LOCUS       NM_017082               2211 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus uromodulin (Umod), mRNA.
ACCESSION   NM_017082
VERSION     NM_017082.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2211)
  AUTHORS   Ma,L., Liu,Y., Landry,N.K., El-Achkar,T.M., Lieske,J.C. and Wu,X.R.
  TITLE     Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in
            transgenic mice causes progressive renal damage and hyperuricemia
  JOURNAL   PLoS One 12 (11), e0186769 (2017)
   PUBMED   29145399
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2211)
  AUTHORS   Johnson,B.G., Dang,L.T., Marsh,G., Roach,A.M., Levine,Z.G.,
            Monti,A., Reyon,D., Feigenbaum,L. and Duffield,J.S.
  TITLE     Uromodulin p.Cys147Trp mutation drives kidney disease by activating
            ER stress and apoptosis
  JOURNAL   J Clin Invest 127 (11), 3954-3969 (2017)
   PUBMED   28990932
REFERENCE   3  (bases 1 to 2211)
  AUTHORS   Trudu,M., Schaeffer,C., Riba,M., Ikehata,M., Brambilla,P.,
            Messa,P., Martinelli-Boneschi,F., Rastaldi,M.P. and Rampoldi,L.
  TITLE     Early involvement of cellular stress and inflammatory signals in
            the pathogenesis of tubulointerstitial kidney disease due to UMOD
            mutations
  JOURNAL   Sci Rep 7 (1), 7383 (2017)
   PUBMED   28785050
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2211)
  AUTHORS   Mary,S., Small,H.Y., Siwy,J., Mullen,W., Giri,A. and Delles,C.
  TITLE     Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone
            Spontaneously Hypertensive Rat
  JOURNAL   Hypertension 69 (5), 910-918 (2017)
   PUBMED   28348009
  REMARK    GeneRIF: Two forms of uromodulin (polymerization competent and
            polymerization incompetent) were found in urine from both
            Wistar-Kyoto and SHRSP, where the polymerization-incompetent form
            was increased in a pregnancy-specific manner in stroke-prone
            spontaneously hypertensive rats.
REFERENCE   5  (bases 1 to 2211)
  AUTHORS   Schaeffer,C., Cattaneo,A., Trudu,M., Santambrogio,S.,
            Bernascone,I., Giachino,D., Caridi,G., Campo,A., Murtas,C.,
            Benoni,S., Izzi,C., De Marchi,M., Amoroso,A., Ghiggeri,G.M.,
            Scolari,F., Bachi,A. and Rampoldi,L.
  TITLE     Urinary secretion and extracellular aggregation of mutant
            uromodulin isoforms
  JOURNAL   Kidney Int 81 (8), 769-778 (2012)
   PUBMED   22237754
REFERENCE   6  (bases 1 to 2211)
  AUTHORS   Yu,H., Papa,F. and Sukhatme,V.P.
  TITLE     Bovine and rodent tamm-horsfall protein (THP) genes: cloning,
            structural analysis, and promoter identification
  JOURNAL   Gene Expr 4 (1-2), 63-75 (1994)
   PUBMED   7531049
REFERENCE   7  (bases 1 to 2211)
  AUTHORS   Fukuoka,S., Freedman,S.D., Yu,H., Sukhatme,V.P. and Scheele,G.A.
  TITLE     GP-2/THP gene family encodes self-binding
            glycosylphosphatidylinositol-anchored proteins in apical secretory
            compartments of pancreas and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1189-1193 (1992)
   PUBMED   1531535
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 Apr 15;89(8):3669]
REFERENCE   8  (bases 1 to 2211)
  AUTHORS   Rindler,M.J., Naik,S.S., Li,N., Hoops,T.C. and Peraldi,M.N.
  TITLE     Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is a
            phosphatidylinositol-linked membrane protein
  JOURNAL   J Biol Chem 265 (34), 20784-20789 (1990)
   PUBMED   2249987
REFERENCE   9  (bases 1 to 2211)
  AUTHORS   Bachmann,S., Koeppen-Hagemann,I. and Kriz,W.
  TITLE     Ultrastructural localization of Tamm-Horsfall glycoprotein (THP) in
            rat kidney as revealed by protein A-gold immunocytochemistry
  JOURNAL   Histochemistry 83 (6), 531-538 (1985)
   PUBMED   3910623
REFERENCE   10 (bases 1 to 2211)
  AUTHORS   Sikri,K.L., Foster,C.L., MacHugh,N. and Marshall,R.D.
  TITLE     Localization of Tamm-Horsfall glycoprotein in the human kidney
            using immuno-fluorescence and immuno-electron microscopical
            techniques
  JOURNAL   J Anat 132 (Pt 4), 597-605 (1981)
   PUBMED   7028707
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017082.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M63510.1, BC081814.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000001.1  183260907-183261016 c
            111-890             JAXUCZ010000001.1  183259088-183259867 c
            891-998             JAXUCZ010000001.1  183258892-183258999 c
            999-1207            JAXUCZ010000001.1  183257332-183257540 c
            1208-1356           JAXUCZ010000001.1  183256346-183256494 c
            1357-1602           JAXUCZ010000001.1  183254300-183254545 c
            1603-1765           JAXUCZ010000001.1  183251227-183251389 c
            1766-1847           JAXUCZ010000001.1  183250171-183250252 c
            1848-1889           JAXUCZ010000001.1  183249433-183249474 c
            1890-2211           JAXUCZ010000001.1  183247676-183247997 c
FEATURES             Location/Qualifiers
     source          1..2211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..2211
                     /gene="Umod"
                     /gene_synonym="THP"
                     /note="uromodulin"
                     /db_xref="GeneID:25128"
                     /db_xref="RGD:3940"
     exon            1..110
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1951
                     /gene="Umod"
                     /gene_synonym="THP"
                     /note="tamm-Horsfall urinary glycoprotein; Urmodulin
                     (Tamm-Horsfall protein)"
                     /codon_start=1
                     /product="uromodulin precursor"
                     /protein_id="NP_058778.2"
                     /db_xref="GeneID:25128"
                     /db_xref="RGD:3940"
                     /translation="MGQLLSLTWLLLVMVVTPWFTVAGANDSPEARRCSECHDNATCV
                     LDGVVTTCSCQAGFTGDGLVCEDIDECATPWTHNCSNSICMNTLGSYECSCQDGFRLT
                     PGLGCIDVNECTEQGLSNCHSLATCVNTEGSYSCVCPKGYRGDGWYCECSPGSCEPGL
                     DCLPQGPSGKLVCQDPCNVYETLTEYWRSTDYGAGYSCDSDMHGWYRFTGQGGVRMAE
                     TCVPVLRCNTAAPMWLNGSHPSSREGIVSRTACAHWSDHCCLWSTEIQVKACPGGFYV
                     YNLTEPPECNLAYCTDPSSVEGTCEECGVDEDCVSDNGRWRCQCKQDFNITDVSLLEH
                     RLECEANEIKISLSKCQLQSLGFMKVFMYLNDRQCSGFSERGERDWMSIVTPARDGPC
                     GTVLRRNETHATYSNTLYLASEIIIRDINIRINFECSYPLDMKVSLKTSLQPMVSALN
                     ISLGGTGKFTVQMALFQNPTYTQPYQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTN
                     CYATPSSNSTDPVKYFIIQDRCPHTEDTTIQVTENGESSQARFSIQMFRFAGNSDLVY
                     LHCEVYLCDTMSEQCKPTCSGTRYRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNL
                     GFLSIWLLLFLSATLTLMVH"
     exon            111..890
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            891..998
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1207
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1356
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1602
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1765
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1847
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1889
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2211
                     /gene="Umod"
                     /gene_synonym="THP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcagagca caaaggatgg ggcagctgct ctctttgacc tggctgctgc tggttatggt
       61 ggtaactccc tggttcactg tagctggagc caatgactca ccagaagcaa gaaggtgttc
      121 tgaatgccac gacaatgcca cctgtgtgtt ggatggggtg gtcaccacat gctcctgcca
      181 ggcaggcttc actggagatg ggctggtgtg tgaggacata gatgagtgtg ccaccccgtg
      241 gactcacaac tgctccaaca gcatctgcat gaacacactg ggctcctacg agtgctcctg
      301 tcaggatggc tttcgtctga cgcctgggct gggctgcatt gatgtgaatg agtgcacaga
      361 gcaggggctc agtaactgtc attccctggc tacctgtgtc aacacggaag gcagctactc
      421 atgcgtgtgt cccaagggct atagagggga tggttggtac tgtgagtgct cccctggctc
      481 ctgtgagcca gggctggact gcttgcctca gggtcccagt ggaaagctgg tgtgccaaga
      541 cccctgcaat gtctatgaaa ccctgactga gtactggcgc agcacagact atggtgccgg
      601 ctactcctgt gactcagata tgcacggctg gtaccggttc acaggccagg gtggcgttcg
      661 catggctgag acctgtgtgc ccgtactgag gtgcaacacg gctgcaccca tgtggctcaa
      721 tggctcgcat ccttcgagca gagagggcat tgtgagccgc acagcctgcg cacactggag
      781 cgaccactgc tgcctgtggt ccacagagat ccaggtgaag gcctgccctg gtggcttcta
      841 tgtttacaac ttgacagagc cccctgagtg caatctggct tactgcaccg atcctagctc
      901 cgtggagggg acttgcgaag aatgcggggt agatgaagac tgcgtatctg ataacggcag
      961 atggcgctgc cagtgtaaac aggacttcaa cattacagat gtctccctcc tggagcacag
     1021 gctggagtgt gaggccaatg aaatcaagat atccctcagc aagtgccagc tacagagttt
     1081 gggctttatg aaggtcttca tgtacctgaa tgacagacag tgctcaggct tcagtgagag
     1141 gggtgaacga gactggatgt ccatagtgac tcctgccagg gatggtccct gtgggacagt
     1201 attgaggaga aatgaaaccc acgccaccta cagcaacacc ctctacctgg caagtgagat
     1261 catcatcagg gatatcaaca tcagaatcaa ctttgaatgc tcttaccctc tggacatgaa
     1321 agtcagtctg aagacctccc tacagcctat ggttagtgcc ttgaacatca gcttgggtgg
     1381 gacaggcaag ttcactgtgc agatggcact gttccagaac cctacctaca cacagcccta
     1441 ccaaggtcct tctgtgatgc tctccactga ggcttttctg tatgtgggca ccatgctgga
     1501 tgggggtgac ttgtcccggt ttgtactgct aatgaccaac tgctatgcca cacccagtag
     1561 caactccacg gaccctgtaa aatacttcat tatccaggac agatgtccac atacagaaga
     1621 tacaaccatt caggtgacag agaatggcga gtcctctcag gcccggttct ctattcagat
     1681 gttccggttt gcaggaaact ccgaccttgt ctaccttcac tgcgaggtgt acctgtgtga
     1741 cactatgagt gagcagtgta aacctacctg ttctggtact agatatcgaa gtgggaactt
     1801 catagatcag acccgtgtcc tgaacttggg tcccatcaca cgacaaggtg tccaggcctc
     1861 agtgtccaag gctgcttcca gcaacttggg gttcctgagc atctggctgc tgctgtttct
     1921 ctcagctact ttgaccctga tggttcattg atggaaaaca gaaaacctgg tgtggctccc
     1981 agttcacttc ctgctggcca ggagtgggga tgcaggctgg taagcagcca ggagagaggg
     2041 agctcacact gcctccagct tgcacttacc cttttccttt aaccctcacc atcaaaaccg
     2101 agttgatatc tttcaatgct gctgattctt caactggaac ttgtaatgtg tctgtacatg
     2161 aagcccctgt ctctttaagg aatgtatcaa aataataagt ttaaaacaat c
//
