LOCUS       NM_001025402            1637 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus uridine monophosphate synthetase (Umps), mRNA.
ACCESSION   NM_001025402 XM_213618
VERSION     NM_001025402.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1637)
  AUTHORS   Pellicer,M., Garcia-Gonzalez,X., Garcia,M.I., Robles,L.,
            Gravalos,C., Garcia-Alfonso,P., Pachon,V., Longo,F., Martinez,V.,
            Blanco,C., Iglesias,I., Sanjurjo,M. and Lopez-Fernandez,L.A.
  TITLE     Identification of new SNPs associated with severe toxicity to
            capecitabine
  JOURNAL   Pharmacol Res 120, 133-137 (2017)
   PUBMED   28347776
REFERENCE   2  (bases 1 to 1637)
  AUTHORS   Wittmann,J.G., Heinrich,D., Gasow,K., Frey,A., Diederichsen,U. and
            Rudolph,M.G.
  TITLE     Structures of the human orotidine-5'-monophosphate decarboxylase
            support a covalent mechanism and provide a framework for drug
            design
  JOURNAL   Structure 16 (1), 82-92 (2008)
   PUBMED   18184586
REFERENCE   3  (bases 1 to 1637)
  AUTHORS   Sigoillot,F.D., Kotsis,D.H., Serre,V., Sigoillot,S.M., Evans,D.R.
            and Guy,H.I.
  TITLE     Nuclear localization and mitogen-activated protein kinase
            phosphorylation of the multifunctional protein CAD
  JOURNAL   J Biol Chem 280 (27), 25611-25620 (2005)
   PUBMED   15890648
REFERENCE   4  (bases 1 to 1637)
  AUTHORS   Evans,D.R. and Guy,H.I.
  TITLE     Mammalian pyrimidine biosynthesis: fresh insights into an ancient
            pathway
  JOURNAL   J Biol Chem 279 (32), 33035-33038 (2004)
   PUBMED   15096496
  REMARK    Review article
REFERENCE   5  (bases 1 to 1637)
  AUTHORS   Krungkrai,J., Wutipraditkul,N., Prapunwattana,P., Krungkrai,S.R.
            and Rochanakij,S.
  TITLE     A nonradioactive high-performance liquid chromatographic microassay
            for uridine 5'-monophosphate synthase, orotate
            phosphoribosyltransferase, and orotidine 5'-monophosphate
            decarboxylase
  JOURNAL   Anal Biochem 299 (2), 162-168 (2001)
   PUBMED   11730338
REFERENCE   6  (bases 1 to 1637)
  AUTHORS   Suchi,M., Mizuno,H., Kawai,Y., Tsuboi,T., Sumi,S., Okajima,K.,
            Hodgson,M.E., Ogawa,H. and Wada,Y.
  TITLE     Molecular cloning of the human UMP synthase gene and
            characterization of point mutations in two hereditary orotic
            aciduria families
  JOURNAL   Am J Hum Genet 60 (3), 525-539 (1997)
   PUBMED   9042911
REFERENCE   7  (bases 1 to 1637)
  AUTHORS   Kunjara,S., Sochor,M., Bennett,M., Greenbaum,A.L. and McLean,P.
  TITLE     Pyrimidine nucleotide synthesis in the rat mammary gland: changes
            in the lactation cycle and effects of diabetes
  JOURNAL   Biochem Med Metab Biol 48 (3), 263-274 (1992)
   PUBMED   1476792
REFERENCE   8  (bases 1 to 1637)
  AUTHORS   Weber,G., Lui,M.S., Jayaram,H.N., Pillwein,K., Natsumeda,Y.,
            Faderan,M.A. and Reardon,M.A.
  TITLE     Regulation of purine and pyrimidine metabolism by insulin and by
            resistance to tiazofurin
  JOURNAL   Adv Enzyme Regul 23, 81-99 (1985)
   PUBMED   3907307
REFERENCE   9  (bases 1 to 1637)
  AUTHORS   Suttle,D.P.
  TITLE     Increased levels of UMP synthase protein and mRNA in
            pyrazofurin-resistant rat hepatoma cells
  JOURNAL   J Biol Chem 258 (12), 7707-7713 (1983)
   PUBMED   6134725
REFERENCE   10 (bases 1 to 1637)
  AUTHORS   McClard,R.W., Black,M.J., Livingstone,L.R. and Jones,M.E.
  TITLE     Isolation and initial characterization of the single polypeptide
            that synthesizes uridine 5'-monophosphate from orotate in Ehrlich
            ascites carcinoma. Purification by tandem affinity chromatography
            of uridine-5'-monophosphate synthase
  JOURNAL   Biochemistry 19 (20), 4699-4706 (1980)
   PUBMED   6893554
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098033.1.
            
            On Jul 15, 2005 this sequence version replaced XM_213618.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098033.1, SRR8487227.220215.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..1637
                     /gene="Umps"
                     /note="uridine monophosphate synthetase"
                     /db_xref="GeneID:288051"
                     /db_xref="RGD:1311908"
     exon            1..158
                     /gene="Umps"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1448
                     /gene="Umps"
                     /note="uridine monophosphate synthase"
                     /codon_start=1
                     /product="uridine 5'-monophosphate synthase"
                     /protein_id="NP_001020573.1"
                     /db_xref="GeneID:288051"
                     /db_xref="RGD:1311908"
                     /translation="MEVARQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIV
                     SRPRLLSQVADILFQTARNAGISFDSVCGVPYTALPLATVICSANHIPMLIRRKETKD
                     YGTKRLVEGEINPGQTCLVIEDVVTSGASVLETVEVLQKEGLKVTDAIVLLDREQGGK
                     DKLQAQGIRLHSVCTLSEMLEILEQQKKIDAEMVGRVKRFIQENVFTAANHNGVPPPE
                     KKACKELSFGARAELPGVHPLASKLLTLMQKKETNLCLSADVSEARELLQLADALGPS
                     ICMLKTHVDILNDFTLDVMEELTTLAKRHEFLIFEDRKFADIGNTVKKQYESGIFKIA
                     SWADVVNAHVVPGSGVVKGLQEVGLPLHRACLLIAEMSSAGSLATGDYTKAAVGMAEE
                     HCEFVIGFISGSRVSMKPEFLHLTPGVQLETGGDHLGQQYNSPQEVVGKRGSDVIIVG
                     RGILAAANRLEAAEMYRKAAWEAYLSRLAVQ"
     exon            159..312
                     /gene="Umps"
                     /inference="alignment:Splign:2.1.0"
     exon            313..984
                     /gene="Umps"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1160
                     /gene="Umps"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1275
                     /gene="Umps"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1606
                     /gene="Umps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatggaggt cgcccgccaa gccctgggcc ccttggtcac cgagctgtat gacgtgcagg
       61 ctttcaagtt cgggagcttc gtgctgaaga gcgggctctc ctccccagtc tacatcgacc
      121 tgcggggcat cgtgtcacgc ccgcgtcttc tcagtcaggt cgcagacatt ttattccaaa
      181 ctgccaggaa tgccgggatc agttttgaca gtgtgtgtgg agttccttat acagcgttac
      241 cactagcaac agttatctgt tcagccaatc atattcccat gctcattagg aggaaggaaa
      301 caaaggatta tggtactaag cgccttgtag aaggagagat taatccgggg cagacctgtc
      361 tggtcatcga ggatgtcgtc accagtgggg ccagcgtttt ggagactgtt gaagttcttc
      421 agaaggaggg tctaaaggtg actgatgcca tcgtgctgtt ggaccgcgag cagggaggca
      481 aggacaagct gcaggctcag ggcatccgtc tccactctgt gtgcacgttg tcggaaatgc
      541 tggagatcct tgagcagcag aaaaagatcg acgctgagat ggtcgggaga gtgaagaggt
      601 tcattcagga gaatgtgttc acagcagcta accataatgg cgttccccct cccgagaaga
      661 aagcatgcaa ggaactgagc tttggcgccc gagcagagct gcctggagtc cacccacttg
      721 cctcaaagct tctcacgctc atgcagaaga aggagaccaa tctgtgtctg tctgctgacg
      781 tgtcggaggc cagagagctg ctgcagctag ccgatgccct aggacccagc atctgcatgc
      841 tcaaaactca tgtcgatatt ctgaacgatt ttactctgga tgtgatggag gagttgacaa
      901 ccctggcaaa acgccatgag tttttaatat ttgaagacag gaaatttgct gatataggaa
      961 acacagttaa aaagcagtat gaaagtggca tctttaaaat agcttcctgg gcagacgtag
     1021 tgaatgccca tgtggtgcca ggctcaggag ttgtgaaggg cttacaggaa gtgggtctgc
     1081 ctttacatcg agcctgcctg ctcattgcag aaatgagctc tgctggctcc ttggccactg
     1141 gagactacac caaagcagca gttgggatgg ctgaggagca ctgtgagttt gtcattggct
     1201 ttatttctgg ctcccgagta agcatgaaac cggagtttct tcacttgacc ccaggagttc
     1261 agttagagac aggaggggat caccttggcc agcagtacaa tagtccccaa gaagtggttg
     1321 gtaaacgagg ttctgatgtc atcattgtgg gccggggaat actcgcagca gcaaaccgcc
     1381 tggaagcagc tgagatgtac agaaaagctg cctgggaagc ttatttgagt aggcttgctg
     1441 tccagtgaga aggcactgaa cgtgggtggt agcccaaagt cgctggcttc aaagaacagt
     1501 gctcagggtc ctgcacaggg tttgtgagag acagactctg cagcaccgtg ttgtgtcttt
     1561 aacttgtaac cactgcactg tactataacg agctctttaa agctttaaaa aaaaaaaaaa
     1621 aaaaaaaaaa aaaaaaa
//
