LOCUS       NM_017188               1264 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus unc-119 lipid binding chaperone (Unc119), mRNA.
ACCESSION   NM_017188
VERSION     NM_017188.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Lee,Y., Chung,S., Baek,I.K., Lee,T.H., Paik,S.Y. and Lee,J.
  TITLE     UNC119a bridges the transmission of Fyn signals to Rab11, leading
            to the completion of cytokinesis
  JOURNAL   Cell Cycle 12 (8), 1303-1315 (2013)
   PUBMED   23535298
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Wright,K.J., Baye,L.M., Olivier-Mason,A., Mukhopadhyay,S., Sang,L.,
            Kwong,M., Wang,W., Pretorius,P.R., Sheffield,V.C., Sengupta,P.,
            Slusarski,D.C. and Jackson,P.K.
  TITLE     An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the
            primary cilium
  JOURNAL   Genes Dev 25 (22), 2347-2360 (2011)
   PUBMED   22085962
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Zhang,H., Constantine,R., Vorobiev,S., Chen,Y., Seetharaman,J.,
            Huang,Y.J., Xiao,R., Montelione,G.T., Gerstner,C.D., Davis,M.W.,
            Inana,G., Whitby,F.G., Jorgensen,E.M., Hill,C.P., Tong,L. and
            Baehr,W.
  TITLE     UNC119 is required for G protein trafficking in sensory neurons
  JOURNAL   Nat Neurosci 14 (7), 874-880 (2011)
   PUBMED   21642972
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Karim,Z., Vepachedu,R., Gorska,M. and Alam,R.
  TITLE     UNC119 inhibits dynamin and dynamin-dependent endocytic processes
  JOURNAL   Cell Signal 22 (1), 128-137 (2010)
   PUBMED   19781630
REFERENCE   5  (bases 1 to 1264)
  AUTHORS   Gorska,M.M., Stafford,S.J., Cen,O., Sur,S. and Alam,R.
  TITLE     Unc119, a novel activator of Lck/Fyn, is essential for T cell
            activation
  JOURNAL   J Exp Med 199 (3), 369-379 (2004)
   PUBMED   14757743
REFERENCE   6  (bases 1 to 1264)
  AUTHORS   Kobayashi,A., Kubota,S., Mori,N., McLaren,M.J. and Inana,G.
  TITLE     Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2
            via a putative conserved domain
  JOURNAL   FEBS Lett 534 (1-3), 26-32 (2003)
   PUBMED   12527357
REFERENCE   7  (bases 1 to 1264)
  AUTHORS   Higashide,T., Murakami,A., McLaren,M.J. and Inana,G.
  TITLE     Cloning of the cDNA for a novel photoreceptor protein
  JOURNAL   J Biol Chem 271 (3), 1797-1804 (1996)
   PUBMED   8576185
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U40999.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U40999.1, BC062057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LE"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1264
                     /gene="Unc119"
                     /gene_synonym="RRG4; Uncl19"
                     /note="unc-119 lipid binding chaperone"
                     /db_xref="GeneID:29402"
                     /db_xref="RGD:3942"
     exon            1..254
                     /gene="Unc119"
                     /gene_synonym="RRG4; Uncl19"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..757
                     /gene="Unc119"
                     /gene_synonym="RRG4; Uncl19"
                     /note="UNC-119 homolog; retinal protein 4; retinal gene 4"
                     /codon_start=1
                     /product="protein unc-119 homolog A"
                     /protein_id="NP_058884.1"
                     /db_xref="GeneID:29402"
                     /db_xref="RGD:3942"
                     /translation="MKVKKGGGGTGPGAEPVPGASNRSVEPTREPGAEAESGSESEPE
                     PGPGPRLGPLQGKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVL
                     FEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFR
                     MIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDS
                     FYFVDDRLVMHNKADYSYSGTP"
     exon            255..368
                     /gene="Unc119"
                     /gene_synonym="RRG4; Uncl19"
                     /inference="alignment:Splign:2.1.0"
     exon            369..471
                     /gene="Unc119"
                     /gene_synonym="RRG4; Uncl19"
                     /inference="alignment:Splign:2.1.0"
     exon            472..644
                     /gene="Unc119"
                     /gene_synonym="RRG4; Uncl19"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1253
                     /gene="Unc119"
                     /gene_synonym="RRG4; Uncl19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcgggc gaggatctgc ggccccgcga ggccatgaag gtgaagaagg gcggcggcgg
       61 gaccggaccg ggggcggagc ccgttcctgg ggcctcgaac cggagcgtgg agcccacgcg
      121 ggagcctggg gcggaagccg agtccgggtc cgagtcggag ccggagccag gcccggggcc
      181 cagactgggg ccgctgcagg gcaagcagcc catcgggccg gaggacgtgc tggggctgca
      241 gcggatcacc ggcgactacc tgtgctcccc tgaggaaaat atctacaaga ttgacttcgt
      301 caggttcaag atccgggaca tggactcagg gactgttctt tttgaaatca agaagccccc
      361 tgtttccgaa cggttgccca tcaaccggcg ggacctggac cccaatgcag ggcgctttgt
      421 tcgataccag ttcacacctg ccttcctccg cctaaggcag gtgggagcca cggtggagtt
      481 cacagtggga gacaagccgg tcaacaactt ccgcatgatt gagaggcact actttcgaaa
      541 ccagctcctc aaaagcttcg acttccactt tggcttctgc attcccagca gcaagaacac
      601 ctgtgagcac atctatgact tcccgcctct ctccgaggag ctaatcagtg agatgattcg
      661 tcatccgtat gagacacagt ctgacagctt ctacttcgtg gatgatcggc tggtgatgca
      721 caacaaggca gactattcct acagcgggac cccctgacct ccaacactgc ccctgaggct
      781 ctggcctgga ccctgtgctg tgacctctcc aacactgtct ctatttgggg atggttccag
      841 tggctctgga ccctgagtca gtcttgagag gaaggttccc cagcatccct aggcaagcct
      901 ctgaagcttg tgggagggac agctcgggag actgtcccca tgttcaggaa ggcctcctgc
      961 aagaggagga cttccggatg cctcactagg tccactgggc ctgagtttca gagtagtgtt
     1021 cccttcttga ctgtgactag atcaggttag ggatccgttc cctgtccctt gcccaccacc
     1081 tccagggtgt ttatagttca cagacaaaga tccacattgg gtaccctggt ctcagtcctg
     1141 gcctcctcca tcaggggcca agaaactgcc cgaggtgtga gcggggtggg tccagattgc
     1201 aacctgtagg acctggacaa actgtatata gttttcaata aaccttttct gttaaaaaaa
     1261 aaaa
//
