., Brose,N. and Cooper,B.H.
  TITLE     The morphological and molecular nature of synaptic vesicle priming
            at presynaptic active zones
  JOURNAL   Neuron 84 (2), 416-431 (2014)
   PUBMED   25374362
  REMARK    Erratum:[Neuron. 2014 Nov 19;84(4):882]
REFERENCE   6  (bases 1 to 7769)
  AUTHORS   Song,Y., Ailenberg,M. and Silverman,M.
  TITLE     Human munc13 is a diacylglycerol receptor that induces apoptosis
            and may contribute to renal cell injury in hyperglycemia
  JOURNAL   Mol Biol Cell 10 (5), 1609-1619 (1999)
   PUBMED   10233166
REFERENCE   7  (bases 1 to 7769)
  AUTHORS   Augustin,I., Betz,A., Herrmann,C., Jo,T. and Brose,N.
  TITLE     Differential expression of two novel Munc13 proteins in rat brain
  JOURNAL   Biochem J 337 (Pt 3) (Pt 3), 363-371 (1999)
   PUBMED   9895278
REFERENCE   8  (bases 1 to 7769)
  AUTHORS   Betz,A., Ashery,U., Rickmann,M., Augustin,I., Neher,E.,
            Sudhof,T.C., Rettig,J. and Brose,N.
  TITLE     Munc13-1 is a presynaptic phorbol ester receptor that enhances
            neurotransmitter release
  JOURNAL   Neuron 21 (1), 123-136 (1998)
   PUBMED   9697857
REFERENCE   9  (bases 1 to 7769)
  AUTHORS   Song,Y., Ailenberg,M. and Silverman,M.
  TITLE     Cloning of a novel gene in the human kidney homologous to rat
            munc13s: its potential role in diabetic nephropathy
  JOURNAL   Kidney Int 53 (6), 1689-1695 (1998)
   PUBMED   9607201
REFERENCE   10 (bases 1 to 7769)
  AUTHORS   Brose,N., Hofmann,K., Hata,Y. and Sudhof,T.C.
  TITLE     Mammalian homologues of Caenorhabditis elegans unc-13 gene define
            novel family of C2-domain proteins
  JOURNAL   J Biol Chem 270 (42), 25273-25280 (1995)
   PUBMED   7559667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 30, 2020 this sequence version replaced NM_022862.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U24071.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000005.1  62245629-62245849
            222-2744            JAXUCZ010000005.1  62252208-62254730
            2745-2767           JAXUCZ010000005.1  62264237-62264259
            2768-2814           JAXUCZ010000005.1  62266419-62266465
            2815-2893           JAXUCZ010000005.1  62268811-62268889
            2894-2899           JAXUCZ010000005.1  62270159-62270164
            2900-2974           JAXUCZ010000005.1  62270930-62271004
            2975-3194           JAXUCZ010000005.1  62271448-62271667
            3195-3422           JAXUCZ010000005.1  62272773-62273000
            3423-3564           JAXUCZ010000005.1  62273572-62273713
            3565-3734           JAXUCZ010000005.1  62275195-62275364
            3735-3850           JAXUCZ010000005.1  62275740-62275855
            3851-4014           JAXUCZ010000005.1  62276119-62276282
            4015-4165           JAXUCZ010000005.1  62276896-62277046
            4166-4234           JAXUCZ010000005.1  62279241-62279309
            4235-4324           JAXUCZ010000005.1  62280773-62280862
            4325-4453           JAXUCZ010000005.1  62281498-62281626
            4454-4578           JAXUCZ010000005.1  62285372-62285496
            4579-4664           JAXUCZ010000005.1  62286130-62286215
            4665-4791           JAXUCZ010000005.1  62291287-62291413
            4792-4888           JAXUCZ010000005.1  62291635-62291731
            4889-5032           JAXUCZ010000005.1  62291941-62292084
            5033-5110           JAXUCZ010000005.1  62292580-62292657
            5111-5188           JAXUCZ010000005.1  62293062-62293139
            5189-5277           JAXUCZ010000005.1  62293606-62293694
            5278-5430           JAXUCZ010000005.1  62293898-62294050
            5431-5554           JAXUCZ010000005.1  62294160-62294283
            5555-5611           JAXUCZ010000005.1  62294391-62294447
            5612-5692           JAXUCZ010000005.1  62294580-62294660
            5693-5840           JAXUCZ010000005.1  62295177-62295324
            5841-5897           JAXUCZ010000005.1  62296701-62296757
            5898-5990           JAXUCZ010000005.1  62297407-62297499
            5991-6150           JAXUCZ010000005.1  62297944-62298103
            6151-7769           JAXUCZ010000005.1  62298266-62299884
FEATURES             Location/Qualifiers
     source          1..7769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..7769
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /note="unc-13 homolog B"
                     /db_xref="GeneID:64830"
                     /db_xref="RGD:619723"
     exon            1..221
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..2744
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..6436
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /note="isoform b is encoded by transcript variant 1;
                     protein unc-13 homolog B"
                     /codon_start=1
                     /product="protein unc-13 homolog B isoform b"
                     /protein_id="NP_074053.2"
                     /db_xref="GeneID:64830"
                     /db_xref="RGD:619723"
                     /translation="MKRLLRESEEEIMLTLGPSSSLSPDQVRTETVCIVKGKSTGPTG
                     SLPEDNFPPPCCESADSTTSGERDRDLAQLGSFEQQASSQPSLACTACASGSDSRELS
                     PASITSCSEPSERNQARPIFPRGPGQRCRHEHQEPLGDVVEYIIRELQGISRLQSEIA
                     ELQQHLNQVRGSVDEVSSCVDSVLSEIEGLHVGSSSLGKVRHGEKAQELHVERSREEA
                     ILYLYGLPEHDGESTVELVDNFLAKHLCVNGMQCNRYVREAYRAGTAPAPRPTVVKLV
                     HPEHRDLILQKSILLQSVGVRVATREEPVWPEGCKNPPKESLSCLQQFQDHSRNHQGK
                     PALQLETGNRRQMSGPHQMRTQNQHRELQASEHQGLSFLPKDGSAKQSDVSKLQDEVK
                     GTSGAPQVISDPCGELSLLHQLEGSSPVLIPKEEDCGKLQIFKQDSQEHKACNVTKLQ
                     SDCNNAIKASSCLSLSGPLKAEKVNAEDRMLGGEDGLDILSPKQLEDLLADKSRRFAT
                     LNPDSAVEEVIIGPETFSNMVHIDLNEEETCTAQVLKNVFDKSSCVLGGSQEDEDVEI
                     KFHTTKLSRAIHHFRLALQGVFQKLENNGSISPEDLESNESGSQSENSDRLLWTVSSG
                     GAHDCSVESPASQGSESLLSVVSGGVGISVQGDQTPQAPSNFSLASNNSPLTNSLLSF
                     PLAPGLGNETCSRPDSPNQGKLSLEQVCAETIYLNKCINNFKNVLREKRLRQKKLLQE
                     LVQTASHLSVEDIPSEGKREALQISDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKP
                     LPLVSDLAMSLVQSRKAGITSAMATRTSLKDEDLKSHVYKKTLQALIYPISCTTPHNF
                     EVWSATTPTYCYECEGLLWGLARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSSKH
                     GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVSKVAHVQQMKTVKQSVLDGTS
                     KWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIFGNLNPVWEEKFHFE
                     CHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKR
                     TDKSAVSGAIRLQINVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVWIPDARG
                     DDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANI
                     NAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPER
                     LQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYS
                     HQYQLQEQPLEEPGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVS
                     AEVMWHLFAQDMKYALEEHEKDRLCKSADYMNLHFKVKWLHNEYVRELPALQGQVPEY
                     PAWFEQFVLQWLDENEDVSLEFLRGALERDKRDGFQQTSEHALFSCSVVDVFTQLNQS
                     FEIIRKLECPDPSILAHYMRRFAKTIGKVLIQYADILSKNFPAYCTKERLPCILMNNM
                     QQLRVQLEKMFEAMGGKELDSEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVR
                     QMADILGQVRGTGNASPNARASVAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVL
                     KELWRVVMNTMERVIVLPPLIDQTGTQLILTAAKELSQLSKLKDHMVREETRNLTPKQ
                     CAVLDLALDTVKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQ
                     TAQVHDGKGIRFTANEDIRPEKGAGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAAN
                     DLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNSWTPKYNETFHFLLGNEEGPE
                     AYELQICVKDYCFAREDRVIGLAVMPLRDVAAKGSCACWCPLGRKIHMDETGMTILRI
                     LSQRSNDEVAREFVKLKSESRSIEEGS"
     exon            2745..2767
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2814
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2893
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2899
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2974
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3194
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3422
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3564
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3734
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3850
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..4014
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4165
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4234
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4235..4324
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4453
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4454..4578
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4579..4664
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4791
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4792..4888
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            4889..5032
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5110
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5111..5188
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5189..5277
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5278..5430
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5431..5554
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5555..5611
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5612..5692
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5693..5840
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5841..5897
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5898..5990
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            5991..6150
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
     exon            6151..7769
                     /gene="Unc13b"
                     /gene_synonym="Munc13-2; Unc13h2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagaataa tagctccttg gttccgtttg ttgcttaggc aggcggctgt gccatggctc
       61 agaaagttca tcctgtggct tctctgtcag tctgaggcgt gcttctgaga ggactactgc
      121 ttaaaggcag cagcacttgc attctaaaac ttgagaattt gtggctttaa tattttcttc
      181 ccttttcatt tccttaacct tattttggtt tcagcaccaa ggatgaaagc caagccagga
      241 tccagagaca tgtgtcaggt ttgaggccta tacatgaggt cattccaggc agtactgtgg
      301 ctaaacctaa gccttcagtt aacaatagtt gttaaaaacc aactcaaaaa agaaaggaag
      361 gaagaagaaa agaaagaaag gggactaggc tcttccaagg ccatttctat tcagcatccc
      421 agcaagaaaa gaggaaaaag aaagaagcaa agagccgtca cctctcctga gggggaaaat
      481 gaaacgactg ttgcgggagt ctgaggaaga aatcatgctg acactgggac cttcatccag
      541 cctctcacca gatcaggtca ggacagagac tgtgtgtatt gtcaagggca agtccacagg
      601 tcctactggg tccttgccag aggacaactt cccaccccct tgctgtgagt cagcagactc
      661 caccactagt ggagagagag atagggacct ggcccaactt ggtagctttg agcagcaagc
      721 cagtagccaa ccttctctgg cctgcactgc ttgtgcttca gggtctgatt ctcgggaact
      781 ctcgcctgcc agcataacaa gctgttcaga gccttcagag agaaaccaag ccaggcccat
      841 attccccaga ggtcctggcc aaagatgtag gcatgagcat caggagcctc tgggagatgt
      901 agtagaatat atcatcagag agctgcaagg aatcagtcgt ctccagtctg agattgctga
      961 gctgcaacag cacttgaacc aagtccgggg ctctgtggat gaagtatcta gctgtgtaga
     1021 ttcagtgctg agtgaaatag aaggcttgca cgtgggtagc agctccctgg gcaaagtacg
     1081 ccatggggaa aaggcccagg aactccatgt agaaagatcc agagaggaag ctattcttta
     1141 tttgtatgga cttcctgaac atgatgggga aagcactgtg gaactggtag ataactttct
     1201 agctaagcac ctctgtgtta atggcatgca gtgcaacagg tatgtcagag aggcatacag
     1261 ggcaggcaca gctcctgccc cccggcccac tgtggtgaaa cttgtccacc cagagcacag
     1321 agacctcatc ttgcaaaaat ccatcctctt gcagagtgtg ggggtcaggg ttgctaccag
     1381 agaggaacca gtctggccag aagggtgtaa gaatccccca aaggagtctc tctcatgctt
     1441 gcaacaattt caagaccaca gtcggaacca tcagggtaaa ccagctcttc agctagaaac
     1501 agggaacaga agacaaatgt cgggaccaca ccagatgagg actcagaatc aacatagaga
     1561 actccaggct tctgagcatc aagggcttag tttcctacca aaggatggct cagcaaaaca
     1621 gagtgatgtg tctaagctgc aggatgaagt aaaaggaaca tcaggagctc cccaggtaat
     1681 cagtgatcct tgtggtgaac tttctctcct ccatcaactt gaggggtctt ccccagtgtt
     1741 aatcccaaaa gaggaagatt gtggaaaatt acagattttc aaacaggaca gccaagagca
     1801 taaggcatgt aacgtgacaa agctacaaag tgattgcaac aatgcaatta aagccagcag
     1861 ttgcctttca ttgtctggac cactgaaagc agagaaggta aacgcagagg acaggatgct
     1921 aggcggtgaa gatggacttg atattctgag cccaaagcag ctggaggacc ttttggcaga
     1981 caagtctagg aggtttgcga ctctgaatcc tgacagcgca gtggaggaag tgatcatagg
     2041 acccgagact ttcagtaaca tggtgcatat tgacctgaat gaagaagaga cctgtactgc
     2101 ccaggtcctt aagaatgtct ttgataagtc ctcatgtgtt ctgggtggct cccaggagga
     2161 tgaagatgta gaaattaaat ttcacacaac taagctgagt cgagcgatcc accacttccg
     2221 tttggctctt cagggggtat ttcagaagct ggagaacaat gggtccatca gtcctgagga
     2281 cctggaaagc aatgagagtg gttcccagtc agaaaacagt gatagacttc tttggacagt
     2341 aagttcagga ggtgcccacg attgttcagt ggagagtcca gcaagtcagg ggagtgagag
     2401 cttgctcagt gtggtctctg gtggagtagg catctctgta cagggtgatc agacacctca
     2461 agcaccaagt aacttctctc ttgcttctaa caactcacct cttacaaact cattgctcag
     2521 tttccctcta gccccaggtc tgggaaacga gacttgttcc aggcctgact ctcctaatca
     2581 aggcaaactg agtttagaac aagtatgtgc agagaccatt taccttaaca aatgcatcaa
     2641 caattttaaa aacgtcctaa gagagaaaag actgaggcag aaaaaacttt tgcaagagct
     2701 agtacagacg gcaagtcatc tttcagtaga agacatcccc tcagaaggaa agcgagaagc
     2761 tcttcagatt tcagatgatg gtgacccctc cttgcctcag tggctcccag aagggccagc
     2821 gggagggctc tatggcatcg acagcatgcc agatctacga agaaagaagc cactgccact
     2881 tgtcagtgat ctggctatgt cactggtcca gtcacggaaa gcagggatta cttccgctat
     2941 ggctacacgt acctctctca aggatgaaga tctgaaatcc catgtgtata agaaaactct
     3001 gcaggcctta atctacccca tctcgtgcac cacgccccac aactttgagg tctggtctgc
     3061 cacgacaccc acctactgct atgagtgtga aggcttgctc tggggccttg cccggcaagg
     3121 catgcgctgc agcgagtgtg gcgtcaagtg ccatgagaag tgccaagacc tgctcaatgc
     3181 cgattgccta cagcgggccg ctgaaaagag ctctaagcac ggagctgagg accggactca
     3241 gaacattatc atggccatga aggaccgtat gaagatccga gaacggaata aaccagagat
     3301 ctttgaggtt atccgggatg tgttcacagt gagcaaagtt gcccacgtgc agcagatgaa
     3361 aacagtaaag cagagtgtcc tggatggcac ctccaagtgg tcggccaaaa ttaccatcac
     3421 ggtggtttgt gcccagggcc tacaagccaa agacaagaca ggatccagtg acccttatgt
     3481 gactgtgcaa gttgggaaaa ccaagaagcg cactaagacc atttttggaa atttgaatcc
     3541 tgtttgggag gagaagttcc attttgagtg ccacaactct tccgatcgaa ttaaggtacg
     3601 tgtgtgggat gaggatgatg acatcaaatc cagagtaaag cagcggctga agcgagagtc
     3661 ggatgatttc cttggccaaa ctatcattga agttcgaacg ctgagtggag agatggatgt
     3721 ctggtataat ctggagaaga gaacagacaa gtcagctgtc tcaggggcta tccgactgca
     3781 aatcaatgtg gagatcaagg gggaggagaa ggtagcccca taccatgtgc aatacacatg
     3841 tctccatgag aatcttttcc attacctcac agacattcag ggcagtggag gagtctggat
     3901 cccagacgct cggggggacg atgcatggaa ggtgtacttt gacgagacag cccaagaaat
     3961 tgtggatgaa tttgccatgc gctatggcat cgagtccata tatcaggcca tgacgcactt
     4021 tgcgtgtttg tcatccaagt acatgtgtcc tggcgtacca gccgtgatga gtaccttact
     4081 ggccaacatc aatgcgtatt atgctcacac aaccgcctcc actaacgtct ctgcatctga
     4141 ccgctttgcc gcctccaact ttggtaaaga aagatttgta aaactgctgg accagctaca
     4201 caactcactg aggatagacc tgtctacata caggaataac tttcctgctg ggagccctga
     4261 gcggctccag gatttaaaat ctacagtgga cttgctgacc agcattactt tcttcaggat
     4321 gaaggtgcaa gaacttcaga gccccccaag agccagccag gtggtaaagg actgtgtgaa
     4381 ggcctgcttg aactctacat atgaatacat cttcaacaac tgccatgacc tctacagtca
     4441 ccaataccag ctgcaggaac aaccactaga ggaaccaggg cccagcattc ggaacttgga
     4501 tttctggccc aaacttatca cactgattgt gtcaatcata gaggaggata agaattccta
     4561 cacacctgtt ctgaaccagt ttcctcagga gttgaatgta ggaaaagtca gtgcagaagt
     4621 gatgtggcac ctgtttgctc aagacatgaa atatgcactg gaggaacatg agaaagaccg
     4681 gctgtgtaag agtgctgact acatgaacct gcacttcaag gtgaagtggc tccacaatga
     4741 atatgtgcgg gagctgcctg ccctccaggg gcaggtgcct gagtacccag cgtggtttga
     4801 gcagttcgtg ctacagtggc tagatgaaaa tgaagacgtg tccctggaat tccttcgtgg
     4861 ggccttggaa cgagataaga gagatgggtt ccagcaaaca tcggagcatg ccttgttttc
     4921 ctgttctgtg gtggacgtct ttacacaact caaccagagc tttgagatca tccggaaatt
     4981 ggaatgtcca gaccccagca tccttgccca ttatatgaga aggtttgcta agaccatcgg
     5041 caaagtgctg atacagtatg cagacatctt atcaaagaac ttcccagctt actgcacaaa
     5101 ggagagactg ccctgtatcc tgatgaacaa catgcagcaa ctgagggtcc agctggagaa
     5161 aatgtttgag gccatgggag gcaaagagct ggactctgaa gctgcagaca gtctgaagga
     5221 gctgcaggtg aaactgaata cagttctgga tgagctcagc atggtgtttg gaaacagctt
     5281 ccaggtgcgg atcgacgagt gtgttcgaca aatggctgac atcctgggcc aagtacgggg
     5341 cacagggaat gcatccccta acgccagagc ctcggtggct caggatgcag atagtgtgct
     5401 gcgacctctc atggatttcc tggatggcaa cctcacactg tttgccactg tgtgtgagaa
     5461 gacagtgctg aagcgagtcc tgaaggagct ctggcgagtg gtgatgaaca ccatggagcg
     5521 ggtcatcgtc ctgcccccac tcattgacca gacaggcacc cagctgatct taactgctgc
     5581 caaggagctg agccagcttt ccaaactcaa ggaccacatg gtacgagagg aaacacggaa
     5641 tctcactcca aagcagtgtg ctgtcctcga cttggccttg gacaccgtca agcaatactt
     5701 ccatgcagga ggcaatggtc tgaagaaaac cttcctggaa aagagcccag acctgcagtc
     5761 tctacgttat gccctctctc tgtatacaca gaccacagac actctcatca agacatttgt
     5821 gcgctcacag actgcccagg tacatgatgg gaaaggtatt aggtttactg ctaacgagga
     5881 cattcggcca gaaaaggggg ctggtgtgga cgaccctgtg ggagaagtct ctattcaggt
     5941 ggacttgttt acacatcctg gcactgggga gcataaggtc acagtgaaag tggtagcagc
     6001 caatgatctc aagtggcaga cagcaggtat gttccggcct tttgtggaag tgaccatggt
     6061 tggcccacac caaagcgata agaagaggaa gttcacaacc aagtctaaaa gtaacagctg
     6121 gactcccaag tacaacgaga cttttcattt cctcctggga aatgaagagg gtcccgaggc
     6181 ctatgaattg cagatatgcg tgaaggatta ctgctttgcc cgggaggatc gtgtgatagg
     6241 actggcagtg atgcccctga gggatgtggc agctaagggc agctgtgcct gctggtgccc
     6301 gttgggccgg aagatccaca tggatgagac aggcatgacc attctccgga ttctgtctca
     6361 gaggagcaat gatgaggtag cccgagagtt cgtgaagctc aagtcagagt ctcgatccat
     6421 agaggaaggg agctgaccat ctctgccatc tttgccttgt gtgccatcca gacagcaccc
     6481 actgctcaga tcagtcaggg agagttagct gtgtagccag cttagagtcc tcgtagtcaa
     6541 aaagctgact ctcccagtta aggatgacta aggagaatct tggggtagtt aagactatgg
     6601 ctctttagag aaaagtcctg aatccccaac cagtaggtct gtggtgctag aagctgagct
     6661 gtagaagcta cttcatggag aggtttttcc acaaatagag agggacagac attccaagag
     6721 tgccagttat tcttggtaga caactgtccc ctccacttcc cacttccacc cttctctaaa
     6781 ccacactttt ccaggtaggc acttatgtgc tcctcattag aacatgttta gaaggcctgg
     6841 agcttgtacc tggctgactc catgatgcac agtggagatt ggccagagca ggaacacaaa
     6901 gaatggaatc cactgtcact tgagcagcag gactggtttg tgtggcttca gtgagaacaa
     6961 ggcttggaaa ctgaacaaga taccttcttc tgcaaagaca ccgagctatt tcctttgctc
     7021 agaatagctg tcataagtca aagcaggttc acatggtgct ttggagccct gagcagaata
     7081 tttctttgga atccaggcac caggggtctc atctgcccag agtactccca gctccctact
     7141 cctgtaagca gggagtgatg cttagaacac acacacacac atacacacac acacacacac
     7201 acacacacac acacacatac cacaacacaa cacaacacaa tatcttatat gtatagactt
     7261 gaaggctaac taaggatcca aggatatttt cttgagtagt ccctgatcaa agccaaaaaa
     7321 taatggaaaa tggtctagaa agaactgttc tcacccatgg ccacaagctt ctggccgtcc
     7381 tccttacaga aagcatctag tctttggcct tcctcttttc tttgggatca gctgctgttc
     7441 cccacggatt ggtcaagcat aaagaaggaa cttggacttt cattcctctg tatgagctgg
     7501 atggaggggg gactttagga cttgctggaa ggtcaaagac aaaccctttc agcaggtcag
     7561 atgagcttcc tggactcttg gtcagaaatg tagcttgatc cttggatttc ctgatagtag
     7621 cctcctgaaa ttgctatgga ctcaacattt tccacagtgc gccacaatac aggaaacaaa
     7681 ctgagcatct ttgctgtttt taattattat atgtgccatt attatgggaa attgtagggt
     7741 agactttaat aaattatctt ataacaact
//
